SI1999259T1 - Usmerjeno vključevanje amino kislin v molekule - Google Patents
Usmerjeno vključevanje amino kislin v molekuleInfo
- Publication number
- SI1999259T1 SI1999259T1 SI200731519T SI200731519T SI1999259T1 SI 1999259 T1 SI1999259 T1 SI 1999259T1 SI 200731519 T SI200731519 T SI 200731519T SI 200731519 T SI200731519 T SI 200731519T SI 1999259 T1 SI1999259 T1 SI 1999259T1
- Authority
- SI
- Slovenia
- Prior art keywords
- molecules
- site
- amino acids
- specific incorporation
- incorporation
- Prior art date
Links
- 150000001413 amino acids Chemical class 0.000 title 1
- 238000010348 incorporation Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77937606P | 2006-03-03 | 2006-03-03 | |
| US77937506P | 2006-03-03 | 2006-03-03 | |
| EP07752295.1A EP1999259B1 (en) | 2006-03-03 | 2007-03-05 | Site-specific incorporation of amino acids into molecules |
| PCT/US2007/005581 WO2007103307A2 (en) | 2006-03-03 | 2007-03-05 | Site-specific incorporation of amino acids into molecules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1999259T1 true SI1999259T1 (sl) | 2014-11-28 |
Family
ID=38462077
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200731519T SI1999259T1 (sl) | 2006-03-03 | 2007-03-05 | Usmerjeno vključevanje amino kislin v molekule |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8518666B2 (enExample) |
| EP (1) | EP1999259B1 (enExample) |
| JP (2) | JP5808882B2 (enExample) |
| AU (2) | AU2007224019A1 (enExample) |
| CA (1) | CA2644474A1 (enExample) |
| DK (1) | DK1999259T3 (enExample) |
| ES (1) | ES2504521T3 (enExample) |
| PL (1) | PL1999259T3 (enExample) |
| PT (1) | PT1999259E (enExample) |
| SI (1) | SI1999259T1 (enExample) |
| WO (1) | WO2007103307A2 (enExample) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20050287639A1 (en) | 2004-05-17 | 2005-12-29 | California Institute Of Technology | Methods of incorporating amino acid analogs into proteins |
| US7632492B2 (en) * | 2006-05-02 | 2009-12-15 | Allozyne, Inc. | Modified human interferon-β polypeptides |
| US20080096819A1 (en) * | 2006-05-02 | 2008-04-24 | Allozyne, Inc. | Amino acid substituted molecules |
| CA2707840A1 (en) * | 2007-08-20 | 2009-02-26 | Allozyne, Inc. | Amino acid substituted molecules |
| US20090148887A1 (en) * | 2007-11-02 | 2009-06-11 | The Scripps Research Institute | Genetically encoded boronate amino acid |
| EP2376647B1 (en) * | 2009-01-12 | 2014-03-05 | Sutro Biopharma, Inc. | Mono charging system for selectively introducing non-native amino acids into proteins using an in vitro protein synthesis system |
| WO2010099477A2 (en) | 2009-02-27 | 2010-09-02 | Atyr Pharma, Inc. | Polypeptide structural motifs associated with cell signaling activity |
| MY189079A (en) * | 2009-12-11 | 2022-01-25 | Univ Case Western Reserve | Insulin analogues with chlorinated amino acids |
| JP6066900B2 (ja) | 2010-04-26 | 2017-01-25 | エータイアー ファーマ, インコーポレイテッド | システイニルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| US8961960B2 (en) | 2010-04-27 | 2015-02-24 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl tRNA synthetases |
| ES2638311T3 (es) | 2010-04-27 | 2017-10-19 | Atyr Pharma, Inc. | Descubrimiento innovador de composiciones terapéuticas, diagnósticas y de anticuerpos relacionadas con fragmentos de proteína de treonil ARNt sintetasas |
| JP6008837B2 (ja) | 2010-04-28 | 2016-10-19 | エータイアー ファーマ, インコーポレイテッド | アラニルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| WO2011139907A2 (en) | 2010-04-29 | 2011-11-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl trna synthetases |
| US8986680B2 (en) | 2010-04-29 | 2015-03-24 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Asparaginyl tRNA synthetases |
| JP6008841B2 (ja) | 2010-05-03 | 2016-10-19 | エータイアー ファーマ, インコーポレイテッド | メチオニルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| US8961961B2 (en) | 2010-05-03 | 2015-02-24 | a Tyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of arginyl-tRNA synthetases |
| AU2011248227B2 (en) | 2010-05-03 | 2016-12-01 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-tRNA synthetases |
| CA2797799C (en) | 2010-05-03 | 2020-12-08 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of seryl-trna synthetases |
| EP2566499B1 (en) | 2010-05-04 | 2017-01-25 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-trna synthetase complex |
| JP6008843B2 (ja) | 2010-05-04 | 2016-10-19 | エータイアー ファーマ, インコーポレイテッド | グルタミル−プロリルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| EP2568996B1 (en) * | 2010-05-14 | 2017-10-04 | aTyr Pharma, Inc. | Therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-trna synthetases |
| AU2011256366C1 (en) | 2010-05-17 | 2017-06-15 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-tRNA synthetases |
| CN103096913B (zh) | 2010-05-27 | 2017-07-18 | Atyr 医药公司 | 与谷氨酰胺酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| CA2800281C (en) | 2010-06-01 | 2021-01-12 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of lysyl-trna synthetases |
| KR20130102534A (ko) | 2010-07-12 | 2013-09-17 | 에이티와이알 파마, 인코포레이티드 | 히스티딜trna 합성효소의 단백질 단편에 관련된 치료적, 진단적, 및 항체 조성물의 혁신적 발견 |
| US8999321B2 (en) | 2010-07-12 | 2015-04-07 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases |
| CA2804278C (en) | 2010-07-12 | 2021-07-13 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of aspartyl-trna synthetases |
| CA2804416C (en) | 2010-07-12 | 2020-04-28 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-trna synthetases |
| JP5964304B2 (ja) | 2010-08-25 | 2016-08-03 | エータイアー ファーマ, インコーポレイテッド | チロシルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| CA2810668A1 (en) * | 2010-09-08 | 2012-03-15 | Halozyme, Inc. | Methods for assessing and identifying or evolving conditionally active therapeutic proteins |
| EP2624857B1 (en) | 2010-10-06 | 2017-08-02 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of tryptophanyl trna synthetases |
| US20140140962A1 (en) * | 2011-04-29 | 2014-05-22 | The Research Foundation Of State University Of New York | Viruses modified with unnatural moieties and methods of use thereof |
| US9714419B2 (en) | 2011-08-09 | 2017-07-25 | Atyr Pharma, Inc. | PEGylated tyrosyl-tRNA synthetase polypeptides |
| WO2013065048A1 (en) * | 2011-11-03 | 2013-05-10 | Yeda Research And Development Co. Ltd. | Transgenic plants resistant to non-protein amino acids |
| US9816084B2 (en) | 2011-12-06 | 2017-11-14 | Atyr Pharma, Inc. | Aspartyl-tRNA synthetases |
| WO2013086228A1 (en) | 2011-12-06 | 2013-06-13 | Atyr Pharma, Inc. | Pegylated aspartyl-trna synthetase polypeptides |
| TWI579296B (zh) | 2011-12-28 | 2017-04-21 | Chugai Pharmaceutical Co Ltd | Cyclization of Peptide Compounds |
| CA2858613A1 (en) | 2011-12-29 | 2013-08-08 | Atyr Pharma, Inc. | Aspartyl-trna synthetase-fc conjugates |
| WO2013188635A2 (en) * | 2012-06-14 | 2013-12-19 | The Trustees Of The University Of Pennsylvania | Novel methods of identifying proteins via n-terminal tagging and selective pull-down |
| ES2708565T3 (es) | 2013-03-15 | 2019-04-10 | Atyr Pharma Inc | Conjugados de Fc-histidil-ARNt sintetasa |
| US20160055293A1 (en) * | 2013-03-29 | 2016-02-25 | University Of Washington Through Its Center For Commercialization | Systems, Algorithms, and Software for Molecular Inversion Probe (MIP) Design |
| EP2876165A1 (en) | 2013-11-22 | 2015-05-27 | ACIB GmbH | Improved method for producing modifed target polypeptides |
| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| EP3269809B1 (en) | 2015-03-13 | 2022-07-27 | Chugai Seiyaku Kabushiki Kaisha | MODIFIED AMINOACYL-tRNA SYNTHETASE AND USE THEREOF |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| GB201600512D0 (en) * | 2016-01-12 | 2016-02-24 | Univ York | Recombinant protein production |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US12391971B2 (en) | 2017-01-31 | 2025-08-19 | Chugai Seiyaku Kabushiki Kaisha | Method for synthesizing peptides in cell-free translation system |
| MX2019008449A (es) | 2017-02-08 | 2019-09-09 | Bristol Myers Squibb Co | Polipetidos de relaxina modificada que comprenden un mejorador farmacocinetico y sus usos. |
| JP6917050B2 (ja) * | 2017-03-06 | 2021-08-11 | 学校法人早稲田大学 | 最適特性を有する非天然型タンパク質の製造方法 |
| EP3612215B1 (en) | 2017-04-20 | 2024-08-28 | aTyr Pharma, Inc. | Compositions for treating lung inflammation |
| EP3636656A4 (en) | 2017-06-09 | 2021-04-14 | Chugai Seiyaku Kabushiki Kaisha | METHOD OF SYNTHESIS OF PEPTIDE WITH N-SUBSTITUTED AMINO ACID |
| JP7295841B2 (ja) * | 2017-07-25 | 2023-06-21 | バイオコン・リミテッド | インスリン&インスリン類似体の配列の同定のためのペプチドマッピング方法 |
| JP7411414B2 (ja) | 2017-12-15 | 2024-01-11 | 中外製薬株式会社 | ペプチドの製造方法、及び塩基の処理方法 |
| CN108588040B (zh) * | 2018-06-08 | 2021-06-15 | 中国医学科学院病原生物学研究所 | 重组MtMetRS、其晶体及它们在制备抗结核药物中的应用 |
| CN111212661B (zh) * | 2018-09-11 | 2023-09-12 | 北京泰德制药股份有限公司 | 白介素-2多肽偶联物及其用途 |
| WO2020095983A1 (ja) | 2018-11-07 | 2020-05-14 | 中外製薬株式会社 | O-置換セリン誘導体の製造方法 |
| CN119143631A (zh) | 2018-11-30 | 2024-12-17 | 中外制药株式会社 | 用于肽化合物或酰胺化合物的脱保护方法和在固相反应中的树脂脱除方法以及用于生产肽化合物的方法 |
| JP7357642B2 (ja) | 2018-12-26 | 2023-10-06 | 中外製薬株式会社 | コドン拡張のための変異tRNA |
| JP2022525333A (ja) * | 2019-03-13 | 2022-05-12 | セント・ジュード・チルドレンズ・リサーチ・ホスピタル | 肺炎連鎖球菌の伝染を低減させるためのワクチン組成物および方法 |
| US12071396B2 (en) | 2019-03-15 | 2024-08-27 | Chugai Seiyaku Kabushiki Kaisha | Method for preparing aromatic amino acid derivative |
| BR112022007535A2 (pt) | 2019-11-07 | 2022-07-12 | Chugai Pharmaceutical Co Ltd | Composto peptídico cíclico tendo ação inibitória de kras |
| JP7744244B2 (ja) | 2019-12-26 | 2025-09-25 | 中外製薬株式会社 | 翻訳用組成物及びペプチドの製造方法 |
| AU2021247169A1 (en) | 2020-03-31 | 2022-10-20 | Protomer Technologies Inc. | Conjugates for selective responsiveness to vicinal diols |
| EP4146665A1 (en) | 2020-05-05 | 2023-03-15 | Genentech, Inc. | Systems and methods for tyrosinase-mediated site-specific protein conjugation |
| KR20230028363A (ko) | 2020-06-25 | 2023-02-28 | 추가이 세이야쿠 가부시키가이샤 | 개변된 유전 암호표를 갖는 번역계 |
| WO2022079639A1 (en) * | 2020-10-17 | 2022-04-21 | Sun Pharmaceutical Industries Limited | Glp-1/gip dual agonists |
| TW202237188A (zh) | 2020-11-19 | 2022-10-01 | 美商普羅托莫科技公司 | 芳族含硼化合物及胰島素類似物 |
| WO2023069816A2 (en) | 2021-09-20 | 2023-04-27 | The Broad Institute, Inc. | Compositions and methods for multiplex decoding of quadruplet codons |
| KR20250005573A (ko) | 2022-05-18 | 2025-01-09 | 프로토머 테크놀로지스 인크. | 방향족 붕소-함유 화합물 및 관련 인슐린 유사체 |
| CN119731319A (zh) * | 2022-06-22 | 2025-03-28 | 芝加哥大学 | 工程化tRNA及其使用方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU668505B2 (en) | 1991-03-18 | 1996-05-09 | Scripps Research Institute, The | Oligosaccharide enzyme substrates and inhibitors: methods and compositions |
| JP2002510966A (ja) | 1997-04-11 | 2002-04-09 | カリフォルニア・インスティテュート・オブ・テクノロジー | 自動蛋白質デザインのための装置および方法 |
| US7449443B2 (en) | 2000-03-23 | 2008-11-11 | California Institute Of Technology | Method for stabilization of proteins using non-natural amino acids |
| EP1490483B1 (en) * | 2001-04-19 | 2015-06-03 | The Scripps Research Institute | In vivo incorporation of unnatural amino acids |
| US7139665B2 (en) * | 2002-02-27 | 2006-11-21 | California Institute Of Technology | Computational method for designing enzymes for incorporation of non natural amino acids into proteins |
| KR20050073559A (ko) | 2002-10-16 | 2005-07-14 | 더 스크립스 리서치 인스티튜트 | 당단백질 합성 |
| BRPI0507159A (pt) | 2004-02-02 | 2007-06-26 | Ambrx Inc | polipeptìdeos em feixe de quatro hélices humanos modificados e seus usos |
| US20050260711A1 (en) | 2004-03-30 | 2005-11-24 | Deepshikha Datta | Modulating pH-sensitive binding using non-natural amino acids |
| US20050287639A1 (en) | 2004-05-17 | 2005-12-29 | California Institute Of Technology | Methods of incorporating amino acid analogs into proteins |
| MX2007000728A (es) | 2004-07-21 | 2007-03-15 | Ambrx Inc | Polipeptidos biosinteticos que utilizan amino acidos no naturalmente codificados. |
| EP1797177A4 (en) | 2004-09-21 | 2008-07-09 | Scripps Research Inst | ADDITION OF PHOTOREGULATED AMINO ACIDS TO THE GENETIC CODE |
| EP1809758A4 (en) | 2004-10-20 | 2009-04-01 | Scripps Research Inst | LOCAL IN VIVO INSTALLATION OF N-ACETYLGALACTOSAMINE AMINO ACIDS IN EU BACTERIA |
| CA2590429C (en) | 2004-12-22 | 2014-10-07 | Ambrx, Inc. | Compositions of aminoacyl-trna synthetase and uses thereof |
| GB2438982A (en) | 2004-12-22 | 2007-12-12 | Ambrx Inc | Compostions containing, methods involving, and uses of non-natural amino acids and polypeptides |
| WO2006132969A2 (en) | 2005-06-03 | 2006-12-14 | Ambrx, Inc. | Incorporation of non-naturally encoded amino acids into proteins |
| JP4829969B2 (ja) | 2005-08-18 | 2011-12-07 | アンブルックス,インコーポレイテッド | tRNA組成物、およびその使用 |
| EP1968635B1 (en) | 2005-12-14 | 2014-09-17 | Ambrx, Inc. | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides |
| CN101384711A (zh) | 2006-01-19 | 2009-03-11 | Ambrx公司 | 具有经调节的免疫原性的非天然氨基酸多肽 |
-
2007
- 2007-03-05 JP JP2008557434A patent/JP5808882B2/ja active Active
- 2007-03-05 DK DK07752295.1T patent/DK1999259T3/da active
- 2007-03-05 CA CA002644474A patent/CA2644474A1/en not_active Abandoned
- 2007-03-05 EP EP07752295.1A patent/EP1999259B1/en not_active Not-in-force
- 2007-03-05 PT PT77522951T patent/PT1999259E/pt unknown
- 2007-03-05 WO PCT/US2007/005581 patent/WO2007103307A2/en not_active Ceased
- 2007-03-05 PL PL07752295T patent/PL1999259T3/pl unknown
- 2007-03-05 ES ES07752295.1T patent/ES2504521T3/es active Active
- 2007-03-05 SI SI200731519T patent/SI1999259T1/sl unknown
- 2007-03-05 US US11/682,272 patent/US8518666B2/en not_active Expired - Fee Related
- 2007-03-05 AU AU2007224019A patent/AU2007224019A1/en not_active Abandoned
-
2013
- 2013-04-30 JP JP2013095341A patent/JP2013146274A/ja active Pending
- 2013-08-16 US US13/969,368 patent/US8980581B2/en active Active
-
2014
- 2014-05-20 AU AU2014202733A patent/AU2014202733A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007103307A2 (en) | 2007-09-13 |
| US20080044854A1 (en) | 2008-02-21 |
| WO2007103307B1 (en) | 2008-05-02 |
| US8980581B2 (en) | 2015-03-17 |
| PT1999259E (pt) | 2014-09-24 |
| JP2009528824A (ja) | 2009-08-13 |
| US20140045261A1 (en) | 2014-02-13 |
| AU2014202733A1 (en) | 2014-06-12 |
| DK1999259T3 (da) | 2014-10-06 |
| US8518666B2 (en) | 2013-08-27 |
| JP2013146274A (ja) | 2013-08-01 |
| AU2007224019A1 (en) | 2007-09-13 |
| JP5808882B2 (ja) | 2015-11-10 |
| CA2644474A1 (en) | 2007-09-13 |
| WO2007103307A3 (en) | 2008-03-13 |
| PL1999259T3 (pl) | 2015-01-30 |
| EP1999259B1 (en) | 2014-06-25 |
| ES2504521T3 (es) | 2014-10-08 |
| EP1999259A2 (en) | 2008-12-10 |
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