DK1999259T3 - Sekvensspecifik inkorporering af aminosyrer i molekyler - Google Patents

Sekvensspecifik inkorporering af aminosyrer i molekyler

Info

Publication number
DK1999259T3
DK1999259T3 DK07752295.1T DK07752295T DK1999259T3 DK 1999259 T3 DK1999259 T3 DK 1999259T3 DK 07752295 T DK07752295 T DK 07752295T DK 1999259 T3 DK1999259 T3 DK 1999259T3
Authority
DK
Denmark
Prior art keywords
molecules
amino acids
sequence specific
specific incorporation
incorporation
Prior art date
Application number
DK07752295.1T
Other languages
Danish (da)
English (en)
Inventor
David A Tirrell
Pin Wang
Inchan Kwon
Soojin Son
Yi Tang
Original Assignee
California Inst Of Techn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Inst Of Techn filed Critical California Inst Of Techn
Application granted granted Critical
Publication of DK1999259T3 publication Critical patent/DK1999259T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK07752295.1T 2006-03-03 2007-03-05 Sekvensspecifik inkorporering af aminosyrer i molekyler DK1999259T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77937606P 2006-03-03 2006-03-03
US77937506P 2006-03-03 2006-03-03
PCT/US2007/005581 WO2007103307A2 (en) 2006-03-03 2007-03-05 Site-specific incorporation of amino acids into molecules

Publications (1)

Publication Number Publication Date
DK1999259T3 true DK1999259T3 (da) 2014-10-06

Family

ID=38462077

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07752295.1T DK1999259T3 (da) 2006-03-03 2007-03-05 Sekvensspecifik inkorporering af aminosyrer i molekyler

Country Status (11)

Country Link
US (2) US8518666B2 (enExample)
EP (1) EP1999259B1 (enExample)
JP (2) JP5808882B2 (enExample)
AU (2) AU2007224019A1 (enExample)
CA (1) CA2644474A1 (enExample)
DK (1) DK1999259T3 (enExample)
ES (1) ES2504521T3 (enExample)
PL (1) PL1999259T3 (enExample)
PT (1) PT1999259E (enExample)
SI (1) SI1999259T1 (enExample)
WO (1) WO2007103307A2 (enExample)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050287639A1 (en) 2004-05-17 2005-12-29 California Institute Of Technology Methods of incorporating amino acid analogs into proteins
US7632492B2 (en) * 2006-05-02 2009-12-15 Allozyne, Inc. Modified human interferon-β polypeptides
US20080096819A1 (en) * 2006-05-02 2008-04-24 Allozyne, Inc. Amino acid substituted molecules
CA2707840A1 (en) * 2007-08-20 2009-02-26 Allozyne, Inc. Amino acid substituted molecules
US20090148887A1 (en) * 2007-11-02 2009-06-11 The Scripps Research Institute Genetically encoded boronate amino acid
EP2376647B1 (en) * 2009-01-12 2014-03-05 Sutro Biopharma, Inc. Mono charging system for selectively introducing non-native amino acids into proteins using an in vitro protein synthesis system
WO2010099477A2 (en) 2009-02-27 2010-09-02 Atyr Pharma, Inc. Polypeptide structural motifs associated with cell signaling activity
MY189079A (en) * 2009-12-11 2022-01-25 Univ Case Western Reserve Insulin analogues with chlorinated amino acids
JP6066900B2 (ja) 2010-04-26 2017-01-25 エータイアー ファーマ， インコーポレイテッド システイニルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
US8961960B2 (en) 2010-04-27 2015-02-24 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl tRNA synthetases
ES2638311T3 (es) 2010-04-27 2017-10-19 Atyr Pharma, Inc. Descubrimiento innovador de composiciones terapéuticas, diagnósticas y de anticuerpos relacionadas con fragmentos de proteína de treonil ARNt sintetasas
JP6008837B2 (ja) 2010-04-28 2016-10-19 エータイアー ファーマ， インコーポレイテッド アラニルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
WO2011139907A2 (en) 2010-04-29 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl trna synthetases
US8986680B2 (en) 2010-04-29 2015-03-24 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Asparaginyl tRNA synthetases
JP6008841B2 (ja) 2010-05-03 2016-10-19 エータイアー ファーマ， インコーポレイテッド メチオニルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
US8961961B2 (en) 2010-05-03 2015-02-24 a Tyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of arginyl-tRNA synthetases
AU2011248227B2 (en) 2010-05-03 2016-12-01 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-tRNA synthetases
CA2797799C (en) 2010-05-03 2020-12-08 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of seryl-trna synthetases
EP2566499B1 (en) 2010-05-04 2017-01-25 aTyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-trna synthetase complex
JP6008843B2 (ja) 2010-05-04 2016-10-19 エータイアー ファーマ， インコーポレイテッド グルタミル−プロリルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
EP2568996B1 (en) * 2010-05-14 2017-10-04 aTyr Pharma, Inc. Therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-trna synthetases
AU2011256366C1 (en) 2010-05-17 2017-06-15 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-tRNA synthetases
CN103096913B (zh) 2010-05-27 2017-07-18 Atyr 医药公司 与谷氨酰胺酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
CA2800281C (en) 2010-06-01 2021-01-12 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of lysyl-trna synthetases
KR20130102534A (ko) 2010-07-12 2013-09-17 에이티와이알 파마, 인코포레이티드 히스티딜­trna 합성효소의 단백질 단편에 관련된 치료적, 진단적, 및 항체 조성물의 혁신적 발견
US8999321B2 (en) 2010-07-12 2015-04-07 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases
CA2804278C (en) 2010-07-12 2021-07-13 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of aspartyl-trna synthetases
CA2804416C (en) 2010-07-12 2020-04-28 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-trna synthetases
JP5964304B2 (ja) 2010-08-25 2016-08-03 エータイアー ファーマ， インコーポレイテッド チロシルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
CA2810668A1 (en) * 2010-09-08 2012-03-15 Halozyme, Inc. Methods for assessing and identifying or evolving conditionally active therapeutic proteins
EP2624857B1 (en) 2010-10-06 2017-08-02 aTyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of tryptophanyl trna synthetases
US20140140962A1 (en) * 2011-04-29 2014-05-22 The Research Foundation Of State University Of New York Viruses modified with unnatural moieties and methods of use thereof
US9714419B2 (en) 2011-08-09 2017-07-25 Atyr Pharma, Inc. PEGylated tyrosyl-tRNA synthetase polypeptides
WO2013065048A1 (en) * 2011-11-03 2013-05-10 Yeda Research And Development Co. Ltd. Transgenic plants resistant to non-protein amino acids
US9816084B2 (en) 2011-12-06 2017-11-14 Atyr Pharma, Inc. Aspartyl-tRNA synthetases
WO2013086228A1 (en) 2011-12-06 2013-06-13 Atyr Pharma, Inc. Pegylated aspartyl-trna synthetase polypeptides
TWI579296B (zh) 2011-12-28 2017-04-21 Chugai Pharmaceutical Co Ltd Cyclization of Peptide Compounds
CA2858613A1 (en) 2011-12-29 2013-08-08 Atyr Pharma, Inc. Aspartyl-trna synthetase-fc conjugates
WO2013188635A2 (en) * 2012-06-14 2013-12-19 The Trustees Of The University Of Pennsylvania Novel methods of identifying proteins via n-terminal tagging and selective pull-down
ES2708565T3 (es) 2013-03-15 2019-04-10 Atyr Pharma Inc Conjugados de Fc-histidil-ARNt sintetasa
US20160055293A1 (en) * 2013-03-29 2016-02-25 University Of Washington Through Its Center For Commercialization Systems, Algorithms, and Software for Molecular Inversion Probe (MIP) Design
EP2876165A1 (en) 2013-11-22 2015-05-27 ACIB GmbH Improved method for producing modifed target polypeptides
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
EP3269809B1 (en) 2015-03-13 2022-07-27 Chugai Seiyaku Kabushiki Kaisha MODIFIED AMINOACYL-tRNA SYNTHETASE AND USE THEREOF
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
GB201600512D0 (en) * 2016-01-12 2016-02-24 Univ York Recombinant protein production
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US12391971B2 (en) 2017-01-31 2025-08-19 Chugai Seiyaku Kabushiki Kaisha Method for synthesizing peptides in cell-free translation system
MX2019008449A (es) 2017-02-08 2019-09-09 Bristol Myers Squibb Co Polipetidos de relaxina modificada que comprenden un mejorador farmacocinetico y sus usos.
JP6917050B2 (ja) * 2017-03-06 2021-08-11 学校法人早稲田大学 最適特性を有する非天然型タンパク質の製造方法
EP3612215B1 (en) 2017-04-20 2024-08-28 aTyr Pharma, Inc. Compositions for treating lung inflammation
EP3636656A4 (en) 2017-06-09 2021-04-14 Chugai Seiyaku Kabushiki Kaisha METHOD OF SYNTHESIS OF PEPTIDE WITH N-SUBSTITUTED AMINO ACID
JP7295841B2 (ja) * 2017-07-25 2023-06-21 バイオコン・リミテッド インスリン＆インスリン類似体の配列の同定のためのペプチドマッピング方法
JP7411414B2 (ja) 2017-12-15 2024-01-11 中外製薬株式会社 ペプチドの製造方法、及び塩基の処理方法
CN108588040B (zh) * 2018-06-08 2021-06-15 中国医学科学院病原生物学研究所 重组MtMetRS、其晶体及它们在制备抗结核药物中的应用
CN111212661B (zh) * 2018-09-11 2023-09-12 北京泰德制药股份有限公司 白介素-2多肽偶联物及其用途
WO2020095983A1 (ja) 2018-11-07 2020-05-14 中外製薬株式会社 Ｏ－置換セリン誘導体の製造方法
CN119143631A (zh) 2018-11-30 2024-12-17 中外制药株式会社 用于肽化合物或酰胺化合物的脱保护方法和在固相反应中的树脂脱除方法以及用于生产肽化合物的方法
JP7357642B2 (ja) 2018-12-26 2023-10-06 中外製薬株式会社 コドン拡張のための変異ｔＲＮＡ
JP2022525333A (ja) * 2019-03-13 2022-05-12 セント・ジュード・チルドレンズ・リサーチ・ホスピタル 肺炎連鎖球菌の伝染を低減させるためのワクチン組成物および方法
US12071396B2 (en) 2019-03-15 2024-08-27 Chugai Seiyaku Kabushiki Kaisha Method for preparing aromatic amino acid derivative
BR112022007535A2 (pt) 2019-11-07 2022-07-12 Chugai Pharmaceutical Co Ltd Composto peptídico cíclico tendo ação inibitória de kras
JP7744244B2 (ja) 2019-12-26 2025-09-25 中外製薬株式会社 翻訳用組成物及びペプチドの製造方法
AU2021247169A1 (en) 2020-03-31 2022-10-20 Protomer Technologies Inc. Conjugates for selective responsiveness to vicinal diols
EP4146665A1 (en) 2020-05-05 2023-03-15 Genentech, Inc. Systems and methods for tyrosinase-mediated site-specific protein conjugation
KR20230028363A (ko) 2020-06-25 2023-02-28 추가이 세이야쿠 가부시키가이샤 개변된 유전 암호표를 갖는 번역계
WO2022079639A1 (en) * 2020-10-17 2022-04-21 Sun Pharmaceutical Industries Limited Glp-1/gip dual agonists
TW202237188A (zh) 2020-11-19 2022-10-01 美商普羅托莫科技公司 芳族含硼化合物及胰島素類似物
WO2023069816A2 (en) 2021-09-20 2023-04-27 The Broad Institute, Inc. Compositions and methods for multiplex decoding of quadruplet codons
KR20250005573A (ko) 2022-05-18 2025-01-09 프로토머 테크놀로지스 인크. 방향족 붕소-함유 화합물 및 관련 인슐린 유사체
CN119731319A (zh) * 2022-06-22 2025-03-28 芝加哥大学 工程化tRNA及其使用方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU668505B2 (en) 1991-03-18 1996-05-09 Scripps Research Institute, The Oligosaccharide enzyme substrates and inhibitors: methods and compositions
JP2002510966A (ja) 1997-04-11 2002-04-09 カリフォルニア・インスティテュート・オブ・テクノロジー 自動蛋白質デザインのための装置および方法
US7449443B2 (en) 2000-03-23 2008-11-11 California Institute Of Technology Method for stabilization of proteins using non-natural amino acids
EP1490483B1 (en) * 2001-04-19 2015-06-03 The Scripps Research Institute In vivo incorporation of unnatural amino acids
US7139665B2 (en) * 2002-02-27 2006-11-21 California Institute Of Technology Computational method for designing enzymes for incorporation of non natural amino acids into proteins
KR20050073559A (ko) 2002-10-16 2005-07-14 더 스크립스 리서치 인스티튜트 당단백질 합성
BRPI0507159A (pt) 2004-02-02 2007-06-26 Ambrx Inc polipeptìdeos em feixe de quatro hélices humanos modificados e seus usos
US20050260711A1 (en) 2004-03-30 2005-11-24 Deepshikha Datta Modulating pH-sensitive binding using non-natural amino acids
US20050287639A1 (en) 2004-05-17 2005-12-29 California Institute Of Technology Methods of incorporating amino acid analogs into proteins
MX2007000728A (es) 2004-07-21 2007-03-15 Ambrx Inc Polipeptidos biosinteticos que utilizan amino acidos no naturalmente codificados.
EP1797177A4 (en) 2004-09-21 2008-07-09 Scripps Research Inst ADDITION OF PHOTOREGULATED AMINO ACIDS TO THE GENETIC CODE
EP1809758A4 (en) 2004-10-20 2009-04-01 Scripps Research Inst LOCAL IN VIVO INSTALLATION OF N-ACETYLGALACTOSAMINE AMINO ACIDS IN EU BACTERIA
CA2590429C (en) 2004-12-22 2014-10-07 Ambrx, Inc. Compositions of aminoacyl-trna synthetase and uses thereof
GB2438982A (en) 2004-12-22 2007-12-12 Ambrx Inc Compostions containing, methods involving, and uses of non-natural amino acids and polypeptides
WO2006132969A2 (en) 2005-06-03 2006-12-14 Ambrx, Inc. Incorporation of non-naturally encoded amino acids into proteins
JP4829969B2 (ja) 2005-08-18 2011-12-07 アンブルックス，インコーポレイテッド ｔＲＮＡ組成物、およびその使用
EP1968635B1 (en) 2005-12-14 2014-09-17 Ambrx, Inc. Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
CN101384711A (zh) 2006-01-19 2009-03-11 Ambrx公司 具有经调节的免疫原性的非天然氨基酸多肽

Also Published As

Publication number Publication date
WO2007103307A2 (en) 2007-09-13
US20080044854A1 (en) 2008-02-21
WO2007103307B1 (en) 2008-05-02
US8980581B2 (en) 2015-03-17
PT1999259E (pt) 2014-09-24
JP2009528824A (ja) 2009-08-13
US20140045261A1 (en) 2014-02-13
AU2014202733A1 (en) 2014-06-12
US8518666B2 (en) 2013-08-27
JP2013146274A (ja) 2013-08-01
AU2007224019A1 (en) 2007-09-13
JP5808882B2 (ja) 2015-11-10
CA2644474A1 (en) 2007-09-13
WO2007103307A3 (en) 2008-03-13
PL1999259T3 (pl) 2015-01-30
EP1999259B1 (en) 2014-06-25
SI1999259T1 (sl) 2014-11-28
ES2504521T3 (es) 2014-10-08
EP1999259A2 (en) 2008-12-10

Similar Documents

Publication Publication Date Title
DK1999259T3 (da) Sekvensspecifik inkorporering af aminosyrer i molekyler
DK1983849T3 (da) Fødevaresammensætning omfattende aminosyrer
DK2035554T3 (da) Celle-fri syntese af proteiner indeholdende ikke-naturlige aminosyrer
DK2046826T3 (da) Exendin-fusionsproteiner
DK1999154T3 (da) Fremstillede heterodimere proteindomæner
PL2025718T3 (pl) Kompozycja żywicy poliamidowej
DK2219469T3 (da) Modificering af enzymatisk disponerede proteiner
DK3438131T3 (da) Oligosaccharidmodifikation og mærkning af proteiner
DE602007010966D1 (de) Neue Hautklammern
NO20081618L (no) Anvendelse av proteiner som en antiskumdannende komponent i drivstoff
DK2257618T3 (da) Fremstilling af glykosylerede polypeptider i mikroalger
PT2339014E (pt) Métodos e composições compreendendo aminoácidos não-naturais
DK2064334T3 (da) Aldehydtags, anvendelser deraf i site-specifik proteinmodificering
DK3118221T3 (da) Proteiner
DE502007000290D1 (de) Neue Verwendungen von Nonenolid
ATE534660T1 (de) Peptidsequenzen und zusammensetzungen
DK2061897T3 (da) Fed-batch-fermenteringsproces med høj celledensitet til fremstilling af rekombinant protein
DK3339445T3 (da) Interleukin -13 bindende proteiner
PL2942355T3 (pl) Nie-hemolityczne białka fuzyjne llo i ich zastosowanie
EP2078419A4 (en) SEGMENT TRACKING IN A FILM
BRPI0905715A2 (pt) Composição farmacêutica e kit de componentes
BRPI0716526A2 (pt) Injetor capilar
DK1989220T3 (da) HIV-fusionsinhibitorpeptider med forbedrede biologiske egenskaber
DK2136649T3 (da) Fremgangsmåde til dispergering af aminosyrer
DK1853279T3 (da) Amid-derivater af hyaluronsyre i osteoarthrose