DK2257618T3 - Fremstilling af glykosylerede polypeptider i mikroalger - Google Patents
Fremstilling af glykosylerede polypeptider i mikroalger Download PDFInfo
- Publication number
- DK2257618T3 DK2257618T3 DK09710039.0T DK09710039T DK2257618T3 DK 2257618 T3 DK2257618 T3 DK 2257618T3 DK 09710039 T DK09710039 T DK 09710039T DK 2257618 T3 DK2257618 T3 DK 2257618T3
- Authority
- DK
- Denmark
- Prior art keywords
- microalges
- glycosyled
- polypeptides
- preparation
- glycosyled polypeptides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/12—Unicellular algae; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01045—Glucosylceramidase (3.2.1.45), i.e. beta-glucocerebrosidase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01096—Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase (3.2.1.96)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
- C12Y305/01052—Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase (3.5.1.52), i.e. glycopeptidase
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08300090A EP2090648A1 (en) | 2008-02-12 | 2008-02-12 | Production of glycosylated polypeptides in microalgae |
| PCT/EP2009/051672 WO2009101160A1 (en) | 2008-02-12 | 2009-02-12 | Production of glycosylated polypeptides in microalgae |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2257618T3 true DK2257618T3 (da) | 2019-07-22 |
Family
ID=39590460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK09710039.0T DK2257618T3 (da) | 2008-02-12 | 2009-02-12 | Fremstilling af glykosylerede polypeptider i mikroalger |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8728761B2 (da) |
| EP (2) | EP2090648A1 (da) |
| JP (1) | JP5628689B2 (da) |
| AU (1) | AU2009214077B2 (da) |
| CA (1) | CA2715107C (da) |
| DK (1) | DK2257618T3 (da) |
| ES (1) | ES2734276T3 (da) |
| HR (1) | HRP20191222T1 (da) |
| HU (1) | HUE044328T2 (da) |
| IL (1) | IL207381A (da) |
| PL (1) | PL2257618T3 (da) |
| PT (1) | PT2257618T (da) |
| WO (1) | WO2009101160A1 (da) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI324181B (en) | 2001-04-16 | 2010-05-01 | Martek Biosciences Corp | Product and process for transformation of thraustochytriales microorganisms |
| CN102648207A (zh) | 2009-03-16 | 2012-08-22 | 马太克生物科学公司 | 在网粘菌门微生物中产生蛋白质 |
| JP5838473B2 (ja) * | 2009-12-28 | 2016-01-06 | サノフィ ワクチン テクノロジーズ エス．エー．エス． | 微細藻類におけるヘマグルチニン−ノイラミニダーゼタンパク質の産生方法 |
| KR20120101572A (ko) * | 2009-12-28 | 2012-09-13 | 메리얼 리미티드 | 재조합 ｎｄｖ 항원 및 이의 용도 |
| IN2012DN06277A (da) * | 2009-12-28 | 2015-09-25 | Dsm Ip Assets Bv | |
| EP2412815A1 (en) * | 2010-07-27 | 2012-02-01 | Universite De Rouen | N-glycosylation in transformed Phaeodactylum tricornutum |
| EP2444495A1 (en) | 2010-10-20 | 2012-04-25 | Algenics | Secretion of recombinant polypeptides in the extracellular medium of diatoms |
| EP2471929A1 (en) * | 2010-12-29 | 2012-07-04 | Algenics | Production of high mannose glycosylated proteins stored in the plastid of microalgae |
| JPWO2014104076A1 (ja) * | 2012-12-26 | 2017-01-12 | 公立大学法人大阪府立大学 | 形質転換ユーグレナ及びその製造方法 |
| US20160010070A1 (en) * | 2013-02-28 | 2016-01-14 | Kinki University | Method for introducing gene to euglena, and transformant therefrom |
| JP2014193154A (ja) * | 2013-02-28 | 2014-10-09 | Euglena Co Ltd | ユーグレナの形質転換体 |
| JP2014193153A (ja) * | 2013-02-28 | 2014-10-09 | Euglena Co Ltd | ユーグレナへの遺伝子導入方法 |
| US9441020B2 (en) | 2013-12-31 | 2016-09-13 | Synthetic Genomics, Inc. | Biomass productivity regulator |
| AU2015293949B2 (en) | 2014-07-21 | 2019-07-25 | Teknologian Tutkimuskeskus Vtt Oy | Production of glycoproteins with mammalian-like N-glycans in filamentous fungi |
| WO2016079739A2 (en) * | 2014-11-20 | 2016-05-26 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Compositions and methods for producing polypeptides with a modified glycosylation pattern in plant cells |
| KR20170124549A (ko) | 2015-03-17 | 2017-11-10 | 그리노파티온 바이오테크 게엠베하 | 글리코실화된 리소좀 단백질, 생산 방법 및 용도 |
| WO2020144358A1 (en) * | 2019-01-10 | 2020-07-16 | Expres2Ion Biotechnologies Aps | Glyco-engineered immunization antigens |
| WO2022219186A2 (en) * | 2021-04-16 | 2022-10-20 | Inbiose N.V. | Fermentative production |
| AU2022256796A1 (en) * | 2021-04-16 | 2023-11-30 | Inbiose N.V. | Cellular production of bioproducts |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997039106A1 (en) * | 1996-04-12 | 1997-10-23 | Martek Biosciences Corporation | Methods and tools for transformation of eukaryotic algae |
| JP2001095588A (ja) * | 1998-12-04 | 2001-04-10 | Research Institute Of Innovative Technology For The Earth | 緑藻のω３脂肪酸不飽和化酵素遺伝子及びその利用 |
| KR20000075076A (ko) * | 1999-05-28 | 2000-12-15 | 최태진 | 형질전환된 미세조류를 이용하여 외래 단백질을 생산하는 방법 |
| ATE373098T1 (de) * | 2000-04-21 | 2007-09-15 | Martek Biosciences Corp | Trophische umwandlung von obligat phototropischen algen durch metabolische manipulation |
| US7863020B2 (en) * | 2000-06-28 | 2011-01-04 | Glycofi, Inc. | Production of sialylated N-glycans in lower eukaryotes |
| US8936930B2 (en) * | 2004-08-05 | 2015-01-20 | Ben-Gurion University Of The Negev Research And Development Authority | Red microalgae expressing exogenous polypeptides and methods of generating and utilizing same |
| WO2008096250A1 (en) * | 2007-02-09 | 2008-08-14 | Centre National De La Recherche Scientifique - Cnrs | Expression of polypeptides from the nuclear genome of ostreococcus sp |
-
2008
- 2008-02-12 EP EP08300090A patent/EP2090648A1/en not_active Withdrawn
-
2009
- 2009-02-12 HU HUE09710039 patent/HUE044328T2/hu unknown
- 2009-02-12 ES ES09710039T patent/ES2734276T3/es active Active
- 2009-02-12 WO PCT/EP2009/051672 patent/WO2009101160A1/en active Application Filing
- 2009-02-12 AU AU2009214077A patent/AU2009214077B2/en active Active
- 2009-02-12 PL PL09710039T patent/PL2257618T3/pl unknown
- 2009-02-12 EP EP09710039.0A patent/EP2257618B1/en active Active
- 2009-02-12 US US12/867,279 patent/US8728761B2/en active Active
- 2009-02-12 JP JP2010545510A patent/JP5628689B2/ja active Active
- 2009-02-12 DK DK09710039.0T patent/DK2257618T3/da active
- 2009-02-12 CA CA2715107A patent/CA2715107C/en active Active
- 2009-02-12 PT PT09710039T patent/PT2257618T/pt unknown
-
2010
- 2010-08-03 IL IL207381A patent/IL207381A/en active IP Right Grant
-
2019
- 2019-07-08 HR HRP20191222TT patent/HRP20191222T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2715107A1 (en) | 2009-08-20 |
| EP2257618B1 (en) | 2019-04-17 |
| IL207381A0 (en) | 2010-12-30 |
| HRP20191222T1 (hr) | 2019-10-04 |
| WO2009101160A1 (en) | 2009-08-20 |
| US8728761B2 (en) | 2014-05-20 |
| AU2009214077B2 (en) | 2014-10-23 |
| US20110045533A1 (en) | 2011-02-24 |
| EP2090648A1 (en) | 2009-08-19 |
| JP2011512128A (ja) | 2011-04-21 |
| ES2734276T3 (es) | 2019-12-05 |
| PL2257618T3 (pl) | 2020-04-30 |
| IL207381A (en) | 2013-11-28 |
| AU2009214077A1 (en) | 2009-08-20 |
| AU2009214077A2 (en) | 2010-08-26 |
| EP2257618A1 (en) | 2010-12-08 |
| CA2715107C (en) | 2021-03-09 |
| PT2257618T (pt) | 2019-07-16 |
| JP5628689B2 (ja) | 2014-11-19 |
| HUE044328T2 (hu) | 2019-10-28 |
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