DK2304029T3 - Overfladevisning af hele antistoffer i eukaryoter - Google Patents
Overfladevisning af hele antistoffer i eukaryoter Download PDFInfo
- Publication number
- DK2304029T3 DK2304029T3 DK09790044.3T DK09790044T DK2304029T3 DK 2304029 T3 DK2304029 T3 DK 2304029T3 DK 09790044 T DK09790044 T DK 09790044T DK 2304029 T3 DK2304029 T3 DK 2304029T3
- Authority
- DK
- Denmark
- Prior art keywords
- eukaryots
- surface display
- whole antibodies
- antibodies
- whole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13433108P | 2008-07-09 | 2008-07-09 | |
US20858309P | 2009-02-25 | 2009-02-25 | |
PCT/US2009/049507 WO2010005863A1 (en) | 2008-07-09 | 2009-07-02 | Surface display of whole antibodies in eukaryotes |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2304029T3 true DK2304029T3 (da) | 2020-10-26 |
Family
ID=41202611
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK09790044.3T DK2304029T3 (da) | 2008-07-09 | 2009-07-02 | Overfladevisning af hele antistoffer i eukaryoter |
Country Status (6)
Country | Link |
---|---|
US (5) | US8067339B2 (da) |
EP (1) | EP2304029B1 (da) |
JP (1) | JP5759371B2 (da) |
CA (1) | CA2730243C (da) |
DK (1) | DK2304029T3 (da) |
WO (1) | WO2010005863A1 (da) |
Families Citing this family (33)
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US20040067532A1 (en) * | 2002-08-12 | 2004-04-08 | Genetastix Corporation | High throughput generation and affinity maturation of humanized antibody |
US8877688B2 (en) | 2007-09-14 | 2014-11-04 | Adimab, Llc | Rationally designed, synthetic antibody libraries and uses therefor |
CA2697193C (en) | 2007-09-14 | 2017-06-06 | Adimab, Inc. | Rationally designed, synthetic antibody libraries and uses therefor |
US8637435B2 (en) * | 2007-11-16 | 2014-01-28 | Merck Sharp & Dohme Corp. | Eukaryotic cell display systems |
WO2009105357A1 (en) * | 2008-02-20 | 2009-08-27 | Glycofi, Inc. | Vectors and yeast strains for protein production |
EP2263089B1 (en) * | 2008-03-03 | 2015-01-28 | GlycoFi, Inc. | Surface display of recombinant proteins in lower eukaryotes |
US8067339B2 (en) * | 2008-07-09 | 2011-11-29 | Merck Sharp & Dohme Corp. | Surface display of whole antibodies in eukaryotes |
CA2789446A1 (en) * | 2010-02-12 | 2011-08-18 | Oncomed Pharmaceuticals, Inc. | Methods for identifying and isolating cells expressing a polypeptide |
AU2011279073B2 (en) | 2010-07-16 | 2016-06-09 | Adimab, Llc | Antibody libraries |
US10106598B2 (en) | 2010-12-01 | 2018-10-23 | Merck Sharp & Dohme Corp. | Surface, anchored Fc-bait antibody display system |
CN103534392A (zh) * | 2010-12-01 | 2014-01-22 | 默沙东公司 | 表面锚定的fc-诱饵抗体展示系统 |
CN103764837A (zh) * | 2011-02-25 | 2014-04-30 | 默沙东公司 | 用于生产具有修饰的o-糖基化的蛋白的酵母菌株 |
ES2605429T3 (es) | 2011-06-15 | 2017-03-14 | Borealis Ag | Mezcla del reactor in situ de un polipropileno nucleado catalizado por Ziegler-Natta y un polipropileno catalizado por metaloceno |
WO2013043582A1 (en) * | 2011-09-23 | 2013-03-28 | Merck Sharp & Dohme Corp. | Cell surface display of ligands for the insulin and/or insulin growth factor 1 receptor and applications thereof |
US9890378B2 (en) | 2012-05-11 | 2018-02-13 | Merck Sharp & Dohme Corp. | Surface anchored light chain bait antibody display system |
WO2014084607A1 (ko) | 2012-11-27 | 2014-06-05 | 아주대학교산학협력단 | 항체 중쇄불변부위의 이종이중체 고효율 형성을 유도하는 ch3 도메인 변이체 쌍, 이의 제조방법, 및 용도 |
AU2013372026B2 (en) * | 2013-01-03 | 2018-11-08 | Merck Patent Gmbh | Method for producing secretable antibodies by expression in saccharomyces cerevisiae |
AU2014337195B2 (en) * | 2013-10-17 | 2018-11-08 | National University Of Singapore | Chimeric receptor that triggers antibody-dependent cell cytotoxicity against multiple tumors |
WO2015100058A1 (en) | 2013-12-23 | 2015-07-02 | Research Corporation Technologies, Inc. | Pichia pastoris surface display system |
USD778947S1 (en) * | 2014-01-29 | 2017-02-14 | Samsung Electronics Co., Ltd | Display screen or portion thereof with icon |
WO2016066260A1 (en) | 2014-10-28 | 2016-05-06 | Merck Patent Gmbh | Methods for non-covalent fc-domain-containing protein display on the surface of cells and methods of screening thereof |
KR101851380B1 (ko) | 2015-10-12 | 2018-04-23 | 아주대학교산학협력단 | 효모접합을 이용한 항체 ch3 도메인 이종이중체 돌연변이쌍 제조 방법 및 이에 의하여 제조된 ch3 돌연변이체 쌍 |
WO2017136734A1 (en) * | 2016-02-04 | 2017-08-10 | Trianni, Inc. | Enhanced production of immunoglobulins |
CA3032736A1 (en) * | 2016-08-05 | 2018-02-08 | Cargill, Incorporated | Leader-modified glucoamylase polypeptides and engineered yeast strains having enhanced bioproduct production |
WO2018041740A1 (en) | 2016-09-01 | 2018-03-08 | Bayer Pharma Aktiengesellschaft | Non-covalent display system using fimgt/dsf |
AU2018219887A1 (en) | 2017-02-08 | 2019-08-22 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer |
KR20190120782A (ko) | 2017-02-20 | 2019-10-24 | 드래곤플라이 쎄라퓨틱스, 인크. | Her2, nkg2d 및 cd16에 결합하는 단백질 |
EP3601558A4 (en) * | 2017-03-24 | 2021-01-06 | Lankenau Institute for Medical Research | METHODS AND COMPOSITIONS FOR CAPTURE OF INDUCTIBLE EXTRACELLULAR MEMBRANE OF MONOCLONAL IMMUNOGLOBULINS SECRETED BY HYBRIDOMAS |
AU2019218136A1 (en) | 2018-02-08 | 2020-08-13 | Dragonfly Therapeutics, Inc. | Antibody variable domains targeting the NKG2D receptor |
WO2021104672A1 (en) | 2019-11-29 | 2021-06-03 | Lallemand Hungary Liquidity Management Llc | Yeast expressing heterologous glucoamylase |
JP2023509476A (ja) * | 2020-01-06 | 2023-03-08 | アイジーエム バイオサイエンシズ インコーポレイテッド | 高度にシアリル化された多量体結合分子 |
JPWO2022190733A1 (da) * | 2021-03-10 | 2022-09-15 | ||
CN113999306B (zh) * | 2021-10-26 | 2024-01-12 | 杏联药业(苏州)有限公司 | 一种获得识别空间构象表位抗体的方法 |
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GB8308235D0 (en) * | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4818700A (en) * | 1985-10-25 | 1989-04-04 | Phillips Petroleum Company | Pichia pastoris argininosuccinate lyase gene and uses thereof |
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US6699658B1 (en) * | 1996-05-31 | 2004-03-02 | Board Of Trustees Of The University Of Illinois | Yeast cell surface display of proteins and uses thereof |
US6300065B1 (en) * | 1996-05-31 | 2001-10-09 | Board Of Trustees Of The University Of Illinois | Yeast cell surface display of proteins and uses thereof |
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EP2137308B1 (en) * | 2007-03-26 | 2016-08-03 | Agenus Inc. | Cell surface display, screening and production of proteins of interest |
CA2697193C (en) | 2007-09-14 | 2017-06-06 | Adimab, Inc. | Rationally designed, synthetic antibody libraries and uses therefor |
SG10201406572TA (en) | 2007-12-19 | 2014-11-27 | Glycofi Inc | Yeast strains for protein production |
WO2009105357A1 (en) | 2008-02-20 | 2009-08-27 | Glycofi, Inc. | Vectors and yeast strains for protein production |
EP2263089B1 (en) | 2008-03-03 | 2015-01-28 | GlycoFi, Inc. | Surface display of recombinant proteins in lower eukaryotes |
US8067339B2 (en) * | 2008-07-09 | 2011-11-29 | Merck Sharp & Dohme Corp. | Surface display of whole antibodies in eukaryotes |
WO2013043582A1 (en) | 2011-09-23 | 2013-03-28 | Merck Sharp & Dohme Corp. | Cell surface display of ligands for the insulin and/or insulin growth factor 1 receptor and applications thereof |
-
2009
- 2009-06-23 US US12/489,900 patent/US8067339B2/en active Active
- 2009-07-02 CA CA2730243A patent/CA2730243C/en active Active
- 2009-07-02 DK DK09790044.3T patent/DK2304029T3/da active
- 2009-07-02 WO PCT/US2009/049507 patent/WO2010005863A1/en active Application Filing
- 2009-07-02 JP JP2011517488A patent/JP5759371B2/ja active Active
- 2009-07-02 EP EP09790044.3A patent/EP2304029B1/en active Active
-
2011
- 2011-10-03 US US13/251,410 patent/US9260712B2/en active Active
-
2016
- 2016-01-27 US US15/007,622 patent/US20170327817A9/en not_active Abandoned
-
2018
- 2018-10-03 US US16/150,674 patent/US11046951B2/en active Active
-
2021
- 2021-06-10 US US17/343,905 patent/US20210317441A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US11046951B2 (en) | 2021-06-29 |
EP2304029A1 (en) | 2011-04-06 |
CA2730243C (en) | 2018-03-06 |
WO2010005863A1 (en) | 2010-01-14 |
EP2304029B1 (en) | 2020-08-26 |
US9260712B2 (en) | 2016-02-16 |
US20190055546A1 (en) | 2019-02-21 |
US20170107509A1 (en) | 2017-04-20 |
US20170327817A9 (en) | 2017-11-16 |
CA2730243A1 (en) | 2010-01-14 |
US20210317441A1 (en) | 2021-10-14 |
US8067339B2 (en) | 2011-11-29 |
US20100009866A1 (en) | 2010-01-14 |
JP2011527576A (ja) | 2011-11-04 |
US20120021948A1 (en) | 2012-01-26 |
JP5759371B2 (ja) | 2015-08-05 |
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