DK2304029T3 - Overfladevisning af hele antistoffer i eukaryoter - Google Patents

Overfladevisning af hele antistoffer i eukaryoter Download PDF

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Publication number
DK2304029T3
DK2304029T3 DK09790044.3T DK09790044T DK2304029T3 DK 2304029 T3 DK2304029 T3 DK 2304029T3 DK 09790044 T DK09790044 T DK 09790044T DK 2304029 T3 DK2304029 T3 DK 2304029T3
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DK
Denmark
Prior art keywords
eukaryots
surface display
whole antibodies
antibodies
whole
Prior art date
Application number
DK09790044.3T
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English (en)
Inventor
Prinz Bianka
Natarajan Sethuraman
Dongxing Zha
Stefan Wildt
Piotr Bobrowicz
Original Assignee
Merck Sharp & Dohme
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Filing date
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Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of DK2304029T3 publication Critical patent/DK2304029T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK09790044.3T 2008-07-09 2009-07-02 Overfladevisning af hele antistoffer i eukaryoter DK2304029T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13433108P 2008-07-09 2008-07-09
US20858309P 2009-02-25 2009-02-25
PCT/US2009/049507 WO2010005863A1 (en) 2008-07-09 2009-07-02 Surface display of whole antibodies in eukaryotes

Publications (1)

Publication Number Publication Date
DK2304029T3 true DK2304029T3 (da) 2020-10-26

Family

ID=41202611

Family Applications (1)

Application Number Title Priority Date Filing Date
DK09790044.3T DK2304029T3 (da) 2008-07-09 2009-07-02 Overfladevisning af hele antistoffer i eukaryoter

Country Status (6)

Country Link
US (5) US8067339B2 (da)
EP (1) EP2304029B1 (da)
JP (1) JP5759371B2 (da)
CA (1) CA2730243C (da)
DK (1) DK2304029T3 (da)
WO (1) WO2010005863A1 (da)

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Also Published As

Publication number Publication date
JP2011527576A (ja) 2011-11-04
WO2010005863A1 (en) 2010-01-14
EP2304029A1 (en) 2011-04-06
US8067339B2 (en) 2011-11-29
CA2730243A1 (en) 2010-01-14
US9260712B2 (en) 2016-02-16
US20190055546A1 (en) 2019-02-21
EP2304029B1 (en) 2020-08-26
JP5759371B2 (ja) 2015-08-05
US20120021948A1 (en) 2012-01-26
US20210317441A1 (en) 2021-10-14
US12084651B2 (en) 2024-09-10
US20100009866A1 (en) 2010-01-14
US20170107509A1 (en) 2017-04-20
CA2730243C (en) 2018-03-06
US11046951B2 (en) 2021-06-29
US20170327817A9 (en) 2017-11-16

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