DK2304029T3 - Overfladevisning af hele antistoffer i eukaryoter - Google Patents

Overfladevisning af hele antistoffer i eukaryoter Download PDF

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Publication number
DK2304029T3
DK2304029T3 DK09790044.3T DK09790044T DK2304029T3 DK 2304029 T3 DK2304029 T3 DK 2304029T3 DK 09790044 T DK09790044 T DK 09790044T DK 2304029 T3 DK2304029 T3 DK 2304029T3
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DK
Denmark
Prior art keywords
eukaryots
surface display
whole antibodies
antibodies
whole
Prior art date
Application number
DK09790044.3T
Other languages
English (en)
Inventor
Prinz Bianka
Natarajan Sethuraman
Dongxing Zha
Stefan Wildt
Piotr Bobrowicz
Original Assignee
Merck Sharp & Dohme
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Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of DK2304029T3 publication Critical patent/DK2304029T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK09790044.3T 2008-07-09 2009-07-02 Overfladevisning af hele antistoffer i eukaryoter DK2304029T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13433108P 2008-07-09 2008-07-09
US20858309P 2009-02-25 2009-02-25
PCT/US2009/049507 WO2010005863A1 (en) 2008-07-09 2009-07-02 Surface display of whole antibodies in eukaryotes

Publications (1)

Publication Number Publication Date
DK2304029T3 true DK2304029T3 (da) 2020-10-26

Family

ID=41202611

Family Applications (1)

Application Number Title Priority Date Filing Date
DK09790044.3T DK2304029T3 (da) 2008-07-09 2009-07-02 Overfladevisning af hele antistoffer i eukaryoter

Country Status (6)

Country Link
US (5) US8067339B2 (da)
EP (1) EP2304029B1 (da)
JP (1) JP5759371B2 (da)
CA (1) CA2730243C (da)
DK (1) DK2304029T3 (da)
WO (1) WO2010005863A1 (da)

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Also Published As

Publication number Publication date
US9260712B2 (en) 2016-02-16
US20170327817A9 (en) 2017-11-16
US8067339B2 (en) 2011-11-29
JP2011527576A (ja) 2011-11-04
JP5759371B2 (ja) 2015-08-05
EP2304029B1 (en) 2020-08-26
US20190055546A1 (en) 2019-02-21
US20120021948A1 (en) 2012-01-26
US20170107509A1 (en) 2017-04-20
EP2304029A1 (en) 2011-04-06
CA2730243A1 (en) 2010-01-14
US20210317441A1 (en) 2021-10-14
WO2010005863A1 (en) 2010-01-14
US11046951B2 (en) 2021-06-29
CA2730243C (en) 2018-03-06
US20100009866A1 (en) 2010-01-14

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