JP2009522277A5 - - Google Patents
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- JP2009522277A5 JP2009522277A5 JP2008548718A JP2008548718A JP2009522277A5 JP 2009522277 A5 JP2009522277 A5 JP 2009522277A5 JP 2008548718 A JP2008548718 A JP 2008548718A JP 2008548718 A JP2008548718 A JP 2008548718A JP 2009522277 A5 JP2009522277 A5 JP 2009522277A5
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| CN102224141B (zh) | 2008-10-23 | 2014-10-08 | 沃泰克斯药物股份有限公司 | N-(4-(7-氮杂双环[2.2.1]庚-7-基)-2-(三氟甲基)苯基)-4-氧代-5-(三氟甲基)-1,4-二氢喹啉-3-甲酰胺的固体形式 |
| US20110257223A1 (en) | 2008-10-23 | 2011-10-20 | Vertex Pharmaceuticals Incorporated | Modulators of Cystic Fibrosis Transmembrane Conductance Regulator |
| EP2382197B1 (en) | 2008-12-30 | 2016-10-05 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| HRP20181261T1 (hr) | 2009-03-20 | 2018-12-14 | Vertex Pharmaceuticals Incorporated | Modulatori regulatora transmembranske provodljivosti cistične fibroze |
| PL2408750T3 (pl) | 2009-03-20 | 2016-02-29 | Vertex Pharma | Sposób otrzymywania modulatorów błonowego regulatora przewodnictwa swoistego dla mukowiscydozy |
| BR112012006031A2 (pt) | 2009-09-17 | 2019-09-24 | Vertex Pharma | processo para preparação de compostos azabicíclicos. |
| MX2012004792A (es) | 2009-10-22 | 2013-02-01 | Vertex Pharma | Composiciones para el tratamiento de fibrosis quistica y otras enfermedades cronicas. |
| CN102666546B (zh) | 2009-10-23 | 2015-09-09 | 沃泰克斯药物股份有限公司 | N-(4-(7-氮杂双环[2.2.1]庚-7-基)-2-(三氟甲基)苯基)-4-氧代-5-(三氟甲基)-1,4-二氢喹啉-3-甲酰胺的固体形式 |
| US8344147B2 (en) | 2009-10-23 | 2013-01-01 | Vertex Pharmaceutical Incorporated | Process for preparing modulators of cystic fibrosis transmembrane conductance regulator |
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| SI2826776T1 (sl) | 2010-03-25 | 2021-02-26 | Vertex Pharmaceuticals Incorporated | Trdna disperzija amorfne oblike (R)-1(2,2-difluorobenzo(D)(1,3)dioksol-5-il)-N-(1-(2,3-dihidroksipropil) -6-fluoro-2-(1-hidroksi-2-metilpropan-2-il)-1H-indol-5-il)- ciklopropankarboksamida |
| MX2012011655A (es) | 2010-04-07 | 2012-11-23 | Vertex Pharma | Formas solidas de acido 3-(6-(1-(2,2-difluorobenzo [d][1-3]dioxol-5-il]ciclopropanocarboxamido)-3-metilpiridin-2-il) benzoico. |
| JP2013523833A (ja) | 2010-04-07 | 2013-06-17 | バーテックス ファーマシューティカルズ インコーポレイテッド | ３−（６−（１−（２，２−ジフルオロベンゾ［ｄ］［１，３］ジオキソール−５−イル）シクロプロパンカルボキサミド）−３−メチルピリジン−２−イル）安息香酸の医薬組成物およびその投与 |
| EP2560649A1 (en) | 2010-04-22 | 2013-02-27 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions and administrations thereof |
| EP2560651A1 (en) | 2010-04-22 | 2013-02-27 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions and administrations thereof |
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| WO2012027247A2 (en) | 2010-08-23 | 2012-03-01 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition of (r)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxy propyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration therof |
| CA2809263A1 (en) | 2010-08-27 | 2012-03-01 | Eleni Dokou | Pharmaceutical composition and administrations thereof |
| US8802700B2 (en) | 2010-12-10 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
| WO2013070961A1 (en) | 2011-11-08 | 2013-05-16 | Vertex Pharmaceuticals Incorporated | Modulators of atp-binding cassette transporters |
| NZ727015A (en) | 2012-01-25 | 2017-12-22 | Vertex Pharma | Formulations of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid |
| JP2015511583A (ja) | 2012-02-27 | 2015-04-20 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | 薬学的組成物およびその投与 |
| US8674108B2 (en) | 2012-04-20 | 2014-03-18 | Vertex Pharmaceuticals Incorporated | Solid forms of N-[2,4-bis(1,1-dimethylethy)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide |
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2006
- 2006-12-28 CA CA2856037A patent/CA2856037C/en active Active
- 2006-12-28 JP JP2008548718A patent/JP5165586B2/ja active Active
- 2006-12-28 NZ NZ569327A patent/NZ569327A/en not_active IP Right Cessation
- 2006-12-28 CN CN201310067369.XA patent/CN103214450B/zh active Active
- 2006-12-28 ES ES06850405T patent/ES2398319T3/es active Active
- 2006-12-28 WO PCT/US2006/049412 patent/WO2007087066A2/en not_active Ceased
- 2006-12-28 CN CN2006800533546A patent/CN101395147B/zh active Active
- 2006-12-28 US US11/647,092 patent/US7691902B2/en active Active
- 2006-12-28 EP EP06850405A patent/EP2016065B1/en active Active
- 2006-12-28 CA CA2635760A patent/CA2635760C/en active Active
- 2006-12-28 AU AU2006336504A patent/AU2006336504C9/en active Active
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2010
- 2010-02-12 US US12/704,605 patent/US8524767B2/en active Active
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2012
- 2012-10-29 JP JP2012237949A patent/JP5697644B2/ja active Active
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2013
- 2013-06-27 US US13/928,719 patent/US8846753B2/en active Active
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2014
- 2014-06-25 JP JP2014130679A patent/JP5845318B2/ja active Active
- 2014-08-05 US US14/451,709 patent/US20150065497A1/en not_active Abandoned
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