JP2009522277A5 - - Google Patents
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- JP2009522277A5 JP2009522277A5 JP2008548718A JP2008548718A JP2009522277A5 JP 2009522277 A5 JP2009522277 A5 JP 2009522277A5 JP 2008548718 A JP2008548718 A JP 2008548718A JP 2008548718 A JP2008548718 A JP 2008548718A JP 2009522277 A5 JP2009522277 A5 JP 2009522277A5
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| US20110251253A1 (en) | 2010-03-25 | 2011-10-13 | Vertex Pharmaceuticals Incorporated | Solid forms of (r)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| HRP20211752T1 (hr) | 2010-04-07 | 2022-02-18 | Vertex Pharmaceuticals Incorporated | Farmaceutski pripravci 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-il)ciklopropankarboksamido)-3-metilpiridin-2-il)benzojeve kiseline i njihova primjena |
| HRP20160682T1 (hr) | 2010-04-07 | 2016-07-29 | Vertex Pharmaceuticals Incorporated | Čvrsti oblici 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-il)ciklopropankarboksiamido)-3-metilpiridin-2-il)benzojeve kiseline |
| AU2011242454A1 (en) | 2010-04-22 | 2012-11-08 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions and administrations thereof |
| NZ603044A (en) | 2010-04-22 | 2015-08-28 | Vertex Pharma | Pharmaceutical compositions comprising cftr modulators and administrations thereof |
| CA2796642A1 (en) | 2010-04-22 | 2011-10-27 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions and administrations thereof |
| TW201202250A (en) | 2010-05-20 | 2012-01-16 | Vertex Pharma | Processes for producing modulators of cystic fibrosis transmembrane conductance regulator |
| CA2798412A1 (en) | 2010-05-20 | 2011-11-24 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions and administrations thereof |
| US8563593B2 (en) | 2010-06-08 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Formulations of (R)-1-(2,2-difluorobenzo[D] [1,3] dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide |
| CA2808501A1 (en) | 2010-08-23 | 2012-03-01 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition of (r)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxy propyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration therof |
| RU2013113627A (ru) | 2010-08-27 | 2014-10-10 | Вертекс Фармасьютикалз Инкорпорейтед | Фармацевтическая композиция и ее введения |
| US8802700B2 (en) | 2010-12-10 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
| IN2014KN00885A (https=) | 2011-11-08 | 2015-10-02 | Vertex Pharma | |
| WO2013112804A1 (en) | 2012-01-25 | 2013-08-01 | Vertex Pharmaceuticals Incorporated | Formulations of 3-(6-(1-(2.2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid |
| EP2819670A1 (en) | 2012-02-27 | 2015-01-07 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administration thereof |
| US8674108B2 (en) | 2012-04-20 | 2014-03-18 | Vertex Pharmaceuticals Incorporated | Solid forms of N-[2,4-bis(1,1-dimethylethy)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide |
-
2006
- 2006-12-28 AU AU2006336504A patent/AU2006336504C9/en active Active
- 2006-12-28 US US11/647,092 patent/US7691902B2/en active Active
- 2006-12-28 WO PCT/US2006/049412 patent/WO2007087066A2/en not_active Ceased
- 2006-12-28 ES ES06850405T patent/ES2398319T3/es active Active
- 2006-12-28 EP EP06850405A patent/EP2016065B1/en active Active
- 2006-12-28 CA CA2635760A patent/CA2635760C/en active Active
- 2006-12-28 CN CN2006800533546A patent/CN101395147B/zh active Active
- 2006-12-28 CA CA2856037A patent/CA2856037C/en active Active
- 2006-12-28 CN CN201310067369.XA patent/CN103214450B/zh active Active
- 2006-12-28 NZ NZ569327A patent/NZ569327A/en not_active IP Right Cessation
- 2006-12-28 JP JP2008548718A patent/JP5165586B2/ja active Active
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2010
- 2010-02-12 US US12/704,605 patent/US8524767B2/en active Active
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2012
- 2012-10-29 JP JP2012237949A patent/JP5697644B2/ja active Active
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2013
- 2013-06-27 US US13/928,719 patent/US8846753B2/en active Active
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2014
- 2014-06-25 JP JP2014130679A patent/JP5845318B2/ja active Active
- 2014-08-05 US US14/451,709 patent/US20150065497A1/en not_active Abandoned
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