CA2635760C - Modulators of atp-binding cassette transporters - Google Patents

Modulators of atp-binding cassette transporters Download PDF

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Publication number
CA2635760C
CA2635760C CA2635760A CA2635760A CA2635760C CA 2635760 C CA2635760 C CA 2635760C CA 2635760 A CA2635760 A CA 2635760A CA 2635760 A CA2635760 A CA 2635760A CA 2635760 C CA2635760 C CA 2635760C
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Prior art keywords
optionally substituted
aliphatic
compound
cycloaliphatic
independently
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CA2635760A
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French (fr)
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CA2635760A1 (en
Inventor
Sara S. Hadida Ruah
Mark T. Miller
Brian Bear
Jason Mccartney
Peter D. J. Grootenhuis
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
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    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
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