JP2009520017A5 - - Google Patents
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- Publication number
- JP2009520017A5 JP2009520017A5 JP2008546663A JP2008546663A JP2009520017A5 JP 2009520017 A5 JP2009520017 A5 JP 2009520017A5 JP 2008546663 A JP2008546663 A JP 2008546663A JP 2008546663 A JP2008546663 A JP 2008546663A JP 2009520017 A5 JP2009520017 A5 JP 2009520017A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl group
- hydroxy
- alkyl
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 13
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 11
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 125000001424 substituent group Chemical group 0.000 claims 7
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- 125000005843 halogen group Chemical group 0.000 claims 5
- 125000003277 amino group Chemical group 0.000 claims 3
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000004430 oxygen atom Chemical group O* 0.000 claims 3
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 3
- 125000006823 (C1-C6) acyl group Chemical group 0.000 claims 2
- FAPVGICIAUIMRB-UHFFFAOYSA-N 7-[(5-fluoro-3,4-dihydro-2h-chromen-4-yl)oxy]-n,n,2-trimethyl-3h-benzimidazole-5-carboxamide Chemical compound C1COC2=CC=CC(F)=C2C1OC1=C(N=C(C)N2)C2=CC(C(=O)N(C)C)=C1 FAPVGICIAUIMRB-UHFFFAOYSA-N 0.000 claims 2
- HCEFDOZABLDEGR-UHFFFAOYSA-N [7-[(5,7-difluoro-3,4-dihydro-2h-chromen-4-yl)oxy]-2-methyl-3h-benzimidazol-5-yl]-pyrrolidin-1-ylmethanone Chemical compound C1=C2NC(C)=NC2=C(OC2C3=C(F)C=C(F)C=C3OCC2)C=C1C(=O)N1CCCC1 HCEFDOZABLDEGR-UHFFFAOYSA-N 0.000 claims 2
- 125000002393 azetidinyl group Chemical group 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 201000006549 dyspepsia Diseases 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000004193 piperazinyl group Chemical group 0.000 claims 2
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 1
- CLIQCDHNPDMGSL-UHFFFAOYSA-N 7-[(5,7-difluoro-3,4-dihydro-2h-chromen-4-yl)oxy]-n,n,2-trimethyl-3h-benzimidazole-5-carboxamide Chemical compound C1COC2=CC(F)=CC(F)=C2C1OC1=C(N=C(C)N2)C2=CC(C(=O)N(C)C)=C1 CLIQCDHNPDMGSL-UHFFFAOYSA-N 0.000 claims 1
- CLIQCDHNPDMGSL-HNNXBMFYSA-N 7-[[(4s)-5,7-difluoro-3,4-dihydro-2h-chromen-4-yl]oxy]-n,n,2-trimethyl-3h-benzimidazole-5-carboxamide Chemical compound C1COC2=CC(F)=CC(F)=C2[C@H]1OC1=C(N=C(C)N2)C2=CC(C(=O)N(C)C)=C1 CLIQCDHNPDMGSL-HNNXBMFYSA-N 0.000 claims 1
- 208000007882 Gastritis Diseases 0.000 claims 1
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- 206010019375 Helicobacter infections Diseases 0.000 claims 1
- 206010028813 Nausea Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010030216 Oesophagitis Diseases 0.000 claims 1
- 206010068319 Oropharyngeal pain Diseases 0.000 claims 1
- 208000008469 Peptic Ulcer Diseases 0.000 claims 1
- 201000007100 Pharyngitis Diseases 0.000 claims 1
- 208000007107 Stomach Ulcer Diseases 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 claims 1
- 201000008629 Zollinger-Ellison syndrome Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000029087 digestion Effects 0.000 claims 1
- 208000010643 digestive system disease Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000000718 duodenal ulcer Diseases 0.000 claims 1
- 230000003628 erosive effect Effects 0.000 claims 1
- 208000006881 esophagitis Diseases 0.000 claims 1
- 201000005917 gastric ulcer Diseases 0.000 claims 1
- 201000000052 gastrinoma Diseases 0.000 claims 1
- 208000029493 gastroesophageal disease Diseases 0.000 claims 1
- 208000018685 gastrointestinal system disease Diseases 0.000 claims 1
- 208000024798 heartburn Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 230000008693 nausea Effects 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 1
- 208000011906 peptic ulcer disease Diseases 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 1
- 230000009747 swallowing Effects 0.000 claims 1
- 231100000397 ulcer Toxicity 0.000 claims 1
- 208000009935 visceral pain Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75218105P | 2005-12-19 | 2005-12-19 | |
| US80294406P | 2006-05-23 | 2006-05-23 | |
| PCT/IB2006/003605 WO2007072146A1 (en) | 2005-12-19 | 2006-12-06 | Chromane substituted benzimidazoles and their use as acid pump inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009520017A JP2009520017A (ja) | 2009-05-21 |
| JP2009520017A5 true JP2009520017A5 (enExample) | 2009-11-26 |
| JP4481344B2 JP4481344B2 (ja) | 2010-06-16 |
Family
ID=37912450
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008546663A Active JP4481344B2 (ja) | 2005-12-19 | 2006-12-06 | クロマン置換ベンゾイミダゾール誘導体及び酸ポンプ阻害剤としてのそれらの使用 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7723321B2 (enExample) |
| EP (1) | EP1963311B1 (enExample) |
| JP (1) | JP4481344B2 (enExample) |
| KR (1) | KR101088247B1 (enExample) |
| CN (2) | CN101341149B (enExample) |
| AR (1) | AR058120A1 (enExample) |
| AT (1) | ATE471319T1 (enExample) |
| BR (2) | BR122020004679B1 (enExample) |
| CA (1) | CA2631880C (enExample) |
| DE (1) | DE602006014996D1 (enExample) |
| DO (1) | DOP2006000285A (enExample) |
| ES (1) | ES2345726T3 (enExample) |
| GT (1) | GT200600514A (enExample) |
| NL (1) | NL2000371C2 (enExample) |
| PE (1) | PE20071182A1 (enExample) |
| TW (1) | TW200732326A (enExample) |
| UY (1) | UY30043A1 (enExample) |
| WO (1) | WO2007072146A1 (enExample) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009000413A1 (en) * | 2007-06-26 | 2008-12-31 | Sanofi-Aventis | A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles |
| CN102470126A (zh) | 2009-07-09 | 2012-05-23 | 拉夸里亚创药株式会社 | 用于治疗与异常肠胃运动有关的疾病的酸泵拮抗剂 |
| KR101472686B1 (ko) | 2013-07-09 | 2014-12-16 | 씨제이헬스케어 주식회사 | 벤즈이미다졸 유도체의 제조방법 |
| KR102084185B1 (ko) | 2013-08-29 | 2020-03-04 | 주식회사 대웅제약 | 테트라히드로사이클로펜타피롤 유도체 및 이의 제조방법 |
| KR102129842B1 (ko) * | 2013-10-02 | 2020-07-06 | 주식회사 대웅제약 | 술포닐인돌 유도체 및 이의 제조방법 |
| US10709714B2 (en) | 2013-11-22 | 2020-07-14 | Clifton Life Sciences LLC | Gastrin antagonists for treatment and prevention of osteoporosis |
| CN105440016B (zh) * | 2014-08-11 | 2018-08-31 | 江苏柯菲平医药股份有限公司 | 吲哚、氮杂吲哚类衍生物、其制备方法及其在医药上的应用 |
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| KR101613245B1 (ko) | 2015-04-27 | 2016-04-18 | 주식회사 대웅제약 | 신규의 4-메톡시 피롤 유도체 또는 이의 염 및 이를 포함하는 약학 조성물 |
| HRP20211046T1 (hr) * | 2015-06-08 | 2021-10-01 | Hk Inno.N Corporation | Upotreba derivata benzimidazola kod noćnog proboja kiseline |
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| BR112019012931A2 (pt) * | 2016-12-20 | 2019-12-10 | Exxonmobil Chemical Patents Inc | processo de polimerização |
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| SE9602286D0 (sv) * | 1996-06-10 | 1996-06-10 | Astra Ab | New compounds |
| GB9914022D0 (en) | 1999-06-17 | 1999-08-18 | Zeneca Ltd | Chemical compounds |
| AR043063A1 (es) | 2002-12-13 | 2005-07-13 | Altana Pharma Ag | Bencimidazoles 6-sustituidos y su uso como inhibidores de secreciones gastricas |
| AR049168A1 (es) * | 2004-05-18 | 2006-07-05 | Altana Pharma Ag | Derivados de benzimidazol |
| ATE442140T1 (de) * | 2005-06-14 | 2009-09-15 | Raqualia Pharma Inc | Chroman-substituierte benzimidazolderivate als säurepumpenantagonisten |
-
2006
- 2006-12-06 EP EP06831708A patent/EP1963311B1/en active Active
- 2006-12-06 CN CN2006800479255A patent/CN101341149B/zh active Active
- 2006-12-06 AT AT06831708T patent/ATE471319T1/de not_active IP Right Cessation
- 2006-12-06 CN CN2011101399640A patent/CN102321077A/zh active Pending
- 2006-12-06 BR BR122020004679-1A patent/BR122020004679B1/pt not_active IP Right Cessation
- 2006-12-06 CA CA2631880A patent/CA2631880C/en active Active
- 2006-12-06 KR KR1020087017466A patent/KR101088247B1/ko active Active
- 2006-12-06 JP JP2008546663A patent/JP4481344B2/ja active Active
- 2006-12-06 BR BRPI0620081A patent/BRPI0620081B8/pt active IP Right Grant
- 2006-12-06 ES ES06831708T patent/ES2345726T3/es active Active
- 2006-12-06 DE DE602006014996T patent/DE602006014996D1/de active Active
- 2006-12-06 WO PCT/IB2006/003605 patent/WO2007072146A1/en not_active Ceased
- 2006-12-13 NL NL2000371A patent/NL2000371C2/nl not_active IP Right Cessation
- 2006-12-18 TW TW095147456A patent/TW200732326A/zh unknown
- 2006-12-18 PE PE2006001625A patent/PE20071182A1/es not_active Application Discontinuation
- 2006-12-18 GT GT200600514A patent/GT200600514A/es unknown
- 2006-12-18 DO DO2006000285A patent/DOP2006000285A/es unknown
- 2006-12-19 US US11/612,583 patent/US7723321B2/en active Active
- 2006-12-19 UY UY30043A patent/UY30043A1/es not_active Application Discontinuation
- 2006-12-19 AR ARP060105611A patent/AR058120A1/es unknown
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