KR101088247B1 - 크로메인 치환된 벤즈이미다졸 및 이들의 산 펌프억제제로서의 용도 - Google Patents

크로메인 치환된 벤즈이미다졸 및 이들의 산 펌프억제제로서의 용도 Download PDF

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KR101088247B1
KR101088247B1 KR1020087017466A KR20087017466A KR101088247B1 KR 101088247 B1 KR101088247 B1 KR 101088247B1 KR 1020087017466 A KR1020087017466 A KR 1020087017466A KR 20087017466 A KR20087017466 A KR 20087017466A KR 101088247 B1 KR101088247 B1 KR 101088247B1
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benzimidazole
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KR20080080195A (ko
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다케시 하나자와
히로키 고이케
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라퀄리아 파마 인코포레이티드
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41841,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/04Drugs for disorders of the respiratory system for throat disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nutrition Science (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020087017466A 2005-12-19 2006-12-06 크로메인 치환된 벤즈이미다졸 및 이들의 산 펌프억제제로서의 용도 Active KR101088247B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US75218105P 2005-12-19 2005-12-19
US60/752,181 2005-12-19
US80294406P 2006-05-23 2006-05-23
US60/802,944 2006-05-23
PCT/IB2006/003605 WO2007072146A1 (en) 2005-12-19 2006-12-06 Chromane substituted benzimidazoles and their use as acid pump inhibitors

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KR20080080195A KR20080080195A (ko) 2008-09-02
KR101088247B1 true KR101088247B1 (ko) 2011-11-30

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US (1) US7723321B2 (enExample)
EP (1) EP1963311B1 (enExample)
JP (1) JP4481344B2 (enExample)
KR (1) KR101088247B1 (enExample)
CN (2) CN102321077A (enExample)
AR (1) AR058120A1 (enExample)
AT (1) ATE471319T1 (enExample)
BR (2) BRPI0620081B8 (enExample)
CA (1) CA2631880C (enExample)
DE (1) DE602006014996D1 (enExample)
DO (1) DOP2006000285A (enExample)
ES (1) ES2345726T3 (enExample)
GT (1) GT200600514A (enExample)
NL (1) NL2000371C2 (enExample)
PE (1) PE20071182A1 (enExample)
TW (1) TW200732326A (enExample)
UY (1) UY30043A1 (enExample)
WO (1) WO2007072146A1 (enExample)

Cited By (13)

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WO2016117814A3 (ko) * 2015-01-20 2016-10-06 씨제이헬스케어 주식회사 벤즈이미다졸 유도체의 신규 결정형 및 이의 제조방법
WO2020045940A1 (en) 2018-08-28 2020-03-05 Cj Healthcare Corporation Pharmaceutical composition comprising antiplatelet agent and gastric acid secretion inhibitor
WO2020170106A1 (en) 2019-02-18 2020-08-27 Hk Inno.N Corporation Pharmaceutical composition comprising benzimidazole derivative compound
KR20210109479A (ko) 2020-02-27 2021-09-06 에이치케이이노엔 주식회사 경구 투여용 약학 조성물
KR20210127108A (ko) 2020-04-13 2021-10-21 에이치케이이노엔 주식회사 벤즈이미다졸 유도체 화합물을 포함하는 약학적 조성물
KR20220141700A (ko) 2021-04-13 2022-10-20 에이치케이이노엔 주식회사 벤즈이미다졸 유도체 화합물을 포함하는 약학적 조성물
WO2023106841A1 (ko) * 2021-12-08 2023-06-15 (주) 팜젠사이언스 벤즈이미다졸 유도체 화합물 및 이의 용도
KR20240028127A (ko) 2022-08-24 2024-03-05 위더스제약주식회사 테고프라잔 고체분산체 조성물
KR20240109898A (ko) 2023-01-05 2024-07-12 위더스제약주식회사 무정형 테고프라잔 고체분산체
KR20240131641A (ko) 2023-02-24 2024-09-02 엠에프씨 주식회사 신규 테고프라잔의 염 결정형 및 이의 용매화물 결정형, 및 이들의 제조방법
KR20240171624A (ko) 2023-05-31 2024-12-09 권대길 치환된 벤즈이미다졸의 결정형 및 이의 제조방법
KR20250066641A (ko) 2023-11-07 2025-05-14 엠에프씨 주식회사 테고프라잔 말리에이트염 1수화물 결정형 및 이의 제조방법
KR20250118583A (ko) 2024-01-30 2025-08-06 진양제약주식회사 테고프라잔을 포함하는 제약 조성물

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WO2009000413A1 (en) * 2007-06-26 2008-12-31 Sanofi-Aventis A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
JP5802898B2 (ja) * 2009-07-09 2015-11-04 ラクオリア創薬株式会社 消化管運動異常が関与する疾患を治療するためのアシッドポンプ拮抗剤
KR101472686B1 (ko) 2013-07-09 2014-12-16 씨제이헬스케어 주식회사 벤즈이미다졸 유도체의 제조방법
KR102084185B1 (ko) 2013-08-29 2020-03-04 주식회사 대웅제약 테트라히드로사이클로펜타피롤 유도체 및 이의 제조방법
KR102129842B1 (ko) * 2013-10-02 2020-07-06 주식회사 대웅제약 술포닐인돌 유도체 및 이의 제조방법
RU2693484C1 (ru) 2013-11-22 2019-07-03 СиЭль БАЙОСАЕНСИЗ ЭлЭлСи Антагонисты гастрина для лечения и профилактики остеопороза
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KR101829685B1 (ko) * 2016-07-28 2018-02-19 씨제이헬스케어 주식회사 안정성 및 용해도가 개선된 주사용 조성물
KR101829705B1 (ko) * 2016-09-21 2018-02-19 씨제이헬스케어 주식회사 안정성이 향상된 주사용 조성물
KR101829706B1 (ko) * 2016-09-21 2018-02-19 씨제이헬스케어 주식회사 벤즈이미다졸 유도체의 산부가염
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KR102233456B1 (ko) * 2017-05-31 2021-03-29 주식회사 대웅제약 4-메톡시피롤 유도체의 중간체 제조 방법
KR102262743B1 (ko) * 2017-07-07 2021-06-09 에이치케이이노엔 주식회사 주사용 조성물
KR20190057569A (ko) 2017-11-20 2019-05-29 제일약품주식회사 7-아미노-1h-인돌-5-카르복사미드 유도체 및 이의 용도
TWI676477B (zh) * 2017-12-05 2019-11-11 南韓商Cj醫藥健康股份有限公司 苯并咪唑衍生物用於夜間酸突破的用途
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CN112851646B (zh) * 2019-11-12 2023-06-13 中国医学科学院药物研究所 特戈拉赞的制备方法
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WO2025037242A1 (en) * 2023-08-14 2025-02-20 Ami Lifesciences Private Limited Solid forms of tegoprazan and process thereof
KR102689851B1 (ko) 2023-09-26 2024-07-30 스마트바이오팜 주식회사 테고프라잔 중간체를 제조하는 방법 및 이에 사용되는 신규 중간체
TW202535866A (zh) * 2023-11-01 2025-09-16 日商拉夸里亞創藥股份有限公司 苯并咪唑化合物的製造製程
CN117903097A (zh) * 2024-01-04 2024-04-19 浙江永太科技股份有限公司 一种特戈拉赞关键中间体母液料的回收方法
KR102825970B1 (ko) 2024-02-16 2025-06-26 스마트바이오팜 주식회사 테고프라잔 중간체를 제조하는 방법 및 이에 사용되는 신규 중간체

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KR101684053B1 (ko) * 2015-01-20 2016-12-08 씨제이헬스케어 주식회사 벤즈이미다졸 유도체의 신규 결정형 및 이의 제조방법
US9908870B2 (en) 2015-01-20 2018-03-06 Cj Healthcare Corporation Crystalline form of a benzimidazole derivative and a preparation method thereof
EA030919B1 (ru) * 2015-01-20 2018-10-31 СиДжей ХЕЛТКЕР КОРПОРЕЙШН Новая кристаллическая форма производного бензимидазола и способ ее получения
WO2016117814A3 (ko) * 2015-01-20 2016-10-06 씨제이헬스케어 주식회사 벤즈이미다졸 유도체의 신규 결정형 및 이의 제조방법
US12128030B2 (en) 2018-08-28 2024-10-29 Hk Inno.N Corporation Pharmaceutical composition comprising antiplatelet agent and gastric acid secretion inhibitor
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WO2020170106A1 (en) 2019-02-18 2020-08-27 Hk Inno.N Corporation Pharmaceutical composition comprising benzimidazole derivative compound
KR20210109479A (ko) 2020-02-27 2021-09-06 에이치케이이노엔 주식회사 경구 투여용 약학 조성물
KR20210127108A (ko) 2020-04-13 2021-10-21 에이치케이이노엔 주식회사 벤즈이미다졸 유도체 화합물을 포함하는 약학적 조성물
KR20220141700A (ko) 2021-04-13 2022-10-20 에이치케이이노엔 주식회사 벤즈이미다졸 유도체 화합물을 포함하는 약학적 조성물
WO2023106842A1 (ko) * 2021-12-08 2023-06-15 (주) 팜젠사이언스 벤즈이미다졸 유도체 화합물 및 이의 용도
WO2023106841A1 (ko) * 2021-12-08 2023-06-15 (주) 팜젠사이언스 벤즈이미다졸 유도체 화합물 및 이의 용도
KR20240028127A (ko) 2022-08-24 2024-03-05 위더스제약주식회사 테고프라잔 고체분산체 조성물
KR20240109898A (ko) 2023-01-05 2024-07-12 위더스제약주식회사 무정형 테고프라잔 고체분산체
KR20240131641A (ko) 2023-02-24 2024-09-02 엠에프씨 주식회사 신규 테고프라잔의 염 결정형 및 이의 용매화물 결정형, 및 이들의 제조방법
KR20240171624A (ko) 2023-05-31 2024-12-09 권대길 치환된 벤즈이미다졸의 결정형 및 이의 제조방법
KR20250066641A (ko) 2023-11-07 2025-05-14 엠에프씨 주식회사 테고프라잔 말리에이트염 1수화물 결정형 및 이의 제조방법
KR20250118583A (ko) 2024-01-30 2025-08-06 진양제약주식회사 테고프라잔을 포함하는 제약 조성물

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CA2631880A1 (en) 2007-06-28
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CN102321077A (zh) 2012-01-18
ATE471319T1 (de) 2010-07-15
JP2009520017A (ja) 2009-05-21
EP1963311B1 (en) 2010-06-16
EP1963311A1 (en) 2008-09-03
HK1125368A1 (en) 2009-08-07
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PJ1302 Judgment (patent court)

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PJ1302 Judgment (patent court)

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PJ1302 Judgment (patent court)

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PJ1303 Judgment (supreme court)

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V15 Decision substituted

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PJ1302 Judgment (patent court)

St.27 status event code: A-5-5-V10-V15-crt-PJ1302

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PJ1303 Judgment (supreme court)

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Decision text: .(2023533, 2023545, 2023548, 2023551, 2023576, 20232637 .)

V15 Decision substituted

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PJ1302 Judgment (patent court)

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Decision date: 20250529

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Appeal request date: 20240629

Appellate body name: Patent Court

Decision text: .(2023538, 2023541, 2023544, 2023556, 2023588, 2023593 .)

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Appeal request date: 20240629

Appellate body name: Patent Court

Decision text: .(2023537, 2023540, 2023543, 2023555, 2023587, 2023591 .)

PJ1303 Judgment (supreme court)

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Decision date: 20251106

Decision authority category: Court of appeal

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Appeal request date: 20250829

Appellate body name: Supreme Court

Decision identifier: 2025300010228

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V15 Decision substituted

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Decision authority category: National patent court

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PJ1303 Judgment (supreme court)

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Decision date: 20251120

Decision authority category: Court of appeal

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Decision authority category: Court of appeal

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