AR058120A1 - Derivados de bencimidazol sustituidos con cromano, una composicion farmaceutica que los contiene y el uso de los mismos en el tratamiento de una enfermedad mediada por la inhibicion de la bomba de acido - Google Patents

Derivados de bencimidazol sustituidos con cromano, una composicion farmaceutica que los contiene y el uso de los mismos en el tratamiento de una enfermedad mediada por la inhibicion de la bomba de acido

Info

Publication number
AR058120A1
AR058120A1 ARP060105611A ARP060105611A AR058120A1 AR 058120 A1 AR058120 A1 AR 058120A1 AR P060105611 A ARP060105611 A AR P060105611A AR P060105611 A ARP060105611 A AR P060105611A AR 058120 A1 AR058120 A1 AR 058120A1
Authority
AR
Argentina
Prior art keywords
group
alkyl
hydroxy
alkyl group
unsubstituted
Prior art date
Application number
ARP060105611A
Other languages
English (en)
Inventor
Takeshi Hanazawa
Hiroki Koike
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37912450&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR058120(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of AR058120A1 publication Critical patent/AR058120A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Reivindicacion 1: Un compuesto de la formula (1): o una de sus sales farmacéuticamente aceptables o sus profármacos, caracterizado porque: -A-B- representa -O-CH2-, -S-CH2-, -CH2-O- o -CH2-S-; X representa un átomo de oxígeno o NH; R1 representa un grupo alquilo C1-6 que está sin sustituir o sustituido con 1 a 2 sustituyentes elegidos independientemente entre el grupo que consiste en un grupo hidroxi y un grupo alcoxi C1-6; R2 y R3 representan independientemente un átomo de hidrogeno, un grupo alquilo C1-6, un grupo cicloalquilo C3-7 o un grupo heteroarilo, estando dicho grupo alquilo C1-6, dicho grupo cicloalquilo C3-7 y dicho grupo heteroarilo sin sustituir o sustituido con 1 a 3 sustituyentes elegidos independientemente entre el grupo que consiste en un átomo de halogeno, un grupo hidroxi, un grupo alcoxi C1-6, un grupo cicloalquilo C3-7, un grupo amino, un grupo alquil C1-6-amino y un grupo di(alquil C1-6)amino; o R2 y R3 tomados junto con el átomo de nitrogeno al que están unidos forman un grupo heterocíclico de 4 a 6 miembros que está sin sustituir o sustituido con 1 a 2 sustituyentes elegidos entre el grupo que consiste un grupo hidroxi, un grupo alquilo C1-6, un grupo acilo C1-6 y un grupo hidroxi-alquilo C1-6; R4, R5, R6 y R7 representan independientemente un átomo de hidrogeno, un átomo de halogeno, un grupo hidroxi, un grupo alquilo C1-6 o un grupo alcoxi C1-6; y R8 representa un átomo de hidrogeno, un grupo hidroxi o un grupo alcoxi C1-6. Composiciones farmacéuticas que contienen tales compuestos y la utilizacion de tales compuestos en el tratamiento de un estado mediado por la actividad antagonista de la bomba de ácido, tales como, pero sin limitarse a ellos, enfermedad gastrointestinal, enfermedad gastroesofágica, enfermedad de reflujo gastroesofágico (GERD), ulcera péptica, ulcera gástrica, ulcera de duodeno, ulceras inducidas por NSAID, gastritis, infeccion por Helicobacter pylori, dispepsia, dispepsia funcional, síndrome de zollinger-Ellison, enfermedad de reflujo no erosivo (NERD), dolor visceral, quemadura solar, náusea, esofaguitos, disfagia, hipersalivacion, trastornos de las vías aéreas o asma.
ARP060105611A 2005-12-19 2006-12-19 Derivados de bencimidazol sustituidos con cromano, una composicion farmaceutica que los contiene y el uso de los mismos en el tratamiento de una enfermedad mediada por la inhibicion de la bomba de acido AR058120A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75218105P 2005-12-19 2005-12-19
US80294406P 2006-05-23 2006-05-23

Publications (1)

Publication Number Publication Date
AR058120A1 true AR058120A1 (es) 2008-01-23

Family

ID=37912450

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060105611A AR058120A1 (es) 2005-12-19 2006-12-19 Derivados de bencimidazol sustituidos con cromano, una composicion farmaceutica que los contiene y el uso de los mismos en el tratamiento de una enfermedad mediada por la inhibicion de la bomba de acido

Country Status (19)

Country Link
US (1) US7723321B2 (es)
EP (1) EP1963311B1 (es)
JP (1) JP4481344B2 (es)
KR (1) KR101088247B1 (es)
CN (2) CN101341149B (es)
AR (1) AR058120A1 (es)
AT (1) ATE471319T1 (es)
BR (2) BRPI0620081B8 (es)
CA (1) CA2631880C (es)
DE (1) DE602006014996D1 (es)
DO (1) DOP2006000285A (es)
ES (1) ES2345726T3 (es)
GT (1) GT200600514A (es)
HK (1) HK1125368A1 (es)
NL (1) NL2000371C2 (es)
PE (1) PE20071182A1 (es)
TW (1) TW200732326A (es)
UY (1) UY30043A1 (es)
WO (1) WO2007072146A1 (es)

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DOP2006000285A (es) 2007-07-31
UY30043A1 (es) 2007-07-31
US7723321B2 (en) 2010-05-25
BRPI0620081B8 (pt) 2021-05-25
NL2000371A1 (nl) 2007-06-20
JP4481344B2 (ja) 2010-06-16
GT200600514A (es) 2007-07-17
KR101088247B1 (ko) 2011-11-30
CN101341149A (zh) 2009-01-07
DE602006014996D1 (de) 2010-07-29
PE20071182A1 (es) 2008-02-07
EP1963311B1 (en) 2010-06-16
BR122020004679B1 (pt) 2021-09-21
KR20080080195A (ko) 2008-09-02
EP1963311A1 (en) 2008-09-03
CA2631880C (en) 2011-03-29
CA2631880A1 (en) 2007-06-28
CN102321077A (zh) 2012-01-18
BRPI0620081B1 (pt) 2020-10-20
BRPI0620081A2 (pt) 2011-11-01
HK1125368A1 (en) 2009-08-07
TW200732326A (en) 2007-09-01
WO2007072146A1 (en) 2007-06-28
US20070142448A1 (en) 2007-06-21
CN101341149B (zh) 2011-06-08
ATE471319T1 (de) 2010-07-15
ES2345726T3 (es) 2010-09-30
JP2009520017A (ja) 2009-05-21
NL2000371C2 (nl) 2007-09-06

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