BRPI0620081B8 - composto e composição farmacêutica. - Google Patents

composto e composição farmacêutica.

Info

Publication number
BRPI0620081B8
BRPI0620081B8 BRPI0620081A BRPI0620081A BRPI0620081B8 BR PI0620081 B8 BRPI0620081 B8 BR PI0620081B8 BR PI0620081 A BRPI0620081 A BR PI0620081A BR PI0620081 A BRPI0620081 A BR PI0620081A BR PI0620081 B8 BRPI0620081 B8 BR PI0620081B8
Authority
BR
Brazil
Prior art keywords
compounds
disease
pharmaceutical composition
pharmaceutically acceptable
acceptable salt
Prior art date
Application number
BRPI0620081A
Other languages
English (en)
Inventor
Koike Hiroki
Hanazawa Takeshi
Original Assignee
Pfizer
Raqualia Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37912450&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0620081(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer, Raqualia Pharma Inc filed Critical Pfizer
Priority to BR122020004679-1A priority Critical patent/BR122020004679B1/pt
Publication of BRPI0620081A2 publication Critical patent/BRPI0620081A2/pt
Publication of BRPI0620081B1 publication Critical patent/BRPI0620081B1/pt
Publication of BRPI0620081B8 publication Critical patent/BRPI0620081B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

composto derivado de benzimidazol e composição farmacêutica. esta invenção refere-se a compostos da fórmula (1): ou um sal farmaceuticamente aceitável deste, em que: a, b, x, r1, r2, r3, r4, r5, r 6, r7 e r8 são cada qual como descrito aqui ou um sal farmaceuticamente aceitável, e composições contendo tais compostos e o uso de tais compostos no tratamento de uma condição mediada por atividade antagonistica de bomba de ácido tal como, porém não limitado á, doença gastrointestinal, doença gastroesofágica, doença de refluxo gastroesofágico (gerd), úlcera péptica, úlcera gástrica, úlcera duodenal, úlceras induzidas por nsaid, gastrite, infecção por helicobacter pylori, dispepsia, dispepsia funcional, síndrome zollinger-ellison, doença do refluxo não erosivo (nerd), dor visceral, azia, náusea, esofagite, disfagia, hipersalivação, distúrbio das vias aéreas ou asma.
BRPI0620081A 2005-12-19 2006-12-06 composto e composição farmacêutica. BRPI0620081B8 (pt)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR122020004679-1A BR122020004679B1 (pt) 2005-12-19 2006-12-06 Composição farmacêutica

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US75218105P 2005-12-19 2005-12-19
US60/752,181 2005-12-19
US80294406P 2006-05-23 2006-05-23
US60/802,944 2006-05-23
PCT/IB2006/003605 WO2007072146A1 (en) 2005-12-19 2006-12-06 Chromane substituted benzimidazoles and their use as acid pump inhibitors

Publications (3)

Publication Number Publication Date
BRPI0620081A2 BRPI0620081A2 (pt) 2011-11-01
BRPI0620081B1 BRPI0620081B1 (pt) 2020-10-20
BRPI0620081B8 true BRPI0620081B8 (pt) 2021-05-25

Family

ID=37912450

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0620081A BRPI0620081B8 (pt) 2005-12-19 2006-12-06 composto e composição farmacêutica.
BR122020004679-1A BR122020004679B1 (pt) 2005-12-19 2006-12-06 Composição farmacêutica

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR122020004679-1A BR122020004679B1 (pt) 2005-12-19 2006-12-06 Composição farmacêutica

Country Status (19)

Country Link
US (1) US7723321B2 (pt)
EP (1) EP1963311B1 (pt)
JP (1) JP4481344B2 (pt)
KR (1) KR101088247B1 (pt)
CN (2) CN101341149B (pt)
AR (1) AR058120A1 (pt)
AT (1) ATE471319T1 (pt)
BR (2) BRPI0620081B8 (pt)
CA (1) CA2631880C (pt)
DE (1) DE602006014996D1 (pt)
DO (1) DOP2006000285A (pt)
ES (1) ES2345726T3 (pt)
GT (1) GT200600514A (pt)
HK (1) HK1125368A1 (pt)
NL (1) NL2000371C2 (pt)
PE (1) PE20071182A1 (pt)
TW (1) TW200732326A (pt)
UY (1) UY30043A1 (pt)
WO (1) WO2007072146A1 (pt)

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BRPI0813271A2 (pt) * 2007-06-26 2014-12-30 Sanofi Aventis Síntese regiosseletiva catalisada por cobre de benzimidazóis e azabenzimidazóis
WO2011004882A1 (ja) * 2009-07-09 2011-01-13 ラクオリア創薬株式会社 消化管運動異常が関与する疾患を治療するためのアシッドポンプ拮抗剤
KR101472686B1 (ko) 2013-07-09 2014-12-16 씨제이헬스케어 주식회사 벤즈이미다졸 유도체의 제조방법
KR102084185B1 (ko) 2013-08-29 2020-03-04 주식회사 대웅제약 테트라히드로사이클로펜타피롤 유도체 및 이의 제조방법
KR102129842B1 (ko) 2013-10-02 2020-07-06 주식회사 대웅제약 술포닐인돌 유도체 및 이의 제조방법
PL3071206T3 (pl) 2013-11-22 2022-01-17 CL BioSciences LLC Antagoniści gastryny (eg yf476, netazepid) do leczenia i zapobiegania osteoporozie
CN105440016B (zh) * 2014-08-11 2018-08-31 江苏柯菲平医药股份有限公司 吲哚、氮杂吲哚类衍生物、其制备方法及其在医药上的应用
KR101684053B1 (ko) * 2015-01-20 2016-12-08 씨제이헬스케어 주식회사 벤즈이미다졸 유도체의 신규 결정형 및 이의 제조방법
KR101613245B1 (ko) 2015-04-27 2016-04-18 주식회사 대웅제약 신규의 4-메톡시 피롤 유도체 또는 이의 염 및 이를 포함하는 약학 조성물
TN2017000510A1 (en) 2015-06-08 2019-04-12 Cj Healthcare Corp Use of benzimidazole derivatives for nocturnal acid breakthrough.
KR101769204B1 (ko) * 2015-08-04 2017-08-17 씨제이헬스케어 주식회사 크로마놀 유도체의 신규한 제조방법
KR101777971B1 (ko) 2016-07-05 2017-09-12 제일약품주식회사 이미다조[1,2-a]피리딘 유도체, 이의 제조방법 및 이의 용도
KR101829685B1 (ko) * 2016-07-28 2018-02-19 씨제이헬스케어 주식회사 안정성 및 용해도가 개선된 주사용 조성물
KR101829706B1 (ko) * 2016-09-21 2018-02-19 씨제이헬스케어 주식회사 벤즈이미다졸 유도체의 산부가염
KR101829705B1 (ko) * 2016-09-21 2018-02-19 씨제이헬스케어 주식회사 안정성이 향상된 주사용 조성물
EP3559051B1 (en) * 2016-12-20 2021-03-24 ExxonMobil Chemical Patents Inc. Polymerization process
KR101960357B1 (ko) * 2016-12-26 2019-03-20 씨제이헬스케어 주식회사 벤즈이미다졸 유도체를 포함하는 신규한 제제
KR102233456B1 (ko) * 2017-05-31 2021-03-29 주식회사 대웅제약 4-메톡시피롤 유도체의 중간체 제조 방법
KR102262743B1 (ko) * 2017-07-07 2021-06-09 에이치케이이노엔 주식회사 주사용 조성물
KR20190057569A (ko) 2017-11-20 2019-05-29 제일약품주식회사 7-아미노-1h-인돌-5-카르복사미드 유도체 및 이의 용도
TWI676477B (zh) * 2017-12-05 2019-11-11 南韓商Ｃｊ醫藥健康股份有限公司 苯并咪唑衍生物用於夜間酸突破的用途
JOP20190198A1 (ar) * 2018-08-28 2020-02-28 Hk Inno N Corp تركيبة صيدلانية تشتمل على عامل مضاد للصفيحات ومثبط إفراز حمض معدي
JOP20190201A1 (ar) * 2018-08-29 2020-02-29 Hk Inno N Corp تركيبة لاستئصال الملوية البوابية
CN109320485B (zh) * 2018-12-02 2021-06-18 江苏慧聚药业有限公司 合成特戈拉赞手性醇的方法
EA202192286A1 (ru) * 2019-02-18 2021-11-18 ЭйчКей ИННО.Эн КОРПОРЕЙШН Фармацевтическая композиция, содержащая соединение-производное бензимидазола
CN112851646B (zh) * 2019-11-12 2023-06-13 中国医学科学院药物研究所 特戈拉赞的制备方法
UY39094A (es) * 2020-02-27 2021-07-30 Hk Inno N Corp Composición farmacéutica que comprende compuesto derivado de bencimidazol
CN111303131B (zh) * 2020-03-19 2021-06-04 江苏慧聚药业有限公司 特戈拉赞(Tegoprazan)类似物及其合成方法
JP2023521197A (ja) 2020-04-13 2023-05-23 エイチケー イノ．エヌ コーポレーション ベンズイミダゾール誘導体化合物を含む医薬組成物
KR20220054211A (ko) 2020-10-23 2022-05-02 에이치케이이노엔 주식회사 벤즈이미다졸 유도체 화합물을 포함하는 구강붕해정 및 이의 제조방법
CN112358450A (zh) * 2020-11-19 2021-02-12 南京艾康生物科技有限公司 一种4-(苄氧基)-2-甲基-1H-苯并[d]咪唑-6-羧酸的合成方法
KR20220141700A (ko) 2021-04-13 2022-10-20 에이치케이이노엔 주식회사 벤즈이미다졸 유도체 화합물을 포함하는 약학적 조성물
CN113527272B (zh) * 2021-08-06 2023-07-21 西安淳甄新材料有限公司 一种特戈拉赞的合成方法
KR102648315B1 (ko) * 2021-12-08 2024-03-15 (주) 팜젠사이언스 벤즈이미다졸 유도체 화합물 및 이의 용도
KR20230099093A (ko) * 2021-12-27 2023-07-04 에이치케이이노엔 주식회사 벤즈이미다졸 유도체의 제조방법
CN114805317A (zh) * 2022-05-20 2022-07-29 江苏威奇达药业有限公司 一种特戈拉赞的制备方法
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Also Published As

Publication number Publication date
AR058120A1 (es) 2008-01-23
GT200600514A (es) 2007-07-17
JP2009520017A (ja) 2009-05-21
PE20071182A1 (es) 2008-02-07
DE602006014996D1 (de) 2010-07-29
WO2007072146A1 (en) 2007-06-28
EP1963311B1 (en) 2010-06-16
US20070142448A1 (en) 2007-06-21
KR20080080195A (ko) 2008-09-02
KR101088247B1 (ko) 2011-11-30
US7723321B2 (en) 2010-05-25
NL2000371C2 (nl) 2007-09-06
HK1125368A1 (en) 2009-08-07
CA2631880C (en) 2011-03-29
EP1963311A1 (en) 2008-09-03
ES2345726T3 (es) 2010-09-30
JP4481344B2 (ja) 2010-06-16
CN102321077A (zh) 2012-01-18
DOP2006000285A (es) 2007-07-31
CA2631880A1 (en) 2007-06-28
CN101341149A (zh) 2009-01-07
CN101341149B (zh) 2011-06-08
BRPI0620081B1 (pt) 2020-10-20
TW200732326A (en) 2007-09-01
BR122020004679B1 (pt) 2021-09-21
BRPI0620081A2 (pt) 2011-11-01
NL2000371A1 (nl) 2007-06-20
UY30043A1 (es) 2007-07-31
ATE471319T1 (de) 2010-07-15

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