AR058120A1 - Derivados de bencimidazol sustituidos con cromano, una composicion farmaceutica que los contiene y el uso de los mismos en el tratamiento de una enfermedad mediada por la inhibicion de la bomba de acido - Google Patents
Derivados de bencimidazol sustituidos con cromano, una composicion farmaceutica que los contiene y el uso de los mismos en el tratamiento de una enfermedad mediada por la inhibicion de la bomba de acidoInfo
- Publication number
- AR058120A1 AR058120A1 ARP060105611A ARP060105611A AR058120A1 AR 058120 A1 AR058120 A1 AR 058120A1 AR P060105611 A ARP060105611 A AR P060105611A AR P060105611 A ARP060105611 A AR P060105611A AR 058120 A1 AR058120 A1 AR 058120A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- alkyl
- hydroxy
- alkyl group
- unsubstituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Biomedical Technology (AREA)
- Nutrition Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75218105P | 2005-12-19 | 2005-12-19 | |
| US80294406P | 2006-05-23 | 2006-05-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR058120A1 true AR058120A1 (es) | 2008-01-23 |
Family
ID=37912450
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060105611A AR058120A1 (es) | 2005-12-19 | 2006-12-19 | Derivados de bencimidazol sustituidos con cromano, una composicion farmaceutica que los contiene y el uso de los mismos en el tratamiento de una enfermedad mediada por la inhibicion de la bomba de acido |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7723321B2 (pt) |
| EP (1) | EP1963311B1 (pt) |
| JP (1) | JP4481344B2 (pt) |
| KR (1) | KR101088247B1 (pt) |
| CN (2) | CN102321077A (pt) |
| AR (1) | AR058120A1 (pt) |
| AT (1) | ATE471319T1 (pt) |
| BR (2) | BRPI0620081B8 (pt) |
| CA (1) | CA2631880C (pt) |
| DE (1) | DE602006014996D1 (pt) |
| DO (1) | DOP2006000285A (pt) |
| ES (1) | ES2345726T3 (pt) |
| GT (1) | GT200600514A (pt) |
| HK (1) | HK1125368A1 (pt) |
| NL (1) | NL2000371C2 (pt) |
| PE (1) | PE20071182A1 (pt) |
| TW (1) | TW200732326A (pt) |
| UY (1) | UY30043A1 (pt) |
| WO (1) | WO2007072146A1 (pt) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2008267444A1 (en) * | 2007-06-26 | 2008-12-31 | Sanofi-Aventis | A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles |
| WO2011004882A1 (ja) * | 2009-07-09 | 2011-01-13 | ラクオリア創薬株式会社 | 消化管運動異常が関与する疾患を治療するためのアシッドポンプ拮抗剤 |
| KR101472686B1 (ko) | 2013-07-09 | 2014-12-16 | 씨제이헬스케어 주식회사 | 벤즈이미다졸 유도체의 제조방법 |
| KR102084185B1 (ko) | 2013-08-29 | 2020-03-04 | 주식회사 대웅제약 | 테트라히드로사이클로펜타피롤 유도체 및 이의 제조방법 |
| KR102129842B1 (ko) * | 2013-10-02 | 2020-07-06 | 주식회사 대웅제약 | 술포닐인돌 유도체 및 이의 제조방법 |
| PL3071206T3 (pl) | 2013-11-22 | 2022-01-17 | CL BioSciences LLC | Antagoniści gastryny (eg yf476, netazepid) do leczenia i zapobiegania osteoporozie |
| CN105440016B (zh) * | 2014-08-11 | 2018-08-31 | 江苏柯菲平医药股份有限公司 | 吲哚、氮杂吲哚类衍生物、其制备方法及其在医药上的应用 |
| KR101684053B1 (ko) * | 2015-01-20 | 2016-12-08 | 씨제이헬스케어 주식회사 | 벤즈이미다졸 유도체의 신규 결정형 및 이의 제조방법 |
| KR101613245B1 (ko) | 2015-04-27 | 2016-04-18 | 주식회사 대웅제약 | 신규의 4-메톡시 피롤 유도체 또는 이의 염 및 이를 포함하는 약학 조성물 |
| DK3305291T3 (da) * | 2015-06-08 | 2021-06-28 | Hk Inno N Corp | Anvendelser af benzimidazolderivat mod natligt syregennembrud |
| KR101769204B1 (ko) * | 2015-08-04 | 2017-08-17 | 씨제이헬스케어 주식회사 | 크로마놀 유도체의 신규한 제조방법 |
| KR101777971B1 (ko) | 2016-07-05 | 2017-09-12 | 제일약품주식회사 | 이미다조[1,2-a]피리딘 유도체, 이의 제조방법 및 이의 용도 |
| KR101829685B1 (ko) * | 2016-07-28 | 2018-02-19 | 씨제이헬스케어 주식회사 | 안정성 및 용해도가 개선된 주사용 조성물 |
| KR101829705B1 (ko) * | 2016-09-21 | 2018-02-19 | 씨제이헬스케어 주식회사 | 안정성이 향상된 주사용 조성물 |
| KR101829706B1 (ko) * | 2016-09-21 | 2018-02-19 | 씨제이헬스케어 주식회사 | 벤즈이미다졸 유도체의 산부가염 |
| US11142591B2 (en) * | 2016-12-20 | 2021-10-12 | Exxonmobil Chemical Patents Inc. | Polymerization process |
| KR101960357B1 (ko) * | 2016-12-26 | 2019-03-20 | 씨제이헬스케어 주식회사 | 벤즈이미다졸 유도체를 포함하는 신규한 제제 |
| KR102233456B1 (ko) * | 2017-05-31 | 2021-03-29 | 주식회사 대웅제약 | 4-메톡시피롤 유도체의 중간체 제조 방법 |
| KR102262743B1 (ko) * | 2017-07-07 | 2021-06-09 | 에이치케이이노엔 주식회사 | 주사용 조성물 |
| KR20190057569A (ko) | 2017-11-20 | 2019-05-29 | 제일약품주식회사 | 7-아미노-1h-인돌-5-카르복사미드 유도체 및 이의 용도 |
| TWI676477B (zh) * | 2017-12-05 | 2019-11-11 | 南韓商Ｃｊ醫藥健康股份有限公司 | 苯并咪唑衍生物用於夜間酸突破的用途 |
| KR20200024413A (ko) * | 2018-08-28 | 2020-03-09 | 에이치케이이노엔 주식회사 | 항혈소판제와 산 분비 억제제를 포함하는 약학 조성물 |
| JOP20190201A1 (ar) * | 2018-08-29 | 2020-02-29 | Hk Inno N Corp | تركيبة لاستئصال الملوية البوابية |
| CN109320485B (zh) * | 2018-12-02 | 2021-06-18 | 江苏慧聚药业有限公司 | 合成特戈拉赞手性醇的方法 |
| JP2022520276A (ja) * | 2019-02-18 | 2022-03-29 | エイチケー イノ．エヌ コーポレーション | ベンズイミダゾール誘導体化合物を含む医薬組成物 |
| CN112851646B (zh) * | 2019-11-12 | 2023-06-13 | 中国医学科学院药物研究所 | 特戈拉赞的制备方法 |
| UY39094A (es) * | 2020-02-27 | 2021-07-30 | Hk Inno N Corp | Composición farmacéutica que comprende compuesto derivado de bencimidazol |
| CN111303131B (zh) * | 2020-03-19 | 2021-06-04 | 江苏慧聚药业有限公司 | 特戈拉赞(Tegoprazan)类似物及其合成方法 |
| KR20210127108A (ko) | 2020-04-13 | 2021-10-21 | 에이치케이이노엔 주식회사 | 벤즈이미다졸 유도체 화합물을 포함하는 약학적 조성물 |
| UY39479A (es) | 2020-10-23 | 2021-11-30 | Hk Inno N Corp | Comprimido de desintegración oral que comprende compuesto derivado de benzimidazol y procedimiento de preparación del mismo |
| CN112358450A (zh) * | 2020-11-19 | 2021-02-12 | 南京艾康生物科技有限公司 | 一种4-(苄氧基)-2-甲基-1H-苯并[d]咪唑-6-羧酸的合成方法 |
| KR20220141700A (ko) | 2021-04-13 | 2022-10-20 | 에이치케이이노엔 주식회사 | 벤즈이미다졸 유도체 화합물을 포함하는 약학적 조성물 |
| CN113527272B (zh) * | 2021-08-06 | 2023-07-21 | 西安淳甄新材料有限公司 | 一种特戈拉赞的合成方法 |
| KR102648315B1 (ko) * | 2021-12-08 | 2024-03-15 | (주) 팜젠사이언스 | 벤즈이미다졸 유도체 화합물 및 이의 용도 |
| KR20230099093A (ko) * | 2021-12-27 | 2023-07-04 | 에이치케이이노엔 주식회사 | 벤즈이미다졸 유도체의 제조방법 |
| CN114805317A (zh) * | 2022-05-20 | 2022-07-29 | 江苏威奇达药业有限公司 | 一种特戈拉赞的制备方法 |
| KR20240028127A (ko) | 2022-08-24 | 2024-03-05 | 위더스제약주식회사 | 테고프라잔 고체분산체 조성물 |
| WO2024045255A1 (zh) * | 2022-08-30 | 2024-03-07 | 上海皓元医药股份有限公司 | 一种特戈拉赞晶型b及其制备方法 |
| WO2024087156A1 (zh) * | 2022-10-28 | 2024-05-02 | 深圳市华先医药科技有限公司 | 4-羟基-n,n,2-三甲基苯并咪唑-6-甲酰胺的可放大生产方法 |
| WO2024087155A1 (zh) * | 2022-10-28 | 2024-05-02 | 深圳市华先医药科技有限公司 | 一种合成4-羟基-n,n,2-三甲基苯并咪唑-6-甲酰胺的方法 |
| KR102638900B1 (ko) | 2023-01-27 | 2024-02-21 | 스마트바이오팜 주식회사 | 테고프라잔 중간체를 제조하는 방법 및 이에 사용되는 신규 중간체 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8604566D0 (sv) * | 1986-10-27 | 1986-10-27 | Haessle Ab | Novel compunds |
| US5444775A (en) | 1993-11-09 | 1995-08-22 | Tobish; John J. | Telephone key selection aid |
| SE9602286D0 (sv) * | 1996-06-10 | 1996-06-10 | Astra Ab | New compounds |
| GB9914022D0 (en) | 1999-06-17 | 1999-08-18 | Zeneca Ltd | Chemical compounds |
| AR043063A1 (es) | 2002-12-13 | 2005-07-13 | Altana Pharma Ag | Bencimidazoles 6-sustituidos y su uso como inhibidores de secreciones gastricas |
| AR049168A1 (es) * | 2004-05-18 | 2006-07-05 | Altana Pharma Ag | Derivados de benzimidazol |
| US7718809B2 (en) * | 2005-06-14 | 2010-05-18 | Raqualia Pharma Inc. | Chromane substituted benzimidazole derivatives as acid pump antagonists |
-
2006
- 2006-12-06 BR BRPI0620081A patent/BRPI0620081B8/pt active IP Right Grant
- 2006-12-06 CN CN2011101399640A patent/CN102321077A/zh active Pending
- 2006-12-06 KR KR1020087017466A patent/KR101088247B1/ko active Protection Beyond IP Right Term
- 2006-12-06 WO PCT/IB2006/003605 patent/WO2007072146A1/en active Application Filing
- 2006-12-06 ES ES06831708T patent/ES2345726T3/es active Active
- 2006-12-06 JP JP2008546663A patent/JP4481344B2/ja active Active
- 2006-12-06 AT AT06831708T patent/ATE471319T1/de not_active IP Right Cessation
- 2006-12-06 CA CA2631880A patent/CA2631880C/en active Active
- 2006-12-06 DE DE602006014996T patent/DE602006014996D1/de active Active
- 2006-12-06 EP EP06831708A patent/EP1963311B1/en active Active
- 2006-12-06 BR BR122020004679-1A patent/BR122020004679B1/pt not_active IP Right Cessation
- 2006-12-06 CN CN2006800479255A patent/CN101341149B/zh active Active
- 2006-12-13 NL NL2000371A patent/NL2000371C2/nl not_active IP Right Cessation
- 2006-12-18 PE PE2006001625A patent/PE20071182A1/es not_active Application Discontinuation
- 2006-12-18 TW TW095147456A patent/TW200732326A/zh unknown
- 2006-12-18 GT GT200600514A patent/GT200600514A/es unknown
- 2006-12-18 DO DO2006000285A patent/DOP2006000285A/es unknown
- 2006-12-19 US US11/612,583 patent/US7723321B2/en active Active
- 2006-12-19 UY UY30043A patent/UY30043A1/es not_active Application Discontinuation
- 2006-12-19 AR ARP060105611A patent/AR058120A1/es unknown
-
2009
- 2009-04-22 HK HK09103724.8A patent/HK1125368A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0620081B1 (pt) | 2020-10-20 |
| CN102321077A (zh) | 2012-01-18 |
| DE602006014996D1 (de) | 2010-07-29 |
| ES2345726T3 (es) | 2010-09-30 |
| GT200600514A (es) | 2007-07-17 |
| JP4481344B2 (ja) | 2010-06-16 |
| ATE471319T1 (de) | 2010-07-15 |
| DOP2006000285A (es) | 2007-07-31 |
| BR122020004679B1 (pt) | 2021-09-21 |
| PE20071182A1 (es) | 2008-02-07 |
| EP1963311B1 (en) | 2010-06-16 |
| CN101341149A (zh) | 2009-01-07 |
| UY30043A1 (es) | 2007-07-31 |
| CN101341149B (zh) | 2011-06-08 |
| US7723321B2 (en) | 2010-05-25 |
| NL2000371C2 (nl) | 2007-09-06 |
| HK1125368A1 (en) | 2009-08-07 |
| CA2631880C (en) | 2011-03-29 |
| JP2009520017A (ja) | 2009-05-21 |
| BRPI0620081A2 (pt) | 2011-11-01 |
| EP1963311A1 (en) | 2008-09-03 |
| US20070142448A1 (en) | 2007-06-21 |
| WO2007072146A1 (en) | 2007-06-28 |
| TW200732326A (en) | 2007-09-01 |
| KR20080080195A (ko) | 2008-09-02 |
| BRPI0620081B8 (pt) | 2021-05-25 |
| NL2000371A1 (nl) | 2007-06-20 |
| KR101088247B1 (ko) | 2011-11-30 |
| CA2631880A1 (en) | 2007-06-28 |
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