JP2009519961A5 - - Google Patents
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- JP2009519961A5 JP2009519961A5 JP2008545882A JP2008545882A JP2009519961A5 JP 2009519961 A5 JP2009519961 A5 JP 2009519961A5 JP 2008545882 A JP2008545882 A JP 2008545882A JP 2008545882 A JP2008545882 A JP 2008545882A JP 2009519961 A5 JP2009519961 A5 JP 2009519961A5
- Authority
- JP
- Japan
- Prior art keywords
- glp
- poly
- polymer complex
- polymer
- moiety
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims 23
- 102100025101 GATA-type zinc finger protein 1 Human genes 0.000 claims 15
- 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 claims 15
- 229920000642 polymer Polymers 0.000 claims 15
- 229920003169 water-soluble polymer Polymers 0.000 claims 9
- 239000002202 Polyethylene glycol Substances 0.000 claims 4
- 229920001223 polyethylene glycol Polymers 0.000 claims 4
- -1 poly (alkylene glycol Chemical compound 0.000 claims 3
- 150000004657 carbamic acid derivatives Chemical class 0.000 claims 2
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims 2
- 150000001733 carboxylic acid esters Chemical class 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 210000004072 lung Anatomy 0.000 claims 2
- 150000007970 thio esters Chemical class 0.000 claims 2
- XLPJNCYCZORXHG-UHFFFAOYSA-N 1-morpholin-4-ylprop-2-en-1-one Chemical compound C=CC(=O)N1CCOCC1 XLPJNCYCZORXHG-UHFFFAOYSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 1
- 229920001389 Poly(hydroxyalkylmethacrylamide) Polymers 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
- 150000001241 acetals Chemical class 0.000 claims 1
- 150000001336 alkenes Chemical class 0.000 claims 1
- 229940061720 alpha hydroxy acid Drugs 0.000 claims 1
- 150000001280 alpha hydroxy acids Chemical class 0.000 claims 1
- 150000008064 anhydrides Chemical class 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 238000000151 deposition Methods 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 150000002466 imines Chemical class 0.000 claims 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 claims 1
- 150000002905 orthoesters Chemical class 0.000 claims 1
- 150000003014 phosphoric acid esters Chemical class 0.000 claims 1
- 229920000765 poly(2-oxazolines) Polymers 0.000 claims 1
- 229920001390 poly(hydroxyalkylmethacrylate) Polymers 0.000 claims 1
- 229920002627 poly(phosphazenes) Polymers 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 229920001897 terpolymer Polymers 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75108205P | 2005-12-16 | 2005-12-16 | |
| US75112105P | 2005-12-16 | 2005-12-16 | |
| US60/751,082 | 2005-12-16 | ||
| US60/751,121 | 2005-12-16 | ||
| PCT/US2006/048181 WO2007075534A2 (en) | 2005-12-16 | 2006-12-18 | Polymer conjugates of glp-1 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009519961A JP2009519961A (ja) | 2009-05-21 |
| JP2009519961A5 true JP2009519961A5 (https=) | 2010-01-28 |
| JP5096363B2 JP5096363B2 (ja) | 2012-12-12 |
Family
ID=38039133
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008545882A Expired - Fee Related JP5096363B2 (ja) | 2005-12-16 | 2006-12-18 | Ｇｌｐ−１のポリマ複合体 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US8293869B2 (https=) |
| EP (2) | EP1968644B1 (https=) |
| JP (1) | JP5096363B2 (https=) |
| ES (1) | ES2390286T3 (https=) |
| WO (1) | WO2007075534A2 (https=) |
Families Citing this family (109)
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2006
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- 2006-12-18 EP EP06847728A patent/EP1968644B1/en active Active
- 2006-12-18 WO PCT/US2006/048181 patent/WO2007075534A2/en not_active Ceased
- 2006-12-18 EP EP11165922A patent/EP2364735A3/en not_active Withdrawn
- 2006-12-18 US US12/086,687 patent/US8293869B2/en not_active Expired - Fee Related
- 2006-12-18 ES ES06847728T patent/ES2390286T3/es active Active
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2012
- 2012-09-14 US US13/617,756 patent/US8580919B2/en not_active Expired - Fee Related
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