JP2007529539A5 - - Google Patents
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- Publication number
- JP2007529539A5 JP2007529539A5 JP2007504041A JP2007504041A JP2007529539A5 JP 2007529539 A5 JP2007529539 A5 JP 2007529539A5 JP 2007504041 A JP2007504041 A JP 2007504041A JP 2007504041 A JP2007504041 A JP 2007504041A JP 2007529539 A5 JP2007529539 A5 JP 2007529539A5
- Authority
- JP
- Japan
- Prior art keywords
- complex
- poly
- group
- hydrogel
- polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000017 hydrogel Substances 0.000 claims 13
- 239000003112 inhibitor Substances 0.000 claims 12
- 229920000642 polymer Polymers 0.000 claims 12
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 6
- -1 carboxylate esters Chemical group 0.000 claims 6
- 239000002131 composite material Substances 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- 229920003169 water-soluble polymer Polymers 0.000 claims 5
- 239000003153 chemical reaction reagent Substances 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims 4
- 150000007970 thio esters Chemical group 0.000 claims 4
- 150000004657 carbamic acid derivatives Chemical group 0.000 claims 3
- 150000004649 carbonic acid derivatives Chemical group 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 239000002243 precursor Substances 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 150000001241 acetals Chemical group 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 150000008064 anhydrides Chemical group 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- 229920001577 copolymer Polymers 0.000 claims 2
- 239000000499 gel Substances 0.000 claims 2
- 150000002466 imines Chemical group 0.000 claims 2
- 229940121292 leronlimab Drugs 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 150000002905 orthoesters Chemical group 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 150000003014 phosphoric acid esters Chemical group 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000006850 spacer group Chemical group 0.000 claims 2
- GXINKQQWHLIBJA-UCIBKFKQSA-N (z)-but-2-enedioic acid;(4,6-dimethylpyrimidin-5-yl)-[4-[(3s)-4-[(1r)-2-methoxy-1-[4-(trifluoromethyl)phenyl]ethyl]-3-methylpiperazin-1-yl]-4-methylpiperidin-1-yl]methanone Chemical compound OC(=O)\C=C/C(O)=O.N([C@@H](COC)C=1C=CC(=CC=1)C(F)(F)F)([C@H](C1)C)CCN1C(CC1)(C)CCN1C(=O)C1=C(C)N=CN=C1C GXINKQQWHLIBJA-UCIBKFKQSA-N 0.000 claims 1
- 108010036239 CD4-IgG(2) Proteins 0.000 claims 1
- WSNMPAVSZJSIMT-UHFFFAOYSA-N COc1c(C)c2COC(=O)c2c(O)c1CC(O)C1(C)CCC(=O)O1 Chemical compound COc1c(C)c2COC(=O)c2c(O)c1CC(O)C1(C)CCC(=O)O1 WSNMPAVSZJSIMT-UHFFFAOYSA-N 0.000 claims 1
- 208000031886 HIV Infections Diseases 0.000 claims 1
- 208000037357 HIV infectious disease Diseases 0.000 claims 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 238000001879 gelation Methods 0.000 claims 1
- 229920001519 homopolymer Polymers 0.000 claims 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 1
- 229920001477 hydrophilic polymer Polymers 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000035515 penetration Effects 0.000 claims 1
- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 230000004962 physiological condition Effects 0.000 claims 1
- 229920000765 poly(2-oxazolines) Polymers 0.000 claims 1
- 229920001584 poly(acrylomorpholines) Polymers 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 125000005415 substituted alkoxy group Chemical group 0.000 claims 1
- 150000003573 thiols Chemical class 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 0 CCC(C)(C)NC(O*(**)=C)=O Chemical compound CCC(C)(C)NC(O*(**)=C)=O 0.000 description 5
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55314604P | 2004-03-15 | 2004-03-15 | |
| US60/553,146 | 2004-03-15 | ||
| PCT/US2005/008632 WO2005089805A2 (en) | 2004-03-15 | 2005-03-15 | Polymer-based compositions and conjugates of hiv entry inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007529539A JP2007529539A (ja) | 2007-10-25 |
| JP2007529539A5 true JP2007529539A5 (https=) | 2008-03-27 |
| JP4805911B2 JP4805911B2 (ja) | 2011-11-02 |
Family
ID=34994420
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007504041A Expired - Fee Related JP4805911B2 (ja) | 2004-03-15 | 2005-03-15 | Ｈｉｖ侵入阻害剤のポリマー系組成物及び複合体 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9446139B2 (https=) |
| EP (1) | EP1725262B1 (https=) |
| JP (1) | JP4805911B2 (https=) |
| KR (1) | KR101276422B1 (https=) |
| CN (1) | CN101132812A (https=) |
| AU (1) | AU2005222641B2 (https=) |
| CA (1) | CA2558583C (https=) |
| MX (1) | MXPA06010505A (https=) |
| WO (1) | WO2005089805A2 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA05007151A (es) * | 2002-12-31 | 2005-09-21 | Nektar Therapeutics Al Corp | Polimeros terminados en maleimida hidroliticamente estables. |
| US7432331B2 (en) * | 2002-12-31 | 2008-10-07 | Nektar Therapeutics Al, Corporation | Hydrolytically stable maleimide-terminated polymers |
| AU2004313242A1 (en) * | 2004-01-07 | 2005-07-28 | Trimeris, Inc. | HIV gp41 HR2-derived synthetic peptides, and their use in therapy to inhibit transmission of human immunodeficiency virus |
| DE102004031258A1 (de) * | 2004-06-29 | 2006-02-09 | Jennissen, Herbert P., Prof. Dr. | Proteinhybride mit polyhydroxyaromatischen Aminosäure-Epitopen |
| WO2006110776A2 (en) | 2005-04-12 | 2006-10-19 | Nektar Therapeutics Al, Corporation | Polyethylene glycol cojugates of antimicrobial agents |
| TWI341844B (en) | 2006-02-02 | 2011-05-11 | Trimeris Inc | Hiv fusion inhibitor peptides with improved biological properties |
| US7462627B2 (en) * | 2006-02-09 | 2008-12-09 | Enzon Pharmaceuticals, Inc. | Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers |
| US7671067B2 (en) * | 2006-02-09 | 2010-03-02 | Enzon Pharmaceuticals, Inc. | Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin |
| US8309680B2 (en) | 2006-02-21 | 2012-11-13 | Nektar Therapeutics | Segmented degradable polymers and conjugates made therefrom |
| EP2089052A4 (en) * | 2006-05-24 | 2011-02-16 | Peg Biosciences | POLYETHYLENE GLYCOL-BASED LINK COMPOUNDS AND BIOLOGICALLY ACTIVE CONJUGATES BASED ON SAID COMPOUNDS |
| PL2054074T3 (pl) | 2006-08-04 | 2015-03-31 | Prolong Pharmaceuticals Llc | Zmodyfikowana erytropoetyna |
| KR20090108082A (ko) * | 2007-02-09 | 2009-10-14 | 엔존 파마슈티컬즈, 인코포레이티드 | 7-에틸-10-하이드록시캄토테신 다분지형 고분자 접합체를 이용한 내성 또는 불응성 암의 치료방법 |
| EP2134181A4 (en) * | 2007-02-28 | 2011-09-28 | Serina Therapeutics Inc | ACTIVATED POLYOXAZOLINES AND COMPOSITION COMPRISING THE SAME |
| US20140011964A1 (en) | 2007-02-28 | 2014-01-09 | Serina Therapeutics, Inc. | Activated Polyoxazolines and Conjugates and Compositions Comprising the Same |
| CA2682848A1 (en) * | 2007-04-03 | 2008-10-16 | Trimeris, Inc. | Novel formulations for delivery of antiviral peptide therapeutics |
| CN101874038A (zh) * | 2007-09-25 | 2010-10-27 | 特里梅里斯公司 | 治疗性抗-hiv肽的合成方法 |
| TW201010732A (en) * | 2008-08-29 | 2010-03-16 | Enzon Pharmaceuticals Inc | Method of treating RAS associated cancer |
| KR20110075029A (ko) * | 2008-10-21 | 2011-07-05 | 엔즌 파마슈티칼스, 인코포레이티드 | 7-에틸-10-하이드록시캄토테신의 다중-암 고분자 컨쥬게이트로 신경모세포종의 치료 |
| PT2501413T (pt) * | 2009-11-18 | 2019-07-10 | Nektar Therapeutics | Formas de sal de ácido de conjugados de polímero-fármaco |
| WO2011084458A2 (en) * | 2009-12-15 | 2011-07-14 | The Johns Hopkins University | Polymer-based compositions and methods for treatment of peritoneal disorders |
| US20110293686A1 (en) * | 2010-05-28 | 2011-12-01 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Anti-viral compositions and methods for administration |
| US20150072438A1 (en) * | 2012-04-18 | 2015-03-12 | Siemens Healthcare Diagnostic Inc. | Compounds and methods for preparation of conjugate reagents |
| CN104109240A (zh) * | 2014-07-13 | 2014-10-22 | 成都市绿科华通科技有限公司 | 一种可作为药物载体的多孔聚乙二醇的制备方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3670276B2 (ja) | 1991-02-08 | 2005-07-13 | プロゲニクス・ファーマスーティカルズ、インコーポレイテッド | ＣＤ４― ガンマ・２キメラ及びＣＤ４ ― ＩｇＧ２・キメラ |
| US5446090A (en) * | 1993-11-12 | 1995-08-29 | Shearwater Polymers, Inc. | Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules |
| US5932462A (en) * | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| US5792462A (en) * | 1995-05-23 | 1998-08-11 | University Of North Carolina At Chapel Hill | Alphavirus RNA replicon systems |
| JP4078032B2 (ja) * | 1998-03-12 | 2008-04-23 | ネクター セラピューティックス エイエル，コーポレイション | 近位の反応性基を持つポリ（エチレングリコール）誘導体 |
| US6656906B1 (en) * | 1998-05-20 | 2003-12-02 | Trimeris, Inc. | Hybrid polypeptides with enhanced pharmacokinetic properties |
| US20040228869A1 (en) | 1998-12-16 | 2004-11-18 | Progenics Pharmaceuticals, Inc. | Synergistic inhibition of HIV-1 fusion and attachment, compositions and antibodies thereto |
| US6469136B1 (en) | 1999-07-07 | 2002-10-22 | Trimeris, Inc. | Methods and composition for peptide synthesis |
| US6541020B1 (en) | 1999-07-09 | 2003-04-01 | Trimeris, Inc. | Methods and compositions for administration of therapeutic reagents |
| US6413507B1 (en) * | 1999-12-23 | 2002-07-02 | Shearwater Corporation | Hydrolytically degradable carbamate derivatives of poly (ethylene glycol) |
| US6602498B2 (en) * | 2000-02-22 | 2003-08-05 | Shearwater Corporation | N-maleimidyl polymer derivatives |
| AU2001247254A1 (en) | 2000-02-29 | 2001-09-12 | Aaron Diamond Aids Research Centre | Sulfated CCR5 peptides for HIV -1 infection |
| MXPA05000796A (es) | 2002-07-24 | 2005-04-19 | Hoffmann La Roche | Aditivos de acidos polialquilenglicolicos. |
| HRP20050024A2 (en) | 2002-07-24 | 2006-02-28 | F. Hoffmann - La Roche Ag | Pegylated t20 polypeptide |
| WO2004013165A1 (en) | 2002-07-24 | 2004-02-12 | F. Hoffmann-La Roche Ag | Pegylated t1249 polypeptide |
| KR20050093856A (ko) * | 2002-09-09 | 2005-09-23 | 넥타르 테라퓨틱스 에이엘, 코포레이션 | 수용성 중합체 알카날 |
| US7556813B2 (en) | 2002-09-27 | 2009-07-07 | Trimeris, Inc. | Antiviral peptide-polymer conjugate comprising a polymer covalently attached to two or more synthetic HIV gp41 HR1 and/or HR2 peptides |
| DE60331860D1 (en) * | 2002-12-30 | 2010-05-06 | Nektar Therapeutics | Mehrarmige polypeptid-poly(ethylenglykol)-blockcopolymere als arzneistoffzufuhrvehikel |
| DE60322111D1 (de) * | 2002-12-31 | 2008-08-21 | Nektar Therapeutics Al Co | Verfahren zur herstellung von hydrogelen aus thiosulfonat-zusammensetzungen und ihre verwendungen |
| JP4490369B2 (ja) * | 2002-12-31 | 2010-06-23 | ネクター セラピューティクス アラバマ，コーポレイション | マレアミド酸ポリマー誘導体及びこれらの生物学的複合体 |
| KR101207247B1 (ko) | 2003-01-06 | 2012-12-03 | 넥타르 테라퓨틱스 | 티올-선택성 수용성 중합체 유도체 |
| BRPI0407882B1 (pt) * | 2003-02-26 | 2021-07-27 | Nektar Therapeutics | Composição compreendendo conjugados de polímero-porção de fator viii e seu método de fabricação |
| EP2644206B1 (en) * | 2003-05-23 | 2019-04-03 | Nektar Therapeutics | PEG derivatives containing two PEG chains |
| CA2556032A1 (en) * | 2004-03-15 | 2005-09-29 | Trimeris, Inc. | Site-specific chemical modification of hiv gp41-derived peptides |
-
2005
- 2005-03-15 KR KR1020067019107A patent/KR101276422B1/ko not_active Expired - Fee Related
- 2005-03-15 US US11/082,229 patent/US9446139B2/en not_active Expired - Fee Related
- 2005-03-15 CN CNA2005800082104A patent/CN101132812A/zh active Pending
- 2005-03-15 JP JP2007504041A patent/JP4805911B2/ja not_active Expired - Fee Related
- 2005-03-15 WO PCT/US2005/008632 patent/WO2005089805A2/en not_active Ceased
- 2005-03-15 MX MXPA06010505A patent/MXPA06010505A/es active IP Right Grant
- 2005-03-15 CA CA2558583A patent/CA2558583C/en not_active Expired - Lifetime
- 2005-03-15 EP EP05725666.1A patent/EP1725262B1/en not_active Expired - Lifetime
- 2005-03-15 AU AU2005222641A patent/AU2005222641B2/en not_active Ceased
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