JP2012526548A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012526548A5 JP2012526548A5 JP2012510752A JP2012510752A JP2012526548A5 JP 2012526548 A5 JP2012526548 A5 JP 2012526548A5 JP 2012510752 A JP2012510752 A JP 2012510752A JP 2012510752 A JP2012510752 A JP 2012510752A JP 2012526548 A5 JP2012526548 A5 JP 2012526548A5
- Authority
- JP
- Japan
- Prior art keywords
- polymer compound
- structural formula
- bond
- peg
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001223 polyethylene glycol Polymers 0.000 claims description 20
- 239000002202 Polyethylene glycol Substances 0.000 claims description 18
- 239000007787 solid Substances 0.000 claims description 10
- -1 4-monomethoxytrityl group Chemical group 0.000 claims description 6
- 125000003342 alkenyl group Chemical group 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 125000000304 alkynyl group Chemical group 0.000 claims description 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 4
- 125000003118 aryl group Chemical group 0.000 claims description 4
- 125000004404 heteroalkyl group Chemical group 0.000 claims description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- 239000001257 hydrogen Substances 0.000 claims description 4
- 125000002103 4,4'-dimethoxytriphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] 0.000 claims description 3
- 125000001072 heteroaryl group Chemical group 0.000 claims description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 150000002431 hydrogen Chemical group 0.000 claims description 2
- 239000011800 void material Substances 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims 25
- 229920001600 hydrophobic polymer Polymers 0.000 claims 11
- 108020004459 Small interfering RNA Proteins 0.000 claims 7
- 239000005289 controlled pore glass Substances 0.000 claims 6
- 229920001477 hydrophilic polymer Polymers 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims 2
- 238000000137 annealing Methods 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 239000002105 nanoparticle Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- WYTZZXDRDKSJID-UHFFFAOYSA-N (3-aminopropyl)triethoxysilane Chemical compound CCO[Si](OCC)(OCC)CCCN WYTZZXDRDKSJID-UHFFFAOYSA-N 0.000 claims 1
- NXLNNXIXOYSCMB-UHFFFAOYSA-N (4-nitrophenyl) carbonochloridate Chemical compound [O-][N+](=O)C1=CC=C(OC(Cl)=O)C=C1 NXLNNXIXOYSCMB-UHFFFAOYSA-N 0.000 claims 1
- JBWYRBLDOOOJEU-UHFFFAOYSA-N 1-[chloro-(4-methoxyphenyl)-phenylmethyl]-4-methoxybenzene Chemical compound C1=CC(OC)=CC=C1C(Cl)(C=1C=CC(OC)=CC=1)C1=CC=CC=C1 JBWYRBLDOOOJEU-UHFFFAOYSA-N 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 150000003973 alkyl amines Chemical class 0.000 claims 1
- 238000003763 carbonization Methods 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 229920000765 poly(2-oxazolines) Polymers 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 0 CCC=CC(C(C1C=*=ICC1)(*=C)c(cc1)ccc1OC)=CCCOI Chemical compound CCC=CC(C(C1C=*=ICC1)(*=C)c(cc1)ccc1OC)=CCCOI 0.000 description 2
- DBWPJNWEBPQPOW-UHFFFAOYSA-N CC(c(cc1)ccc1OC)(C(C=C1)=CCC1OC)O Chemical compound CC(c(cc1)ccc1OC)(C(C=C1)=CCC1OC)O DBWPJNWEBPQPOW-UHFFFAOYSA-N 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2009-0042297 | 2009-05-14 | ||
| KR1020090042297A KR101224828B1 (ko) | 2009-05-14 | 2009-05-14 | ｓｉＲＮＡ 접합체 및 그 제조방법 |
| PCT/KR2010/003039 WO2010131916A2 (ko) | 2009-05-14 | 2010-05-13 | siRNA 접합체 및 그 제조방법 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013098798A Division JP5797688B2 (ja) | 2009-05-14 | 2013-05-08 | ｓｉＲＮＡ接合体及びその製造方法 |
| JP2014244541A Division JP2015107115A (ja) | 2009-05-14 | 2014-12-02 | ｓｉＲＮＡ接合体及びその製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012526548A JP2012526548A (ja) | 2012-11-01 |
| JP2012526548A5 true JP2012526548A5 (https=) | 2013-05-30 |
| JP5758381B2 JP5758381B2 (ja) | 2015-08-05 |
Family
ID=43085466
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012510752A Active JP5758381B2 (ja) | 2009-05-14 | 2010-05-13 | ｓｉＲＮＡ接合体及びその製造方法 |
| JP2013098798A Active JP5797688B2 (ja) | 2009-05-14 | 2013-05-08 | ｓｉＲＮＡ接合体及びその製造方法 |
| JP2014244541A Pending JP2015107115A (ja) | 2009-05-14 | 2014-12-02 | ｓｉＲＮＡ接合体及びその製造方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013098798A Active JP5797688B2 (ja) | 2009-05-14 | 2013-05-08 | ｓｉＲＮＡ接合体及びその製造方法 |
| JP2014244541A Pending JP2015107115A (ja) | 2009-05-14 | 2014-12-02 | ｓｉＲＮＡ接合体及びその製造方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US8779114B2 (https=) |
| EP (3) | EP2626427A3 (https=) |
| JP (3) | JP5758381B2 (https=) |
| KR (1) | KR101224828B1 (https=) |
| CN (3) | CN102439148B (https=) |
| AU (1) | AU2010248239B2 (https=) |
| BR (1) | BRPI1012141B1 (https=) |
| CA (2) | CA2761749C (https=) |
| RU (2) | RU2558258C2 (https=) |
| WO (1) | WO2010131916A2 (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101224828B1 (ko) | 2009-05-14 | 2013-01-22 | (주)바이오니아 | ｓｉＲＮＡ 접합체 및 그 제조방법 |
| WO2013089522A1 (ko) * | 2011-12-15 | 2013-06-20 | (주)바이오니아 | 신규한 올리고뉴클레오티드 접합체 및 그 용도 |
| KR101722948B1 (ko) * | 2012-01-05 | 2017-04-04 | (주)바이오니아 | 리간드가 결합된 이중나선 올리고 ｒｎａ 구조체 및 그 제조방법 |
| JP6060178B2 (ja) * | 2012-01-05 | 2017-01-18 | バイオニア コーポレーションＢｉｏｎｅｅｒ Ｃｏｒｐｏｒａｔｉｏｎ | 高効率のナノ粒子型二本鎖オリゴｒｎａ構造体およびその製造方法 |
| US9649388B2 (en) * | 2012-01-18 | 2017-05-16 | Bioneer Corporation | Magnetic nanoparticle-samirna complex and method for preparing same |
| EP2812091B1 (en) | 2012-09-17 | 2021-03-10 | W.R. Grace & CO. - CONN. | Chromatography media and devices |
| KR20150064065A (ko) * | 2012-10-05 | 2015-06-10 | (주)바이오니아 | 엠피레귤린 특이적 이중 나선 올리고 rna, 그러한 이중나선 올리고 rna 를 포함하는 이중나선 올리고 rna 구조체 및 이를 포함하는 호흡기 질환의 예방 또는 치료용 조성물 |
| JP6446269B2 (ja) * | 2012-12-06 | 2018-12-26 | 協和発酵バイオ株式会社 | アジュバント用二重鎖リボ核酸 |
| CN110592082A (zh) * | 2013-07-05 | 2019-12-20 | 柏业公司 | 呼吸疾病相关基因特异性siRNA、含有siRNA的双螺旋寡RNA结构及其用途 |
| CN105705639A (zh) * | 2013-07-05 | 2016-06-22 | 柏业公司 | 登革病毒相关的基因特异性siRNA、包含该siRNA的双链寡RNA分子、和包含它们的用于抑制登革病毒复制的组合物 |
| BR112016000160B1 (pt) | 2013-07-05 | 2021-06-08 | Bioneer Corporation | estrutura de oligonucleotídeo tipo nanopartícula melhorada tendo alta eficiência e método para a preparação da mesma |
| KR20150006743A (ko) * | 2013-07-09 | 2015-01-19 | (주)바이오니아 | 간암 연관 유전자 특이적 siRNA, 그러한 siRNA를 포함하는 이중나선 올리고 RNA 구조체 및 이를 포함하는 암 예방 또는 치료용 조성물 |
| KR20150006742A (ko) * | 2013-07-09 | 2015-01-19 | (주)바이오니아 | 간암 연관 유전자 특이적 siRNA, 그러한 siRNA를 포함하는 이중나선 올리고 RNA 구조체 및 이를 포함하는 암 예방 또는 치료용 조성물 |
| EP3128008B1 (en) * | 2014-04-04 | 2024-05-29 | Bioneer Corporation | Double-stranded oligo rna and pharmaceutical composition comprising same for preventing or treating fibrosis or respiratory diseases |
| PL3137209T3 (pl) | 2014-05-02 | 2023-01-02 | W.R. Grace & Co. - Conn. | Funkcjonalizowany materiał nośnikowy i sposoby wytwarzania oraz stosowania funkcjonalizowanego materiału nośnikowego |
| WO2016061310A2 (en) * | 2014-10-15 | 2016-04-21 | University Of Connecticut | Bio-reducible self-assembled liquid crystalline block copolymer for drug delivery |
| KR102566292B1 (ko) | 2015-06-05 | 2023-08-10 | 더블유.알. 그레이스 앤드 캄파니-콘. | 흡착성 바이오프로세싱 정화제와 이의 제조 및 사용 방법 |
| WO2016204515A1 (ko) * | 2015-06-15 | 2016-12-22 | (주)바이오니아 | STAT3 유전자 특이적 siRNA, 그러한 siRNA를 포함하는 이중나선 올리고 RNA 구조체, 이를 포함하는 조성물 및 이의 용도 |
| KR101861738B1 (ko) | 2016-08-24 | 2018-05-29 | (주)바이오니아 | 마이크로 rna를 포함하는 이중나선 올리고 rna 구조체 |
| KR20190123351A (ko) * | 2017-03-22 | 2019-10-31 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 개질된 올리고뉴클레오티드 및 이의 치료 용도 |
| CA3083970A1 (en) * | 2017-12-01 | 2019-06-06 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, composition and conjugate comprising the same, and preparation method and use thereof |
| DK3719128T3 (da) | 2017-12-01 | 2025-03-03 | Suzhou Ribo Life Science Co Ltd | Dobbelt-strenget oligonukleotid, sammensætning og konjugat bestaende dobbelt-strenget oligonukleotid, fremgangsmåde herfor og anvendelse heraf |
| EP3719126B1 (en) | 2017-12-01 | 2025-01-01 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, composition and conjugate containing nucleic acid, preparation method therefor and use thereof |
| CN110944675B9 (zh) | 2017-12-01 | 2024-08-09 | 苏州瑞博生物技术股份有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| EP3719127A4 (en) | 2017-12-01 | 2021-10-20 | Suzhou Ribo Life Science Co., Ltd. | NUCLEIC ACID, COMPOSITION AND CONJUGATE WITH IT, MANUFACTURING METHOD AND USE |
| AU2018394875B2 (en) | 2017-12-29 | 2023-08-03 | Suzhou Ribo Life Science Co., Ltd. | Conjugates and preparation and use thereof |
| KR102141124B1 (ko) * | 2018-01-30 | 2020-08-04 | (주)바이오니아 | 이중 가닥 miRNA를 포함하는 이중나선 올리고뉴클레오타이드 구조체 및 이의 용도 |
| KR102746742B1 (ko) | 2018-05-25 | 2024-12-26 | (주)바이오니아 | 엠피레귤린 유전자 특이적 이중가닥 올리고뉴클레오티드 및 이를 포함하는 섬유증 관련 질환 및 호흡기 관련 질환 예방 및 치료용 조성물 |
| WO2020038377A1 (zh) | 2018-08-21 | 2020-02-27 | 苏州瑞博生物技术有限公司 | 一种核酸、含有该核酸的药物组合物和缀合物及其用途 |
| US11896674B2 (en) | 2018-09-30 | 2024-02-13 | Suzhou Ribo Life Science Co., Ltd. | SiRNA conjugate, preparation method therefor and use thereof |
| KR102473989B1 (ko) | 2018-11-28 | 2022-12-07 | (주)바이오니아 | 안드로젠 수용체 특이적 서열을 포함하는 이중나선 올리고뉴클레오티드 구조체, 및 이를 포함하는 탈모 예방 및 발모용 조성물 |
| WO2020135673A1 (zh) | 2018-12-28 | 2020-07-02 | 苏州瑞博生物技术有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| WO2020149644A1 (ko) | 2019-01-15 | 2020-07-23 | (주)바이오니아 | Dkk1 유전자를 표적으로 하는 이중나선 올리고뉴클레오티드, 이를 포함하는 구조체 및 이를 포함하는 탈모 예방 또는 발모용 조성물 |
| AU2020280439B2 (en) | 2019-05-22 | 2025-08-14 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, pharmaceutical composition, conjugate, preparation method, and use |
| US12590304B2 (en) | 2019-05-22 | 2026-03-31 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, pharmaceutical composition, conjugate, preparation method, and use |
| KR20220011689A (ko) | 2019-05-22 | 2022-01-28 | 쑤저우 리보 라이프 사이언스 컴퍼니, 리미티드 | 핵산, 약제학적 조성물, 접합체, 제조 방법, 및 용도 |
| CN113795582B (zh) | 2019-05-24 | 2024-05-24 | 苏州瑞博生物技术股份有限公司 | 核酸、药物组合物与缀合物及制备方法和用途 |
| KR102757180B1 (ko) | 2019-11-22 | 2025-01-21 | (주)바이오니아 | Ctgf 유전자 특이적 이중가닥 올리고뉴클레오티드 및 이를 포함하는 섬유증 관련 질환 및 호흡기 관련 질환 예방 및 치료용 조성물 |
| EP4151236A4 (en) | 2020-05-14 | 2024-06-26 | Bioneer Corporation | Composition for preventing or treating obesity-related disease containing amphiregulin-specific double-stranded oligonucleotide structure |
| AU2021275643A1 (en) | 2020-05-22 | 2022-12-15 | Bioneer Corporation | Double-stranded oligonucleotide and composition for treating covid-19 containing same |
| KR102272800B1 (ko) | 2020-06-30 | 2021-07-05 | 국방과학연구소 | 코로나바이러스 특이적 이중가닥 올리고뉴클레오티드 및 이를 포함하는 코로나바이러스 감염증-19 예방 및 치료용 조성물 |
| WO2022182188A1 (ko) | 2021-02-25 | 2022-09-01 | (주)바이오니아 | 이중가닥 mirna를 유효성분으로 포함하는 모발의 회백색화 개선, 발모 촉진 및/또는 탈모의 예방 또는 개선용 조성물 |
| CA3210813A1 (en) | 2021-03-08 | 2022-09-15 | Han-Oh Park | Composition for administration of double-stranded oligonucleotide structures using ultrasonic nebulizer for prevention or treatment of respiratory viral infection including covid-19, pulmonary fibrosis caused by viral infection, or respiratory disease |
| CR20250257A (es) | 2022-12-02 | 2025-08-28 | Shanghai Argo Biopharmaceutical Co Ltd | Análogos de ácidos nucleicos bicíclicos abásicos y compuestos oligoméricos preparados a partir de estos |
| CN115747220A (zh) * | 2022-12-04 | 2023-03-07 | 山西医科大学第二医院 | 主动靶向型阳离子碳点携载Survivin siRNA递送系统及其应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5451463A (en) * | 1989-08-28 | 1995-09-19 | Clontech Laboratories, Inc. | Non-nucleoside 1,3-diol reagents for labeling synthetic oligonucleotides |
| US5141813A (en) * | 1989-08-28 | 1992-08-25 | Clontech Laboratories, Inc. | Multifunctional controlled pore glass reagent for solid phase oligonucleotide synthesis |
| US6221959B1 (en) | 1994-11-18 | 2001-04-24 | Supratek Pharma, Inc. | Polynucleotide compositions |
| US6348583B1 (en) * | 1999-08-30 | 2002-02-19 | Bio-Rad Laboratories, Inc. | Poly(ether-thioether), poly(ether-sulfoxide) and poly(ether-sulfone) nucleic acids |
| US7491805B2 (en) * | 2001-05-18 | 2009-02-17 | Sirna Therapeutics, Inc. | Conjugates and compositions for cellular delivery |
| AU2003295600A1 (en) | 2002-11-14 | 2004-06-15 | Dharmacon, Inc. | Functional and hyperfunctional sirna |
| US8324365B2 (en) * | 2003-04-03 | 2012-12-04 | Korea Advanced Institute Of Science And Technology | Conjugate for gene transfer comprising oligonucleotide and hydrophilic polymer, polyelectrolyte complex micelles formed from the conjugate, and methods for preparation thereof |
| US7851615B2 (en) * | 2003-04-17 | 2010-12-14 | Alnylam Pharmaceuticals, Inc. | Lipophilic conjugated iRNA agents |
| JP4579911B2 (ja) * | 2003-06-03 | 2010-11-10 | アイシス・ファーマシューティカルズ・インコーポレイテッド | スルビビン発現の調節 |
| KR101147147B1 (ko) * | 2004-04-01 | 2012-05-25 | 머크 샤프 앤드 돔 코포레이션 | Ｒｎａ 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드 |
| CA2619533C (en) | 2005-08-17 | 2014-02-04 | Bioneer Corporation | Sirna-hydrophilic polymer conjugates for intracellular delivery of sirna and method thereof |
| CN101346393B (zh) | 2005-11-02 | 2015-07-22 | 普洛体维生物治疗公司 | 修饰的siRNA分子及其应用 |
| EP2046954A2 (en) * | 2006-07-31 | 2009-04-15 | Curevac GmbH | NUCLEIC ACID OF FORMULA (I): GIXmGn, OR (II): CIXmCn, IN PARTICULAR AS AN IMMUNE-STIMULATING AGENT/ADJUVANT |
| EP2025348A1 (en) * | 2007-08-13 | 2009-02-18 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Targeted block copolymer micelles |
| EP2195428B1 (en) * | 2007-09-19 | 2013-12-11 | Applied Biosystems, LLC | SiRNA SEQUENCE-INDEPENDENT MODIFICATION FORMATS FOR REDUCING OFF-TARGET PHENOTYPIC EFFECTS IN RNAi, AND STABILIZED FORMS THEREOF |
| TW200927177A (en) * | 2007-10-24 | 2009-07-01 | Nat Inst Of Advanced Ind Scien | Lipid-modified double-stranded RNA having potent RNA interference effect |
| KR101224828B1 (ko) | 2009-05-14 | 2013-01-22 | (주)바이오니아 | ｓｉＲＮＡ 접합체 및 그 제조방법 |
-
2009
- 2009-05-14 KR KR1020090042297A patent/KR101224828B1/ko active Active
-
2010
- 2010-05-13 JP JP2012510752A patent/JP5758381B2/ja active Active
- 2010-05-13 CA CA2761749A patent/CA2761749C/en active Active
- 2010-05-13 US US13/319,885 patent/US8779114B2/en active Active
- 2010-05-13 BR BRPI1012141A patent/BRPI1012141B1/pt active IP Right Grant
- 2010-05-13 AU AU2010248239A patent/AU2010248239B2/en active Active
- 2010-05-13 CN CN201080021324.3A patent/CN102439148B/zh active Active
- 2010-05-13 RU RU2011150787/10A patent/RU2558258C2/ru active
- 2010-05-13 EP EP13159602.5A patent/EP2626427A3/en not_active Withdrawn
- 2010-05-13 EP EP10775118.2A patent/EP2463371B1/en active Active
- 2010-05-13 CN CN201210301551.2A patent/CN102888404B/zh active Active
- 2010-05-13 CN CN201310147988.XA patent/CN103233003B/zh active Active
- 2010-05-13 WO PCT/KR2010/003039 patent/WO2010131916A2/ko not_active Ceased
- 2010-05-13 EP EP13185358.2A patent/EP2682466B1/en active Active
- 2010-05-13 CA CA2871888A patent/CA2871888A1/en not_active Abandoned
-
2012
- 2012-09-13 US US13/613,071 patent/US8772472B2/en active Active
-
2013
- 2013-05-08 JP JP2013098798A patent/JP5797688B2/ja active Active
- 2013-11-21 RU RU2013151977/10A patent/RU2571218C2/ru active
-
2014
- 2014-05-30 US US14/291,656 patent/US20140350233A1/en not_active Abandoned
- 2014-05-30 US US14/291,540 patent/US9211343B2/en active Active
- 2014-12-02 JP JP2014244541A patent/JP2015107115A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012526548A5 (https=) | ||
| RU2011150787A (ru) | КОНЪЮГАТ миРНК И СПОСОБ ЕГО ПОЛУЧЕНИЯ | |
| Hosseinkhani | Nanomaterials in advanced medicine | |
| Chakraborty et al. | Harnessing the physicochemical properties of DNA as a multifunctional biomaterial for biomedical and other applications | |
| JP2013525080A5 (https=) | ||
| JP2011092201A5 (https=) | ||
| JP2011528654A5 (https=) | ||
| JP5600846B2 (ja) | キトサン基材高分子接合体及びその製造方法 | |
| JP2009535462A (ja) | 化学的に異なる末端基を含むポリ（エチレングリコール） | |
| CA2679070C (en) | Oligomer-antihistamine conjugates | |
| Ramezani et al. | Graphene-based hybrid nanomaterials for biomedical applications | |
| ES2809481T3 (es) | Estructura de oligonucleótidos de tipo nanopartícula mejorada que tiene alta eficiencia y método para preparar la misma | |
| JP2013510181A5 (https=) | ||
| RU2016103695A (ru) | СВЯЗАННАЯ С РЕСПИРАТОРНЫМ ЗАБОЛЕВАНИЕМ ГЕН-СПЕЦИФИЧЕСКАЯ миРНК, ДВУСПИРАЛЬНАЯ КОНСТРУКЦИЯ ОЛИГО-РНК, СОДЕРЖАЩАЯ миРНК, И СОДЕРЖАЩАЯ ЕЕ КОМПОЗИЦИЯ ДЛЯ ПРЕДУПРЕЖДЕНИЯ ИЛИ ЛЕЧЕНИЯ РЕСПИРАТОРНОГО ЗАБОЛЕВАНИЯ | |
| US8921426B2 (en) | Cationic bis-urea compounds as effective antimicrobial agents | |
| WO2015083377A1 (en) | Polycarbonates bearing aromatic n-heterocycles for drug delivery | |
| Cao et al. | Dual-functionalized covalent triazine framework nanosheets as hierarchical nonviral vectors for intracellular gene delivery | |
| JP2007070277A5 (https=) | ||
| JP2010540488A5 (https=) | ||
| RU2012105579A (ru) | Способ конъюгирования полимера с белком, конъюгат, полученный указанным способом, композиция и лекарственное средство на его основе и способ лечения с их помощью | |
| KR101541969B1 (ko) | 단백질 전달용 나노 복합체 및 이의 제조방법 | |
| Choi et al. | Synthesis of antibacterial poly ((2-methylsulfinyl) ethyl acrylate-co-acrylic acid)-based electrospun nanofibers | |
| CN102614522A (zh) | 树状大分子修饰多壁碳纳米管复合材料负载阿霉素的制备 | |
| RU2010126662A (ru) | Связывающие мср-1 нуклеиновые кислоты и их применение | |
| CN105705639A (zh) | 登革病毒相关的基因特异性siRNA、包含该siRNA的双链寡RNA分子、和包含它们的用于抑制登革病毒复制的组合物 |