JP2012526548A5 - - Google Patents
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- JP2012526548A5 JP2012526548A5 JP2012510752A JP2012510752A JP2012526548A5 JP 2012526548 A5 JP2012526548 A5 JP 2012526548A5 JP 2012510752 A JP2012510752 A JP 2012510752A JP 2012510752 A JP2012510752 A JP 2012510752A JP 2012526548 A5 JP2012526548 A5 JP 2012526548A5
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- 229920001223 polyethylene glycol Polymers 0.000 claims description 20
- 239000002202 Polyethylene glycol Substances 0.000 claims description 18
- 239000007787 solid Substances 0.000 claims description 10
- -1 4-monomethoxytrityl group Chemical group 0.000 claims description 6
- 125000003342 alkenyl group Chemical group 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 125000000304 alkynyl group Chemical group 0.000 claims description 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 4
- 125000003118 aryl group Chemical group 0.000 claims description 4
- 125000004404 heteroalkyl group Chemical group 0.000 claims description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- 239000001257 hydrogen Substances 0.000 claims description 4
- 125000002103 4,4'-dimethoxytriphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] 0.000 claims description 3
- 125000001072 heteroaryl group Chemical group 0.000 claims description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 150000002431 hydrogen Chemical group 0.000 claims description 2
- 239000011800 void material Substances 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims 25
- 229920001600 hydrophobic polymer Polymers 0.000 claims 11
- 108020004459 Small interfering RNA Proteins 0.000 claims 7
- 239000005289 controlled pore glass Substances 0.000 claims 6
- 229920001477 hydrophilic polymer Polymers 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims 2
- 238000000137 annealing Methods 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 239000002105 nanoparticle Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- WYTZZXDRDKSJID-UHFFFAOYSA-N (3-aminopropyl)triethoxysilane Chemical compound CCO[Si](OCC)(OCC)CCCN WYTZZXDRDKSJID-UHFFFAOYSA-N 0.000 claims 1
- NXLNNXIXOYSCMB-UHFFFAOYSA-N (4-nitrophenyl) carbonochloridate Chemical compound [O-][N+](=O)C1=CC=C(OC(Cl)=O)C=C1 NXLNNXIXOYSCMB-UHFFFAOYSA-N 0.000 claims 1
- JBWYRBLDOOOJEU-UHFFFAOYSA-N 1-[chloro-(4-methoxyphenyl)-phenylmethyl]-4-methoxybenzene Chemical compound C1=CC(OC)=CC=C1C(Cl)(C=1C=CC(OC)=CC=1)C1=CC=CC=C1 JBWYRBLDOOOJEU-UHFFFAOYSA-N 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 150000003973 alkyl amines Chemical class 0.000 claims 1
- 238000003763 carbonization Methods 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 229920000765 poly(2-oxazolines) Polymers 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 0 CCC=CC(C(C1C=*=ICC1)(*=C)c(cc1)ccc1OC)=CCCOI Chemical compound CCC=CC(C(C1C=*=ICC1)(*=C)c(cc1)ccc1OC)=CCCOI 0.000 description 2
- DBWPJNWEBPQPOW-UHFFFAOYSA-N CC(c(cc1)ccc1OC)(C(C=C1)=CCC1OC)O Chemical compound CC(c(cc1)ccc1OC)(C(C=C1)=CCC1OC)O DBWPJNWEBPQPOW-UHFFFAOYSA-N 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2009-0042297 | 2009-05-14 | ||
| KR1020090042297A KR101224828B1 (ko) | 2009-05-14 | 2009-05-14 | ｓｉＲＮＡ 접합체 및 그 제조방법 |
| PCT/KR2010/003039 WO2010131916A2 (ko) | 2009-05-14 | 2010-05-13 | siRNA 접합체 및 그 제조방법 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013098798A Division JP5797688B2 (ja) | 2009-05-14 | 2013-05-08 | ｓｉＲＮＡ接合体及びその製造方法 |
| JP2014244541A Division JP2015107115A (ja) | 2009-05-14 | 2014-12-02 | ｓｉＲＮＡ接合体及びその製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012526548A JP2012526548A (ja) | 2012-11-01 |
| JP2012526548A5 true JP2012526548A5 (https=) | 2013-05-30 |
| JP5758381B2 JP5758381B2 (ja) | 2015-08-05 |
Family
ID=43085466
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012510752A Active JP5758381B2 (ja) | 2009-05-14 | 2010-05-13 | ｓｉＲＮＡ接合体及びその製造方法 |
| JP2013098798A Active JP5797688B2 (ja) | 2009-05-14 | 2013-05-08 | ｓｉＲＮＡ接合体及びその製造方法 |
| JP2014244541A Pending JP2015107115A (ja) | 2009-05-14 | 2014-12-02 | ｓｉＲＮＡ接合体及びその製造方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013098798A Active JP5797688B2 (ja) | 2009-05-14 | 2013-05-08 | ｓｉＲＮＡ接合体及びその製造方法 |
| JP2014244541A Pending JP2015107115A (ja) | 2009-05-14 | 2014-12-02 | ｓｉＲＮＡ接合体及びその製造方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US8779114B2 (https=) |
| EP (3) | EP2463371B1 (https=) |
| JP (3) | JP5758381B2 (https=) |
| KR (1) | KR101224828B1 (https=) |
| CN (3) | CN102439148B (https=) |
| AU (1) | AU2010248239B2 (https=) |
| BR (1) | BRPI1012141B1 (https=) |
| CA (2) | CA2761749C (https=) |
| RU (2) | RU2558258C2 (https=) |
| WO (1) | WO2010131916A2 (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101224828B1 (ko) | 2009-05-14 | 2013-01-22 | (주)바이오니아 | ｓｉＲＮＡ 접합체 및 그 제조방법 |
| CA2859127C (en) * | 2011-12-15 | 2017-04-25 | Bioneer Corporation | Novel oligonucleotide conjugates and use thereof |
| KR101722948B1 (ko) * | 2012-01-05 | 2017-04-04 | (주)바이오니아 | 리간드가 결합된 이중나선 올리고 ｒｎａ 구조체 및 그 제조방법 |
| CN104114704A (zh) * | 2012-01-05 | 2014-10-22 | 株式会社百奥尼 | 高效率的纳米颗粒型双螺旋寡rna结构体及其制备方法 |
| WO2013109057A1 (ko) * | 2012-01-18 | 2013-07-25 | (주)바이오니아 | 자성나노입자-samirna 복합체 및 그 제조방법 |
| RU2015114330A (ru) | 2012-09-17 | 2016-11-10 | У.Р. Грейс Энд Ко.-Конн. | Хроматографические среды и устройства |
| CA2887069A1 (en) | 2012-10-05 | 2014-04-10 | Bioneer Corporation | Amphiregulin-specific double-helical oligo-rna, double-helical oligo-rna structure comprising double-helical oligo-rna, and composition for preventing or treating respiratory diseases containing same |
| EP2930180B1 (en) * | 2012-12-06 | 2021-11-10 | Kyowa Hakko Bio Co., Ltd. | Double-stranded ribonucleic acid for adjuvants |
| US9695421B2 (en) | 2013-07-05 | 2017-07-04 | Bioneer Corporation | Dengue virus-specific siRNA, double helix oligo-RNA structure comprising siRNA, and composition for suppressing proliferation of dengue virus comprising RNA structure |
| WO2015002513A2 (ko) * | 2013-07-05 | 2015-01-08 | (주)바이오니아 | 호흡기 질환 연관 유전자 특이적 siRNA, 그러한 siRNA를 포함하는 이중나선 올리고 RNA 구조체 및 이를 포함하는 호흡기 질환 예방 또는 치료용 조성물 |
| CN105705638B (zh) * | 2013-07-05 | 2019-11-26 | 柏业公司 | 改善的具有高效能的纳米颗粒型寡核苷酸结构及其制备方法 |
| KR20150006742A (ko) * | 2013-07-09 | 2015-01-19 | (주)바이오니아 | 간암 연관 유전자 특이적 siRNA, 그러한 siRNA를 포함하는 이중나선 올리고 RNA 구조체 및 이를 포함하는 암 예방 또는 치료용 조성물 |
| KR20150006743A (ko) * | 2013-07-09 | 2015-01-19 | (주)바이오니아 | 간암 연관 유전자 특이적 siRNA, 그러한 siRNA를 포함하는 이중나선 올리고 RNA 구조체 및 이를 포함하는 암 예방 또는 치료용 조성물 |
| CN106459974A (zh) * | 2014-04-04 | 2017-02-22 | 柏业公司 | 新颖的双链寡rna和包含它的用于预防或治疗纤维化或呼吸系统疾病的药物组合物 |
| JP6914189B2 (ja) | 2014-05-02 | 2021-08-04 | ダブリュー・アール・グレース・アンド・カンパニー−コーンＷ Ｒ Ｇｒａｃｅ ＆ Ｃｏ−Ｃｏｎｎ | 官能化担体材料並びに官能化担体材料を作製及び使用する方法 |
| CN107922559B (zh) * | 2014-10-15 | 2020-07-24 | 康涅狄格大学 | 用于药物递送的生物可还原的自装配液晶嵌段共聚物 |
| CN107921407B (zh) | 2015-06-05 | 2022-07-05 | 格雷斯公司 | 生物处理吸附澄清剂及其制备和使用方法 |
| WO2016204515A1 (ko) * | 2015-06-15 | 2016-12-22 | (주)바이오니아 | STAT3 유전자 특이적 siRNA, 그러한 siRNA를 포함하는 이중나선 올리고 RNA 구조체, 이를 포함하는 조성물 및 이의 용도 |
| KR101861738B1 (ko) | 2016-08-24 | 2018-05-29 | (주)바이오니아 | 마이크로 rna를 포함하는 이중나선 올리고 rna 구조체 |
| AU2018237139A1 (en) * | 2017-03-22 | 2019-10-17 | The Regents Of The University Of California | Modified oligonucleotides and therapeutic uses thereof |
| WO2019105437A1 (zh) * | 2017-12-01 | 2019-06-06 | 苏州瑞博生物技术有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| WO2019105435A1 (zh) | 2017-12-01 | 2019-06-06 | 苏州瑞博生物技术有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| CN110945130B (zh) | 2017-12-01 | 2024-04-09 | 苏州瑞博生物技术股份有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| CA3083968C (en) | 2017-12-01 | 2024-04-23 | Suzhou Ribo Life Science Co., Ltd. | Double-stranded oligonucleotide, composition and conjugate comprising double-stranded oligonucleotide, preparation method thereof and use thereof |
| JP7365052B2 (ja) | 2017-12-01 | 2023-10-19 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 核酸、当該核酸を含む組成物及び複合体ならびに調製方法と使用 |
| EP3732185B1 (en) | 2017-12-29 | 2025-02-26 | Suzhou Ribo Life Science Co., Ltd. | Conjugates and preparation and use thereof |
| KR102141124B1 (ko) * | 2018-01-30 | 2020-08-04 | (주)바이오니아 | 이중 가닥 miRNA를 포함하는 이중나선 올리고뉴클레오타이드 구조체 및 이의 용도 |
| KR102746742B1 (ko) | 2018-05-25 | 2024-12-26 | (주)바이오니아 | 엠피레귤린 유전자 특이적 이중가닥 올리고뉴클레오티드 및 이를 포함하는 섬유증 관련 질환 및 호흡기 관련 질환 예방 및 치료용 조성물 |
| US11918600B2 (en) | 2018-08-21 | 2024-03-05 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, pharmaceutical composition and conjugate containing nucleic acid, and use thereof |
| EP3862024A4 (en) | 2018-09-30 | 2022-08-17 | Suzhou Ribo Life Science Co., Ltd. | SIRNA CONJUGATE, METHOD FOR ITS PRODUCTION AND ITS USE |
| KR102473989B1 (ko) * | 2018-11-28 | 2022-12-07 | (주)바이오니아 | 안드로젠 수용체 특이적 서열을 포함하는 이중나선 올리고뉴클레오티드 구조체, 및 이를 포함하는 탈모 예방 및 발모용 조성물 |
| US12496347B2 (en) | 2018-12-28 | 2025-12-16 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, composition and conjugate containing nucleic acid, preparation method therefor and use thereof |
| WO2020149644A1 (ko) | 2019-01-15 | 2020-07-23 | (주)바이오니아 | Dkk1 유전자를 표적으로 하는 이중나선 올리고뉴클레오티드, 이를 포함하는 구조체 및 이를 포함하는 탈모 예방 또는 발모용 조성물 |
| AU2020280438B2 (en) | 2019-05-22 | 2025-03-06 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, pharmaceutical composition, conjugate, preparation method, and use |
| WO2020233680A1 (zh) | 2019-05-22 | 2020-11-26 | 苏州瑞博生物技术股份有限公司 | 核酸、药物组合物与缀合物及制备方法和用途 |
| JP7610268B2 (ja) | 2019-05-22 | 2025-01-08 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 核酸、薬物組成物及び複合体ならびに調製方法と使用 |
| EP3978609A4 (en) | 2019-05-24 | 2024-02-07 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, pharmaceutical composition, conjugate, preparation method, and use |
| KR102757180B1 (ko) | 2019-11-22 | 2025-01-21 | (주)바이오니아 | Ctgf 유전자 특이적 이중가닥 올리고뉴클레오티드 및 이를 포함하는 섬유증 관련 질환 및 호흡기 관련 질환 예방 및 치료용 조성물 |
| AU2021270895B2 (en) | 2020-05-14 | 2025-01-30 | Bioneer Corporation | Composition for preventing or treating obesity-related disease containing amphiregulin-specific double-stranded oligonucleotide structure |
| CN116157521A (zh) | 2020-05-22 | 2023-05-23 | 柏业公司 | 双链寡核苷酸和用于治疗covid-19的含有其的组合物 |
| KR102272800B1 (ko) | 2020-06-30 | 2021-07-05 | 국방과학연구소 | 코로나바이러스 특이적 이중가닥 올리고뉴클레오티드 및 이를 포함하는 코로나바이러스 감염증-19 예방 및 치료용 조성물 |
| CN116847888A (zh) * | 2021-02-25 | 2023-10-03 | 柏业公司 | 用于减轻毛发变白、促进毛发生长和/或预防或减轻脱发的包含双链miRNA作为活性成分的组合物 |
| CN117677402A (zh) | 2021-03-08 | 2024-03-08 | 柏业公司 | 用于使用超声雾化器施用用于预防或治疗包括covid-19的呼吸道病毒感染、由病毒感染引起的肺纤维化或呼吸道疾病的双链寡核苷酸结构的组合物 |
| CN120225676A (zh) | 2022-12-02 | 2025-06-27 | 上海舶望制药有限公司 | 双环脱碱基核酸类似物以及由它们制备的寡聚化合物 |
| CN115747220A (zh) * | 2022-12-04 | 2023-03-07 | 山西医科大学第二医院 | 主动靶向型阳离子碳点携载Survivin siRNA递送系统及其应用 |
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| AU2007280690C1 (en) * | 2006-07-31 | 2012-08-23 | Curevac Gmbh | Nucleic acid of formula (I): GIXmGn, or (II): CIXmCn, in particular as an immune-stimulating agent/adjuvant |
| EP2025348A1 (en) * | 2007-08-13 | 2009-02-18 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Targeted block copolymer micelles |
| DK2548962T3 (en) * | 2007-09-19 | 2016-04-11 | Applied Biosystems Llc | Sirna sequence-independent modification formats to reduce off-target phenotype effects in RNAI and stabilized forms thereof |
| TW200927177A (en) * | 2007-10-24 | 2009-07-01 | Nat Inst Of Advanced Ind Scien | Lipid-modified double-stranded RNA having potent RNA interference effect |
| KR101224828B1 (ko) | 2009-05-14 | 2013-01-22 | (주)바이오니아 | ｓｉＲＮＡ 접합체 및 그 제조방법 |
-
2009
- 2009-05-14 KR KR1020090042297A patent/KR101224828B1/ko active Active
-
2010
- 2010-05-13 EP EP10775118.2A patent/EP2463371B1/en active Active
- 2010-05-13 EP EP13159602.5A patent/EP2626427A3/en not_active Withdrawn
- 2010-05-13 CA CA2761749A patent/CA2761749C/en active Active
- 2010-05-13 WO PCT/KR2010/003039 patent/WO2010131916A2/ko not_active Ceased
- 2010-05-13 CN CN201080021324.3A patent/CN102439148B/zh active Active
- 2010-05-13 JP JP2012510752A patent/JP5758381B2/ja active Active
- 2010-05-13 CN CN201210301551.2A patent/CN102888404B/zh active Active
- 2010-05-13 BR BRPI1012141A patent/BRPI1012141B1/pt active IP Right Grant
- 2010-05-13 US US13/319,885 patent/US8779114B2/en active Active
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- 2010-05-13 AU AU2010248239A patent/AU2010248239B2/en active Active
- 2010-05-13 RU RU2011150787/10A patent/RU2558258C2/ru active
- 2010-05-13 EP EP13185358.2A patent/EP2682466B1/en active Active
- 2010-05-13 CA CA2871888A patent/CA2871888A1/en not_active Abandoned
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2012
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2013
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2014
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- 2014-12-02 JP JP2014244541A patent/JP2015107115A/ja active Pending
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