JP2013525080A5 - - Google Patents

Download PDF

Info

Publication number
JP2013525080A5
JP2013525080A5 JP2013509279A JP2013509279A JP2013525080A5 JP 2013525080 A5 JP2013525080 A5 JP 2013525080A5 JP 2013509279 A JP2013509279 A JP 2013509279A JP 2013509279 A JP2013509279 A JP 2013509279A JP 2013525080 A5 JP2013525080 A5 JP 2013525080A5
Authority
JP
Japan
Prior art keywords
optionally substituted
solid support
alkyl
heteroarylalkyl
arylalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2013509279A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013525080A (ja
JP5964815B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2011/035422 external-priority patent/WO2011140392A1/en
Publication of JP2013525080A publication Critical patent/JP2013525080A/ja
Publication of JP2013525080A5 publication Critical patent/JP2013525080A5/ja
Application granted granted Critical
Publication of JP5964815B2 publication Critical patent/JP5964815B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2013509279A 2010-05-05 2011-05-05 固体担体からの放出制御薬物 Active JP5964815B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33174210P 2010-05-05 2010-05-05
US61/331,742 2010-05-05
PCT/US2011/035422 WO2011140392A1 (en) 2010-05-05 2011-05-05 Controlled drug release from solid supports

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016050380A Division JP6250723B2 (ja) 2010-05-05 2016-03-15 固体担体からの放出制御薬物

Publications (3)

Publication Number Publication Date
JP2013525080A JP2013525080A (ja) 2013-06-20
JP2013525080A5 true JP2013525080A5 (https=) 2014-06-19
JP5964815B2 JP5964815B2 (ja) 2016-08-03

Family

ID=44904089

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2013509279A Active JP5964815B2 (ja) 2010-05-05 2011-05-05 固体担体からの放出制御薬物
JP2016050380A Active JP6250723B2 (ja) 2010-05-05 2016-03-15 固体担体からの放出制御薬物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2016050380A Active JP6250723B2 (ja) 2010-05-05 2016-03-15 固体担体からの放出制御薬物

Country Status (6)

Country Link
US (1) US8946405B2 (https=)
EP (1) EP2566334B1 (https=)
JP (2) JP5964815B2 (https=)
CN (1) CN103025164B (https=)
DK (1) DK2566334T3 (https=)
WO (1) WO2011140392A1 (https=)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009091531A2 (en) * 2008-01-16 2009-07-23 The General Hospital Corporation Uniform-sized, multi-drug carrying and photosensitive liposomes for advance drug delivery
ES2584381T3 (es) 2010-05-05 2016-09-27 Prolynx Llc Liberación controlada de compuestos activos desde conjugados macromoleculares
IN2014DN00101A (https=) 2011-06-06 2015-05-15 Starpharma Pty Ltd
CA2848142C (en) 2011-09-07 2021-05-18 Prolynx Llc Hydrogels with biodegradable crosslinking
WO2013036857A1 (en) * 2011-09-07 2013-03-14 Prolynx Llc Sulfone linkers
CA2873112A1 (en) * 2012-05-11 2013-11-14 Alexander Krantz Site-specific labeling and targeted delivery of proteins for the treatment of cancer
EP2925256A4 (en) * 2013-01-22 2016-08-17 Prolynx Llc SEALANTS HAVING CONTROLLED DEGRADATION
ES2966631T3 (es) 2013-06-19 2024-04-23 Univ California Estructuras químicas para el suministro localizado de agentes terapéuticos
KR20160075665A (ko) 2013-10-22 2016-06-29 프로린크스 엘엘시 소마토스타틴 및 그 유사체의 컨쥬게이트
KR102442906B1 (ko) * 2013-12-19 2022-09-14 씨젠 인크. 표적화된-약물 컨쥬게이트와 함께 사용되는 메틸렌 카바메이트 링커
CN106659796B (zh) * 2014-03-14 2021-04-30 加利福尼亚大学董事会 Tco缀合物和治疗剂递送方法
CA3007976C (en) 2016-01-08 2023-09-26 Ascendis Pharma Growth Disorders A/S Cnp prodrugs with large carrier moieties
EP3400021A1 (en) 2016-01-08 2018-11-14 Ascendis Pharma Growth Disorders A/S Controlled-release cnp agonists with low npr-c binding
IL259827B2 (en) 2016-01-08 2025-07-01 Ascendis Pharma Growth Disorders As Controlled-release CNP agonists with low initial NPR-B activity
WO2017118700A1 (en) 2016-01-08 2017-07-13 Ascendis Pharma Growth Disorders A/S Controlled-release cnp agonists with increased nep stability
DK3400019T3 (da) 2016-01-08 2022-10-24 Ascendis Pharma Growth Disorders As CNP-prodrugs med bærerbinding ved ringenheden
ES3064816T3 (en) 2016-01-08 2026-04-29 Ascendis Pharma Growth Disorders As Controlled-release cnp agonists with reduced side-effects
MY208384A (en) * 2016-03-01 2025-05-05 Ascendis Pharma Bone Diseases As Pth prodrugs
KR20180129825A (ko) * 2016-03-16 2018-12-05 프로린크스 엘엘시 엑세나타이드 유사체의 연장된 방출 컨쥬게이트
US11896671B2 (en) 2016-07-13 2024-02-13 Ascendis Pharma A/S Conjugation method for carrier-linked prodrugs
US11564974B2 (en) 2016-09-29 2023-01-31 Ascendis Pharma Growth Disorders A/S Combination therapy with controlled-release CNP agonists
HRP20230383T1 (hr) 2016-09-29 2023-07-07 Ascendis Pharma Bone Diseases A/S Pth spojevi s malim omjerima maksimalne prema minimalnoj koncentraciji
US12453778B2 (en) 2016-09-29 2025-10-28 Ascendis Pharma Bone Diseases A/S Incremental dose finding in controlled-release PTH compounds
KR102627405B1 (ko) 2016-09-29 2024-01-18 아센디스 파마 본 디지즈 에이/에스 조절 방출 pth 화합물을 위한 투여 용법
TWI773730B (zh) 2017-02-22 2022-08-11 瑞典商阿斯特捷利康公司 治療性樹枝狀聚合物
AR111190A1 (es) 2017-03-22 2019-06-12 Genentech Inc Composiciones en hidrogel de prodrogas entrecruzadas de ácido hialurónico y métodos relacionados
JOP20190245A1 (ar) 2017-04-20 2019-10-15 Novartis Ag أنظمة توصيل إطلاق مستدام تتضمن روابط بلا أثر لنقطة الربط
WO2019058374A1 (en) 2017-09-19 2019-03-28 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. N-METHYLATED CYCLIC PEPTIDES AND PRODRUGS THEREOF
US20200323962A1 (en) * 2017-09-19 2020-10-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Lipophilic peptide prodrugs
MX2020007442A (es) 2018-01-12 2020-09-14 Prolynx Llc Protocolo para minimizar la toxicidad de dosificaciones de combinacion y agente formador de imagen para verificacion.
EP3765096A1 (en) 2018-03-12 2021-01-20 Boston Scientific Scimed Inc. Scavenging methods, and scavenging system for radiocontrast agents
CN111918665B (zh) 2018-03-28 2024-11-26 阿森迪斯药物肿瘤股份有限公司 Il-2缀合物
AU2019246390B2 (en) 2018-03-28 2025-03-27 Ascendis Pharma A/S Conjugates
CN112334152A (zh) 2018-05-18 2021-02-05 阿森迪斯药物骨疾病股份有限公司 Pth缀合物的起始剂量
WO2020014750A1 (en) 2018-07-19 2020-01-23 Starpharma Pty Ltd Therapeutic dendrimer
US12071517B2 (en) 2018-07-19 2024-08-27 Starpharma Pty Ltd. Therapeutic dendrimer
WO2020064847A1 (en) 2018-09-26 2020-04-02 Ascendis Pharma A/S Degradable hyaluronic acid hydrogels
EP3856256A1 (en) 2018-09-26 2021-08-04 Ascendis Pharma A/S Novel hydrogel conjugates
WO2020064844A1 (en) 2018-09-26 2020-04-02 Ascendis Pharma A/S Treatment of infections
TW202027794A (zh) 2018-10-03 2020-08-01 瑞士商諾華公司 血管生成素樣3多肽之持續遞送
CA3125488A1 (en) 2019-01-04 2020-07-09 Ascendis Pharma Oncology Division A/S Induction of sustained local inflammation
EP3906065B1 (en) 2019-01-04 2025-04-30 Ascendis Pharma Oncology Division A/S Prr agonist for use in the treatment of cancer
PH12021551591A1 (en) 2019-01-04 2022-04-18 Ascendis Pharma Oncology Div A/S Conjugates of pattern recognition receptor agonists
AU2020204785A1 (en) 2019-01-04 2021-06-03 Ascendis Pharma Oncology Division A/S Sustained local drug levels for innate immune agonists
MX2021008708A (es) 2019-02-11 2021-09-21 Ascendis Pharma Growth Disorders As Formulaciones farmaceuticas secas de conjugados de peptido natriuretico tipo c (cnp).
MY209748A (en) 2019-02-11 2025-07-31 Ascendis Pharma Bone Diseases As Liquid pharmaceutical formulations of pth conjugates
CN119970617A (zh) 2019-04-05 2025-05-13 普罗林科斯有限责任公司 改良偶联接头
CN114126638A (zh) * 2019-04-26 2022-03-01 普罗林科斯有限责任公司 缓慢释放的细胞因子偶联物
US12527871B2 (en) 2019-06-05 2026-01-20 Boston Scientific Scimed, Inc. Click chemistry capturable platinum-based antineoplastic agents
WO2020254617A1 (en) 2019-06-21 2020-12-24 Ascendis Pharma Oncology Division A/S Anti-ctla4 compounds with localized pk properties
WO2020254613A1 (en) 2019-06-21 2020-12-24 Ascendis Pharma Oncology Division A/S Controlled-release tyrosine kinase inhibitor compounds with localized pk properties
WO2020254612A1 (en) 2019-06-21 2020-12-24 Ascendis Pharma Oncology Division A/S Controlled-release tyrosine kinase inhibitor compounds with localized pd properties
AU2020295725A1 (en) 2019-06-21 2021-12-02 Ascendis Pharma Oncology Division A/S Anti-CTLA4 conjugates
WO2020254603A1 (en) * 2019-06-21 2020-12-24 Ascendis Pharma A/S CONJUGATES OF π-ELECTRON-PAIR-DONATING HETEROAROMATIC NITROGEN-COMPRISING COMPOUNDS
TW202114660A (zh) 2019-06-21 2021-04-16 丹麥商阿仙帝斯製藥公司 酪胺酸激酶抑制劑結合物
WO2020254607A1 (en) 2019-06-21 2020-12-24 Ascendis Pharma Oncology Division A/S Anti-ctla4 compounds with localized pd properties
CA3153644A1 (en) * 2019-09-30 2021-04-08 Beijing Xuanyi Pharmasciences Co., Ltd. Protein-macromolecule conjugates and methods of use thereof
MX2022007371A (es) 2020-01-13 2022-07-12 Ascendis Pharma Bone Diseases As Tratamiento del hipoparatiroidismo.
EP4146281A1 (en) 2020-05-04 2023-03-15 Ascendis Pharma A/S Hydrogel irradiation
KR20230019889A (ko) 2020-06-03 2023-02-09 아센디스 파마 온콜로지 디비전 에이/에스 Il-2 서열 및 이의 용도
TW202219060A (zh) 2020-08-28 2022-05-16 丹麥商阿森迪斯腫瘤製藥有限公司 醣基化il-2蛋白及其用途
WO2022064035A1 (en) 2020-09-28 2022-03-31 Ascendis Pharma Bone Diseases A/S Improvement of physical and mental well-being of patients with hypoparathyroidism
JP2024514095A (ja) 2021-04-01 2024-03-28 アセンディス ファーマ エー/エス 炎症によって誘発される疾患を治療するための長時間作用型成長ホルモンの使用
IL311539A (en) 2021-09-22 2024-05-01 Ascendis Pharma Bone Diseases As Long-acting pth compound treatments
US20250017948A1 (en) * 2021-10-19 2025-01-16 The United States Government As Represented By The Department Of Veterans Affairs Cannabinoid compositions for gastroesophageal disorders
WO2023110758A1 (en) 2021-12-13 2023-06-22 Ascendis Pharma Growth Disorders A/S Effective doses of cnp conjugates
MX2024006698A (es) 2021-12-13 2024-06-19 Ascendis Pharma Oncology Div A/S Tratamientos de cancer con agonistas de los receptores tipo toll 7 y 8 (tlr7/8).
EP4529454A1 (en) 2022-05-23 2025-04-02 Ascendis Pharma Growth Disorders A/S Liquid pharmaceutical formulations of cnp compounds
CN114874624B (zh) * 2022-05-27 2023-04-07 深圳市博致远科技有限公司 一种导热吸波室温固化硅橡胶产品及其制备方法
JP2025537527A (ja) 2022-11-02 2025-11-18 アセンディス ファーマ ボーン ディジージズ エー/エス 2つのpth化合物を含むpth治療レジメン
WO2024104922A1 (en) 2022-11-14 2024-05-23 Ascendis Pharma Growth Disorders A/S Method of improving skeletal muscle function
TW202434299A (zh) 2023-01-05 2024-09-01 丹麥商阿仙帝斯製藥公司 製造水凝膠微球之方法
TW202430223A (zh) 2023-01-05 2024-08-01 丹麥商阿仙帝斯眼科製藥有限公司 用於治療眼部病症之藥物結合物
EP4676535A1 (en) 2023-03-06 2026-01-14 Ascendis Pharma A/S Multi-albumin binding compounds
JP2026509773A (ja) 2023-03-06 2026-03-25 アセンディス ファーマ エー/エス アルブミン結合性部分を含む薬物化合物
WO2024184351A1 (en) 2023-03-06 2024-09-12 Ascendis Pharma A/S Compounds of drugs with an albumin binding moiety
AU2024240722A1 (en) 2023-03-20 2025-09-18 Ascendis Pharma Growth Disorders A/S Method of treatment of a thoracolumbar deformity in a human subject with achondroplasia
CN121175071A (zh) 2023-05-09 2025-12-19 阿森迪斯药物肿瘤股份有限公司 使用il-2缀合物的新型癌症治疗方法
IL326658A (en) 2023-09-04 2026-04-01 Ascendis Pharma Bone Diseases As PTH treatment in chronic kidney disease
WO2025208117A1 (en) * 2024-03-29 2025-10-02 Maha Therapeutics, Inc. Cleavable ester compounds and uses thereof
WO2026013135A1 (en) 2024-07-10 2026-01-15 Ascendis Pharma A/S Albumin-binding reagents
WO2026013138A1 (en) 2024-07-10 2026-01-15 Ascendis Pharma A/S Compounds with improved albumin-binding
WO2026013136A1 (en) 2024-07-10 2026-01-15 Ascendis Pharma A/S Albumin-binding compounds

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3563968A (en) 1967-10-03 1971-02-16 Gaf Corp Process for the preparation of functional polymers from n-vinyl pyrrolidone
US4265233A (en) 1978-04-12 1981-05-05 Unitika Ltd. Material for wound healing
US4769445A (en) 1985-03-04 1988-09-06 Pennwalt Corporation Process for the solid phase synthesis of peptides which contain sulfated tyrosine
US6033719A (en) 1996-04-25 2000-03-07 Medtronic, Inc. Method for covalent attachment of biomolecules to surfaces of medical devices
US6273913B1 (en) 1997-04-18 2001-08-14 Cordis Corporation Modified stent useful for delivery of drugs along stent strut
MXPA02011891A (es) 2000-06-02 2004-04-02 Eidgenoess Tech Hochschule Reacciones de adicion conjugadas para la entrega controlada de compuestos farmaceuticamente activos.
US7264822B2 (en) * 2002-04-03 2007-09-04 Poly-Med, Inc. Conjugated drug-polymer coated stent
US7647099B2 (en) 2002-04-29 2010-01-12 Rocky Mountain Biosystems, Inc. Controlled release transdermal drug delivery
US7732535B2 (en) 2002-09-05 2010-06-08 Advanced Cardiovascular Systems, Inc. Coating for controlled release of drugs from implantable medical devices
PL1620118T3 (pl) 2003-04-08 2014-11-28 Yeda Res & Dev Leki odwracalnie pegylowane
WO2008071387A1 (en) * 2006-12-11 2008-06-19 Topotarget A/S Prodrugs of diphenyl ox- indol- 2 -one compounds for the treatment of cancers
US7863387B2 (en) * 2007-10-25 2011-01-04 Boston Scientific Scimed, Inc. Dehydrofluorination and surface modification of fluoropolymers for drug delivery applications
ES2672526T3 (es) 2008-06-26 2018-06-14 Prolynx Llc Profármacos y conjugados de fármaco-macromolécula que presentan velocidades de liberación de fármaco controladas
US8703907B2 (en) * 2010-05-05 2014-04-22 Prolynx Llc Controlled drug release from dendrimers
ES2584381T3 (es) 2010-05-05 2016-09-27 Prolynx Llc Liberación controlada de compuestos activos desde conjugados macromoleculares

Similar Documents

Publication Publication Date Title
JP2013525080A5 (https=)
JP2010511721A5 (https=)
JP2007246474A5 (https=)
JP2007502293A5 (https=)
JP2012523457A5 (https=)
JP2012526548A5 (https=)
JP2021512167A5 (https=)
JP2011528654A5 (https=)
JP2007511527A5 (https=)
JP2012533546A5 (https=)
JP2008543743A5 (https=)
JP2011513410A5 (https=)
JP2009535358A5 (https=)
JP2007502295A5 (https=)
JP2009536660A5 (https=)
JP2005532287A5 (https=)
JP2014515406A5 (https=)
JP2009542716A5 (https=)
JP2012530713A5 (https=)
JP2010521485A5 (https=)
JP2023538524A5 (https=)
JPWO2021049504A5 (https=)
JP2005527542A5 (https=)
JP2013506674A5 (https=)
JP2019526546A5 (https=)