JP2013525080A5 - - Google Patents

Download PDF

Info

Publication number
JP2013525080A5
JP2013525080A5 JP2013509279A JP2013509279A JP2013525080A5 JP 2013525080 A5 JP2013525080 A5 JP 2013525080A5 JP 2013509279 A JP2013509279 A JP 2013509279A JP 2013509279 A JP2013509279 A JP 2013509279A JP 2013525080 A5 JP2013525080 A5 JP 2013525080A5
Authority
JP
Japan
Prior art keywords
optionally substituted
solid support
alkyl
heteroarylalkyl
arylalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2013509279A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013525080A (ja
JP5964815B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2011/035422 external-priority patent/WO2011140392A1/en
Publication of JP2013525080A publication Critical patent/JP2013525080A/ja
Publication of JP2013525080A5 publication Critical patent/JP2013525080A5/ja
Application granted granted Critical
Publication of JP5964815B2 publication Critical patent/JP5964815B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2013509279A 2010-05-05 2011-05-05 固体担体からの放出制御薬物 Active JP5964815B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33174210P 2010-05-05 2010-05-05
US61/331,742 2010-05-05
PCT/US2011/035422 WO2011140392A1 (en) 2010-05-05 2011-05-05 Controlled drug release from solid supports

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016050380A Division JP6250723B2 (ja) 2010-05-05 2016-03-15 固体担体からの放出制御薬物

Publications (3)

Publication Number Publication Date
JP2013525080A JP2013525080A (ja) 2013-06-20
JP2013525080A5 true JP2013525080A5 (https=) 2014-06-19
JP5964815B2 JP5964815B2 (ja) 2016-08-03

Family

ID=44904089

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2013509279A Active JP5964815B2 (ja) 2010-05-05 2011-05-05 固体担体からの放出制御薬物
JP2016050380A Active JP6250723B2 (ja) 2010-05-05 2016-03-15 固体担体からの放出制御薬物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2016050380A Active JP6250723B2 (ja) 2010-05-05 2016-03-15 固体担体からの放出制御薬物

Country Status (6)

Country Link
US (1) US8946405B2 (https=)
EP (1) EP2566334B1 (https=)
JP (2) JP5964815B2 (https=)
CN (1) CN103025164B (https=)
DK (1) DK2566334T3 (https=)
WO (1) WO2011140392A1 (https=)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110105995A1 (en) * 2008-01-16 2011-05-05 Zhu Ting F Uniform-sized, multi-drug carrying, and photosensitive liposomes for advanced drug delivery
EP2566335B1 (en) 2010-05-05 2016-06-29 Prolynx Llc Controlled release of active compounds from macromolecular conjugates
BR112013031556B1 (pt) 2011-06-06 2022-03-29 Starpharma Pty Ltd Macromoléculas, uso das mesmas para tratar ou suprimir o crescimento de um câncer e composições farmacêuticas
KR102109067B1 (ko) 2011-09-07 2020-05-13 프로린크스 엘엘시 생분해성 교차결합을 가지는 하이드로젤
WO2013036857A1 (en) * 2011-09-07 2013-03-14 Prolynx Llc Sulfone linkers
CA2873112A1 (en) * 2012-05-11 2013-11-14 Alexander Krantz Site-specific labeling and targeted delivery of proteins for the treatment of cancer
WO2014116717A1 (en) * 2013-01-22 2014-07-31 Prolynx Llc Sealants having controlled degradation
US10130711B2 (en) 2013-06-19 2018-11-20 The Regents Of The University Of California Chemical structures for localized delivery of therapeutic agents
SG10201803370XA (en) * 2013-10-22 2018-06-28 Prolynx Llc Conjugates of somatostatin and its analogs
JP6701077B2 (ja) * 2013-12-19 2020-05-27 シアトル ジェネティックス, インコーポレイテッド 標的化薬物結合体と使用するためのメチレンカルバメートリンカー
ES2880468T3 (es) 2014-03-14 2021-11-24 Univ California Conjugados de TCO y métodos para el suministro de agentes terapéuticos
LT3400019T (lt) 2016-01-08 2022-12-12 Ascendis Pharma Growth Disorders A/S Cnp provaistai su prie žiedo fragmento prijungtu nešikliu
MX2018008061A (es) 2016-01-08 2018-08-23 Ascendis Pharma Growth Disorders As Profarmacos de peptido natriuretico tipo c (cnp) con porciones portadoras grandes.
WO2017118707A1 (en) 2016-01-08 2017-07-13 Ascendis Pharma Growth Disorders A/S Controlled-release cnp agonists with reduced side-effects
IL259827B2 (en) 2016-01-08 2025-07-01 Ascendis Pharma Growth Disorders As Controlled-release CNP agonists with low initial NPR-B activity
NZ743487A (en) 2016-01-08 2023-02-24 Ascendis Pharma Growth Disorders As Controlled-release cnp agonists with increased nep stability
IL297375B2 (en) 2016-01-08 2024-02-01 Ascendis Pharma Growth Disorders As Controlled-release CNP agonists with low NPR–C binding
MX2018009938A (es) 2016-03-01 2019-03-14 Ascendis Pharma Bone Diseases As Profarmacos de hormona paratiroidea (pth).
EP3922269A1 (en) * 2016-03-16 2021-12-15 Prolynx LLC Extended release conjugates of exenatide analogs
US11896671B2 (en) 2016-07-13 2024-02-13 Ascendis Pharma A/S Conjugation method for carrier-linked prodrugs
MA46428B1 (fr) 2016-09-29 2025-02-28 Ascendis Pharma Bone Diseases A/S Composés de pth à libération contrôlée
CN109789189B (zh) 2016-09-29 2024-01-23 阿森迪斯药物骨疾病股份有限公司 控释pth化合物的剂量方案
HUE062117T2 (hu) 2016-09-29 2023-09-28 Ascendis Pharma Growth Disorders As Kombinációs terápia szabályozott felszabadulású CNP agonistákkal
EP3518961B1 (en) 2016-09-29 2023-02-22 Ascendis Pharma Bone Diseases A/S Pth compounds with low peak-to-trough ratios
TWI773730B (zh) 2017-02-22 2022-08-11 瑞典商阿斯特捷利康公司 治療性樹枝狀聚合物
SG10202107829YA (en) 2017-03-22 2021-08-30 Genentech Inc Hydrogel cross-linked hyaluronic acid prodrug compositions and methods
JOP20190245A1 (ar) 2017-04-20 2019-10-15 Novartis Ag أنظمة توصيل إطلاق مستدام تتضمن روابط بلا أثر لنقطة الربط
WO2019058367A1 (en) * 2017-09-19 2019-03-28 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. LIPOPHILIC PRODRUGS BASED ON PEPTIDES
US11965041B2 (en) 2017-09-19 2024-04-23 Technische Universitaet Muenchen N-methylated cyclic peptides and their prodrugs
MX2020007306A (es) 2018-01-12 2020-09-25 Prolynx Llc Tratamiento sinergico de cancer.
EP3765096A1 (en) * 2018-03-12 2021-01-20 Boston Scientific Scimed Inc. Scavenging methods, and scavenging system for radiocontrast agents
EP3773681A1 (en) 2018-03-28 2021-02-17 Ascendis Pharma A/S Conjugates
WO2019185705A1 (en) 2018-03-28 2019-10-03 Ascendis Pharma A/S Il-2 conjugates
PL3793587T3 (pl) 2018-05-18 2025-09-22 Ascendis Pharma Bone Diseases A/S Dawka początkowa koniugatów PTH
BR112021000658A2 (pt) 2018-07-19 2021-04-13 Starpharma Pty Ltd Dendrímero, composições, composição farmacêutica, método de tratamento de câncer, uso de dendrímero, método, uso, dendrímero ou composição, processo de produção de dendrímero e intermediários para a produção de dendrímero
US12071517B2 (en) 2018-07-19 2024-08-27 Starpharma Pty Ltd. Therapeutic dendrimer
IL281690B2 (en) 2018-09-26 2025-01-01 Ascendis Pharma As New hydrogel bracelets
WO2020064847A1 (en) 2018-09-26 2020-04-02 Ascendis Pharma A/S Degradable hyaluronic acid hydrogels
WO2020064844A1 (en) 2018-09-26 2020-04-02 Ascendis Pharma A/S Treatment of infections
AR116566A1 (es) 2018-10-03 2021-05-19 Novartis Ag Administración sostenida de polipéptidos similares a la angiopoyetina 3
BR112021010043A2 (pt) 2019-01-04 2021-10-26 Ascendis Pharma Oncology Division A/S Níveis de fármaco locais sustentados para agonistas imunes inatos
EP3906065B1 (en) 2019-01-04 2025-04-30 Ascendis Pharma Oncology Division A/S Prr agonist for use in the treatment of cancer
AU2020204786A1 (en) 2019-01-04 2021-06-10 Ascendis Pharma Oncology Division A/S Induction of sustained local inflammation
TW202500188A (zh) 2019-01-04 2025-01-01 丹麥商阿仙帝斯製藥公司 模式辨別受體(pattern recognition receptor)促效劑的共軛物
EP3923906A1 (en) 2019-02-11 2021-12-22 Ascendis Pharma Growth Disorders A/S Dry pharmaceutical formulations of cnp conjugates
CA3129357A1 (en) 2019-02-11 2020-08-20 Ascendis Pharma Bone Diseases A/S Liquid pharmaceutical formulations of pth conjugates
WO2020206358A1 (en) 2019-04-05 2020-10-08 Prolynx Llc Improved conjugation linkers
KR20220004134A (ko) * 2019-04-26 2022-01-11 프로린크스 엘엘시 서방형 사이토카인 컨쥬게이트
WO2020247151A1 (en) 2019-06-05 2020-12-10 Boston Scientific Scimed, Inc. Click chemistry capturable platinum-based antineoplastic agents
AU2020295721B2 (en) * 2019-06-21 2025-04-03 Ascendis Pharma A/S Conjugates of π-electron-pair-donating heteroaromatic nitrogen-comprising compounds
WO2020254612A1 (en) 2019-06-21 2020-12-24 Ascendis Pharma Oncology Division A/S Controlled-release tyrosine kinase inhibitor compounds with localized pd properties
WO2020254607A1 (en) 2019-06-21 2020-12-24 Ascendis Pharma Oncology Division A/S Anti-ctla4 compounds with localized pd properties
EP3986479A1 (en) 2019-06-21 2022-04-27 Ascendis Pharma Oncology Division A/S Anti-ctla4 conjugates
WO2020254617A1 (en) 2019-06-21 2020-12-24 Ascendis Pharma Oncology Division A/S Anti-ctla4 compounds with localized pk properties
CA3143278A1 (en) 2019-06-21 2020-12-24 Ascendis Pharma Oncology Division A/S Tyrosine kinase inhibitor conjugates
WO2020254613A1 (en) 2019-06-21 2020-12-24 Ascendis Pharma Oncology Division A/S Controlled-release tyrosine kinase inhibitor compounds with localized pk properties
CA3153644A1 (en) * 2019-09-30 2021-04-08 Beijing Xuanyi Pharmasciences Co., Ltd. Protein-macromolecule conjugates and methods of use thereof
MX2022007371A (es) 2020-01-13 2022-07-12 Ascendis Pharma Bone Diseases As Tratamiento del hipoparatiroidismo.
CA3175974A1 (en) 2020-05-04 2021-11-11 Oliver Boris Stauch Hydrogel irradiation
MX2022014082A (es) 2020-06-03 2022-12-07 Ascendis Pharma Oncology Div A/S Secuencias de interleucina (il-2) y usos de las mismas.
JP2023540701A (ja) 2020-08-28 2023-09-26 アセンディス ファーマ オンコロジー ディヴィジョン エー/エス グリコシル化il-2タンパク質及びその使用
AU2021349316A1 (en) 2020-09-28 2023-04-27 Ascendis Pharma Bone Diseases A/S Improvement of physical and mental well-being of patients with hypoparathyroidism
BR112023018802A2 (pt) 2021-04-01 2023-10-31 Ascendis Pharma As Uso de hormônio de crescimento de ação prolongada para o tratamento de doenças induzidas por inflamação
IL311539A (en) 2021-09-22 2024-05-01 Ascendis Pharma Bone Diseases As Long-acting pth compound treatments
WO2023069510A1 (en) * 2021-10-19 2023-04-27 The United States Government As Represented By The Department Of Veterans Affairs Cannabinoid compositions for gastroesophageal disorders
CA3236278A1 (en) 2021-12-13 2023-06-22 Kennett Sprogoe Effective doses of cnp conjugates
US20250032638A1 (en) 2021-12-13 2025-01-30 Ascendis Pharma Oncology Division A/S Novel Cancer Treatments with TLR7/8 Agonists
IL316466A (en) 2022-05-23 2024-12-01 Ascendis Pharma Growth Disorders As Liquid pharmaceutical formulations of cnp compounds
CN114874624B (zh) * 2022-05-27 2023-04-07 深圳市博致远科技有限公司 一种导热吸波室温固化硅橡胶产品及其制备方法
WO2024094673A1 (en) 2022-11-02 2024-05-10 Ascendis Pharma Bone Diseases A/S Pth treatment regimen comprising two pth compounds
WO2024104922A1 (en) 2022-11-14 2024-05-23 Ascendis Pharma Growth Disorders A/S Method of improving skeletal muscle function
TW202434299A (zh) 2023-01-05 2024-09-01 丹麥商阿仙帝斯製藥公司 製造水凝膠微球之方法
TW202430223A (zh) 2023-01-05 2024-08-01 丹麥商阿仙帝斯眼科製藥有限公司 用於治療眼部病症之藥物結合物
WO2024184354A1 (en) 2023-03-06 2024-09-12 Ascendis Pharma A/S Multi-albumin binding compounds
AU2024232125A1 (en) 2023-03-06 2025-08-28 Ascendis Pharma A/S Compounds of drugs with an albumin binding moiety
WO2024184352A1 (en) 2023-03-06 2024-09-12 Ascendis Pharma A/S Drug compounds comprising albumin-binding moieties
AU2024240722A1 (en) 2023-03-20 2025-09-18 Ascendis Pharma Growth Disorders A/S Method of treatment of a thoracolumbar deformity in a human subject with achondroplasia
CN121175071A (zh) 2023-05-09 2025-12-19 阿森迪斯药物肿瘤股份有限公司 使用il-2缀合物的新型癌症治疗方法
WO2025051711A1 (en) 2023-09-04 2025-03-13 Ascendis Pharma Bone Diseases A/S Pth treatment of chronic kidney disease
WO2025208117A1 (en) * 2024-03-29 2025-10-02 Maha Therapeutics, Inc. Cleavable ester compounds and uses thereof
WO2026013135A1 (en) 2024-07-10 2026-01-15 Ascendis Pharma A/S Albumin-binding reagents
WO2026013138A1 (en) 2024-07-10 2026-01-15 Ascendis Pharma A/S Compounds with improved albumin-binding
WO2026013136A1 (en) 2024-07-10 2026-01-15 Ascendis Pharma A/S Albumin-binding compounds

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3563968A (en) 1967-10-03 1971-02-16 Gaf Corp Process for the preparation of functional polymers from n-vinyl pyrrolidone
US4265233A (en) 1978-04-12 1981-05-05 Unitika Ltd. Material for wound healing
US4769445A (en) 1985-03-04 1988-09-06 Pennwalt Corporation Process for the solid phase synthesis of peptides which contain sulfated tyrosine
US6033719A (en) 1996-04-25 2000-03-07 Medtronic, Inc. Method for covalent attachment of biomolecules to surfaces of medical devices
US6273913B1 (en) 1997-04-18 2001-08-14 Cordis Corporation Modified stent useful for delivery of drugs along stent strut
ATE541587T1 (de) * 2000-06-02 2012-02-15 Eidgenoess Tech Hochschule Konjugat-additionsreaktionen zur kontrollierten abgabe von pharmazeutisch wirksamen substanzen
US7264822B2 (en) * 2002-04-03 2007-09-04 Poly-Med, Inc. Conjugated drug-polymer coated stent
WO2003092764A2 (en) 2002-04-29 2003-11-13 Kevin Marchitto Controlled release transdermal drug delivery
US7732535B2 (en) 2002-09-05 2010-06-08 Advanced Cardiovascular Systems, Inc. Coating for controlled release of drugs from implantable medical devices
CA2521784C (en) 2003-04-08 2012-03-27 Yeda Research And Development Co. Ltd. Reversible pegylated drugs
EP2102158A1 (en) 2006-12-11 2009-09-23 Topo Target A/S Prodrugs of diphenyl ox- indol- 2 -one compounds for the treatment of cancers
US7863387B2 (en) * 2007-10-25 2011-01-04 Boston Scientific Scimed, Inc. Dehydrofluorination and surface modification of fluoropolymers for drug delivery applications
WO2009158668A1 (en) 2008-06-26 2009-12-30 Prolynx Llc Prodrugs and drug-macromolecule conjugates having controlled drug release rates
US8703907B2 (en) * 2010-05-05 2014-04-22 Prolynx Llc Controlled drug release from dendrimers
EP2566335B1 (en) * 2010-05-05 2016-06-29 Prolynx Llc Controlled release of active compounds from macromolecular conjugates

Similar Documents

Publication Publication Date Title
JP2013525080A5 (https=)
JP2010511721A5 (https=)
JP2007246474A5 (https=)
JP2007502293A5 (https=)
JP2012523457A5 (https=)
JP2012526548A5 (https=)
JP2021512167A5 (https=)
JP2011528654A5 (https=)
JP2008543743A5 (https=)
JP2007502295A5 (https=)
JP2005532287A5 (https=)
JP2014515406A5 (https=)
JP2009542716A5 (https=)
JP2012530713A5 (https=)
JP2010521485A5 (https=)
JP2016531121A5 (https=)
JP2012505871A5 (https=)
JP2014527974A5 (https=)
JP2010531363A5 (https=)
JPWO2021049504A5 (https=)
JP2005527542A5 (https=)
JP2013506674A5 (https=)
JP2019526546A5 (https=)
JP2020502116A5 (https=)
JP2004523478A5 (https=)