JPWO2021049504A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2021049504A5 JPWO2021049504A5 JP2021545555A JP2021545555A JPWO2021049504A5 JP WO2021049504 A5 JPWO2021049504 A5 JP WO2021049504A5 JP 2021545555 A JP2021545555 A JP 2021545555A JP 2021545555 A JP2021545555 A JP 2021545555A JP WO2021049504 A5 JPWO2021049504 A5 JP WO2021049504A5
- Authority
- JP
- Japan
- Prior art keywords
- conjugate
- biantennary
- pharmaceutically acceptable
- acceptable salt
- integer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- OVRNDRQMDRJTHS-KEWYIRBNSA-N N-acetyl-D-galactosamine Chemical group CC(=O)N[C@H]1C(O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-KEWYIRBNSA-N 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 5
- 108091034117 Oligonucleotide Proteins 0.000 claims 3
- 210000004185 liver Anatomy 0.000 claims 2
- 210000004738 parenchymal cell Anatomy 0.000 claims 2
- -1 5-acetamido-2-hydroxymethyl-3,4-dihydroxytetrahydropyran-6-yl group Chemical group 0.000 claims 1
- MBLBDJOUHNCFQT-UHFFFAOYSA-N N-acetyl-D-galactosamine Natural products CC(=O)NC(C=O)C(O)C(O)C(O)CO MBLBDJOUHNCFQT-UHFFFAOYSA-N 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 230000000144 pharmacologic effect Effects 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019164564 | 2019-09-10 | ||
| JP2019164564 | 2019-09-10 | ||
| PCT/JP2020/034022 WO2021049504A1 (ja) | 2019-09-10 | 2020-09-09 | 肝臓送達用ＧａｌＮＡｃ－オリゴヌクレオチドコンジュゲートおよび製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2021049504A1 JPWO2021049504A1 (https=) | 2021-03-18 |
| JPWO2021049504A5 true JPWO2021049504A5 (https=) | 2023-08-14 |
| JP7636333B2 JP7636333B2 (ja) | 2025-02-26 |
Family
ID=74866171
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021545555A Active JP7636333B2 (ja) | 2019-09-10 | 2020-09-09 | 肝臓送達用ＧａｌＮＡｃ－オリゴヌクレオチドコンジュゲートおよび製造方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20220378920A1 (https=) |
| EP (1) | EP4029520A4 (https=) |
| JP (1) | JP7636333B2 (https=) |
| KR (1) | KR20220061972A (https=) |
| CN (2) | CN119326905A (https=) |
| AU (1) | AU2020345317A1 (https=) |
| BR (1) | BR112022004461A2 (https=) |
| CA (1) | CA3150715A1 (https=) |
| IL (1) | IL291251B1 (https=) |
| TW (1) | TWI896556B (https=) |
| WO (1) | WO2021049504A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL312811A (en) | 2021-11-16 | 2024-07-01 | Shanghai Argo Biopharmaceutical Co Ltd | Composition and method for inhibiting angiotensinogen (agt) protein expression |
| EP4495240A1 (en) | 2022-03-16 | 2025-01-22 | Daiichi Sankyo Company, Limited | Sirna for suppressing expression of transferrin receptor-2 |
| US20250188477A1 (en) | 2022-03-16 | 2025-06-12 | Daiichi Sankyo Company, Limited | CHEMICALLY MODIFIED OLIGONUCLEOTIDE HAVING RNAi ACTIVITY |
| TW202430499A (zh) | 2022-10-05 | 2024-08-01 | 日商第一三共股份有限公司 | 具有２分支型之ｎ－乙醯基－ｄ－半乳糖胺結構之化合物的製造方法 |
| WO2024175051A1 (zh) * | 2023-02-23 | 2024-08-29 | 奥安医药（苏州）有限公司 | 一种疏水层析制备寡核苷酸的方法 |
| WO2025199466A1 (en) | 2024-03-22 | 2025-09-25 | Purdue Research Foundation | Liver-specific asialoglycoprotein receptor targeting ligands, conjugates comprising same, and related compositions and methods of use |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0787982A (ja) | 1993-01-29 | 1995-04-04 | Sankyo Co Ltd | 修飾オリゴデオキシリボヌクレオチド |
| US6096881A (en) | 1997-05-30 | 2000-08-01 | Hybridon, Inc. | Sulfur transfer reagents for oligonucleotide synthesis |
| JP4236812B2 (ja) | 1997-09-12 | 2009-03-11 | エクシコン エ／エス | オリゴヌクレオチド類似体 |
| ES2234563T5 (es) | 1999-02-12 | 2018-01-17 | Daiichi Sankyo Company, Limited | Nuevos análogos de nucleósidos y oligonucleótidos |
| US6261840B1 (en) | 2000-01-18 | 2001-07-17 | Isis Pharmaceuticals, Inc. | Antisense modulation of PTP1B expression |
| CA2429814C (en) | 2000-12-01 | 2014-02-18 | Thomas Tuschl | Rna interference mediating small rna molecules |
| DE60310944T3 (de) | 2002-08-05 | 2017-08-03 | Silence Therapeutics Gmbh | Weitere neue formen von interferierende rns moleküle |
| EP2392660A3 (en) | 2002-11-25 | 2012-03-28 | Masafumi Matsuo | ENA Nucleic Acid Drugs Modifying Splicing in mRNA Precursor |
| US8470791B2 (en) * | 2007-03-22 | 2013-06-25 | Santaris Pharma A/S | RNA antagonist compounds for the inhibition of Apo-B100 expression |
| WO2009073809A2 (en) * | 2007-12-04 | 2009-06-11 | Alnylam Pharmaceuticals, Inc. | Carbohydrate conjugates as delivery agents for oligonucleotides |
| TWI455944B (zh) | 2008-07-01 | 2014-10-11 | Daiichi Sankyo Co Ltd | 雙股多核苷酸 |
| WO2010052715A2 (en) | 2008-11-07 | 2010-05-14 | Ramot At Tel Aviv University Ltd. | Devices and methods for local treatment of cardiovascular diseases |
| WO2011053614A1 (en) | 2009-10-30 | 2011-05-05 | Merck Sharp & Dohme Corp. | Crystalline cdm-nag and methods for producing same |
| CA2812046A1 (en) | 2010-09-15 | 2012-03-22 | Alnylam Pharmaceuticals, Inc. | Modified irna agents |
| WO2012074038A1 (ja) | 2010-12-02 | 2012-06-07 | 第一三共株式会社 | 修飾１本鎖ポリヌクレオチド |
| CN104837996A (zh) | 2012-11-15 | 2015-08-12 | 罗氏创新中心哥本哈根有限公司 | 抗apob反义缀合物化合物 |
| WO2014089146A1 (en) * | 2012-12-04 | 2014-06-12 | Isis Pharmaceuticals, Inc. | Compositions and methods for in vivo delivery of antisense compounds |
| WO2014109384A1 (ja) | 2013-01-10 | 2014-07-17 | 塩野義製薬株式会社 | 架橋型核酸誘導体の製造方法 |
| DK2992098T3 (da) * | 2013-05-01 | 2019-06-17 | Ionis Pharmaceuticals Inc | Sammensætninger og fremgangsmåder til modulering af hbv- og ttr-ekspression |
| TW201534578A (zh) | 2013-07-08 | 2015-09-16 | Daiichi Sankyo Co Ltd | 新穎脂質 |
| WO2015006740A2 (en) | 2013-07-11 | 2015-01-15 | Alnylam Pharmaceuticals, Inc. | Oligonucleotide-ligand conjugates and process for their preparation |
| JP6482475B2 (ja) | 2014-01-07 | 2019-03-13 | レナセラピューティクス株式会社 | アンチセンスオリゴヌクレオチド及び糖誘導体を含む二本鎖オリゴヌクレオチド |
| CN106795200B (zh) | 2014-10-10 | 2020-06-19 | 豪夫迈·罗氏有限公司 | Galnac亚磷酰胺、其核酸缀合物及其用途 |
| KR20180031025A (ko) | 2015-07-31 | 2018-03-27 | 아크투루스 쎄라퓨틱스, 인크. | 약물 전달을 위한 다중 리간드 제제 |
| BR112018003910B1 (pt) | 2015-11-16 | 2022-03-22 | F. Hoffmann-La Roche Ag | Derivado de fosforamidita galnac, processo para a preparação de um derivado de fosforamidita galnac de fórmula i e uso dos derivados de fosforamidita galnac de fórmula i |
| AU2017213404A1 (en) * | 2016-01-29 | 2018-09-20 | Kyowa Kirin Co., Ltd. | Nucleic acid conjugate |
| WO2017178656A1 (en) * | 2016-04-14 | 2017-10-19 | Roche Innovation Center Copenhagen A/S | TRITYL-MONO-GalNAc COMPOUNDS AND THEIR USE |
| US10781175B2 (en) * | 2016-07-15 | 2020-09-22 | Am Chemicals Llc | Solid supports and phosphoramidite building blocks for oligonucleotide conjugates |
| EP3570892A4 (en) * | 2017-01-18 | 2020-11-25 | Alnylam Pharmaceuticals, Inc. | ENDOSOMAL CLIVABLE LINKS |
| WO2019008713A1 (ja) | 2017-07-05 | 2019-01-10 | オリンパス株式会社 | 超音波プローブ及び超音波処置アッセンブリ |
| TW201920668A (zh) | 2017-08-02 | 2019-06-01 | 日商協和醱酵麒麟有限公司 | 核酸複合體 |
| KR102398295B1 (ko) * | 2018-03-09 | 2022-05-17 | 다이이찌 산쿄 가부시키가이샤 | 당원병 Ia형 치료약 |
| PE20211783A1 (es) * | 2018-11-08 | 2021-09-08 | Aligos Therapeutics Inc | Polimeros oligonucleotidos que inhiben el transporte de antigenos y metodos |
| IL292286A (en) * | 2019-10-18 | 2022-06-01 | Daiichi Sankyo Co Ltd | Production method for bicyclic phosphoramidite |
-
2020
- 2020-09-09 IL IL291251A patent/IL291251B1/en unknown
- 2020-09-09 BR BR112022004461A patent/BR112022004461A2/pt unknown
- 2020-09-09 US US17/641,741 patent/US20220378920A1/en active Pending
- 2020-09-09 CA CA3150715A patent/CA3150715A1/en active Pending
- 2020-09-09 JP JP2021545555A patent/JP7636333B2/ja active Active
- 2020-09-09 CN CN202411210395.8A patent/CN119326905A/zh active Pending
- 2020-09-09 EP EP20863189.5A patent/EP4029520A4/en active Pending
- 2020-09-09 AU AU2020345317A patent/AU2020345317A1/en active Pending
- 2020-09-09 WO PCT/JP2020/034022 patent/WO2021049504A1/ja not_active Ceased
- 2020-09-09 TW TW109130882A patent/TWI896556B/zh active
- 2020-09-09 KR KR1020227007900A patent/KR20220061972A/ko active Pending
- 2020-09-09 CN CN202080077913.7A patent/CN114616332B/zh active Active