JP2007269797A5 - - Google Patents
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- Publication number
- JP2007269797A5 JP2007269797A5 JP2007121321A JP2007121321A JP2007269797A5 JP 2007269797 A5 JP2007269797 A5 JP 2007269797A5 JP 2007121321 A JP2007121321 A JP 2007121321A JP 2007121321 A JP2007121321 A JP 2007121321A JP 2007269797 A5 JP2007269797 A5 JP 2007269797A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- ester
- acceptable salt
- compound
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 37
- 150000003839 salts Chemical class 0.000 claims 37
- 150000002148 esters Chemical class 0.000 claims 34
- 239000008194 pharmaceutical composition Substances 0.000 claims 25
- 125000000217 alkyl group Chemical group 0.000 claims 22
- 229910052739 hydrogen Inorganic materials 0.000 claims 18
- 239000001257 hydrogen Substances 0.000 claims 18
- 150000002431 hydrogen Chemical class 0.000 claims 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 7
- 230000002401 inhibitory effect Effects 0.000 claims 7
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- 230000001419 dependent effect Effects 0.000 claims 5
- 229940011871 estrogen Drugs 0.000 claims 5
- 239000000262 estrogen Substances 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 5
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 125000004043 oxo group Chemical group O=* 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 125000002252 acyl group Chemical group 0.000 claims 3
- 206010065687 Bone loss Diseases 0.000 claims 2
- 125000002877 alkyl aryl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- -1 amino, substituted amino Chemical group 0.000 claims 2
- 210000000988 bone and bone Anatomy 0.000 claims 2
- 208000015114 central nervous system disease Diseases 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 125000004434 sulfur atom Chemical group 0.000 claims 2
- 206010003694 Atrophy Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 229910002651 NO3 Inorganic materials 0.000 claims 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 206010040799 Skin atrophy Diseases 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 1
- 125000004450 alkenylene group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000000732 arylene group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 230000037444 atrophy Effects 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- BUIVJNVIIAIIFZ-MUSFGAPCSA-N estratriene group Chemical group C[C@@]12C=CC=C1C1=CCC3CCCC[C@@H]3[C@H]1CC2 BUIVJNVIIAIIFZ-MUSFGAPCSA-N 0.000 claims 1
- 239000000328 estrogen antagonist Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- 150000002825 nitriles Chemical class 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- JCBJVAJGLKENNC-UHFFFAOYSA-N potassium;ethoxymethanedithioic acid Chemical compound [K+].CCOC(S)=S JCBJVAJGLKENNC-UHFFFAOYSA-N 0.000 claims 1
- 208000002815 pulmonary hypertension Diseases 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/998,877 | 1997-12-24 | ||
| US08/998,877 US6054446A (en) | 1997-12-24 | 1997-12-24 | Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006271307A Division JP3968114B2 (ja) | 1997-12-24 | 2006-10-02 | 新規な抗エストロゲンステロイド、ならびに関連の薬学的組成物および使用法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007269797A JP2007269797A (ja) | 2007-10-18 |
| JP2007269797A5 true JP2007269797A5 (https=) | 2009-10-01 |
| JP4718512B2 JP4718512B2 (ja) | 2011-07-06 |
Family
ID=25545637
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP53517299A Withdrawn JP2001525855A (ja) | 1997-12-24 | 1998-12-23 | 新規な抗エストロゲンステロイド、ならびに関連の薬学的組成物および使用法 |
| JP2006271306A Expired - Lifetime JP4959276B2 (ja) | 1997-12-24 | 2006-10-02 | 新規な抗エストロゲンステロイド、ならびに関連の薬学的組成物および使用法 |
| JP2006271307A Expired - Fee Related JP3968114B2 (ja) | 1997-12-24 | 2006-10-02 | 新規な抗エストロゲンステロイド、ならびに関連の薬学的組成物および使用法 |
| JP2007121321A Expired - Lifetime JP4718512B2 (ja) | 1997-12-24 | 2007-05-01 | 新規な抗エストロゲンステロイド、ならびに関連の薬学的組成物および使用法 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP53517299A Withdrawn JP2001525855A (ja) | 1997-12-24 | 1998-12-23 | 新規な抗エストロゲンステロイド、ならびに関連の薬学的組成物および使用法 |
| JP2006271306A Expired - Lifetime JP4959276B2 (ja) | 1997-12-24 | 2006-10-02 | 新規な抗エストロゲンステロイド、ならびに関連の薬学的組成物および使用法 |
| JP2006271307A Expired - Fee Related JP3968114B2 (ja) | 1997-12-24 | 2006-10-02 | 新規な抗エストロゲンステロイド、ならびに関連の薬学的組成物および使用法 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US6054446A (https=) |
| EP (4) | EP1310509B1 (https=) |
| JP (4) | JP2001525855A (https=) |
| KR (1) | KR100464739B1 (https=) |
| CN (2) | CN101130567B (https=) |
| AU (1) | AU749597C (https=) |
| BR (1) | BR9814435A (https=) |
| CA (1) | CA2281844C (https=) |
| DE (2) | DE69812433T2 (https=) |
| HU (1) | HUP0100136A3 (https=) |
| IL (1) | IL136972A0 (https=) |
| NO (1) | NO317978B1 (https=) |
| RU (1) | RU2233288C2 (https=) |
| WO (1) | WO1999033859A2 (https=) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6908910B2 (en) | 1993-08-06 | 2005-06-21 | The Children's Medical Center Corporation | Estrogenic compounds as anti-mitotic agents |
| US5504074A (en) | 1993-08-06 | 1996-04-02 | Children's Medical Center Corporation | Estrogenic compounds as anti-angiogenic agents |
| ATE506986T1 (de) * | 1999-08-13 | 2011-05-15 | Curadis Gmbh | Substanzen und mittel zur positiven beeinflussung von kollagen |
| US7087592B1 (en) | 1999-08-23 | 2006-08-08 | Entre Med, Inc. | Compositions comprising purified 2-methoxyestradiol and methods of producing same |
| AUPQ342599A0 (en) * | 1999-10-14 | 1999-11-04 | University Of Melbourne, The | Conjugates and uses thereof |
| WO2001058919A2 (en) * | 2000-02-11 | 2001-08-16 | Sri International | Synthesis of anti-estrogenic and other therapeutic steroids from 21-hydroxy-19-norpregna-4-en-3-one |
| US6953785B2 (en) | 2000-04-24 | 2005-10-11 | Kyowa Hakko Kogyo Co., Ltd. | Estra-1,3,5(10)-triene derivatives |
| US8244809B2 (en) * | 2000-06-20 | 2012-08-14 | United States Postal Service | System and methods for electronic message content identification |
| US7135581B2 (en) | 2000-08-18 | 2006-11-14 | Entremed, Inc. | Antiangiogenic agents |
| US6995278B2 (en) | 2000-08-18 | 2006-02-07 | Entre Med, Inc. | Antiangiogenic agents |
| US6503894B1 (en) | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
| DE60128251T2 (de) * | 2000-11-03 | 2008-01-10 | Washington University | Östronderivate mit zellschützender wirkung |
| AU2001288386B2 (en) * | 2000-11-27 | 2006-11-02 | Entremed, Inc. | 2-substituted estrogens as antiangiogenic agents |
| JP2002241395A (ja) * | 2001-02-16 | 2002-08-28 | Taiho Yakuhin Kogyo Kk | エストラ−４，６−ジエン−３，１７−ジオンの製造方法 |
| US20050079156A1 (en) * | 2001-11-06 | 2005-04-14 | Grace Wong | Method of treating endometreosis |
| US20050002900A1 (en) * | 2001-11-06 | 2005-01-06 | Grace Wong | Method of treating estrogen responsive breast cancer |
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| DE10307103A1 (de) | 2003-02-19 | 2004-09-09 | Schering Ag | Antitumor wirksame 2-substituierte D-Homostra-1,3,5(10)-trien-3-yl sulfamate |
| JP2006526025A (ja) | 2003-05-28 | 2006-11-16 | エントレメッド インコーポレイテッド | 抗血管新生剤 |
| EP1658036A2 (en) * | 2003-08-26 | 2006-05-24 | Board of Regents of the University of Texas System | Estrogen receptor modulators and uses thereof |
| US7498322B2 (en) | 2004-03-12 | 2009-03-03 | Entremed, Inc. | Antiangiogenic agents |
| US20060264413A1 (en) * | 2005-04-18 | 2006-11-23 | Sri International | Method and composition for inhibiting cell proliferation and angiogenesis |
| CN101282646B (zh) * | 2005-07-12 | 2013-03-27 | Dmi生物科学公司 | 治疗疾病的方法和产品 |
| TW200740442A (en) * | 2005-08-29 | 2007-11-01 | Taiho Pharmaceutical Co Ltd | Therapeutic agent for hypertension |
| EP1947107B1 (en) * | 2005-10-27 | 2012-10-17 | SRI International | Process for production of steroid compound |
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| SG185311A1 (en) | 2007-10-16 | 2012-11-29 | Repros Therapeutics Inc | Trans-clomiphene for metabolic syndrome |
| ES2523769T3 (es) | 2009-06-22 | 2014-12-01 | Ampio Pharmaceuticals, Inc. | Procedimiento de tratamiento de enfermedades |
| RU2422455C1 (ru) * | 2009-10-13 | 2011-06-27 | Федеральное государственное образовательное учреждение высшего профессионального образования Санкт-Петербургский государственный университет | ДИАЦЕТАТ РАЦЕМИЧЕСКОГО 3,17β-ДИГИДРОКСИ-7α,18-ДИМЕТИЛ-6-ОКСАЭСТРА-1,3,5( 10 ),8(9)-ТЕТРАЕНА, ОБЛАДАЮЩИЙ ОСТЕОПРОТЕКТОРНЫМ, ГИПОХОЛЕСТЕРИНЕМИЧЕСКИМ И АНТИОКСИДАНТНЫМ ДЕЙСТВИЕМ |
| AU2011242988B2 (en) * | 2010-04-19 | 2013-02-07 | Sri International | Compositions and method for the treatment of multiple myeloma |
| KR20200144591A (ko) | 2010-06-16 | 2020-12-29 | 앙도르쉐르슈 인코포레이티드 | 에스트로겐-관련 질병의 치료 또는 예방 방법 |
| US20130123222A1 (en) * | 2011-11-10 | 2013-05-16 | Sri International, Inc. | Synergistic Anti-Cancer Activity of SR16388 with Anti-Mitotic Drugs |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| BR112014012444B1 (pt) | 2011-11-23 | 2021-12-14 | Therapeuticsmd, Inc | Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher |
| JP2015508825A (ja) | 2012-02-29 | 2015-03-23 | レプロス セラピューティクス インコーポレイティド | アンドロゲン欠乏症を治療するための併用療法 |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| EP2934546A4 (en) | 2012-12-19 | 2016-06-22 | Ampio Pharmaceuticals Inc | METHOD OF DISEASE TREATMENT |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| RU2016143081A (ru) | 2014-05-22 | 2018-06-26 | Терапьютиксмд, Инк. | Натуральные комбинированные гормонозаместительные составы и терапии |
| JPWO2017010515A1 (ja) | 2015-07-14 | 2018-07-05 | ノーベルファーマ株式会社 | エストロゲン受容体α阻害作用を有するエストロゲン受容体βパーシャルアゴニスト及びこれを用いた婦人科疾患治療剤 |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| US11633382B2 (en) | 2015-11-10 | 2023-04-25 | Paracrine Therapeutics Ab | Treatment of ER-negative breast cancer with an PDGF-CC inhibitor and anti-estrogen |
| US20170157143A1 (en) * | 2015-12-02 | 2017-06-08 | Helix Twelve Pharmaceuticals Corporation, Inc. | Norpregnane derivatives for the risk reduction of breast cancer |
| US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
| US9931349B2 (en) | 2016-04-01 | 2018-04-03 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
| CN107805247B (zh) * | 2017-10-31 | 2020-09-29 | 上海长征富民金山制药有限公司 | 一种用于制备抗肾纤维化药物和/或抗慢性肾病药的β-咔啉化合物的制备工艺及其应用 |
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| JPH07101977A (ja) * | 1993-10-05 | 1995-04-18 | Kureha Chem Ind Co Ltd | ホルモン作用を軽減した新規なエストラジオール誘導体及びその増殖因子阻害剤 |
| US5446053A (en) | 1993-12-21 | 1995-08-29 | Eli Lilly And Company | Methods of inhibiting dysfunctional uterine bleeding |
| US5447941A (en) | 1993-12-21 | 1995-09-05 | Eli Lilly And Company | Methods of inhibiting pulmonary hypertensive diseases with raloxifene and related benzothiophenes |
| US5578613A (en) | 1993-12-21 | 1996-11-26 | Eli Lilly And Company | Methods for inhibiting weight gain or inducing weight loss |
| US5593987A (en) | 1993-12-21 | 1997-01-14 | Eli Lilly And Company | Methods of inhibiting breast disorders |
| US5461064A (en) | 1993-12-21 | 1995-10-24 | Eli Lilly And Company | Methods of inhibiting atrophy of the skin and vagina |
| US5451589A (en) | 1993-12-21 | 1995-09-19 | Eli Lilly And Company | Methods of inhibiting ovarian dysgenesis, delayed puberty, or sexual infantilism |
| US6417198B1 (en) | 1993-12-21 | 2002-07-09 | Eli Lilly And Company | Methods of inhibiting CNS problems in post-menopausal women |
| US5591753A (en) | 1994-01-28 | 1997-01-07 | Eli Lilly And Company | Combination treatment for osteoporosis |
| US5478847A (en) | 1994-03-02 | 1995-12-26 | Eli Lilly And Company | Methods of use for inhibiting bone loss and lowering serum cholesterol |
| FR2718138B1 (fr) * | 1994-04-01 | 1996-04-26 | Roussel Uclaf | Nouveaux stéroïdes comportant en position 20 une chaîne aminosubstituée, procédé et intermédiaires de préparation, application comme médicaments et compositions pharmaceutiques les renfermant. |
| US5612317A (en) * | 1994-08-04 | 1997-03-18 | Holick; Michael F. | Method for delivering estrogen |
| GB9518858D0 (en) * | 1995-09-14 | 1995-11-15 | Pharmacia Spa | Phenylsubstituted 4-azasteroid fluoroderivatives |
| US5843904A (en) * | 1995-12-20 | 1998-12-01 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1βconverting enzyme |
| DE19635525A1 (de) * | 1996-08-20 | 1998-02-26 | Schering Ag | 7alpha-(xi-Aminoalkyl)-estratriene, Verfahren zu deren Herstellung, pharmazeutische Präparate, die diese 7alpha(xi-Aminoalkyl-estratriene enthalten sowie deren Verwendung zur Herstellung von Arzneimitteln |
| US5866560A (en) * | 1996-08-20 | 1999-02-02 | Schering Ag | 7α-(ξ-aminoalkyl)-estratrienes, process for their production, pharmaceutical preparations which contain these 7α-(ξ-aminoalkyl)-estratrienes as well as their use for the production of pharmaceutical agents |
| US5945412A (en) * | 1996-12-09 | 1999-08-31 | Merck & Co., Inc. | Methods and compositions for preventing and treating bone loss |
| RU58668U1 (ru) | 2006-06-05 | 2006-11-27 | Открытое акционерное общество "Нижегородский машиностроительный завод" | Водогрейный котел |
-
1997
- 1997-12-24 US US08/998,877 patent/US6054446A/en not_active Expired - Lifetime
-
1998
- 1998-12-23 WO PCT/US1998/027406 patent/WO1999033859A2/en not_active Ceased
- 1998-12-23 KR KR10-1999-7007640A patent/KR100464739B1/ko not_active Expired - Fee Related
- 1998-12-23 CA CA002281844A patent/CA2281844C/en not_active Expired - Fee Related
- 1998-12-23 EP EP03000183A patent/EP1310509B1/en not_active Expired - Lifetime
- 1998-12-23 DE DE69812433T patent/DE69812433T2/de not_active Expired - Lifetime
- 1998-12-23 EP EP07015863A patent/EP1847548A3/en not_active Withdrawn
- 1998-12-23 EP EP10177213.5A patent/EP2305694A3/en not_active Withdrawn
- 1998-12-23 DE DE69839893T patent/DE69839893D1/de not_active Expired - Lifetime
- 1998-12-23 RU RU2000116270/04A patent/RU2233288C2/ru not_active IP Right Cessation
- 1998-12-23 EP EP98964882A patent/EP1056768B1/en not_active Expired - Lifetime
- 1998-12-23 CN CN200710128699XA patent/CN101130567B/zh not_active Expired - Lifetime
- 1998-12-23 HU HU0100136A patent/HUP0100136A3/hu unknown
- 1998-12-23 BR BR9814435-9A patent/BR9814435A/pt not_active Application Discontinuation
- 1998-12-23 CN CNB988137011A patent/CN1332974C/zh not_active Expired - Fee Related
- 1998-12-23 AU AU20104/99A patent/AU749597C/en not_active Ceased
- 1998-12-23 JP JP53517299A patent/JP2001525855A/ja not_active Withdrawn
- 1998-12-23 IL IL13697298A patent/IL136972A0/xx not_active IP Right Cessation
- 1998-12-24 US US09/220,408 patent/US6281205B1/en not_active Expired - Lifetime
-
2000
- 2000-06-22 NO NO20003254A patent/NO317978B1/no not_active IP Right Cessation
-
2001
- 2001-07-30 US US09/918,890 patent/US6455517B1/en not_active Expired - Lifetime
-
2006
- 2006-10-02 JP JP2006271306A patent/JP4959276B2/ja not_active Expired - Lifetime
- 2006-10-02 JP JP2006271307A patent/JP3968114B2/ja not_active Expired - Fee Related
-
2007
- 2007-05-01 JP JP2007121321A patent/JP4718512B2/ja not_active Expired - Lifetime
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