TWI896556B - 用於肝臟遞送之GalNAc-寡核苷酸結合物 - Google Patents

用於肝臟遞送之GalNAc-寡核苷酸結合物

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Publication number
TWI896556B
TWI896556B TW109130882A TW109130882A TWI896556B TW I896556 B TWI896556 B TW I896556B TW 109130882 A TW109130882 A TW 109130882A TW 109130882 A TW109130882 A TW 109130882A TW I896556 B TWI896556 B TW I896556B
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Taiwan
Prior art keywords
compound
oligonucleotide
galnac
conjugate
group
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TW109130882A
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English (en)
Chinese (zh)
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TW202123973A (zh
Inventor
小泉誠
岩本充廣
關口幸子
伊藤健太郎
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日商第一三共股份有限公司
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TW109130882A 2019-09-10 2020-09-09 用於肝臟遞送之GalNAc-寡核苷酸結合物 TWI896556B (zh)

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JP2019164564 2019-09-10
JP2019-164564 2019-09-10

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TW202123973A TW202123973A (zh) 2021-07-01
TWI896556B true TWI896556B (zh) 2025-09-11

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US (1) US20220378920A1 (https=)
EP (1) EP4029520A4 (https=)
JP (1) JP7636333B2 (https=)
KR (1) KR20220061972A (https=)
CN (2) CN119326905A (https=)
AU (1) AU2020345317A1 (https=)
BR (1) BR112022004461A2 (https=)
CA (1) CA3150715A1 (https=)
IL (1) IL291251B1 (https=)
TW (1) TWI896556B (https=)
WO (1) WO2021049504A1 (https=)

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US20250188477A1 (en) 2022-03-16 2025-06-12 Daiichi Sankyo Company, Limited CHEMICALLY MODIFIED OLIGONUCLEOTIDE HAVING RNAi ACTIVITY
TW202430499A (zh) 2022-10-05 2024-08-01 日商第一三共股份有限公司 具有２分支型之ｎ－乙醯基－ｄ－半乳糖胺結構之化合物的製造方法
WO2024175051A1 (zh) * 2023-02-23 2024-08-29 奥安医药（苏州）有限公司 一种疏水层析制备寡核苷酸的方法
WO2025199466A1 (en) 2024-03-22 2025-09-25 Purdue Research Foundation Liver-specific asialoglycoprotein receptor targeting ligands, conjugates comprising same, and related compositions and methods of use

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