CN119326905A - 用于递送至肝脏的GalNAc-寡核苷酸偶联物及其制备方法 - Google Patents

用于递送至肝脏的GalNAc-寡核苷酸偶联物及其制备方法 Download PDF

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CN119326905A
CN119326905A CN202411210395.8A CN202411210395A CN119326905A CN 119326905 A CN119326905 A CN 119326905A CN 202411210395 A CN202411210395 A CN 202411210395A CN 119326905 A CN119326905 A CN 119326905A
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oligonucleotide
galnac
compound
group
conjugate
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小泉诚
岩本充广
关口幸子
伊藤健太郎
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Daiichi Sankyo Co Ltd
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Daiichi Sankyo Co Ltd
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CN202411210395.8A 2019-09-10 2020-09-09 用于递送至肝脏的GalNAc-寡核苷酸偶联物及其制备方法 Pending CN119326905A (zh)

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JP2019164564 2019-09-10
JP2019-164564 2019-09-10
CN202080077913.7A CN114616332B (zh) 2019-09-10 2020-09-09 用于递送至肝脏的GalNAc-寡核苷酸偶联物及其制备方法
PCT/JP2020/034022 WO2021049504A1 (ja) 2019-09-10 2020-09-09 肝臓送達用ＧａｌＮＡｃ－オリゴヌクレオチドコンジュゲートおよび製造方法

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CN202080077913.7A Active CN114616332B (zh) 2019-09-10 2020-09-09 用于递送至肝脏的GalNAc-寡核苷酸偶联物及其制备方法

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IL312811A (en) 2021-11-16 2024-07-01 Shanghai Argo Biopharmaceutical Co Ltd Composition and method for inhibiting angiotensinogen (agt) protein expression
EP4495240A1 (en) 2022-03-16 2025-01-22 Daiichi Sankyo Company, Limited Sirna for suppressing expression of transferrin receptor-2
US20250188477A1 (en) 2022-03-16 2025-06-12 Daiichi Sankyo Company, Limited CHEMICALLY MODIFIED OLIGONUCLEOTIDE HAVING RNAi ACTIVITY
TW202430499A (zh) 2022-10-05 2024-08-01 日商第一三共股份有限公司 具有２分支型之ｎ－乙醯基－ｄ－半乳糖胺結構之化合物的製造方法
WO2024175051A1 (zh) * 2023-02-23 2024-08-29 奥安医药（苏州）有限公司 一种疏水层析制备寡核苷酸的方法
WO2025199466A1 (en) 2024-03-22 2025-09-25 Purdue Research Foundation Liver-specific asialoglycoprotein receptor targeting ligands, conjugates comprising same, and related compositions and methods of use

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