JP2010537008A5 - - Google Patents
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- Publication number
- JP2010537008A5 JP2010537008A5 JP2010522143A JP2010522143A JP2010537008A5 JP 2010537008 A5 JP2010537008 A5 JP 2010537008A5 JP 2010522143 A JP2010522143 A JP 2010522143A JP 2010522143 A JP2010522143 A JP 2010522143A JP 2010537008 A5 JP2010537008 A5 JP 2010537008A5
- Authority
- JP
- Japan
- Prior art keywords
- glu
- cys
- poly
- polymer
- nitric oxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920000642 polymer Polymers 0.000 claims 20
- 239000002131 composite material Substances 0.000 claims 15
- PABVKUJVLNMOJP-WHFBIAKZSA-N Glu-Cys Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](CS)C(O)=O PABVKUJVLNMOJP-WHFBIAKZSA-N 0.000 claims 12
- RITKHVBHSGLULN-WHFBIAKZSA-N L-gamma-glutamyl-L-cysteine Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(O)=O RITKHVBHSGLULN-WHFBIAKZSA-N 0.000 claims 12
- 108010068906 gamma-glutamylcysteine Proteins 0.000 claims 12
- 239000011976 maleic acid Substances 0.000 claims 10
- 238000000034 method Methods 0.000 claims 10
- 239000000227 bioadhesive Substances 0.000 claims 9
- -1 poly (methyl vinyl Chemical group 0.000 claims 9
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- 239000002202 Polyethylene glycol Substances 0.000 claims 6
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims 6
- 229920001223 polyethylene glycol Polymers 0.000 claims 6
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 5
- 125000005647 linker group Chemical group 0.000 claims 5
- 239000002840 nitric oxide donor Substances 0.000 claims 5
- 229920002732 Polyanhydride Polymers 0.000 claims 4
- 150000004007 S-nitroso compounds Chemical class 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 229920001577 copolymer Polymers 0.000 claims 4
- 125000000524 functional group Chemical group 0.000 claims 4
- 230000002209 hydrophobic effect Effects 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 229920001983 poloxamer Polymers 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 3
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 3
- 150000001335 aliphatic alkanes Chemical class 0.000 claims 3
- 239000011248 coating agent Substances 0.000 claims 3
- 238000000576 coating method Methods 0.000 claims 3
- 235000014113 dietary fatty acids Nutrition 0.000 claims 3
- 239000000194 fatty acid Substances 0.000 claims 3
- 229930195729 fatty acid Natural products 0.000 claims 3
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical group O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 229920002959 polymer blend Polymers 0.000 claims 3
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 3
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 3
- 229920002554 vinyl polymer Polymers 0.000 claims 3
- OJGVRWVZHGUOLY-BQBZGAKWSA-N (2s)-5-[[(2r)-1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-2-(hydroxymethylamino)-5-oxopentanoic acid Chemical compound OCN[C@H](C(O)=O)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O OJGVRWVZHGUOLY-BQBZGAKWSA-N 0.000 claims 2
- KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical compound C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 claims 2
- 229920001661 Chitosan Polymers 0.000 claims 2
- 239000001856 Ethyl cellulose Substances 0.000 claims 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 2
- 108010024636 Glutathione Proteins 0.000 claims 2
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 2
- HKBNQXMLSMKLJV-BQBZGAKWSA-N L-gamma-glutamyl-L-cysteinyl-beta-alanine Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCCC(O)=O HKBNQXMLSMKLJV-BQBZGAKWSA-N 0.000 claims 2
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims 2
- 229920001400 block copolymer Polymers 0.000 claims 2
- 150000001733 carboxylic acid esters Chemical class 0.000 claims 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 2
- 235000018417 cysteine Nutrition 0.000 claims 2
- 229920001249 ethyl cellulose Polymers 0.000 claims 2
- 235000019325 ethyl cellulose Nutrition 0.000 claims 2
- 150000002191 fatty alcohols Chemical class 0.000 claims 2
- HKBNQXMLSMKLJV-UHFFFAOYSA-N gamma-L-glutamyl-L-cysteinyl-beta-alanine Natural products OC(=O)C(N)CCC(=O)NC(CS)C(=O)NCCC(O)=O HKBNQXMLSMKLJV-UHFFFAOYSA-N 0.000 claims 2
- 229960003180 glutathione Drugs 0.000 claims 2
- 108700020537 homoglutathione Proteins 0.000 claims 2
- 239000004005 microsphere Substances 0.000 claims 2
- 239000002121 nanofiber Substances 0.000 claims 2
- CCCMONHAUSKTEQ-UHFFFAOYSA-N octadec-1-ene Chemical compound CCCCCCCCCCCCCCCCC=C CCCMONHAUSKTEQ-UHFFFAOYSA-N 0.000 claims 2
- 229960000502 poloxamer Drugs 0.000 claims 2
- 229940074982 poly(vinylpyrrolidone-co-vinyl-acetate) Drugs 0.000 claims 2
- 229920001451 polypropylene glycol Polymers 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- ICRHORQIUXBEPA-UHFFFAOYSA-N thionitrous acid Chemical compound SN=O ICRHORQIUXBEPA-UHFFFAOYSA-N 0.000 claims 2
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical class N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 1
- PKYAVRMYTBBRLS-FXQIFTODSA-N Glu-Cys-Glu Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(O)=O)C(O)=O PKYAVRMYTBBRLS-FXQIFTODSA-N 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical class OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- DUKURNFHYQXCJG-UHFFFAOYSA-N Lewis A pentasaccharide Chemical class OC1C(O)C(O)C(C)OC1OC1C(OC2C(C(O)C(O)C(CO)O2)O)C(NC(C)=O)C(OC2C(C(OC3C(OC(O)C(O)C3O)CO)OC(CO)C2O)O)OC1CO DUKURNFHYQXCJG-UHFFFAOYSA-N 0.000 claims 1
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical class CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 claims 1
- 206010072170 Skin wound Diseases 0.000 claims 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Chemical class NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims 1
- 238000000151 deposition Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 238000001523 electrospinning Methods 0.000 claims 1
- 108700031574 gamma-glutamyl-cysteinyl-glutamic acid Proteins 0.000 claims 1
- 229960002442 glucosamine Drugs 0.000 claims 1
- 230000035876 healing Effects 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 238000000707 layer-by-layer assembly Methods 0.000 claims 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 229950006780 n-acetylglucosamine Drugs 0.000 claims 1
- 229920000141 poly(maleic anhydride) Polymers 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 238000009987 spinning Methods 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 238000005507 spraying Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2,599,082 | 2007-08-27 | ||
| CA002599082A CA2599082A1 (en) | 2007-08-27 | 2007-08-27 | Supramacromolecular polymer complexes providing controlled nitric oxide release for healing wounds |
| PCT/CA2008/001484 WO2009026680A1 (en) | 2007-08-27 | 2008-08-20 | Supramacrqmolecular polymer complexes providing controlled nitric oxide release for healing wounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010537008A JP2010537008A (ja) | 2010-12-02 |
| JP2010537008A5 true JP2010537008A5 (https=) | 2011-10-13 |
| JP5346340B2 JP5346340B2 (ja) | 2013-11-20 |
Family
ID=40385170
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010522143A Expired - Fee Related JP5346340B2 (ja) | 2007-08-27 | 2008-08-20 | 創傷を治癒するため制御された酸化窒素放出を提供する超高分子ポリマー複合体 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8992945B2 (https=) |
| EP (1) | EP2201077A4 (https=) |
| JP (1) | JP5346340B2 (https=) |
| CA (2) | CA2599082A1 (https=) |
| WO (1) | WO2009026680A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2731298T3 (es) | 2005-05-27 | 2019-11-14 | Univ North Carolina Chapel Hill | Partículas de liberación de óxido nítrico para agentes terapéuticos de óxido nítrico y aplicaciones biomédicas |
| CA2671595A1 (en) * | 2009-07-09 | 2011-01-09 | Ping I. Lee | Controlled nitric oxide delivery from aqueous s-nitrosothiol conjugated polymers and their complexes |
| WO2011022652A1 (en) | 2009-08-21 | 2011-02-24 | Novan, Inc. | Topical gels |
| CA2771389C (en) | 2009-08-21 | 2019-04-09 | Novan, Inc. | Wound dressings, methods of using the same and methods of forming the same |
| US8591876B2 (en) | 2010-12-15 | 2013-11-26 | Novan, Inc. | Methods of decreasing sebum production in the skin |
| WO2012118829A2 (en) | 2011-02-28 | 2012-09-07 | Novan, Inc. | Tertiary s-nitrosothiol-modified nitricoxide-releasing xerogels and methods of using the same |
| AU2013300035A1 (en) * | 2012-08-06 | 2015-02-26 | South Dakota Board Of Regents | Directional eluting implantable medical device |
| US9884943B2 (en) | 2012-09-21 | 2018-02-06 | Michigan Technological University | No-releasing polymers and uses thereof |
| JP2016514171A (ja) * | 2013-02-07 | 2016-05-19 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | Ｓ−ニトロソ−ｎ−アセチルペニシラミン（ｓｎａｐ）をドープした安定性の向上した血栓形成抵抗性／殺菌性の酸化窒素放出性ポリマー |
| EP3016613B1 (en) * | 2013-07-03 | 2018-10-10 | The American University in Cairo | Bio-compatible apitherapeutic nanofibers |
| JP6357156B2 (ja) | 2013-09-02 | 2018-07-11 | テルモ株式会社 | 医療用具およびその製造方法 |
| EP3139962B1 (en) | 2014-05-05 | 2020-12-23 | Advanced Medical Solutions Israel (Sealantis) Ltd | Biological adhesives and sealants and methods of using the same |
| WO2016025550A1 (en) * | 2014-08-14 | 2016-02-18 | Rohm And Haas Company | Polymer with releasable gas |
| GB201506236D0 (en) * | 2015-04-13 | 2015-05-27 | Jellagen Pty Ltd | Modified collagen, methods of manufacture thereof |
| CN105568401A (zh) * | 2015-12-12 | 2016-05-11 | 大连理工大学 | 一种超声雾化辅助静电纺丝技术 |
| US11111362B2 (en) * | 2016-09-26 | 2021-09-07 | Becton, Dickinson And Company | Breathable films with microbial barrier properties |
| EP3570927A4 (en) | 2017-01-21 | 2020-12-23 | Biocrede Inc. | MEDICAL PRODUCTS AND METHODS FOR THE CONTROLLED RELEASE OF NITROGEN OXIDE |
| CN108498879B (zh) | 2017-02-28 | 2021-12-28 | 苏州安德佳生物科技有限公司 | 黏膜下注射用组合物和试剂组合及其应用 |
| EP3395377A1 (en) * | 2017-04-28 | 2018-10-31 | Borealis AG | Soft polypropylene composition with improved properties |
| CN109694887A (zh) * | 2017-10-24 | 2019-04-30 | 朱一民 | 重组酵母菌及其用于制造生物质酒精的用途 |
| CN110025821A (zh) * | 2018-01-12 | 2019-07-19 | 北京环球利康科技有限公司 | 使用生物相容性止血剂和组织封闭剂的组合物处理活动性出血的方法 |
| CN110284263B (zh) * | 2019-06-13 | 2022-03-08 | 上海交通大学 | 叠层复合纳米纤维的制备方法 |
| US11814519B2 (en) * | 2020-03-26 | 2023-11-14 | Virginia Commonwealth University | Nitric oxide-releasing 3D-printing compositions and uses thereof |
| CN114146880B (zh) * | 2021-12-06 | 2023-02-28 | 中国石油大学(华东) | 一种超声雾化辅助层层自组装制备氢气阻隔涂层的方法 |
| CN115125669B (zh) * | 2022-07-15 | 2023-08-11 | 华中科技大学同济医学院附属协和医院 | 一种超声响应性释放一氧化氮电纺膜及其制备方法 |
| DE102024102999A1 (de) * | 2024-02-02 | 2025-08-07 | Acandis Gmbh | Liner für einen medizinischen Katheter; Medizinischer Katheter mit einem Liner; Verfahren zur Herstellung eines Liners für einen medizinischen Katheter |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61186309A (ja) * | 1985-02-13 | 1986-08-20 | Toyobo Co Ltd | 口腔粘膜適用組成物 |
| US6255277B1 (en) * | 1993-09-17 | 2001-07-03 | Brigham And Women's Hospital | Localized use of nitric oxide-adducts to prevent internal tissue damage |
| US5770645A (en) * | 1996-08-02 | 1998-06-23 | Duke University Medical Center | Polymers for delivering nitric oxide in vivo |
| US6221425B1 (en) * | 1998-01-30 | 2001-04-24 | Advanced Cardiovascular Systems, Inc. | Lubricious hydrophilic coating for an intracorporeal medical device |
| IT1303793B1 (it) * | 1998-11-27 | 2001-02-23 | Promefarm S R L | "composizione farmaceutica comprendente un composto organico donatoredi ossido nitrico (no)" |
| US6706274B2 (en) * | 2001-01-18 | 2004-03-16 | Scimed Life Systems, Inc. | Differential delivery of nitric oxide |
| US20050113510A1 (en) * | 2001-05-01 | 2005-05-26 | Feldstein Mikhail M. | Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components |
| CA2446064A1 (en) * | 2001-05-02 | 2002-11-07 | Nitromed, Inc. | Nitrosated and nitrosylated nebivolol and its metabolites, compositions and methods of use |
| GB0125222D0 (en) * | 2001-10-19 | 2001-12-12 | Barts & London Nhs Trust | Composition for the treatment of microbial infections |
| AU2003240164A1 (en) * | 2002-06-07 | 2003-12-22 | Ranbaxy Laboratories Limited | Extended release formulation of divalproex sodium |
| US8211455B2 (en) * | 2002-06-19 | 2012-07-03 | Boston Scientific Scimed, Inc. | Implantable or insertable medical devices for controlled delivery of a therapeutic agent |
| US20060240065A1 (en) * | 2005-04-26 | 2006-10-26 | Yung-Ming Chen | Compositions for medical devices containing agent combinations in controlled volumes |
| ES2540929T3 (es) * | 2005-02-01 | 2015-07-14 | Emisphere Technologies, Inc. | Sistema de administración de retención gástrica y liberación controlada |
| GB0505035D0 (en) * | 2005-03-11 | 2005-04-20 | Insense Ltd | Improvements relating to skin dressings |
| US7517914B2 (en) * | 2005-04-04 | 2009-04-14 | Boston Scientificscimed, Inc. | Controlled degradation materials for therapeutic agent delivery |
| BRPI0503201B8 (pt) * | 2005-07-28 | 2021-05-25 | Sci Tech Produtos Medicos Ltda | stents revestidos com blendas poliméricas hidrofílicas, eluidoras de óxido nítrico e s-nitrosotióis |
| JP4812394B2 (ja) * | 2005-10-19 | 2011-11-09 | 扶桑薬品工業株式会社 | 鎮痛用組成物 |
-
2007
- 2007-08-27 CA CA002599082A patent/CA2599082A1/en not_active Abandoned
-
2008
- 2008-08-20 CA CA2697862A patent/CA2697862A1/en not_active Abandoned
- 2008-08-20 EP EP08783394A patent/EP2201077A4/en not_active Withdrawn
- 2008-08-20 JP JP2010522143A patent/JP5346340B2/ja not_active Expired - Fee Related
- 2008-08-20 US US12/675,498 patent/US8992945B2/en not_active Expired - Fee Related
- 2008-08-20 WO PCT/CA2008/001484 patent/WO2009026680A1/en not_active Ceased
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