JP2009510138A5 - - Google Patents
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- Publication number
- JP2009510138A5 JP2009510138A5 JP2008533890A JP2008533890A JP2009510138A5 JP 2009510138 A5 JP2009510138 A5 JP 2009510138A5 JP 2008533890 A JP2008533890 A JP 2008533890A JP 2008533890 A JP2008533890 A JP 2008533890A JP 2009510138 A5 JP2009510138 A5 JP 2009510138A5
- Authority
- JP
- Japan
- Prior art keywords
- dosage form
- pharmaceutical dosage
- active ingredient
- form according
- prevention
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000004480 active ingredient Substances 0.000 claims description 35
- 238000000034 method Methods 0.000 claims description 12
- 230000004048 modification Effects 0.000 claims description 9
- 238000012986 modification Methods 0.000 claims description 9
- 230000002265 prevention Effects 0.000 claims description 8
- 239000007787 solid Substances 0.000 claims description 7
- 230000009863 secondary prevention Effects 0.000 claims description 6
- 239000013078 crystal Substances 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 238000002844 melting Methods 0.000 claims description 4
- 230000008018 melting Effects 0.000 claims description 4
- 208000001435 Thromboembolism Diseases 0.000 claims description 3
- 239000002552 dosage form Substances 0.000 claims 34
- 239000002775 capsule Substances 0.000 claims 7
- 239000002671 adjuvant Substances 0.000 claims 6
- 238000001125 extrusion Methods 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000000155 melt Substances 0.000 claims 3
- 238000002156 mixing Methods 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 3
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 2
- 238000007924 USP release method Methods 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 238000004090 dissolution Methods 0.000 claims 2
- 238000011978 dissolution method Methods 0.000 claims 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 238000001556 precipitation Methods 0.000 claims 2
- -1 3-oxo-4-morpholinyl Chemical group 0.000 claims 1
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- 206010051055 Deep vein thrombosis Diseases 0.000 claims 1
- 208000030831 Peripheral arterial occlusive disease Diseases 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 208000010378 Pulmonary Embolism Diseases 0.000 claims 1
- 206010038563 Reocclusion Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 208000032109 Transient ischaemic attack Diseases 0.000 claims 1
- 206010047249 Venous thrombosis Diseases 0.000 claims 1
- 239000008351 acetate buffer Substances 0.000 claims 1
- 238000002399 angioplasty Methods 0.000 claims 1
- 210000004351 coronary vessel Anatomy 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 238000010309 melting process Methods 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 239000004014 plasticizer Substances 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 150000005846 sugar alcohols Chemical group 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- DENPQNAWGQXKCU-UHFFFAOYSA-N thiophene-2-carboxamide Chemical compound NC(=O)C1=CC=CS1 DENPQNAWGQXKCU-UHFFFAOYSA-N 0.000 claims 1
- 230000009466 transformation Effects 0.000 claims 1
- 201000010875 transient cerebral ischemia Diseases 0.000 claims 1
- KGFYHTZWPPHNLQ-AWEZNQCLSA-N rivaroxaban Chemical compound S1C(Cl)=CC=C1C(=O)NC[C@@H]1OC(=O)N(C=2C=CC(=CC=2)N2C(COCC2)=O)C1 KGFYHTZWPPHNLQ-AWEZNQCLSA-N 0.000 description 2
- 200000000007 Arterial disease Diseases 0.000 description 1
- 108010074860 Factor Xa Proteins 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 208000004043 venous thromboembolism Diseases 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005047561.2 | 2005-10-04 | ||
| DE102005047561A DE102005047561A1 (de) | 2005-10-04 | 2005-10-04 | Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung |
| PCT/EP2006/009178 WO2007039122A2 (de) | 2005-10-04 | 2006-09-21 | Feste, oral applizierbare pharmazeutische darreichungsformen mit schneller wirkstofffreisetzung |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009510138A JP2009510138A (ja) | 2009-03-12 |
| JP2009510138A5 true JP2009510138A5 (enExample) | 2009-12-03 |
| JP5147703B2 JP5147703B2 (ja) | 2013-02-20 |
Family
ID=37852804
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008533890A Expired - Fee Related JP5147703B2 (ja) | 2005-10-04 | 2006-09-21 | 経口投与でき、かつ活性成分の迅速な放出を有する固形医薬投与形態 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US8586082B2 (enExample) |
| EP (1) | EP1957048A2 (enExample) |
| JP (1) | JP5147703B2 (enExample) |
| KR (1) | KR101445398B1 (enExample) |
| CN (1) | CN101321517B (enExample) |
| AR (1) | AR056564A1 (enExample) |
| AU (1) | AU2006299192B2 (enExample) |
| BR (1) | BRPI0616874A2 (enExample) |
| CA (1) | CA2624306C (enExample) |
| CR (1) | CR9864A (enExample) |
| CU (1) | CU23808B7 (enExample) |
| DE (1) | DE102005047561A1 (enExample) |
| DO (1) | DOP2006000209A (enExample) |
| EC (1) | ECSP088339A (enExample) |
| GT (1) | GT200600445A (enExample) |
| IL (1) | IL190618A0 (enExample) |
| MY (1) | MY143351A (enExample) |
| NZ (1) | NZ567094A (enExample) |
| PE (1) | PE20070588A1 (enExample) |
| RU (1) | RU2440119C2 (enExample) |
| SV (1) | SV2009002857A (enExample) |
| TW (1) | TWI389691B (enExample) |
| UA (1) | UA90545C2 (enExample) |
| UY (1) | UY29835A1 (enExample) |
| WO (1) | WO2007039122A2 (enExample) |
| ZA (1) | ZA200802873B (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19962924A1 (de) | 1999-12-24 | 2001-07-05 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
| DE10129725A1 (de) * | 2001-06-20 | 2003-01-02 | Bayer Ag | Kombinationstherapie substituierter Oxazolidinone |
| DE10300111A1 (de) | 2003-01-07 | 2004-07-15 | Bayer Healthcare Ag | Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid |
| DE10355461A1 (de) | 2003-11-27 | 2005-06-23 | Bayer Healthcare Ag | Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung |
| DE102004062475A1 (de) * | 2004-12-24 | 2006-07-06 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung |
| EP1685841A1 (en) | 2005-01-31 | 2006-08-02 | Bayer Health Care Aktiengesellschaft | Prevention and treatment of thromboembolic disorders |
| DE102005045518A1 (de) | 2005-09-23 | 2007-03-29 | Bayer Healthcare Ag | 2-Aminoethoxyessigsäure-Derivate und ihre Verwendung |
| NZ567092A (en) | 2005-10-04 | 2011-05-27 | Bayer Schering Pharma Ag | Novel polymorphous form and the amorphous form of 5-chloro-N-({ (5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidine-5-yl}-methyl)-2-thiophene carboxamide |
| DE102005047561A1 (de) | 2005-10-04 | 2007-04-05 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung |
| MX2011000277A (es) | 2008-07-08 | 2011-06-22 | Ratiopharm Gmbh | Composiciones farmaceuticas que comprenden 5-cloro-n-({(5s)-2-oxo- 3-[4-(3-oxo-4-morfolinil)-fenil]-1,3-oxazolidin-5-il}-metil)-2-ti ofencarboxamida. |
| EP2317980A2 (en) * | 2008-08-11 | 2011-05-11 | Ratiopharm GmbH | Pharmaceutical compositions of rivaroxaban with modified release properties |
| US7816355B1 (en) | 2009-04-28 | 2010-10-19 | Apotex Pharmachem Inc | Processes for the preparation of rivaroxaban and intermediates thereof |
| GB0909680D0 (en) | 2009-06-05 | 2009-07-22 | Euro Celtique Sa | Dosage form |
| EP2266541A1 (en) | 2009-06-18 | 2010-12-29 | Krka Tovarna Zdravil, D.D., Novo Mesto | Solid pharmaceutical composition comprising rivaroxaban |
| HRP20161617T4 (hr) | 2009-06-18 | 2019-06-28 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Čvrsti farmaceutski sastav koji sadrži rivaroksaban |
| EP2485715A1 (en) | 2009-10-06 | 2012-08-15 | Ratiopharm GmbH | Pharmaceutical compositions comprising rivaroxaban |
| EP2308472A1 (en) | 2009-10-06 | 2011-04-13 | ratiopharm GmbH | Pharmaceutical compositions comprising rivaroxaban |
| WO2011141489A1 (en) | 2010-05-10 | 2011-11-17 | Euro-Celtique S.A. | Manufacturing of active-free granules and tablets comprising the same |
| NZ603170A (en) | 2010-05-10 | 2015-04-24 | Euro Celtique Sa | Combination of active loaded granules with additional actives |
| KR101858797B1 (ko) | 2010-05-10 | 2018-05-16 | 유로-셀티큐 에스.에이. | 히드로모르폰 및 날록손을 포함하는 제약 조성물 |
| US8906949B2 (en) * | 2010-05-21 | 2014-12-09 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Orally disintegrating tablets of zolmitriptan and process for preparing the same |
| EP2404920A1 (en) | 2010-07-06 | 2012-01-11 | Sandoz AG | Crystalline form of Rivaroxaban dihydrate |
| DE102010063127A1 (de) | 2010-12-15 | 2012-06-21 | Bayer Schering Pharma Aktiengesellschaft | Flüssige, oral applizierbare pharmazeutische Zusammensetzungen enthaltend 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid |
| WO2013022924A1 (en) | 2011-08-08 | 2013-02-14 | Teva Pharmaceutical Industries Ltd. | Pharmaceutical formulations |
| EP2808011A1 (en) * | 2013-05-29 | 2014-12-03 | Sandoz Ag | Process for the preparation of a pharmaceutical composition comprising Rivaroxaban |
| CN103550166A (zh) * | 2013-10-31 | 2014-02-05 | 江苏阿尔法药业有限公司 | 一种利伐沙班口服微球制剂 |
| UA116405C2 (uk) | 2013-11-13 | 2018-03-12 | Євро-Селтік С.А. | Гідроморфон та налоксон для лікування болю та синдрому опіоїдної дисфункції кишечнику |
| WO2015124995A1 (en) | 2014-02-19 | 2015-08-27 | Aurobindo Pharma Ltd | Solid dosage forms of rivaroxaban |
| KR101499867B1 (ko) * | 2014-04-22 | 2015-03-06 | 에스케이케미칼주식회사 | 활성 성분 (i) 함유 조성물 및 이의 제조 방법 |
| KR102333463B1 (ko) * | 2014-07-02 | 2021-12-03 | 한미약품 주식회사 | 리바록사반을 포함하는 경구 투여용 약학 조성물 및 이의 제조방법 |
| CN104666262B (zh) * | 2015-02-03 | 2017-09-15 | 山东新时代药业有限公司 | 一种利伐沙班片 |
| WO2017175792A1 (ja) * | 2016-04-06 | 2017-10-12 | アステラス製薬株式会社 | 速溶出性三次元造形物、速溶出性三次元造形物用フィラメント及び速溶出性三次元造形物用材料 |
| WO2018127938A1 (en) * | 2017-01-04 | 2018-07-12 | Jubeln Lifesciences Pvt. Ltd. | Oral dispersible film composition |
| EP3796915A4 (en) | 2018-11-16 | 2022-01-26 | Santa Farma Ilaç Sanayi A.S. | ORAL FORMULATIONS CONTAINING RIVAROXABAN |
| JP7305527B2 (ja) * | 2018-11-30 | 2023-07-10 | 大原薬品工業株式会社 | リバーロキサバンと嬌味剤を含有する固形製剤 |
| US11073030B1 (en) * | 2020-05-21 | 2021-07-27 | Raytheon Technologies Corporation | Airfoil attachment for gas turbine engines |
| JP7511596B2 (ja) * | 2021-03-10 | 2024-07-05 | 日本ジェネリック株式会社 | リバーロキサバン含有錠剤 |
| GR1010231B (el) | 2021-03-24 | 2022-05-10 | Φαρματεν Α.Β.Ε.Ε., | Φαρμακευτικο σκευασμα που περιλαμβανει ριβαροξαμπανη και μεθοδος παρασκευης αυτου |
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| DE10110747A1 (de) | 2001-03-07 | 2002-09-12 | Bayer Ag | Substituierte 2,6-Diamino-3,5-dicyano-4-aryl-pyridine und ihre Verwendung |
| DE10110754A1 (de) | 2001-03-07 | 2002-09-19 | Bayer Ag | Substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung |
| DE10115922A1 (de) | 2001-03-30 | 2002-10-10 | Bayer Ag | Cyclisch substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung |
| DE10115945A1 (de) | 2001-03-30 | 2002-10-02 | Bayer Ag | Substituierte 2-Carba-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung |
| DE10129725A1 (de) | 2001-06-20 | 2003-01-02 | Bayer Ag | Kombinationstherapie substituierter Oxazolidinone |
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| US20040185097A1 (en) | 2003-01-31 | 2004-09-23 | Glenmark Pharmaceuticals Ltd. | Controlled release modifying complex and pharmaceutical compositions thereof |
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| KR100629771B1 (ko) * | 2004-01-27 | 2006-09-28 | 씨제이 주식회사 | 결정성이 감소되거나 무정형화된 올티프라즈의 제조방법 |
| DE102004062475A1 (de) | 2004-12-24 | 2006-07-06 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung |
| EP1685841A1 (en) | 2005-01-31 | 2006-08-02 | Bayer Health Care Aktiengesellschaft | Prevention and treatment of thromboembolic disorders |
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| NZ567092A (en) | 2005-10-04 | 2011-05-27 | Bayer Schering Pharma Ag | Novel polymorphous form and the amorphous form of 5-chloro-N-({ (5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidine-5-yl}-methyl)-2-thiophene carboxamide |
| DE102005047561A1 (de) | 2005-10-04 | 2007-04-05 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung |
| DE102005047558A1 (de) | 2005-10-04 | 2008-02-07 | Bayer Healthcare Ag | Kombinationstherapie substituierter Oxazolidinone zur Prophylaxe und Behandlung von cerebralen Durchblutungsstörungen |
| DE102005048824A1 (de) | 2005-10-10 | 2007-04-12 | Bayer Healthcare Ag | Behandlung und Prophylaxe von Mikroangiopathien |
-
2005
- 2005-10-04 DE DE102005047561A patent/DE102005047561A1/de not_active Withdrawn
-
2006
- 2006-09-21 US US12/089,148 patent/US8586082B2/en active Active
- 2006-09-21 EP EP06792199A patent/EP1957048A2/de not_active Withdrawn
- 2006-09-21 AU AU2006299192A patent/AU2006299192B2/en active Active
- 2006-09-21 WO PCT/EP2006/009178 patent/WO2007039122A2/de not_active Ceased
- 2006-09-21 MY MYPI20080998A patent/MY143351A/en unknown
- 2006-09-21 UA UAA200805665A patent/UA90545C2/ru unknown
- 2006-09-21 JP JP2008533890A patent/JP5147703B2/ja not_active Expired - Fee Related
- 2006-09-21 KR KR1020087010702A patent/KR101445398B1/ko not_active Expired - Fee Related
- 2006-09-21 BR BRPI0616874-4A patent/BRPI0616874A2/pt not_active Application Discontinuation
- 2006-09-21 CA CA2624306A patent/CA2624306C/en active Active
- 2006-09-21 RU RU2008116831/15A patent/RU2440119C2/ru active
- 2006-09-21 CN CN2006800455481A patent/CN101321517B/zh not_active Expired - Fee Related
- 2006-09-21 NZ NZ567094A patent/NZ567094A/en not_active IP Right Cessation
- 2006-10-02 DO DO2006000209A patent/DOP2006000209A/es unknown
- 2006-10-03 PE PE2006001198A patent/PE20070588A1/es not_active Application Discontinuation
- 2006-10-03 TW TW095136623A patent/TWI389691B/zh not_active IP Right Cessation
- 2006-10-03 UY UY29835A patent/UY29835A1/es not_active Application Discontinuation
- 2006-10-04 AR ARP060104365A patent/AR056564A1/es unknown
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2008
- 2008-04-02 EC EC2008008339A patent/ECSP088339A/es unknown
- 2008-04-02 ZA ZA200802873A patent/ZA200802873B/xx unknown
- 2008-04-02 SV SV2008002857A patent/SV2009002857A/es active IP Right Grant
- 2008-04-03 CR CR9864A patent/CR9864A/es not_active Application Discontinuation
- 2008-04-03 IL IL190618A patent/IL190618A0/en unknown
- 2008-04-04 CU CU20080052A patent/CU23808B7/es active IP Right Grant
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