PE20070588A1 - Formas de presentacion farmaceuticas solidas de administracion oral con liberacion rapida del principio activo - Google Patents
Formas de presentacion farmaceuticas solidas de administracion oral con liberacion rapida del principio activoInfo
- Publication number
- PE20070588A1 PE20070588A1 PE2006001198A PE2006001198A PE20070588A1 PE 20070588 A1 PE20070588 A1 PE 20070588A1 PE 2006001198 A PE2006001198 A PE 2006001198A PE 2006001198 A PE2006001198 A PE 2006001198A PE 20070588 A1 PE20070588 A1 PE 20070588A1
- Authority
- PE
- Peru
- Prior art keywords
- active principle
- polymer
- oral administration
- solid pharmaceutical
- presentation forms
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
SE REFIERE A UNA COMPOSICION FARMACEUTICA SOLIDA DE ADMINISTRACION ORAL CON LIBERACION RAPIDA QUE COMPRENDE EL PRINCIPIO ACTIVO 5-CLORO-N-({(5S)-2-OXO-3-[4-(3-OXO-4-MORFOLINIL)-FENIL]-1,3-OXAZOLIDIN-5-IL}-METIL)-2-TIOFENOCARBOXAMIDA, EN UNA CANTIDAD DE 20 MG Y EN FORMA AMORFA, EL CUAL SE LIBERA EL 80% EN UN PLAZO MAXIMO DE 2 HORAS. EL PROCEDIMIENTO PARA AMORFIZAR DICHO PRICIPIO ACTIVO ES SELECCIONADO DE a) POR FUSION UTILIZANDO UNO O VARIOS COADYUVANTES TAL COMO POLIETILENGLICOL O b) POR EXTRUSION DE MASA FUNDIDA EN EL CUAL SE EMPLEA COMO POLIMERO HIDROXIPROPILCELULOSA O PILIVINILPIRROLIDONA Y SE ANADE UN ALCOHOL DE AZUCAR COMO PLASTIFICANTE DEL POLIMERO Y/O PARA REDUCIR LA TEMPERATURA DE FUSION DEL PRINCIPIO ACTIVO. LAS FORMAS DE PRESENTACION FARMACEUTICAS PREFERIDAS SON CAPSULA, SOBRE, COMPRIMIDO O MICROPARTICULADA. DICHO PRINCIPIO ACTIVO ES UN INHIBIDOR DEL FACTOR DE COAGULACION Xa, POR LO QUE ES UTIL PARA EL TRATAMIENTO DE ENFERMEDADES TROMBOENBOLICAS, INFARTO AL MIOCARDIO, ANGINA DE PECHO, EMBOLIAS PULMONARES
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102005047561A DE102005047561A1 (de) | 2005-10-04 | 2005-10-04 | Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20070588A1 true PE20070588A1 (es) | 2007-08-17 |
Family
ID=37852804
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2006001198A PE20070588A1 (es) | 2005-10-04 | 2006-10-03 | Formas de presentacion farmaceuticas solidas de administracion oral con liberacion rapida del principio activo |
Country Status (27)
Country | Link |
---|---|
US (1) | US8586082B2 (es) |
EP (1) | EP1957048A2 (es) |
JP (1) | JP5147703B2 (es) |
KR (1) | KR101445398B1 (es) |
CN (1) | CN101321517B (es) |
AR (1) | AR056564A1 (es) |
AU (1) | AU2006299192B2 (es) |
BR (1) | BRPI0616874A2 (es) |
CA (1) | CA2624306C (es) |
CR (1) | CR9864A (es) |
CU (1) | CU23808B7 (es) |
DE (1) | DE102005047561A1 (es) |
DO (1) | DOP2006000209A (es) |
EC (1) | ECSP088339A (es) |
GT (1) | GT200600445A (es) |
HK (1) | HK1127284A1 (es) |
IL (1) | IL190618A0 (es) |
MY (1) | MY143351A (es) |
NZ (1) | NZ567094A (es) |
PE (1) | PE20070588A1 (es) |
RU (1) | RU2440119C2 (es) |
SV (1) | SV2009002857A (es) |
TW (1) | TWI389691B (es) |
UA (1) | UA90545C2 (es) |
UY (1) | UY29835A1 (es) |
WO (1) | WO2007039122A2 (es) |
ZA (1) | ZA200802873B (es) |
Families Citing this family (37)
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DE19962924A1 (de) | 1999-12-24 | 2001-07-05 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
DE10129725A1 (de) * | 2001-06-20 | 2003-01-02 | Bayer Ag | Kombinationstherapie substituierter Oxazolidinone |
DE10300111A1 (de) | 2003-01-07 | 2004-07-15 | Bayer Healthcare Ag | Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid |
DE10355461A1 (de) | 2003-11-27 | 2005-06-23 | Bayer Healthcare Ag | Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung |
DE102004062475A1 (de) * | 2004-12-24 | 2006-07-06 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung |
EP1685841A1 (en) | 2005-01-31 | 2006-08-02 | Bayer Health Care Aktiengesellschaft | Prevention and treatment of thromboembolic disorders |
DE102005045518A1 (de) | 2005-09-23 | 2007-03-29 | Bayer Healthcare Ag | 2-Aminoethoxyessigsäure-Derivate und ihre Verwendung |
DE102005047561A1 (de) | 2005-10-04 | 2007-04-05 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung |
EP1934208B1 (de) | 2005-10-04 | 2011-03-23 | Bayer Schering Pharma Aktiengesellschaft | Neue polymorphe form von 5-chlor-n-({ ( 5s )-2-0x0-3-[4-( 3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl} -methyl)-2-thiophencarboxamid |
CN102105138A (zh) | 2008-07-08 | 2011-06-22 | 德国通益药业有限公司 | 包含5-氯-n-({(5s)-2-氧代-3-[4-(3-氧代-4-吗啉基)-苯基]-1,3-噁唑烷-5-基}-甲基)-2-噻吩羧酰胺的药物组合物 |
CA2733611A1 (en) * | 2008-08-11 | 2010-02-18 | Ratiopharm Gmbh | Pharmaceutical compositions with modified release properties comprising 5-chloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid |
US7816355B1 (en) | 2009-04-28 | 2010-10-19 | Apotex Pharmachem Inc | Processes for the preparation of rivaroxaban and intermediates thereof |
GB0909680D0 (en) | 2009-06-05 | 2009-07-22 | Euro Celtique Sa | Dosage form |
EP2266541A1 (en) | 2009-06-18 | 2010-12-29 | Krka Tovarna Zdravil, D.D., Novo Mesto | Solid pharmaceutical composition comprising rivaroxaban |
WO2010146179A2 (en) | 2009-06-18 | 2010-12-23 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Solid pharmaceutical composition comprising rivaroxaban |
US20120231076A1 (en) | 2009-10-06 | 2012-09-13 | Ratiopharm Gmbh | Pharmaceutical compositions comprising rivaroxaban |
EP2308472A1 (en) | 2009-10-06 | 2011-04-13 | ratiopharm GmbH | Pharmaceutical compositions comprising rivaroxaban |
WO2011141490A1 (en) | 2010-05-10 | 2011-11-17 | Euro-Celtique S.A. | Combination of active loaded granules with additional actives |
AU2011252040C1 (en) | 2010-05-10 | 2015-04-02 | Euro-Celtique S.A. | Manufacturing of active-free granules and tablets comprising the same |
PE20130657A1 (es) | 2010-05-10 | 2013-06-15 | Euro Celtique Sa | Composiciones farmaceuticas que comprenden hidromorfona y naloxona |
US8906949B2 (en) * | 2010-05-21 | 2014-12-09 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Orally disintegrating tablets of zolmitriptan and process for preparing the same |
EP2404920A1 (en) | 2010-07-06 | 2012-01-11 | Sandoz AG | Crystalline form of Rivaroxaban dihydrate |
DE102010063127A1 (de) | 2010-12-15 | 2012-06-21 | Bayer Schering Pharma Aktiengesellschaft | Flüssige, oral applizierbare pharmazeutische Zusammensetzungen enthaltend 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid |
WO2013022924A1 (en) | 2011-08-08 | 2013-02-14 | Teva Pharmaceutical Industries Ltd. | Pharmaceutical formulations |
EP2808011A1 (en) * | 2013-05-29 | 2014-12-03 | Sandoz Ag | Process for the preparation of a pharmaceutical composition comprising Rivaroxaban |
CN103550166A (zh) * | 2013-10-31 | 2014-02-05 | 江苏阿尔法药业有限公司 | 一种利伐沙班口服微球制剂 |
DE112014005175T5 (de) | 2013-11-13 | 2016-07-21 | Euro-Celtique S.A. | Hydromorphon und Naloxon für die Behandlung von Schmerzen und Opioid-Darm-Dysfunktions-Syndrom |
WO2015124995A1 (en) | 2014-02-19 | 2015-08-27 | Aurobindo Pharma Ltd | Solid dosage forms of rivaroxaban |
KR101499867B1 (ko) * | 2014-04-22 | 2015-03-06 | 에스케이케미칼주식회사 | 활성 성분 (i) 함유 조성물 및 이의 제조 방법 |
KR102333463B1 (ko) * | 2014-07-02 | 2021-12-03 | 한미약품 주식회사 | 리바록사반을 포함하는 경구 투여용 약학 조성물 및 이의 제조방법 |
CN104666262B (zh) * | 2015-02-03 | 2017-09-15 | 山东新时代药业有限公司 | 一种利伐沙班片 |
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EP1685841A1 (en) | 2005-01-31 | 2006-08-02 | Bayer Health Care Aktiengesellschaft | Prevention and treatment of thromboembolic disorders |
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DE102005048824A1 (de) | 2005-10-10 | 2007-04-12 | Bayer Healthcare Ag | Behandlung und Prophylaxe von Mikroangiopathien |
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2005
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2006
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- 2006-09-21 KR KR1020087010702A patent/KR101445398B1/ko active IP Right Grant
- 2006-09-21 BR BRPI0616874-4A patent/BRPI0616874A2/pt not_active Application Discontinuation
- 2006-09-21 MY MYPI20080998A patent/MY143351A/en unknown
- 2006-09-21 CN CN2006800455481A patent/CN101321517B/zh active Active
- 2006-09-21 WO PCT/EP2006/009178 patent/WO2007039122A2/de active Application Filing
- 2006-09-21 RU RU2008116831/15A patent/RU2440119C2/ru active
- 2006-09-21 EP EP06792199A patent/EP1957048A2/de not_active Withdrawn
- 2006-09-21 JP JP2008533890A patent/JP5147703B2/ja active Active
- 2006-09-21 UA UAA200805665A patent/UA90545C2/ru unknown
- 2006-09-21 US US12/089,148 patent/US8586082B2/en active Active
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