PE20060015A1 - Composiciones de liberacion prolongada que comprenden torasemida y un polimero formador de matriz - Google Patents
Composiciones de liberacion prolongada que comprenden torasemida y un polimero formador de matrizInfo
- Publication number
- PE20060015A1 PE20060015A1 PE2005000267A PE2005000267A PE20060015A1 PE 20060015 A1 PE20060015 A1 PE 20060015A1 PE 2005000267 A PE2005000267 A PE 2005000267A PE 2005000267 A PE2005000267 A PE 2005000267A PE 20060015 A1 PE20060015 A1 PE 20060015A1
- Authority
- PE
- Peru
- Prior art keywords
- torasemide
- prolonged release
- forming polymer
- compositions including
- release compositions
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- NGBFQHCMQULJNZ-UHFFFAOYSA-N Torsemide Chemical compound CC(C)NC(=O)NS(=O)(=O)C1=CN=CC=C1NC1=CC=CC(C)=C1 NGBFQHCMQULJNZ-UHFFFAOYSA-N 0.000 title abstract 2
- 229920000642 polymer Polymers 0.000 title abstract 2
- 230000002035 prolonged effect Effects 0.000 title abstract 2
- 229960005461 torasemide Drugs 0.000 title abstract 2
- 239000011159 matrix material Substances 0.000 title 1
- OKMWKBLSFKFYGZ-UHFFFAOYSA-N 1-behenoylglycerol Chemical compound CCCCCCCCCCCCCCCCCCCCCC(=O)OCC(O)CO OKMWKBLSFKFYGZ-UHFFFAOYSA-N 0.000 abstract 1
- -1 DISGREGANTS Substances 0.000 abstract 1
- 239000001828 Gelatine Substances 0.000 abstract 1
- 208000004880 Polyuria Diseases 0.000 abstract 1
- 239000004372 Polyvinyl alcohol Substances 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 229920002678 cellulose Polymers 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 230000035619 diuresis Effects 0.000 abstract 1
- 230000001882 diuretic effect Effects 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 229940049654 glyceryl behenate Drugs 0.000 abstract 1
- 239000000314 lubricant Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 229920002451 polyvinyl alcohol Polymers 0.000 abstract 1
- ISXSCDLOGDJUNJ-UHFFFAOYSA-N tert-butyl prop-2-enoate Chemical compound CC(C)(C)OC(=O)C=C ISXSCDLOGDJUNJ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A COMPOSICIONES ORALES DE LIBERACION PROLONGADA QUE COMPRENDE EL PRINCIPIO ACTIVO TORASEMIDA, EN UNA PROPORCION DE 0,5 AL 20%; UN POLIMERO FORMADOR DE MATRICES, SELECCIONADOS DEL GRUPO DE: ACRILICOS, CELULOSICOS, BEHENATO DE GLICERILO, GOMA GUAR, GOMA XANTANA, QUITOSANO, GELATINA, ALCOHOL POLIVINILICO, SUS SIMILARES Y MEZCLAS DE ESTOS, LOS QUE SE ENCUENTRA EN UNA PROPORCION DE 1 AL 50%, ADEMAS COMPRENDEN UNO O MAS EXCIPIENTES ELEGIDOS ENTRE DILUYENTES, AGLUTINANTES, DISGREGANTES, LUBRICANTES Y SIMILARES. ESTAS COMPOSICIONES PRESENTAN UNA ACTIVIDAD DIURETICA Y MANTIENEN LA DIURESIS EN UN TIEMPO MAXIMO DE 24 HORAS Y PREFERENTEMENTE 12 HORAS, EVITANDO ASI POSIBLES PROBLEMAS DE NICTURIA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200400740A ES2244324B1 (es) | 2004-03-25 | 2004-03-25 | Composiciones diureticas de liberacion prolongada. |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20060015A1 true PE20060015A1 (es) | 2006-02-02 |
Family
ID=34962072
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2005000267A PE20060015A1 (es) | 2004-03-25 | 2005-03-09 | Composiciones de liberacion prolongada que comprenden torasemida y un polimero formador de matriz |
Country Status (20)
Country | Link |
---|---|
US (1) | US20080187585A1 (es) |
EP (1) | EP1732517B1 (es) |
JP (1) | JP4871258B2 (es) |
KR (1) | KR101203763B1 (es) |
CN (1) | CN1946379B (es) |
AR (1) | AR048432A1 (es) |
AU (1) | AU2005227095B2 (es) |
BR (1) | BRPI0509165A (es) |
CA (1) | CA2562142C (es) |
ES (2) | ES2244324B1 (es) |
MX (1) | MXPA06010833A (es) |
NO (1) | NO336582B1 (es) |
PA (1) | PA8627401A1 (es) |
PE (1) | PE20060015A1 (es) |
PL (1) | PL1732517T3 (es) |
PT (1) | PT1732517T (es) |
RU (2) | RU2006137671A (es) |
TW (1) | TWI351957B (es) |
UY (1) | UY28809A1 (es) |
WO (1) | WO2005092291A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10463622B2 (en) * | 2013-10-06 | 2019-11-05 | Sarfez Pharmaceuticals, Inc. | Treatments and formulations comprising Torsemide |
US10596119B1 (en) * | 2018-11-08 | 2020-03-24 | Sarfez Pharmaceuticals, Inc. | Methods of treatment comprising torsemide |
WO2015050570A1 (en) * | 2013-10-06 | 2015-04-09 | Shah Salim | Controlled-release formulations comprising torsemide |
EP3031471A1 (en) * | 2014-12-12 | 2016-06-15 | Ceva Sante Animale | Veterinary composition for the treatment of pulmonary edema associated with heart failure in domestic animals |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3305935C2 (de) * | 1983-02-21 | 1985-05-30 | Medice Chem.-Pharm. Fabrik Pütter GmbH & Co KG, 5860 Iserlohn | Kaliumneutrales Saluretikum mit antihypertensiver Wirkung |
DE3529529A1 (de) * | 1985-08-17 | 1987-02-19 | Boehringer Mannheim Gmbh | Verfahren zur herstellung einer stabilen modifikation von torasemid |
GB8601204D0 (en) * | 1986-01-18 | 1986-02-19 | Boots Co Plc | Therapeutic agents |
JP3586471B2 (ja) * | 1991-06-25 | 2004-11-10 | 三菱ウェルファーマ株式会社 | トラセミド含有医薬組成物 |
DE19637082A1 (de) * | 1996-09-12 | 1998-03-19 | Boehringer Mannheim Gmbh | Schnellzerfallende Pellets |
GB9816899D0 (en) * | 1998-08-05 | 1998-09-30 | Boots Co Plc | Therapeutic agents |
KR20020025217A (ko) * | 1999-08-11 | 2002-04-03 | 추후보정 | 토르세미드 동질이상 |
HUP0600143A2 (en) * | 2000-02-17 | 2006-10-28 | Teva Pharma | A stable pharmaceutical formulation comprising torsemide modification ii |
DE10013289A1 (de) * | 2000-03-17 | 2001-09-20 | Knoll Ag | Torasemid enthaltende pharmazeutische Zubereitungen |
US20030119882A1 (en) * | 2001-10-22 | 2003-06-26 | Markus Maegerlein | Solid pharmaceutical composition containing torasemide |
US20030091630A1 (en) * | 2001-10-25 | 2003-05-15 | Jenny Louie-Helm | Formulation of an erodible, gastric retentive oral dosage form using in vitro disintegration test data |
US20030104052A1 (en) * | 2001-10-25 | 2003-06-05 | Bret Berner | Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract |
US20030152622A1 (en) * | 2001-10-25 | 2003-08-14 | Jenny Louie-Helm | Formulation of an erodible, gastric retentive oral diuretic |
US6863901B2 (en) * | 2001-11-30 | 2005-03-08 | Collegium Pharmaceutical, Inc. | Pharmaceutical composition for compressed annular tablet with molded triturate tablet for both intraoral and oral administration |
HRP20020124A2 (en) * | 2002-02-11 | 2003-10-31 | Pliva D D | Sustained/controlled release solid formulation as a novel drug delivery system with reduced risk of dose dumping |
MXPA06006677A (es) * | 2003-12-12 | 2006-08-31 | Penwest Pharmaceuticals Co | Formas de dosis de torasemida de liberacion sostenida. |
-
2004
- 2004-03-25 ES ES200400740A patent/ES2244324B1/es not_active Expired - Lifetime
-
2005
- 2005-03-09 PE PE2005000267A patent/PE20060015A1/es active IP Right Grant
- 2005-03-14 UY UY28809A patent/UY28809A1/es unknown
- 2005-03-16 AR ARP050101017A patent/AR048432A1/es not_active Application Discontinuation
- 2005-03-18 TW TW094108282A patent/TWI351957B/zh not_active IP Right Cessation
- 2005-03-23 WO PCT/EP2005/051340 patent/WO2005092291A1/en active Application Filing
- 2005-03-23 ES ES05717133.2T patent/ES2632354T3/es active Active
- 2005-03-23 BR BRPI0509165-9A patent/BRPI0509165A/pt not_active Application Discontinuation
- 2005-03-23 CA CA2562142A patent/CA2562142C/en active Active
- 2005-03-23 RU RU2006137671/15A patent/RU2006137671A/ru unknown
- 2005-03-23 CN CN2005800093895A patent/CN1946379B/zh not_active Expired - Fee Related
- 2005-03-23 JP JP2007504420A patent/JP4871258B2/ja not_active Expired - Fee Related
- 2005-03-23 PL PL05717133T patent/PL1732517T3/pl unknown
- 2005-03-23 AU AU2005227095A patent/AU2005227095B2/en not_active Ceased
- 2005-03-23 US US10/594,004 patent/US20080187585A1/en not_active Abandoned
- 2005-03-23 EP EP05717133.2A patent/EP1732517B1/en active Active
- 2005-03-23 KR KR1020067021596A patent/KR101203763B1/ko active IP Right Grant
- 2005-03-23 MX MXPA06010833A patent/MXPA06010833A/es active IP Right Grant
- 2005-03-23 PT PT57171332T patent/PT1732517T/pt unknown
- 2005-03-24 PA PA20058627401A patent/PA8627401A1/es unknown
-
2006
- 2006-10-24 NO NO20064834A patent/NO336582B1/no not_active IP Right Cessation
-
2010
- 2010-11-03 RU RU2010145009/15A patent/RU2449778C1/ru active
Also Published As
Publication number | Publication date |
---|---|
NO20064834L (no) | 2006-12-07 |
US20080187585A1 (en) | 2008-08-07 |
ES2244324B1 (es) | 2006-11-16 |
NO336582B1 (no) | 2015-09-28 |
ES2632354T3 (es) | 2017-09-12 |
WO2005092291A1 (en) | 2005-10-06 |
EP1732517A1 (en) | 2006-12-20 |
KR101203763B1 (ko) | 2012-11-23 |
PA8627401A1 (es) | 2005-11-25 |
UY28809A1 (es) | 2005-07-29 |
RU2006137671A (ru) | 2008-04-27 |
AU2005227095A1 (en) | 2005-10-06 |
ES2244324A1 (es) | 2005-12-01 |
BRPI0509165A (pt) | 2007-09-11 |
EP1732517B1 (en) | 2017-05-03 |
AR048432A1 (es) | 2006-04-26 |
CN1946379A (zh) | 2007-04-11 |
PL1732517T3 (pl) | 2017-09-29 |
AU2005227095B2 (en) | 2010-10-28 |
CA2562142A1 (en) | 2005-10-06 |
RU2449778C1 (ru) | 2012-05-10 |
CN1946379B (zh) | 2012-05-16 |
KR20060130756A (ko) | 2006-12-19 |
JP2007530510A (ja) | 2007-11-01 |
JP4871258B2 (ja) | 2012-02-08 |
TWI351957B (en) | 2011-11-11 |
MXPA06010833A (es) | 2006-12-15 |
PT1732517T (pt) | 2017-08-03 |
TW200531693A (en) | 2005-10-01 |
CA2562142C (en) | 2012-06-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration |