|
AU2002311919B8
(en)
|
2001-05-11 |
2007-03-22 |
Ludwig Institute For Cancer Research Ltd |
Specific binding proteins and uses thereof
|
|
US20100056762A1
(en)
|
2001-05-11 |
2010-03-04 |
Old Lloyd J |
Specific binding proteins and uses thereof
|
|
US20110313230A1
(en)
|
2001-05-11 |
2011-12-22 |
Terrance Grant Johns |
Specific binding proteins and uses thereof
|
|
DK3248613T3
(da)
*
|
2005-07-18 |
2022-03-14 |
Seagen Inc |
Beta-glucuronid-lægemiddel-linkerkonjugater
|
|
US7750116B1
(en)
*
|
2006-02-18 |
2010-07-06 |
Seattle Genetics, Inc. |
Antibody drug conjugate metabolites
|
|
EP2032606B1
(en)
|
2006-05-30 |
2013-11-27 |
Genentech, Inc. |
Antibodies and immunoconjugates and uses therefor
|
|
BRPI0717638A2
(pt)
|
2006-10-27 |
2013-11-12 |
Genentech Inc |
Anticorpors e imunoconjugados e usos para os mesmos
|
|
US9090693B2
(en)
|
2007-01-25 |
2015-07-28 |
Dana-Farber Cancer Institute |
Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease
|
|
CA2680854C
(en)
|
2007-03-15 |
2017-02-14 |
Ludwig Institute For Cancer Research |
Treatment method using egfr antibodies and src inhibitors and related formulations
|
|
FR2914306B1
(fr)
*
|
2007-04-02 |
2009-07-03 |
Biocydex Soc Par Actions Simpl |
Oligomeres de cyclodextrines, vecteurs de molecules actives
|
|
PE20090943A1
(es)
|
2007-07-16 |
2009-08-05 |
Genentech Inc |
Anticuerpos anti-cd79b e inmunoconjugados
|
|
EP2176295B1
(en)
|
2007-07-16 |
2014-11-19 |
Genentech, Inc. |
Humanized anti-cd79b antibodies and immunoconjugates and methods of use
|
|
CN108424454B
(zh)
|
2007-08-14 |
2022-05-31 |
路德维格癌症研究所有限公司 |
靶向egf受体的单克隆抗体175及其衍生物和用途
|
|
FR2920877B1
(fr)
*
|
2007-09-10 |
2010-01-22 |
Commissariat Energie Atomique |
Substrats fluorescents saccharidiques, leur procede de procede de preparation et leurs utisations.
|
|
EA020696B1
(ru)
|
2007-10-12 |
2015-01-30 |
Сиэтл Дженетикс, Инк. |
Способ лечения лимфомы ходжкина с использованием комбинации гемцитабина и конъюгата антитела против cd30 с ауристатином
|
|
DK2211904T3
(en)
|
2007-10-19 |
2016-10-24 |
Seattle Genetics Inc |
Cd19-binding agents and uses thereof
|
|
KR101607346B1
(ko)
|
2008-01-31 |
2016-03-29 |
제넨테크, 인크. |
항-ｃｄ７９ｂ 항체 및 면역접합체 및 사용 방법
|
|
EP2240495B1
(en)
|
2008-02-01 |
2015-07-15 |
Genentech, Inc. |
Nemorubicin metabolite and analog reagents, antibody-drug conjugates and methods
|
|
AU2009270988A1
(en)
|
2008-07-15 |
2010-01-21 |
Genentech, Inc. |
Anthracycline derivative conjugates, process for their preparation and their use as antitumor compounds
|
|
EP2326350B1
(en)
|
2008-09-08 |
2013-09-04 |
Psma Development Company, L.L.C. |
Compounds for killing psma-expressing, taxane-resistant cancer cells
|
|
RU2587621C2
(ru)
|
2009-04-01 |
2016-06-20 |
Дженентек, Инк. |
АНТИТЕЛА К FcRH5, ИХ ИММУНОКОНЪЮГАТЫ И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
|
|
US20110076232A1
(en)
|
2009-09-29 |
2011-03-31 |
Ludwig Institute For Cancer Research |
Specific binding proteins and uses thereof
|
|
CA2795349C
(en)
*
|
2010-04-15 |
2016-11-29 |
Seattle Genetics, Inc. |
Targeted pyrrolobenzodiazepine conjugates
|
|
NZ701208A
(en)
|
2010-06-03 |
2016-05-27 |
Genentech Inc |
Immuno-pet imaging of antibodies and immunoconjugates and uses thereof
|
|
KR101897307B1
(ko)
|
2010-12-02 |
2018-09-10 |
네르비아노 메디칼 사이언시스 에스.알.엘. |
모르폴리닐 안트라사이클린 유도체의 제조 방법
|
|
JOP20210044A1
(ar)
|
2010-12-30 |
2017-06-16 |
Takeda Pharmaceuticals Co |
الأجسام المضادة لـ cd38
|
|
WO2012094653A2
(en)
*
|
2011-01-07 |
2012-07-12 |
Massachusetts Institute Of Technology |
Compositions and methods for macromolecular drug delivery
|
|
CN104906592B
(zh)
*
|
2011-02-25 |
2017-11-03 |
广州南沙龙沙有限公司 |
用于蛋白质药物偶联物的支链联接体
|
|
WO2012113847A1
(en)
*
|
2011-02-25 |
2012-08-30 |
Lonza Ltd |
Branched linker for protein drug conjugates
|
|
US9835624B2
(en)
|
2011-05-02 |
2017-12-05 |
The Regents Of The University Of California |
Compositions and methods for detecting mycobacterium
|
|
MX393973B
(es)
|
2011-05-08 |
2025-03-24 |
Legochem Biosciences Inc |
Conjugados de proteína-agente activo y método para su preparación.
|
|
CN108892709A
(zh)
*
|
2011-05-18 |
2018-11-27 |
欧莫德里斯制药公司 |
改良的肽药物
|
|
UA112434C2
(uk)
|
2011-05-27 |
2016-09-12 |
Ґлаксо Ґруп Лімітед |
Антигензв'язувальний білок, який специфічно зв'язується з всма
|
|
CA2841313C
(en)
*
|
2011-07-19 |
2023-10-24 |
Cellmosaic, Llc |
Sugar alcohol-based crosslinking reagents, macromolecules, therapeutic bioconjugates, and synthetic methods thereof
|
|
US10598653B2
(en)
|
2011-11-01 |
2020-03-24 |
Bionomics Inc. |
Methods of blocking cancer stem cell growth
|
|
EP2592103A1
(en)
|
2011-11-08 |
2013-05-15 |
Adriacell S.p.A. |
Polymer aldehyde derivatives
|
|
EP3575794A1
(en)
|
2012-02-10 |
2019-12-04 |
Seattle Genetics, Inc. |
Detection and treatment of cd30+ cancers
|
|
CN104640572B
(zh)
*
|
2012-05-15 |
2018-04-27 |
索伦托医疗有限公司 |
药物偶联物，偶联方法，及其用途
|
|
JP6280546B2
(ja)
|
2012-06-26 |
2018-02-14 |
デル マー ファーマシューティカルズ |
ジアンヒドロガラクチトール、ジアセチルジアンヒドロガラクチトール、ジブロモズルシトール、又はこれらの類似体若しくは誘導体を用いた、遺伝子多型又はａｈｉ１の調節不全若しくは変異を有する患者におけるチロシンキナーゼインヒビター抵抗性悪性腫瘍を処置するための方法
|
|
JP2015529655A
(ja)
|
2012-08-02 |
2015-10-08 |
ステルス ペプチドズ インターナショナル インコーポレイテッド |
アテローム性硬化症の処置方法
|
|
WO2014089177A2
(en)
|
2012-12-04 |
2014-06-12 |
Massachusetts Institute Of Technology |
Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines
|
|
JP2016513098A
(ja)
|
2013-02-07 |
2016-05-12 |
イミューノメディクス、インコーポレイテッドＩｍｍｕｎｏｍｅｄｉｃｓ， Ｉｎｃ． |
癌の標的治療用抗体と抱合した極めて強力なプロドラック形態の２−ピロリノドキソルビシン（ｐ２ｐｄｏｘ）
|
|
US9498540B2
(en)
|
2013-03-15 |
2016-11-22 |
Novartis Ag |
Cell proliferation inhibitors and conjugates thereof
|
|
HK1220626A1
(zh)
|
2013-03-15 |
2017-05-12 |
The Centre For Drug Research And Development |
具细胞毒性和抗有丝分裂的化合物以及其使用方法
|
|
EP2968589A1
(en)
|
2013-03-15 |
2016-01-20 |
AbbVie Inc. |
Antibody drug conjugate (adc) purification
|
|
MX2015012549A
(es)
|
2013-03-15 |
2016-06-21 |
Abbvie Deutschland |
Formulaciones de conjugado anticuerpo anti-egfr-farmaco.
|
|
KR20160061911A
(ko)
|
2013-04-08 |
2016-06-01 |
데니스 엠. 브라운 |
최적하 투여된 화학 화합물의 치료 효과
|
|
PL2991683T3
(pl)
|
2013-05-02 |
2020-03-31 |
Glykos Finland Oy |
Koniugaty glikoproteiny lub glikanu z toksycznym ładunkiem
|
|
US10208125B2
(en)
|
2013-07-15 |
2019-02-19 |
University of Pittsburgh—of the Commonwealth System of Higher Education |
Anti-mucin 1 binding agents and uses thereof
|
|
AU2014332442B2
(en)
|
2013-08-26 |
2019-12-19 |
Biontech Research And Development, Inc. |
Nucleic acids encoding human antibodies to Sialyl-Lewis
|
|
WO2015048312A1
(en)
|
2013-09-26 |
2015-04-02 |
Costim Pharmaceuticals Inc. |
Methods for treating hematologic cancers
|
|
NZ758049A
(en)
|
2013-10-15 |
2024-03-22 |
Seagen Inc |
Pegylated drug-linkers for improved ligand-drug conjugate pharmacokinetics
|
|
KR102442906B1
(ko)
|
2013-12-19 |
2022-09-14 |
씨젠 인크. |
표적화된-약물 컨쥬게이트와 함께 사용되는 메틸렌 카바메이트 링커
|
|
WO2015095953A1
(en)
|
2013-12-27 |
2015-07-02 |
The Centre For Drug Research And Development |
Sulfonamide-containing linkage systems for drug conjugates
|
|
PE20170255A1
(es)
|
2014-01-24 |
2017-03-22 |
Dana Farber Cancer Inst Inc |
Moleculas de anticuerpo que se unen a pd-1 y usos de las mismas
|
|
HUE045065T2
(hu)
|
2014-01-31 |
2019-12-30 |
Novartis Ag |
TIM-3 antitest molekulák és felhasználásaik
|
|
FR3017298B1
(fr)
*
|
2014-02-07 |
2016-03-04 |
Centre Nat Rech Scient |
Conjugues et pro-drogues pour le traitement du cancer et de maladies inflammatoires
|
|
KR102442436B1
(ko)
|
2014-03-14 |
2022-09-15 |
노파르티스 아게 |
Lag-3에 대한 항체 분자 및 그의 용도
|
|
AR099812A1
(es)
|
2014-03-21 |
2016-08-17 |
Abbvie Inc |
Anticuerpos y conjugados de anticuerpo y fármaco anti-egfr
|
|
EP3502132A1
(en)
|
2014-05-28 |
2019-06-26 |
Stealth BioTherapeutics Corp |
Therapeutic compositions including therapeutic small molecules and uses thereof
|
|
KR101628872B1
(ko)
|
2014-05-28 |
2016-06-09 |
주식회사 레고켐 바이오사이언스 |
자가-희생 기를 포함하는 화합물
|
|
WO2015183995A2
(en)
|
2014-05-28 |
2015-12-03 |
Stealth Peptides International, Inc. |
Therapeutic compositions including frataxin, lactoferrin, and mitochondrial energy generating enzymes, and uses thereof
|
|
US9856324B2
(en)
|
2014-06-04 |
2018-01-02 |
MabVax Therapeutics, Inc. |
Human monoclonal antibodies to ganglioside GD2
|
|
EP3154587B1
(en)
|
2014-06-13 |
2020-01-15 |
Tenboron OY |
Conjugates comprising an anti-egfr1 antibody
|
|
EP3160513B1
(en)
|
2014-06-30 |
2020-02-12 |
Glykos Finland Oy |
Saccharide derivative of a toxic payload and antibody conjugates thereof
|
|
KR20170060042A
(ko)
|
2014-09-13 |
2017-05-31 |
노파르티스 아게 |
Alk 억제제의 조합 요법
|
|
ES2905569T3
(es)
|
2014-09-17 |
2022-04-11 |
Zymeworks Inc |
Compuestos citotóxicos y antimitóticos y métodos para utilizarlos
|
|
AU2015339012B2
(en)
|
2014-10-31 |
2020-11-05 |
Abbvie Biotherapeutics Inc. |
Anti-CS1 antibodies and antibody drug conjugates
|
|
US10077287B2
(en)
|
2014-11-10 |
2018-09-18 |
Bristol-Myers Squibb Company |
Tubulysin analogs and methods of making and use
|
|
JP6864953B2
(ja)
|
2014-12-09 |
2021-04-28 |
アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル |
Ａｘｌに対するヒトモノクローナル抗体
|
|
CN113209306A
(zh)
|
2014-12-09 |
2021-08-06 |
艾伯维公司 |
具有细胞渗透性的bcl-xl抑制剂的抗体药物缀合物
|
|
CN111620861A
(zh)
|
2014-12-09 |
2020-09-04 |
艾伯维公司 |
具有低细胞渗透性的bcl-xl抑制性化合物以及包括它的抗体药物缀合物
|
|
BR112017014937A2
(pt)
|
2015-01-14 |
2018-03-13 |
Bristol-Myers Squibb Company |
dímeros de benzodiazepina ligados em ponte a heteroarileno, conjugados dos mesmos, e métodos de preparação e uso
|
|
DK3270965T3
(da)
*
|
2015-03-18 |
2020-06-08 |
Seattle Genetics Inc |
Cd48-antistoffer og konjugater deraf
|
|
HRP20211058T8
(hr)
|
2015-07-29 |
2021-11-26 |
Novartis Ag |
Kombinirane terapije koje sadrže molekule antitijela protiv lag-3
|
|
WO2017051254A1
(en)
|
2015-09-25 |
2017-03-30 |
Legochem Biosciences, Inc. |
Compositions and methods related to anti-egfr antibody drug conjugates
|
|
WO2017051249A1
(en)
|
2015-09-25 |
2017-03-30 |
Legochem Biosciences, Inc. |
Compositions and methods related to anti-cd19 antibody drug conjugates
|
|
KR20180058737A
(ko)
*
|
2015-10-07 |
2018-06-01 |
더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 |
암 선택적 표지화 및 표적화를 위한 트리거-활성화 대사성 당 전구체
|
|
WO2017060397A1
(en)
|
2015-10-09 |
2017-04-13 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for predicting the survival time of subjects suffering from melanoma metastases
|
|
WO2017067944A1
(en)
|
2015-10-19 |
2017-04-27 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for predicting the survival time of subjects suffering from triple negative breast cancer
|
|
CN107029242A
(zh)
*
|
2015-11-03 |
2017-08-11 |
财团法人工业技术研究院 |
抗体药物复合物及其制造方法
|
|
AU2016359230B2
(en)
|
2015-11-25 |
2020-04-23 |
Ligachem Biosciences Inc. |
Conjugates comprising self-immolative groups and methods related thereto
|
|
KR102847348B1
(ko)
|
2015-11-25 |
2025-08-19 |
주식회사 리가켐바이오사이언스 |
펩타이드 그룹을 포함하는 접합체 및 이와 관련된 제조방법
|
|
AU2016359235B2
(en)
|
2015-11-25 |
2022-09-15 |
Ligachem Biosciences Inc. |
Antibody-drug conjugates comprising branched linkers and methods related thereto
|
|
AU2016365114A1
(en)
|
2015-11-30 |
2018-05-17 |
Abbvie Biotherapeutics Inc. |
Anti-huLRRC15 antibody drug conjugates and methods for their use
|
|
AU2016365117A1
(en)
|
2015-11-30 |
2018-05-31 |
Abbvie Biotherapeutics Inc. |
Anti-huLRRC15 antibody drug conjugates and methods for their use
|
|
US11793880B2
(en)
|
2015-12-04 |
2023-10-24 |
Seagen Inc. |
Conjugates of quaternized tubulysin compounds
|
|
KR20180090290A
(ko)
|
2015-12-04 |
2018-08-10 |
시애틀 지네틱스, 인크. |
사차화 튜불리신 화합물들의 컨쥬게이트들
|
|
US11013690B2
(en)
*
|
2016-01-04 |
2021-05-25 |
Academia Sinica |
Esterification/saponification-based method for liposomal encapsulation of hydrophilic glucuronides
|
|
WO2017161414A1
(en)
|
2016-03-22 |
2017-09-28 |
Bionomics Limited |
Administration of an anti-lgr5 monoclonal antibody
|
|
CN109641955B
(zh)
|
2016-03-22 |
2022-07-08 |
国家医疗保健研究所 |
人源化抗claudin-1抗体及其用途
|
|
CN109843919A
(zh)
|
2016-03-25 |
2019-06-04 |
西雅图基因公司 |
用于制备聚乙二醇化的药物-接头及其中间体的方法
|
|
WO2017197045A1
(en)
|
2016-05-11 |
2017-11-16 |
Movassaghi Mohammad |
Convergent and enantioselective total synthesis of communesin analogs
|
|
SI3626273T1
(sl)
|
2016-05-17 |
2021-04-30 |
Abbvie Biotherapeutics Inc. |
Konjugati protitelesa proti CMET in zdravila ter postopki za njihovo uporabo
|
|
BR112018075639A2
(pt)
|
2016-06-08 |
2019-04-09 |
Abbvie Inc. |
conjugados de anticorpo fármaco anti-egfr
|
|
AU2017279550A1
(en)
|
2016-06-08 |
2019-01-03 |
Abbvie Inc. |
Anti-B7-H3 antibodies and antibody drug conjugates
|
|
WO2017214462A2
(en)
|
2016-06-08 |
2017-12-14 |
Abbvie Inc. |
Anti-cd98 antibodies and antibody drug conjugates
|
|
AU2017277534A1
(en)
|
2016-06-08 |
2019-01-03 |
Abbvie Inc. |
Anti-EGFR antibody drug conjugates
|
|
RU2018147224A
(ru)
|
2016-06-08 |
2020-07-14 |
Эббви Инк. |
Конъюгаты антитела к egfr и лекарственного средства
|
|
MX2018015285A
(es)
|
2016-06-08 |
2019-09-18 |
Abbvie Inc |
Anticuerpos anti-b7-h3 y conjugados de anticuerpo y farmaco.
|
|
US20200147235A1
(en)
|
2016-06-08 |
2020-05-14 |
Abbvie Inc. |
Anti-cd98 antibodies and antibody drug conjugates
|
|
JP2019524651A
(ja)
|
2016-06-08 |
2019-09-05 |
アッヴィ・インコーポレイテッド |
抗ｃｄ９８抗体及び抗体薬物コンジュゲート
|
|
WO2017214322A1
(en)
|
2016-06-08 |
2017-12-14 |
Abbvie Inc. |
Anti-b7-h3 antibodies and antibody drug conjugates
|
|
WO2018025168A1
(en)
|
2016-08-03 |
2018-02-08 |
Pfizer Inc. |
Heteroaryl sulfone-based conjugation handles, methods for their preparation, and their use in synthesizing antibody drug conjugates
|
|
TWI851531B
(zh)
|
2016-08-09 |
2024-08-11 |
美商思進公司 |
具有改善之生理化學性質之具自我穩定連接子之藥物結合物
|
|
CN109641911B
(zh)
|
2016-08-19 |
2023-02-21 |
百时美施贵宝公司 |
seco-环丙吡咯并吲哚化合物和其抗体-药物缀合物以及制备和使用方法
|
|
US10398783B2
(en)
|
2016-10-20 |
2019-09-03 |
Bristol-Myers Squibb Company |
Antiproliferative compounds and conjugates made therefrom
|
|
CA3080270A1
(en)
|
2016-10-25 |
2018-05-03 |
Inserm (Institut National De La Sante Et De La Recherche Medicale) |
Monoclonal antibodies binding to the cd160 transmembrane isoform
|
|
CN110022938A
(zh)
*
|
2016-11-14 |
2019-07-16 |
千禧制药公司 |
抗cd30抗体药物缀合物的非成年人给药
|
|
EP3538098A4
(en)
*
|
2016-11-14 |
2020-07-29 |
Cho Pharma Inc |
ANTIBODY-DRUG CONJUGATES
|
|
HRP20210922T1
(hr)
*
|
2016-11-23 |
2021-09-03 |
Eli Lilly And Company |
Konjugati protutijela protiv met s lijekom
|
|
US11135307B2
(en)
|
2016-11-23 |
2021-10-05 |
Mersana Therapeutics, Inc. |
Peptide-containing linkers for antibody-drug conjugates
|
|
JP7244987B2
(ja)
|
2016-12-14 |
2023-03-23 |
シージェン インコーポレイテッド |
多剤抗体薬物コンジュゲート
|
|
EP3554544A4
(en)
|
2016-12-16 |
2020-07-29 |
Bluefin Biomedicine, Inc. |
ANTI-PROTEIN 1 ANTIBODY CONTAINING AN ANTI-CUB DOMAIN (CDCP1), ANTIBODY-DRUG CONJUGATES AND THEIR METHODS OF USE
|
|
KR102085798B1
(ko)
|
2016-12-28 |
2020-03-06 |
주식회사 인투셀 |
베타-갈락토사이드가 도입된 자가-희생 기를 포함하는 화합물
|
|
WO2018138591A1
(en)
|
2017-01-24 |
2018-08-02 |
Pfizer Inc. |
Calicheamicin derivatives and antibody drug conjugates thereof
|
|
US11299509B2
(en)
|
2017-02-10 |
2022-04-12 |
The Board Of Trustees Of The University Of Illinois |
Trigger-activatable sugar conjugates for cancer-selective labeling and targeting
|
|
WO2018146253A1
(en)
|
2017-02-10 |
2018-08-16 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical compositions for the treatment of cancers associated with activation of the mapk pathway
|
|
KR102648564B1
(ko)
|
2017-03-24 |
2024-03-19 |
씨젠 인크. |
글루쿠로니드 약물-링커의 제조 공정 및 그 중간물
|
|
CA3058360A1
(en)
|
2017-03-29 |
2018-10-04 |
Legochem Biosciences, Inc. |
Pyrrolobenzodiazepine dimer prodrug and ligand-linker conjugate compound of the same
|
|
US11932650B2
(en)
|
2017-05-11 |
2024-03-19 |
Massachusetts Institute Of Technology |
Potent agelastatin derivatives as modulators for cancer invasion and metastasis
|
|
US11666657B2
(en)
|
2017-05-16 |
2023-06-06 |
Universite De Strasbourg |
Protein-drug conjugates and their use in the treatment of cancers
|
|
US20210403573A1
(en)
|
2017-06-22 |
2021-12-30 |
INSERM (Institut National de la Santé et de la Recherche Médicale |
Methods and pharmaceutical compositions for the treatment of fibrosis with agents capable of inhibiting the activation of mucosal-associated invariant t (mait) cells
|
|
US10508115B2
(en)
|
2017-08-16 |
2019-12-17 |
Bristol-Myers Squibb Company |
Toll-like receptor 7 (TLR7) agonists having heteroatom-linked aromatic moieties, conjugates thereof, and methods and uses therefor
|
|
US10487084B2
(en)
|
2017-08-16 |
2019-11-26 |
Bristol-Myers Squibb Company |
Toll-like receptor 7 (TLR7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor
|
|
US10472361B2
(en)
|
2017-08-16 |
2019-11-12 |
Bristol-Myers Squibb Company |
Toll-like receptor 7 (TLR7) agonists having a benzotriazole moiety, conjugates thereof, and methods and uses therefor
|
|
US10494370B2
(en)
|
2017-08-16 |
2019-12-03 |
Bristol-Myers Squibb Company |
Toll-like receptor 7 (TLR7) agonists having a pyridine or pyrazine moiety, conjugates thereof, and methods and uses therefor
|
|
US10457681B2
(en)
|
2017-08-16 |
2019-10-29 |
Bristol_Myers Squibb Company |
Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor
|
|
US11707531B2
(en)
|
2017-09-11 |
2023-07-25 |
F-star Therapeutics, Inc. |
Compounds, compositions, and methods for the treatment of disease
|
|
US11584774B2
(en)
|
2017-09-11 |
2023-02-21 |
F-star Therapeutics, Inc. |
Compounds, compositions, and methods for the treatment of disease
|
|
US10640508B2
(en)
|
2017-10-13 |
2020-05-05 |
Massachusetts Institute Of Technology |
Diazene directed modular synthesis of compounds with quaternary carbon centers
|
|
WO2019073069A1
(en)
|
2017-10-13 |
2019-04-18 |
Boehringer Ingelheim International Gmbh |
HUMAN ANTIBODIES AGAINST THOMSEN-NEW ANTIGEN (TN)
|
|
EP3498293A1
(en)
|
2017-12-15 |
2019-06-19 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Treatment of monogenic diseases with an anti-cd45rc antibody
|
|
WO2019183131A1
(en)
|
2018-03-19 |
2019-09-26 |
Bioventures, Llc |
Periostin antibodies and methods of using the same
|
|
WO2019209811A1
(en)
|
2018-04-24 |
2019-10-31 |
Bristol-Myers Squibb Company |
Macrocyclic toll-like receptor 7 (tlr7) agonists
|
|
UA129352C2
(uk)
|
2018-05-07 |
2025-03-26 |
Генмаб А/С |
Способи лікування раку за допомогою комбінації антитіла до pd-1 і кон'югата антитіла до тканинного фактора та лікарського засобу
|
|
TW202506732A
(zh)
|
2018-05-07 |
2025-02-16 |
丹麥商珍美寶股份有限公司 |
使用抗ｐｄ－１抗體與抗組織因子抗體－藥物共軛體之組合以治療癌症之方法
|
|
CN112601555A
(zh)
|
2018-05-09 |
2021-04-02 |
乐高化学生物科学股份有限公司 |
与抗cd19抗体药物结合物相关的组合物和方法
|
|
MX2020012674A
(es)
|
2018-05-29 |
2021-02-09 |
Bristol Myers Squibb Co |
Porciones autoinmolantes modificadas para usarse en profarmacos y conjugados y metodos de uso y fabricacion.
|
|
KR102870868B1
(ko)
|
2018-06-01 |
2025-10-15 |
노파르티스 아게 |
Bcma에 대한 결합 분자 및 이의 용도
|
|
AU2019301697A1
(en)
*
|
2018-07-13 |
2021-01-07 |
Il-2Rx, Inc. |
Compounds, compositions, methods, and uses for treating cancer and immunological disorders
|
|
JP2020019723A
(ja)
*
|
2018-07-30 |
2020-02-06 |
国立大学法人 鹿児島大学 |
抗ＣＤ７０抗体とＩｇＧ結合ペプチドの複合体
|
|
US11554120B2
(en)
|
2018-08-03 |
2023-01-17 |
Bristol-Myers Squibb Company |
1H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists and methods and uses therefor
|
|
EP3853251A1
(en)
|
2018-09-19 |
2021-07-28 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical composition for the treatment of cancers resistant to immune checkpoint therapy
|
|
EP3626265A1
(en)
|
2018-09-21 |
2020-03-25 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Anti-human cd45rc antibodies and uses thereof
|
|
GB201817321D0
(en)
|
2018-10-24 |
2018-12-05 |
Nanna Therapeutics Ltd |
Microbeads for tagless encoded chemical library screening
|
|
TWI844571B
(zh)
|
2018-10-30 |
2024-06-11 |
丹麥商珍美寶股份有限公司 |
使用抗血管內皮生長因子（ｖｅｇｆ）抗體與抗組織因子（ｔｆ）抗體－藥物共軛體之組合以治療癌症之方法
|
|
WO2020094609A1
(en)
|
2018-11-06 |
2020-05-14 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical compositions for the treatment of acute myeloid leukemia by eradicating leukemic stem cells
|
|
EP3894543A1
(en)
|
2018-12-14 |
2021-10-20 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Isolated mhc-derived human peptides and uses thereof for stimulating and activating the suppressive function of cd8cd45rc low tregs
|
|
WO2020163225A1
(en)
|
2019-02-05 |
2020-08-13 |
Seattle Genetics, Inc. |
Anti-cd228 antibodies and antibody-drug conjugates
|
|
CN113795264A
(zh)
|
2019-03-19 |
2021-12-14 |
瓦尔希伯伦私人肿瘤研究基金会 |
采用Omomyc和结合PD-1或CTLA-4的抗体治疗癌症的联合疗法
|
|
US12037378B2
(en)
|
2019-05-21 |
2024-07-16 |
Novartis Ag |
Variant CD58 domains and uses thereof
|
|
JP7489407B2
(ja)
|
2019-05-21 |
2024-05-23 |
ノバルティス アーゲー |
Ｃｄ１９結合分子及びその使用
|
|
US11535634B2
(en)
|
2019-06-05 |
2022-12-27 |
Massachusetts Institute Of Technology |
Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
|
|
BR112022002067A2
(pt)
|
2019-08-08 |
2022-06-14 |
Regeneron Pharma |
Formatos de molécula de ligação ao antígeno
|
|
CA3149494A1
(en)
|
2019-08-12 |
2021-02-18 |
Purinomia Biotech, Inc. |
Methods and compositions for promoting and potentiating t-cell mediated immune responses through adcc targeting of cd39 expressing cells
|
|
EP4025233A4
(en)
*
|
2019-09-04 |
2023-07-12 |
Seagen Inc. |
Double-digestion assay for analyzing ligand-drug conjugates
|
|
KR20210028544A
(ko)
|
2019-09-04 |
2021-03-12 |
주식회사 레고켐 바이오사이언스 |
인간 ror1에 대한 항체를 포함하는 항체 약물 접합체 및 이의 용도
|
|
CN114728073B
(zh)
|
2019-09-19 |
2024-12-27 |
思进股份有限公司 |
药物从生物活性化合物的内化缀合物的选择性释放
|
|
WO2021064184A1
(en)
|
2019-10-04 |
2021-04-08 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical composition for the treatment of ovarian cancer, breast cancer or pancreatic cancer
|
|
US20210324031A1
(en)
*
|
2019-10-16 |
2021-10-21 |
Clarence Hurt |
Compounds, compositions, methods, and uses for treating leptin resistance, obesity, diabetes mellitus and metabolic syndrome
|
|
US12435116B2
(en)
*
|
2019-10-16 |
2025-10-07 |
Clarence Hurt |
Compounds, compositions, methods, and uses for treating insulin resistance, type 2 diabetes and metabolic syndrome
|
|
MX2022005330A
(es)
|
2019-11-05 |
2022-05-26 |
Regeneron Pharma |
Moleculas de union multiespecificas con scfv en el extremo nterminal.
|
|
TW202132343A
(zh)
|
2019-11-07 |
2021-09-01 |
丹麥商珍美寶股份有限公司 |
使用抗ｐｄ－１抗體與抗組織因子抗體－藥物共軛體之組合以治療癌症之方法
|
|
TW202131954A
(zh)
|
2019-11-07 |
2021-09-01 |
丹麥商珍美寶股份有限公司 |
利用鉑類劑與抗組織因子抗體－藥物共軛體之組合來治療癌症之方法
|
|
WO2021092287A1
(en)
|
2019-11-08 |
2021-05-14 |
North Carolina State University |
Cross-linking compounds and methods of use thereof
|
|
TWI877278B
(zh)
|
2019-12-30 |
2025-03-21 |
美商思進公司 |
以非海藻糖苷化抗－ｃｄ７０抗體治療癌症之方法
|
|
JP2023516080A
(ja)
|
2020-03-06 |
2023-04-17 |
ジーオー セラピューティクス，インコーポレイテッド |
抗グリコｃｄ４４抗体およびその使用
|
|
US20230128499A1
(en)
|
2020-03-27 |
2023-04-27 |
Novartis Ag |
Bispecific combination therapy for treating proliferative diseases and autoimmune diseases
|
|
AU2021251875A1
(en)
|
2020-04-10 |
2022-11-03 |
Seagen Inc. |
Charge variant linkers
|
|
EP4153628A1
(en)
|
2020-05-20 |
2023-03-29 |
Institut Curie |
Single domain antibodies and their use in cancer therapies
|
|
EP4171652A1
(en)
|
2020-06-29 |
2023-05-03 |
Genmab A/S |
Anti-tissue factor antibody-drug conjugates and their use in the treatment of cancer
|
|
EP4189071A1
(en)
|
2020-08-03 |
2023-06-07 |
Institut National de la Santé et de la Recherche Médicale (INSERM) |
Population of treg cells functionally committed to exert a regulatory activity and their use for adoptive therapy
|
|
CN112062855B
(zh)
|
2020-08-26 |
2024-08-30 |
北京天诺健成医药科技有限公司 |
一种含有衔接器的药物治疗剂的开发和应用
|
|
WO2022079270A1
(en)
|
2020-10-16 |
2022-04-21 |
Université D'aix-Marseille |
Anti-gpc4 single domain antibodies
|
|
CN114685657B
(zh)
|
2020-12-31 |
2024-08-16 |
康诺亚生物医药科技（成都）有限公司 |
一种功能增强型抗体阻断剂的开发及其应用
|
|
US20240317890A1
(en)
|
2021-01-14 |
2024-09-26 |
Institut Curie |
Her2 single domain antibodies variants and cars thereof
|
|
JP2024503508A
(ja)
|
2021-01-15 |
2024-01-25 |
シージェン インコーポレイテッド |
免疫調節性抗体－薬物コンジュゲート
|
|
CN117062527A
(zh)
|
2021-01-19 |
2023-11-14 |
埃里莫斯制药有限责任公司 |
作为冠状病毒抗病毒剂的Terameprocol和去甲二氢愈创木酸（NDGA）衍生物
|
|
AR124681A1
(es)
|
2021-01-20 |
2023-04-26 |
Abbvie Inc |
Conjugados anticuerpo-fármaco anti-egfr
|
|
BR112023015561A2
(pt)
|
2021-02-03 |
2023-11-14 |
Univ Minnesota |
Compostos imunoestimuiladores e conjugados
|
|
WO2022182415A1
(en)
|
2021-02-24 |
2022-09-01 |
Massachusetts Institute Of Technology |
Himastatin derivatives, and processes of preparation thereof, and uses thereof
|
|
EP4301782A1
(en)
|
2021-03-05 |
2024-01-10 |
Go Therapeutics, Inc. |
Anti-glyco-cd44 antibodies and their uses
|
|
BR112023018676A2
(pt)
|
2021-03-18 |
2023-10-10 |
Seagen Inc |
Conjugado anticorpo-fármaco, composição farmacêutica, métodos de tratamento de uma doença ou condição e de um câncer, e, composição de conjugado ligante-fármaco
|
|
CA3213625A1
(en)
|
2021-03-18 |
2022-09-22 |
Seagen Inc. |
Selective drug release from internalized conjugates of biologically active compounds
|
|
WO2022200303A1
(en)
|
2021-03-23 |
2022-09-29 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for the diagnosis and treatment of t cell-lymphomas
|
|
EP4320153A1
(en)
|
2021-04-09 |
2024-02-14 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for the treatment of anaplastic large cell lymphoma
|
|
AU2022283467A1
(en)
|
2021-05-28 |
2023-12-07 |
Seagen Inc. |
Anthracycline antibody conjugates
|
|
US20250101126A1
(en)
|
2021-08-05 |
2025-03-27 |
Go Therapeutics, Inc. |
Anti-glyco-muc4 antibodies and their uses
|
|
CN118354789A
(zh)
|
2021-09-03 |
2024-07-16 |
Go医疗股份有限公司 |
抗糖-cMET抗体及其用途
|
|
EP4396232A1
(en)
|
2021-09-03 |
2024-07-10 |
Go Therapeutics, Inc. |
Anti-glyco-lamp1 antibodies and their uses
|
|
PL4401842T3
(pl)
|
2021-09-16 |
2025-11-24 |
Aboleris Pharma |
Domeny wiążące przeciwko ludzkiemu CD45RC i ich zastosowania
|
|
US20250051440A1
(en)
|
2021-12-14 |
2025-02-13 |
Institut National de la Santé et de la Recherche Médicale |
Depletion of nk cells for the treatment of adverse post-ischemic cardiac remodeling
|
|
WO2023144303A1
(en)
|
2022-01-31 |
2023-08-03 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Cd38 as a biomarker and biotarget in t-cell lymphomas
|
|
WO2023198648A1
(en)
|
2022-04-11 |
2023-10-19 |
Institut National de la Santé et de la Recherche Médicale |
Methods for the diagnosis and treatment of t-cell malignancies
|
|
WO2023198874A1
(en)
|
2022-04-15 |
2023-10-19 |
Institut National de la Santé et de la Recherche Médicale |
Methods for the diagnosis and treatment of t cell-lymphomas
|
|
EP4518905A1
(en)
|
2022-05-06 |
2025-03-12 |
Seagen Inc. |
Immunomodulatory antibody-drug conjugates
|
|
WO2023213960A1
(en)
|
2022-05-06 |
2023-11-09 |
Genmab A/S |
Methods of treating cancer with anti-tissue factor antibody-drug conjugates
|
|
CN119256007B
(zh)
*
|
2022-05-31 |
2025-10-31 |
山东博安生物技术股份有限公司 |
抗cd228抗体及其药物偶联物
|
|
JP2025525296A
(ja)
|
2022-06-27 |
2025-08-05 |
トライオール インコーポレイテッド |
自壊性基を含む化合物及びそれを含むリガンド－薬物コンジュゲート
|
|
JP2025525904A
(ja)
|
2022-08-03 |
2025-08-07 |
シージェン インコーポレイテッド |
免疫刺激性抗ｐｄ－ｌ１－薬物コンジュゲート
|
|
WO2024052685A1
(en)
|
2022-09-09 |
2024-03-14 |
MyricX Pharma Limited |
Cytotoxic imidazo[1,2-a]pyridine compounds and their use in therapy
|
|
EP4608429A1
(en)
|
2022-10-25 |
2025-09-03 |
Peptomyc, S.L. |
Combination therapy for the treatment of cancer
|
|
KR20240125071A
(ko)
|
2022-11-01 |
2024-08-19 |
앱티스 주식회사 |
Fc 결합성 유닛을 포함하는 화합물 및 이를 이용하여 제조된 컨쥬게이트
|
|
TW202440164A
(zh)
|
2022-12-13 |
2024-10-16 |
美商克林提克斯醫藥股份有限公司 |
生長抑素亞型-2受體（sst2r）靶向治療劑及其用途
|
|
KR20250148746A
(ko)
|
2023-01-13 |
2025-10-14 |
리제너론 파아마슈티컬스, 인크. |
Fgfr3 결합 분자 및 그의 사용 방법
|
|
AU2024213541A1
(en)
*
|
2023-01-30 |
2025-08-07 |
Primelink Biotherapeutics (Shenzhen) Co., Ltd. |
Polymer-drug conjugates
|
|
WO2024166056A1
(en)
*
|
2023-02-10 |
2024-08-15 |
Pinotbio, Inc. |
Linker for antibody-drug conjugate
|
|
AU2024237541A1
(en)
|
2023-03-13 |
2025-08-28 |
Heidelberg Pharma Research Gmbh |
Subcutaneously administered antibody-drug conjugates for use in cancer treatment
|
|
CN121311250A
(zh)
|
2023-03-22 |
2026-01-09 |
信立泰生物医药公司 |
抗5t4抗原结合结构域、抗体-药物缀合物及其使用方法
|
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