JP2014502957A5 - - Google Patents
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- JP2014502957A5 JP2014502957A5 JP2013535097A JP2013535097A JP2014502957A5 JP 2014502957 A5 JP2014502957 A5 JP 2014502957A5 JP 2013535097 A JP2013535097 A JP 2013535097A JP 2013535097 A JP2013535097 A JP 2013535097A JP 2014502957 A5 JP2014502957 A5 JP 2014502957A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- antibody
- inhibitor
- auristatin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40576710P | 2010-10-22 | 2010-10-22 | |
| US61/405,767 | 2010-10-22 | ||
| US201161445785P | 2011-02-23 | 2011-02-23 | |
| US61/445,785 | 2011-02-23 | ||
| PCT/US2011/057130 WO2012054748A2 (en) | 2010-10-22 | 2011-10-20 | Synergistic effects between auristatin-based antibody drug conjugates and inhibitors of the pi3k-akt mtor pathway |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016252182A Division JP6467400B2 (ja) | 2010-10-22 | 2016-12-27 | アウリスタチン系抗体薬物複合体とＰＩ３Ｋ−ＡＫＴ ｍＴＯＲ経路インヒビターの間の相乗効果 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014502957A JP2014502957A (ja) | 2014-02-06 |
| JP2014502957A5 true JP2014502957A5 (https=) | 2014-12-04 |
| JP6121906B2 JP6121906B2 (ja) | 2017-04-26 |
Family
ID=45975893
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013535097A Active JP6121906B2 (ja) | 2010-10-22 | 2011-10-20 | アウリスタチン系抗体薬物複合体とＰＩ３Ｋ−ＡＫＴｍＴＯＲ経路インヒビターの間の相乗効果 |
| JP2016252182A Active JP6467400B2 (ja) | 2010-10-22 | 2016-12-27 | アウリスタチン系抗体薬物複合体とＰＩ３Ｋ−ＡＫＴ ｍＴＯＲ経路インヒビターの間の相乗効果 |
| JP2019003384A Pending JP2019070021A (ja) | 2010-10-22 | 2019-01-11 | アウリスタチン系抗体薬物複合体とＰＩ３Ｋ−ＡＫＴ ｍＴＯＲ経路インヒビターの間の相乗効果 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016252182A Active JP6467400B2 (ja) | 2010-10-22 | 2016-12-27 | アウリスタチン系抗体薬物複合体とＰＩ３Ｋ−ＡＫＴ ｍＴＯＲ経路インヒビターの間の相乗効果 |
| JP2019003384A Pending JP2019070021A (ja) | 2010-10-22 | 2019-01-11 | アウリスタチン系抗体薬物複合体とＰＩ３Ｋ−ＡＫＴ ｍＴＯＲ経路インヒビターの間の相乗効果 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US9272052B2 (https=) |
| EP (2) | EP3581206B8 (https=) |
| JP (3) | JP6121906B2 (https=) |
| CN (2) | CN103561759B (https=) |
| AU (1) | AU2011316917B2 (https=) |
| CA (1) | CA2815363C (https=) |
| ES (2) | ES3004351T3 (https=) |
| TW (1) | TWI545134B (https=) |
| WO (1) | WO2012054748A2 (https=) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2011316917B2 (en) | 2010-10-22 | 2016-02-25 | Seagen Inc. | Synergistic effects between auristatin-based antibody drug conjugates and inhibitors of the PI3K-AKT mTOR pathway |
| WO2012171020A1 (en) | 2011-06-10 | 2012-12-13 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
| AU2013256336B2 (en) | 2012-05-01 | 2018-02-01 | The Children's Hospital Of Philadelphia | Compositions and methods for treating B-lymphoid malignancies |
| KR102557309B1 (ko) * | 2012-05-15 | 2023-07-20 | 씨젠 인크. | 자가-안정화 링커 접합체 |
| US9504756B2 (en) | 2012-05-15 | 2016-11-29 | Seattle Genetics, Inc. | Self-stabilizing linker conjugates |
| WO2014058947A1 (en) * | 2012-10-12 | 2014-04-17 | Sanofi | Compositions and methods for treating cancer using pi3k inhibitor and anti-cd19 maytansinoid immunoconjugate |
| WO2014089177A2 (en) | 2012-12-04 | 2014-06-12 | Massachusetts Institute Of Technology | Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines |
| US10208125B2 (en) | 2013-07-15 | 2019-02-19 | University of Pittsburgh—of the Commonwealth System of Higher Education | Anti-mucin 1 binding agents and uses thereof |
| MX2016003256A (es) | 2013-09-12 | 2016-06-07 | Halozyme Inc | Anticuerpos modificados del receptor de factor de crecimiento anti-epidermico y metodos de uso de los mismos. |
| BR112016012538A2 (pt) | 2013-12-17 | 2017-09-26 | Novartis Ag | peptídeos citotóxicos e conjugados dos mesmos |
| CN106132434A (zh) * | 2014-04-07 | 2016-11-16 | 西雅图基因公司 | 抗‑cd19抗体和抗体‑药物偶联物的稳定制剂 |
| SG11201607133QA (en) * | 2014-04-08 | 2016-09-29 | Seattle Genetics Inc | Optimal dosing of a cd19-antibody drug conjugate |
| EP2930188A1 (en) * | 2014-04-13 | 2015-10-14 | Affimed Therapeutics AG | Trifunctional antigen-binding molecule |
| BR112016024363A2 (pt) * | 2014-04-25 | 2017-10-10 | Pf Medicament | conjugado de anticorpo-fármaco e seu uso para tratamento de câncer |
| RU2692563C2 (ru) * | 2014-04-25 | 2019-06-25 | Пьер Фабр Медикамент | Конъюгат антитела против igf-1r с лекарственным средством и его применение для лечения рака |
| CN106573956A (zh) | 2014-06-13 | 2017-04-19 | 诺华股份有限公司 | 澳瑞他汀衍生物及其缀合物 |
| EP3160513B1 (en) | 2014-06-30 | 2020-02-12 | Glykos Finland Oy | Saccharide derivative of a toxic payload and antibody conjugates thereof |
| MX2017004580A (es) * | 2014-10-10 | 2017-06-27 | Pfizer | Combinaciones de auristatina sinergica. |
| AU2016297786A1 (en) * | 2015-07-24 | 2018-02-08 | Noeleen Melody | Quinstatin compounds |
| SMT202100541T1 (it) * | 2015-08-21 | 2021-11-12 | Morphosys Ag | Combinazioni e loro usi |
| WO2017161206A1 (en) | 2016-03-16 | 2017-09-21 | Halozyme, Inc. | Conjugates containing conditionally active antibodies or antigen-binding fragments thereof, and methods of use |
| US10918627B2 (en) | 2016-05-11 | 2021-02-16 | Massachusetts Institute Of Technology | Convergent and enantioselective total synthesis of Communesin analogs |
| MA45862A (fr) * | 2016-08-04 | 2021-05-05 | Millennium Pharm Inc | Combinaison d'inhibiteurs du protéasome et d'anticorps anti-cd30 |
| MX2019001302A (es) | 2016-08-09 | 2019-06-12 | Seattle Genetics Inc | Conjugados de farmaco con enlazadores autoestabilizantes que tienen propiedades fisioquimicas mejoradas. |
| EP3554544A4 (en) | 2016-12-16 | 2020-07-29 | Bluefin Biomedicine, Inc. | ANTI-PROTEIN 1 ANTIBODY CONTAINING AN ANTI-CUB DOMAIN (CDCP1), ANTIBODY-DRUG CONJUGATES AND THEIR METHODS OF USE |
| WO2018209239A1 (en) | 2017-05-11 | 2018-11-15 | Massachusetts Institute Of Technology | Potent agelastatin derivatives as modulators for cancer invasion and metastasis |
| US11434303B2 (en) | 2017-06-28 | 2022-09-06 | Bluefin Biomedicine, Inc. | Anti-LY6H antibodies and antibody drug conjugates |
| US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
| WO2019088176A1 (ja) * | 2017-10-31 | 2019-05-09 | 国立大学法人神戸大学 | 抗体薬物複合体効果増強剤 |
| WO2019119822A1 (en) * | 2017-12-23 | 2019-06-27 | Uwell Biopharma Inc. | Pharmaceutical chimeric receptor composition and method thereof |
| CA3093731A1 (en) * | 2018-03-23 | 2019-09-26 | Seattle Genetics, Inc. | Use of antibody drug conjugates comprising tubulin disrupting agents to treat solid tumor |
| JP2020019723A (ja) * | 2018-07-30 | 2020-02-06 | 国立大学法人 鹿児島大学 | 抗ＣＤ７０抗体とＩｇＧ結合ペプチドの複合体 |
| CA3118397A1 (en) * | 2018-11-01 | 2020-05-07 | Shandong Newtime Pharmaceutical Co., Ltd. | Bispecific antibody targeting cd3 and bcma, and uses thereof |
| US11535634B2 (en) | 2019-06-05 | 2022-12-27 | Massachusetts Institute Of Technology | Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof |
| WO2021178253A1 (en) * | 2020-03-03 | 2021-09-10 | Systimmune, Inc. | Anti-cd19 antibodies and methods of using and making thereof |
| WO2022122889A1 (en) * | 2020-12-10 | 2022-06-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for detecting the activation of mtor pathway |
| WO2022182415A1 (en) | 2021-02-24 | 2022-09-01 | Massachusetts Institute Of Technology | Himastatin derivatives, and processes of preparation thereof, and uses thereof |
| AU2022238571A1 (en) * | 2021-03-18 | 2023-09-14 | Seagen Inc. | Selective drug release from internalized conjugates of biologically active compounds |
| KR20250134734A (ko) | 2022-12-16 | 2025-09-11 | 페온 테라퓨틱스 리미티드 | Cub 도메인-함유 단백질 1(cdcp1)에 대한 항체 및 이의 용도 |
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-
2011
- 2011-10-20 AU AU2011316917A patent/AU2011316917B2/en active Active
- 2011-10-20 CN CN201180051054.5A patent/CN103561759B/zh active Active
- 2011-10-20 TW TW100138137A patent/TWI545134B/zh active
- 2011-10-20 ES ES19173675T patent/ES3004351T3/es active Active
- 2011-10-20 CN CN201610826795.0A patent/CN106563128B/zh active Active
- 2011-10-20 JP JP2013535097A patent/JP6121906B2/ja active Active
- 2011-10-20 US US13/879,012 patent/US9272052B2/en active Active
- 2011-10-20 CA CA2815363A patent/CA2815363C/en active Active
- 2011-10-20 EP EP19173675.0A patent/EP3581206B8/en active Active
- 2011-10-20 EP EP11835158.4A patent/EP2629801B3/en active Active
- 2011-10-20 WO PCT/US2011/057130 patent/WO2012054748A2/en not_active Ceased
- 2011-10-20 ES ES11835158T patent/ES2730941T7/es active Active
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2016
- 2016-01-27 US US15/008,365 patent/US10201615B2/en active Active
- 2016-12-27 JP JP2016252182A patent/JP6467400B2/ja active Active
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2018
- 2018-12-19 US US16/226,509 patent/US11607460B2/en active Active
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2019
- 2019-01-11 JP JP2019003384A patent/JP2019070021A/ja active Pending
-
2023
- 2023-02-09 US US18/166,491 patent/US12496353B2/en active Active
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