JP2014533279A5 - - Google Patents
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- Publication number
- JP2014533279A5 JP2014533279A5 JP2014541315A JP2014541315A JP2014533279A5 JP 2014533279 A5 JP2014533279 A5 JP 2014533279A5 JP 2014541315 A JP2014541315 A JP 2014541315A JP 2014541315 A JP2014541315 A JP 2014541315A JP 2014533279 A5 JP2014533279 A5 JP 2014533279A5
- Authority
- JP
- Japan
- Prior art keywords
- fragment
- antibody
- use according
- cycle
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161557815P | 2011-11-09 | 2011-11-09 | |
| US61/557,815 | 2011-11-09 | ||
| US201161569113P | 2011-12-09 | 2011-12-09 | |
| US61/569,113 | 2011-12-09 | ||
| PCT/US2012/064395 WO2013071068A2 (en) | 2011-11-09 | 2012-11-09 | Treatment of hematologic malignancies with an anti-cxcr4 antibody |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014533279A JP2014533279A (ja) | 2014-12-11 |
| JP2014533279A5 true JP2014533279A5 (https=) | 2015-12-24 |
| JP6541350B2 JP6541350B2 (ja) | 2019-07-10 |
Family
ID=47179025
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014541315A Expired - Fee Related JP6541350B2 (ja) | 2011-11-09 | 2012-11-09 | 抗ｃｘｃｒ４抗体による血液悪性腫瘍の処置 |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US10428151B2 (https=) |
| EP (1) | EP2776032B1 (https=) |
| JP (1) | JP6541350B2 (https=) |
| KR (1) | KR102024957B1 (https=) |
| CN (1) | CN104039320B (https=) |
| AU (1) | AU2012335553B2 (https=) |
| BR (1) | BR112014011144A2 (https=) |
| CA (1) | CA2855155A1 (https=) |
| CY (1) | CY1121331T1 (https=) |
| DK (1) | DK2776032T3 (https=) |
| EA (1) | EA026153B1 (https=) |
| ES (1) | ES2705001T3 (https=) |
| HR (1) | HRP20182183T1 (https=) |
| HU (1) | HUE043001T2 (https=) |
| IL (1) | IL232517B (https=) |
| LT (1) | LT2776032T (https=) |
| MX (1) | MX357100B (https=) |
| PL (1) | PL2776032T3 (https=) |
| PT (1) | PT2776032T (https=) |
| RS (1) | RS58102B1 (https=) |
| SG (1) | SG11201401386XA (https=) |
| SI (1) | SI2776032T1 (https=) |
| SM (1) | SMT201900026T1 (https=) |
| WO (1) | WO2013071068A2 (https=) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2009003306A (es) * | 2006-10-02 | 2009-04-23 | Medarex Inc | Anticuerpos humanos que se unen a cxcr4 y sus usos. |
| ES2624981T3 (es) | 2011-07-01 | 2017-07-18 | Dana-Farber Cancer Institute, Inc. | Descubrimiento de una mutación somática en el gen MYD88 en linfoma linfoplasmocitario |
| CA2920377A1 (en) * | 2013-08-05 | 2015-02-12 | Cambridge Enterprise Limited | Inhibition of cxcr4 signaling in cancer immunotherapy |
| AU2014318614B2 (en) | 2013-09-12 | 2021-01-07 | Dana-Farber Cancer Institute Inc. | Methods for evaluating and treating Waldenstrom's macroglobulinemia |
| CN105899536A (zh) * | 2013-11-06 | 2016-08-24 | 百时美施贵宝公司 | 用抗cxcr4抗体治疗c1013g/cxcr4相关的华氏巨球蛋白血症 |
| AU2014360426B2 (en) | 2013-12-06 | 2020-05-07 | Dana-Farber Cancer Institute, Inc. | Methods to distinguish Waldenstrom's Macroglobulinemia from IgM monoclonal gammopathy of undetermined significance |
| EP3079683A4 (en) | 2013-12-13 | 2017-12-20 | Dana-Farber Cancer Institute, Inc. | Methods to treat lymphoplasmacytic lymphoma |
| WO2015093949A2 (en) * | 2013-12-17 | 2015-06-25 | Aimm Therapeutics B.V. | Means and methods for counteracting myeloproliferative or lymphoproliferative disorders |
| CN106573976B (zh) * | 2014-02-06 | 2020-05-05 | 耶达研究及发展有限公司 | 抗cd84抗体、包含所述抗体的组合物及其用途 |
| EP3125919A4 (en) * | 2014-02-19 | 2018-01-03 | Microconstants China Inc. | Chemokine receptor antagonist and its combinational therapy |
| ES2924394T3 (es) * | 2015-01-09 | 2022-10-06 | Adalta Ltd | Moléculas de unión a CXCR4 |
| KR20250004095A (ko) | 2015-04-17 | 2025-01-07 | 브리스톨-마이어스 스큅 컴퍼니 | 항-pd-1 항체 및 또 다른 항체의 조합물을 포함하는 조성물 |
| JP2018516969A (ja) | 2015-06-12 | 2018-06-28 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｐｄ−１およびｃｘｃｒ４シグナル伝達経路の組合せ遮断による癌の処置 |
| US10786547B2 (en) | 2015-07-16 | 2020-09-29 | Biokine Therapeutics Ltd. | Compositions, articles of manufacture and methods for treating cancer |
| KR20180063885A (ko) | 2015-09-24 | 2018-06-12 | 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 | 전이 감소를 위한 방법 및 조성물 |
| AU2016352910A1 (en) * | 2015-11-09 | 2018-05-31 | The General Hospital Corporation D.B.A Massachusetts General Hospital | Unit dose formulations for use as an anti-fugetactic agent |
| KR102033920B1 (ko) * | 2016-02-23 | 2019-10-18 | 바이오라인알엑스 리미티드 | 급성 골수성 백혈병을 치료하는 방법 |
| JP2019518006A (ja) | 2016-04-29 | 2019-06-27 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | Ｍｙｄ８８変異型疾患における治療標的としてのｈｃｋ |
| LT3458053T (lt) | 2016-05-20 | 2022-02-25 | Biohaven Pharmaceutical Holding Company Ltd. | Riluzolo, rilizolo provaistų arba riluzolo analogų panaudojimas kartu su imunoterapijomis vėžio formų gydymui |
| CA3027296A1 (en) * | 2016-06-16 | 2017-12-21 | Centre National De La Recherche Scientifique | Compounds useful for decreasing interferon level |
| RU2769282C2 (ru) | 2016-06-20 | 2022-03-30 | Кимаб Лимитед | Анти-PD-L1 и IL-2 цитокины |
| US20190389958A1 (en) * | 2017-01-31 | 2019-12-26 | Msm Protein Technologies, Inc. | Anti-cxcr4 antibodies |
| TWI738314B (zh) * | 2017-02-21 | 2021-09-01 | 美商庫拉腫瘤技術股份有限公司 | 以法呢基轉移酶(farnesyltransferase)抑制劑治療癌症之方法 |
| EP3601355A1 (en) | 2017-03-31 | 2020-02-05 | Bristol-Myers Squibb Company | Methods of treating tumor |
| CN111247169A (zh) | 2017-10-15 | 2020-06-05 | 百时美施贵宝公司 | 治疗肿瘤的方法 |
| WO2019113456A1 (en) * | 2017-12-08 | 2019-06-13 | The Medical College Of Wisconsin, Inc. | Chemokine variants as immune stimulants |
| ES2973728T3 (es) * | 2018-03-13 | 2024-06-24 | Fundacion Para La Investigacion Biomedica Del Hospital Univ La Paz | Anticuerpo anti-CXCR4 combinado con linfocitos citolíticos naturales activados y expandidos para inmunoterapia contra el cáncer |
| EP3768715A1 (en) | 2018-03-23 | 2021-01-27 | Bristol-Myers Squibb Company | Antibodies against mica and/or micb and uses thereof |
| CN120943884A (zh) | 2018-03-27 | 2025-11-14 | 百时美施贵宝公司 | 使用紫外线信号实时监测滴度 |
| KR20200139724A (ko) | 2018-03-30 | 2020-12-14 | 브리스톨-마이어스 스큅 컴퍼니 | 종양을 치료하는 방법 |
| US20220135619A1 (en) | 2019-02-24 | 2022-05-05 | Bristol-Myers Squibb Company | Methods of isolating a protein |
| KR20220012292A (ko) | 2019-05-23 | 2022-02-03 | 브리스톨-마이어스 스큅 컴퍼니 | 세포 배양 배지를 모니터링하는 방법 |
| KR20220098732A (ko) | 2019-10-08 | 2022-07-12 | 다나-파버 캔서 인스티튜트 인크. | 요법, 특히 myd88 돌연변이된 질환에 사용하기 위한 hck 억제제로서의 피라졸로피리미딘 유도체 |
| CN116406369A (zh) | 2020-10-05 | 2023-07-07 | 百时美施贵宝公司 | 用于浓缩蛋白质的方法 |
| JP2024501029A (ja) | 2020-12-28 | 2024-01-10 | ブリストル－マイヤーズ スクイブ カンパニー | Ｐｄ１／ｐｄ－ｌ１抗体の皮下投与 |
| EP4314068A1 (en) | 2021-04-02 | 2024-02-07 | The Regents Of The University Of California | Antibodies against cleaved cdcp1 and uses thereof |
| JP2025509274A (ja) | 2022-03-09 | 2025-04-11 | ブリストル－マイヤーズ スクイブ カンパニー | 治療用タンパク質の一過性発現 |
| CN120813375A (zh) * | 2023-01-30 | 2025-10-17 | 凯玛布有限公司 | 抗体 |
| WO2025145207A1 (en) | 2023-12-29 | 2025-07-03 | Bristol-Myers Squibb Company | Combination therapy of kras inhibitor and treg-depleting agent |
| CN119119196B (zh) * | 2024-08-01 | 2025-09-09 | 青岛大学 | 一种基于Motixafortide-喜树碱缀合物及其制备方法和应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| CA2117953C (en) | 1993-10-14 | 2001-12-11 | Tasuku Honjo | Human stromal derived factor 1 alpha and 1 beta and dnas encoding the same |
| US6794132B2 (en) | 1999-10-02 | 2004-09-21 | Biosite, Inc. | Human antibodies |
| CA2430013C (en) | 2000-11-30 | 2011-11-22 | Medarex, Inc. | Transgenic transchromosomal rodents for making human antibodies |
| JP4751326B2 (ja) | 2003-09-04 | 2011-08-17 | メダレックス インコーポレイテッド | 発現ベクター |
| WO2006089141A2 (en) | 2005-02-18 | 2006-08-24 | Dana-Farber Cancer Institute | Antibodies against cxcr4 and methods of use thereof |
| US8569280B2 (en) * | 2005-04-25 | 2013-10-29 | Immune Disease Institute | Methods for the treatment of multiple myeloma |
| WO2007101235A2 (en) * | 2006-02-28 | 2007-09-07 | Pharma Mar, S.A. | Improved antitumoral treatments |
| MX2009003306A (es) * | 2006-10-02 | 2009-04-23 | Medarex Inc | Anticuerpos humanos que se unen a cxcr4 y sus usos. |
| FR2915102B1 (fr) | 2007-04-23 | 2014-05-16 | Pf Medicament | Utilisation d'un anticorps anti-cxcr4 pour le traitement du cancer |
| CN102027015A (zh) * | 2008-05-14 | 2011-04-20 | 伊莱利利公司 | 抗cxcr4抗体 |
| US9005963B2 (en) | 2008-10-14 | 2015-04-14 | Ablynx N.V. | Amino acid sequences directed against cellular receptors for viruses and bacteria |
| JP5709766B2 (ja) * | 2009-03-12 | 2015-04-30 | ジェネンテック， インコーポレイテッド | 造血器腫瘍の治療のためのホスホイノシチド３キナーゼ阻害剤化合物と化学療法剤の併用 |
| TWI546537B (zh) * | 2009-05-19 | 2016-08-21 | 維維亞生技公司 | 提供針對血液腫瘤之體外個人化藥物測試之方法 |
| JP5655147B2 (ja) | 2010-08-20 | 2015-01-14 | セルリアン・ファーマ・インコーポレイテッド | 治療用ペプチド−ポリマーの複合体、粒子、組成物および関連の方法 |
-
2012
- 2012-11-09 CN CN201280066551.7A patent/CN104039320B/zh not_active Expired - Fee Related
- 2012-11-09 BR BR112014011144A patent/BR112014011144A2/pt not_active Application Discontinuation
- 2012-11-09 WO PCT/US2012/064395 patent/WO2013071068A2/en not_active Ceased
- 2012-11-09 DK DK12787343.8T patent/DK2776032T3/en active
- 2012-11-09 US US14/356,996 patent/US10428151B2/en active Active
- 2012-11-09 EA EA201490957A patent/EA026153B1/ru not_active IP Right Cessation
- 2012-11-09 LT LTEP12787343.8T patent/LT2776032T/lt unknown
- 2012-11-09 JP JP2014541315A patent/JP6541350B2/ja not_active Expired - Fee Related
- 2012-11-09 AU AU2012335553A patent/AU2012335553B2/en not_active Ceased
- 2012-11-09 ES ES12787343T patent/ES2705001T3/es active Active
- 2012-11-09 RS RS20181552A patent/RS58102B1/sr unknown
- 2012-11-09 CA CA2855155A patent/CA2855155A1/en not_active Abandoned
- 2012-11-09 KR KR1020147012396A patent/KR102024957B1/ko not_active Expired - Fee Related
- 2012-11-09 SG SG11201401386XA patent/SG11201401386XA/en unknown
- 2012-11-09 PL PL12787343T patent/PL2776032T3/pl unknown
- 2012-11-09 SM SM20190026T patent/SMT201900026T1/it unknown
- 2012-11-09 MX MX2014005267A patent/MX357100B/es active IP Right Grant
- 2012-11-09 HR HRP20182183TT patent/HRP20182183T1/hr unknown
- 2012-11-09 EP EP12787343.8A patent/EP2776032B1/en active Active
- 2012-11-09 HU HUE12787343A patent/HUE043001T2/hu unknown
- 2012-11-09 SI SI201231459T patent/SI2776032T1/sl unknown
- 2012-11-09 PT PT12787343T patent/PT2776032T/pt unknown
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2014
- 2014-05-08 IL IL232517A patent/IL232517B/en active IP Right Grant
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2019
- 2019-01-15 CY CY20191100051T patent/CY1121331T1/el unknown
- 2019-10-01 US US16/590,152 patent/US20200231683A1/en not_active Abandoned