JP2008545652A5 - - Google Patents
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- JP2008545652A5 JP2008545652A5 JP2008512402A JP2008512402A JP2008545652A5 JP 2008545652 A5 JP2008545652 A5 JP 2008545652A5 JP 2008512402 A JP2008512402 A JP 2008512402A JP 2008512402 A JP2008512402 A JP 2008512402A JP 2008545652 A5 JP2008545652 A5 JP 2008545652A5
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- Prior art keywords
- fluoro
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- group
- nhr
- Prior art date
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- 125000000217 alkyl group Chemical group 0.000 claims 70
- 125000003545 alkoxy group Chemical group 0.000 claims 43
- 150000001875 compounds Chemical class 0.000 claims 35
- 125000004414 alkyl thio group Chemical group 0.000 claims 32
- 229910052739 hydrogen Inorganic materials 0.000 claims 32
- 239000001257 hydrogen Substances 0.000 claims 32
- 125000001153 fluoro group Chemical group F* 0.000 claims 30
- 229910052757 nitrogen Inorganic materials 0.000 claims 29
- 125000001072 heteroaryl group Chemical group 0.000 claims 26
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 25
- 229910052799 carbon Inorganic materials 0.000 claims 22
- 125000001424 substituent group Chemical group 0.000 claims 21
- 229910052736 halogen Inorganic materials 0.000 claims 20
- 150000002367 halogens Chemical class 0.000 claims 20
- 108020005497 Nuclear hormone receptors Proteins 0.000 claims 19
- 150000002431 hydrogen Chemical class 0.000 claims 19
- 101700080519 nhr-23 Proteins 0.000 claims 15
- 125000005418 aryl aryl group Chemical group 0.000 claims 13
- 125000000753 cycloalkyl group Chemical group 0.000 claims 12
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 12
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 12
- 125000006310 cycloalkyl amino group Chemical group 0.000 claims 11
- 229910052760 oxygen Inorganic materials 0.000 claims 11
- 101700061999 nhr-3 Proteins 0.000 claims 10
- 125000003107 substituted aryl group Chemical group 0.000 claims 10
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 9
- OKTJSMMVPCPJKN-UHFFFAOYSA-N carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 8
- -1 monoalkylamino Chemical group 0.000 claims 8
- 125000003282 alkyl amino group Chemical group 0.000 claims 7
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 5
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 5
- 208000006971 Mastocytoma Diseases 0.000 claims 4
- 150000001345 alkine derivatives Chemical class 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 4
- 201000006512 mast cell neoplasm Diseases 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 150000001336 alkenes Chemical class 0.000 claims 3
- 125000002947 alkylene group Chemical group 0.000 claims 3
- 125000002950 monocyclic group Chemical group 0.000 claims 3
- 239000000651 prodrug Substances 0.000 claims 3
- 229940002612 prodrugs Drugs 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims 2
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims 2
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 2
- 125000004199 4-trifluoromethylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C(F)(F)F 0.000 claims 2
- 206010000880 Acute myeloid leukaemia Diseases 0.000 claims 2
- 206010003210 Arteriosclerosis Diseases 0.000 claims 2
- 208000006673 Asthma Diseases 0.000 claims 2
- 206010003571 Astrocytoma Diseases 0.000 claims 2
- 210000000988 Bone and Bones Anatomy 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 241000282465 Canis Species 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
- 208000007342 Diabetic Nephropathy Diseases 0.000 claims 2
- 206010061835 Diabetic nephropathy Diseases 0.000 claims 2
- 206010014561 Emphysema Diseases 0.000 claims 2
- 206010014950 Eosinophilia Diseases 0.000 claims 2
- 206010051066 Gastrointestinal stromal tumour Diseases 0.000 claims 2
- 208000005017 Glioblastoma Diseases 0.000 claims 2
- 206010020583 Hypercalcaemia Diseases 0.000 claims 2
- 206010020880 Hypertrophy Diseases 0.000 claims 2
- 206010022489 Insulin resistance Diseases 0.000 claims 2
- 206010024324 Leukaemias Diseases 0.000 claims 2
- 208000007046 Leukemia, Myeloid, Acute Diseases 0.000 claims 2
- 206010025650 Malignant melanoma Diseases 0.000 claims 2
- 208000008585 Mastocytosis Diseases 0.000 claims 2
- 206010027476 Metastasis Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 206010029260 Neuroblastoma Diseases 0.000 claims 2
- 208000009905 Neurofibromatosis Diseases 0.000 claims 2
- 208000001132 Osteoporosis Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 2
- 206010038540 Renal tubular necrosis Diseases 0.000 claims 2
- 206010039073 Rheumatoid arthritis Diseases 0.000 claims 2
- 206010039085 Rhinitis allergic Diseases 0.000 claims 2
- 206010039491 Sarcoma Diseases 0.000 claims 2
- 210000004116 Schwann Cells Anatomy 0.000 claims 2
- 208000000587 Small Cell Lung Carcinoma Diseases 0.000 claims 2
- 206010041067 Small cell lung cancer Diseases 0.000 claims 2
- 206010057644 Testis cancer Diseases 0.000 claims 2
- 206010052779 Transplant rejections Diseases 0.000 claims 2
- 201000005510 acute lymphocytic leukemia Diseases 0.000 claims 2
- 201000010105 allergic rhinitis Diseases 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 201000001320 atherosclerosis Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 201000009030 carcinoma Diseases 0.000 claims 2
- 230000001684 chronic Effects 0.000 claims 2
- 201000011231 colorectal cancer Diseases 0.000 claims 2
- 201000010989 colorectal carcinoma Diseases 0.000 claims 2
- 125000004663 dialkyl amino group Chemical group 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 201000011243 gastrointestinal stromal tumor Diseases 0.000 claims 2
- 125000005549 heteroarylene group Chemical group 0.000 claims 2
- 230000000148 hypercalcaemia Effects 0.000 claims 2
- 201000001421 hyperglycemia Diseases 0.000 claims 2
- 201000004933 in situ carcinoma Diseases 0.000 claims 2
- 230000002757 inflammatory Effects 0.000 claims 2
- 201000006334 interstitial nephritis Diseases 0.000 claims 2
- 230000004130 lipolysis Effects 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 125000006578 monocyclic heterocycloalkyl group Chemical group 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 201000008383 nephritis Diseases 0.000 claims 2
- 201000004931 neurofibromatosis Diseases 0.000 claims 2
- 201000008968 osteosarcoma Diseases 0.000 claims 2
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 2
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 2
- 229910052698 phosphorus Inorganic materials 0.000 claims 2
- 230000001850 reproductive Effects 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 201000010874 syndrome Diseases 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- 201000003120 testicular cancer Diseases 0.000 claims 2
- 125000004001 thioalkyl group Chemical group 0.000 claims 2
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- 210000001185 Bone Marrow Anatomy 0.000 claims 1
- 206010018364 Glomerulonephritis Diseases 0.000 claims 1
- 208000005777 Lupus Nephritis Diseases 0.000 claims 1
- 108010058398 Macrophage Colony-Stimulating Factor Receptor Proteins 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 108010014608 Proto-Oncogene Proteins c-kit Proteins 0.000 claims 1
- 102000016971 Proto-Oncogene Proteins c-kit Human genes 0.000 claims 1
- 125000004171 alkoxy aryl group Chemical group 0.000 claims 1
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 claims 1
- 238000010276 construction Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 1
- 230000001404 mediated Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 201000009251 multiple myeloma Diseases 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68206305P | 2005-05-17 | 2005-05-17 | |
| US68205105P | 2005-05-17 | 2005-05-17 | |
| US68204205P | 2005-05-17 | 2005-05-17 | |
| US69296005P | 2005-06-22 | 2005-06-22 | |
| US69275005P | 2005-06-22 | 2005-06-22 | |
| PCT/US2006/018726 WO2007013896A2 (en) | 2005-05-17 | 2006-05-16 | Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008545652A JP2008545652A (ja) | 2008-12-18 |
| JP2008545652A5 true JP2008545652A5 (US07846941-20101207-C00217.png) | 2009-07-02 |
Family
ID=37683773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008512402A Pending JP2008545652A (ja) | 2005-05-17 | 2006-05-16 | ｃ−ｋｉｔおよびｃ−ｆｍｓ活性を調節する化合物およびその用途 |
Country Status (14)
Families Citing this family (97)
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2010
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