JP2008539225A5 - - Google Patents
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- Publication number
- JP2008539225A5 JP2008539225A5 JP2008508731A JP2008508731A JP2008539225A5 JP 2008539225 A5 JP2008539225 A5 JP 2008539225A5 JP 2008508731 A JP2008508731 A JP 2008508731A JP 2008508731 A JP2008508731 A JP 2008508731A JP 2008539225 A5 JP2008539225 A5 JP 2008539225A5
- Authority
- JP
- Japan
- Prior art keywords
- alcohol
- ginseng saponin
- ginseng
- precipitate
- hours
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000208340 Araliaceae Species 0.000 claims description 37
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 34
- 235000008434 ginseng Nutrition 0.000 claims description 34
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 33
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 33
- 229930182490 saponin Natural products 0.000 claims description 30
- 150000007949 saponins Chemical class 0.000 claims description 30
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims description 29
- 235000019441 ethanol Nutrition 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 17
- 239000003795 chemical substances by application Substances 0.000 claims description 16
- 239000002244 precipitate Substances 0.000 claims description 13
- 238000005185 salting out Methods 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 9
- 239000013078 crystal Substances 0.000 claims description 8
- AGBCLJAHARWNLA-DQUQINEDSA-N Ginsenoside RG2 Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@@H]2[C@H]3C(C)(C)[C@@H](O)CC[C@]3(C)[C@@H]3[C@@]([C@@]4(CC[C@@H]([C@H]4[C@H](O)C3)[C@@](C)(O)CCC=C(C)C)C)(C)C2)O[C@H](CO)[C@@H](O)[C@@H]1O AGBCLJAHARWNLA-DQUQINEDSA-N 0.000 claims description 7
- 239000006228 supernatant Substances 0.000 claims description 7
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 6
- 238000011033 desalting Methods 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
- 239000011347 resin Substances 0.000 claims description 4
- 229920005989 resin Polymers 0.000 claims description 4
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 3
- 239000000945 filler Substances 0.000 claims description 3
- 229920006395 saturated elastomer Polymers 0.000 claims description 3
- 235000002639 sodium chloride Nutrition 0.000 claims description 3
- 238000001179 sorption measurement Methods 0.000 claims description 3
- 241000196324 Embryophyta Species 0.000 claims description 2
- AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 claims description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 claims description 2
- 235000011130 ammonium sulphate Nutrition 0.000 claims description 2
- 239000003729 cation exchange resin Substances 0.000 claims description 2
- 238000004090 dissolution Methods 0.000 claims description 2
- 235000013399 edible fruits Nutrition 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 231100000252 nontoxic Toxicity 0.000 claims description 2
- 230000003000 nontoxic effect Effects 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 239000011780 sodium chloride Substances 0.000 claims description 2
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 2
- 235000011152 sodium sulphate Nutrition 0.000 claims description 2
- 235000010265 sodium sulphite Nutrition 0.000 claims description 2
- 238000000605 extraction Methods 0.000 claims 4
- 238000001953 recrystallisation Methods 0.000 claims 3
- 241000168720 Panax japonicus Species 0.000 claims 2
- 238000001556 precipitation Methods 0.000 claims 2
- 238000003809 water extraction Methods 0.000 claims 2
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 238000005137 deposition process Methods 0.000 claims 1
- 235000017709 saponins Nutrition 0.000 description 18
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000012043 crude product Substances 0.000 description 3
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 102000010909 Monoamine Oxidase Human genes 0.000 description 2
- 108010062431 Monoamine oxidase Proteins 0.000 description 2
- 235000002791 Panax Nutrition 0.000 description 2
- 241000208343 Panax Species 0.000 description 2
- -1 Protopanaxatriol glycoside Chemical class 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 239000003463 adsorbent Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000013355 food flavoring agent Nutrition 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229960002748 norepinephrine Drugs 0.000 description 2
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 230000000946 synaptic effect Effects 0.000 description 2
- 235000012222 talc Nutrition 0.000 description 2
- 239000000454 talc Substances 0.000 description 2
- 229910052623 talc Inorganic materials 0.000 description 2
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 241000209524 Araceae Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 244000000626 Daucus carota Species 0.000 description 1
- 235000002767 Daucus carota Nutrition 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical class CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 102000006835 Lamins Human genes 0.000 description 1
- 108010047294 Lamins Proteins 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 240000004371 Panax ginseng Species 0.000 description 1
- 235000002789 Panax ginseng Nutrition 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 239000003655 absorption accelerator Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000001430 anti-depressive effect Effects 0.000 description 1
- 239000000935 antidepressant agent Substances 0.000 description 1
- 229940005513 antidepressants Drugs 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 229910000020 calcium bicarbonate Inorganic materials 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 235000011148 calcium chloride Nutrition 0.000 description 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
- 239000008116 calcium stearate Substances 0.000 description 1
- 235000013539 calcium stearate Nutrition 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000000246 fibrin derivative Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- VOJREVRIHQPQTJ-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO.CCCCCCCCCCCCCCCCO VOJREVRIHQPQTJ-UHFFFAOYSA-N 0.000 description 1
- 229960004801 imipramine Drugs 0.000 description 1
- BCGWQEUPMDMJNV-UHFFFAOYSA-N imipramine Chemical compound C1CC2=CC=CC=C2N(CCCN(C)C)C2=CC=CC=C21 BCGWQEUPMDMJNV-UHFFFAOYSA-N 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 210000005053 lamin Anatomy 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- BBEUDPAEKGPXDG-UHFFFAOYSA-N protopanaxatriol Natural products CC(CCC=C(C)C)C1CCC2(C)C1C(O)CC3C4(C)CCC(O)C(C)(C)C4C(O)CC23C BBEUDPAEKGPXDG-UHFFFAOYSA-N 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 238000009938 salting Methods 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/KR2005/001204 WO2006115307A1 (en) | 2005-04-26 | 2005-04-26 | Method of extracting ginsengnoside rg2m, pharmaceutical composition including ginsengnoside rg2, and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008539225A JP2008539225A (ja) | 2008-11-13 |
| JP2008539225A5 true JP2008539225A5 (enExample) | 2011-06-16 |
| JP4773512B2 JP4773512B2 (ja) | 2011-09-14 |
Family
ID=37214911
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008508731A Expired - Fee Related JP4773512B2 (ja) | 2005-04-26 | 2005-04-26 | 人参サポニンＲｇ２の抽出方法及びその抽出物を含む医薬組成物とその用途 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US7884195B2 (enExample) |
| EP (1) | EP1895966A4 (enExample) |
| JP (1) | JP4773512B2 (enExample) |
| WO (1) | WO2006115307A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100438876C (zh) | 2006-06-09 | 2008-12-03 | 上海中药创新研究中心 | 20(s)-原人参二醇在制备抗抑郁药物中的应用 |
| US9314493B2 (en) | 2007-05-28 | 2016-04-19 | Amorepacific Corporation | Method for treating vascular inflammation, improving skin beauty and improving male sexual function using ginseng berry |
| KR20080104600A (ko) * | 2007-05-28 | 2008-12-03 | (주)아모레퍼시픽 | 인삼 열매 추출물을 함유하는 혈행촉진, 혈관신생촉진, 및허혈성 심질환 치료용 조성물 |
| KR20080105470A (ko) * | 2007-05-31 | 2008-12-04 | (주)아모레퍼시픽 | 인삼 열매 추출물을 함유하는 비만 예방 및 개선용 식품조성물 |
| WO2008155998A1 (ja) * | 2007-06-21 | 2008-12-24 | Nagase & Co., Ltd. | 抗不安抗うつ剤 |
| KR101614110B1 (ko) * | 2008-11-28 | 2016-04-21 | (주)아모레퍼시픽 | 동맥경화 예방 또는 치료용 조성물 |
| US20100278944A1 (en) * | 2009-05-04 | 2010-11-04 | Naturex, S.A. | Application of american ginseng to enhance neurocognitive function |
| US9956241B2 (en) | 2009-05-04 | 2018-05-01 | Naturex, S.A. | Application of American Ginseng to enhance neurocognitive function |
| KR101593618B1 (ko) * | 2009-05-26 | 2016-02-15 | (주)아모레퍼시픽 | 사포닌의 생체 이용률 증진 조성물 |
| CN102532234A (zh) * | 2010-12-10 | 2012-07-04 | 北京本草天源药物研究院 | 一种人参皂苷Rg1的提取纯化方法 |
| KR101451629B1 (ko) * | 2012-09-19 | 2014-10-21 | 제너럴바이오(주) | 스미자임 ＡＣ를 이용한 진세노사이드 Ｒｇ2의 제조방법 |
| EP2977051A4 (en) * | 2013-03-01 | 2016-10-05 | Kim S Korean Ginseng Co Ltd | GINSENOSIDZUSAMMENSETZUNG |
| JP6527744B2 (ja) * | 2014-04-16 | 2019-06-05 | 花王株式会社 | ニンジン抽出物の製造方法 |
| CN104483437B (zh) * | 2014-12-10 | 2016-06-15 | 常熟雷允上制药有限公司 | 一种抗肿瘤中药组合物的质量检测方法 |
| WO2017088080A1 (es) * | 2015-11-25 | 2017-06-01 | Natural Response S.A. | Método para la obtención de saponinas a partir de plantas |
| CN110974858A (zh) * | 2019-03-28 | 2020-04-10 | 泰州医药城国科化物生物医药科技有限公司 | 一种精制的西洋参总皂苷组分及纯化制备西洋参总皂苷的方法 |
| CN110025645B (zh) * | 2019-04-28 | 2021-05-04 | 云南汉德生物技术有限公司 | 一种提取西洋参总皂苷的方法 |
| CN110095551B (zh) * | 2019-06-12 | 2021-09-14 | 蚌埠医学院 | 一种人参皂苷的分离检测方法 |
| CN110585226B (zh) * | 2019-11-14 | 2020-08-11 | 江西厚朴贯众科技有限公司 | 金线莲苷在制备改善认知功能障碍的药物中的用途 |
| CN117327135A (zh) * | 2022-06-24 | 2024-01-02 | 中国中医科学院中药研究所 | 一种增加糖类及糖苷类成分浸出的方法及其应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1560202A (enExample) * | 1963-04-23 | 1969-03-21 | ||
| DE2828851A1 (de) | 1978-06-30 | 1980-01-10 | Shigeru Arichi | Neue antitumormittel |
| US6083932A (en) * | 1997-04-18 | 2000-07-04 | Cv Technologies Inc. | Pharmaceutical compositions derived from ginseng and methods of treatment using same |
| KR20000006625A (ko) | 1998-07-20 | 2000-02-07 | 묵인희 | 인삼추출물을 포함하는 치매 치료제 |
| JP2000191539A (ja) | 1998-12-22 | 2000-07-11 | Japan Science & Technology Corp | ジンセノサイドＲｂ１からなる脳細胞又は神経細胞保護剤 |
| WO2001015717A1 (en) * | 1999-08-30 | 2001-03-08 | Japan Science And Technology Corporation | Brain cell or nerve cell protecting agents comprising ginseng |
| CN1156281C (zh) | 2000-01-31 | 2004-07-07 | 吉林省中医中药研究院 | 人参皂甙Rg2在制备治疗心、脑血管疾病药物中的应用 |
| KR100448667B1 (ko) | 2001-04-25 | 2004-09-13 | (주) 디지탈바이오텍 | 진세노사이드 가수분해물을 함유하는 퇴행성 뇌질환의예방 및 치료용 조성물 |
| KR100472380B1 (ko) | 2001-12-18 | 2005-03-08 | 나승열 | 인삼 진세노사이드를 함유하는 카이네이트에 의한 해마씨추체신경세포의 사멸 또는 손상의 예방 및 치료용 조성물 |
| KR100425022B1 (ko) * | 2002-01-05 | 2004-03-27 | 롯데제과주식회사 | 가공인삼 추출물 및 이를 함유하는 약제 조성물 |
| KR20040036451A (ko) * | 2002-10-26 | 2004-04-30 | 한국과학기술연구원 | 진세노사이드 Ｒｇ３ 또는 진세노사이드 Ｒｈ２를포함하는 글루타메이트 매개 신경독성 억제 조성물 |
| KR20050018226A (ko) | 2003-08-14 | 2005-02-23 | 주식회사 진생사이언스 | 진세노사이드를 함유하는 마그네슘-뉴클레오티드-작동성금속 이온통로 또는 세포내 칼슘고갈에 의해 작동되는칼슘통로 활성화 조성물 |
| CN100339085C (zh) * | 2003-09-23 | 2007-09-26 | 天津天士力制药股份有限公司 | 治疗心脑血管疾病的中药组合物 |
-
2005
- 2005-04-26 EP EP05738291A patent/EP1895966A4/en not_active Withdrawn
- 2005-04-26 US US11/912,804 patent/US7884195B2/en not_active Expired - Fee Related
- 2005-04-26 JP JP2008508731A patent/JP4773512B2/ja not_active Expired - Fee Related
- 2005-04-26 WO PCT/KR2005/001204 patent/WO2006115307A1/en not_active Ceased
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