JP2008526881A5 - - Google Patents
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- Publication number
- JP2008526881A5 JP2008526881A5 JP2007550519A JP2007550519A JP2008526881A5 JP 2008526881 A5 JP2008526881 A5 JP 2008526881A5 JP 2007550519 A JP2007550519 A JP 2007550519A JP 2007550519 A JP2007550519 A JP 2007550519A JP 2008526881 A5 JP2008526881 A5 JP 2008526881A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkoxy
- alkylureyl
- haloalkyl
- carboxamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 238000000034 method Methods 0.000 claims 36
- -1 alkyl thiocarboxamide Chemical compound 0.000 claims 23
- 125000000217 alkyl group Chemical group 0.000 claims 19
- 125000004414 alkyl thio group Chemical group 0.000 claims 16
- 125000003545 alkoxy group Chemical group 0.000 claims 14
- 229910052736 halogen Inorganic materials 0.000 claims 13
- 150000002367 halogens Chemical class 0.000 claims 13
- 125000001188 haloalkyl group Chemical group 0.000 claims 11
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 11
- 125000004423 acyloxy group Chemical group 0.000 claims 10
- 125000005431 alkyl carboxamide group Chemical group 0.000 claims 10
- 125000002252 acyl group Chemical group 0.000 claims 9
- 125000003282 alkyl amino group Chemical group 0.000 claims 9
- 125000004093 cyano group Chemical group *C#N 0.000 claims 9
- 125000004995 haloalkylthio group Chemical group 0.000 claims 9
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 8
- 125000005392 carboxamide group Chemical class NC(=O)* 0.000 claims 8
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 8
- 125000004663 dialkyl amino group Chemical group 0.000 claims 8
- 125000005432 dialkylcarboxamide group Chemical group 0.000 claims 8
- 125000004438 haloalkoxy group Chemical group 0.000 claims 8
- 125000004440 haloalkylsulfinyl group Chemical group 0.000 claims 8
- 125000004441 haloalkylsulfonyl group Chemical group 0.000 claims 8
- 125000001072 heteroaryl group Chemical group 0.000 claims 8
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 8
- 125000001424 substituent group Chemical group 0.000 claims 8
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 7
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 7
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 6
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 6
- 125000005422 alkyl sulfonamido group Chemical group 0.000 claims 6
- 239000002585 base Substances 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 6
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 claims 4
- 229910052783 alkali metal Inorganic materials 0.000 claims 4
- 125000004422 alkyl sulphonamide group Chemical group 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 4
- 125000005363 dialkylsulfonamide group Chemical group 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 239000002904 solvent Substances 0.000 claims 4
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 3
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 claims 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000004768 (C1-C4) alkylsulfinyl group Chemical group 0.000 claims 2
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 2
- 229910000288 alkali metal carbonate Inorganic materials 0.000 claims 2
- 150000008041 alkali metal carbonates Chemical class 0.000 claims 2
- 229910000102 alkali metal hydride Inorganic materials 0.000 claims 2
- 150000008046 alkali metal hydrides Chemical class 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- UKFWSNCTAHXBQN-UHFFFAOYSA-N ammonium iodide Chemical compound [NH4+].[I-] UKFWSNCTAHXBQN-UHFFFAOYSA-N 0.000 claims 2
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 2
- 125000001475 halogen functional group Chemical group 0.000 claims 2
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 2
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 claims 1
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 1
- 125000004771 (C1-C4) haloalkylsulfinyl group Chemical group 0.000 claims 1
- 125000001769 aryl amino group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 125000005112 cycloalkylalkoxy group Chemical group 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 1
- 125000005223 heteroarylcarbonyl group Chemical group 0.000 claims 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-M iodide Chemical compound [I-] XMBWDFGMSWQBCA-UHFFFAOYSA-M 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 1
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical group [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 claims 1
- 229940124530 sulfonamide Drugs 0.000 claims 1
- 150000003456 sulfonamides Chemical class 0.000 claims 1
- 150000003457 sulfones Chemical class 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- 125000003396 thiol group Chemical class [H]S* 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64262705P | 2005-01-10 | 2005-01-10 | |
| PCT/US2006/000565 WO2006076243A1 (en) | 2005-01-10 | 2006-01-09 | Processes for preparing 4-(phenoxy-5-methyl-pyrimidin-4-yloxy)piperidine-1-carboxylic acid derivatives and related compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008526881A JP2008526881A (ja) | 2008-07-24 |
| JP2008526881A5 true JP2008526881A5 (enExample) | 2009-07-02 |
Family
ID=36297260
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007550519A Withdrawn JP2008526881A (ja) | 2005-01-10 | 2006-01-09 | ４−（フェノキシ−５−メチル−ピリミジン−４−イルオキシ）ピペリジン−１−カルボン酸誘導体および関連化合物を調製する方法 |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US7812159B2 (enExample) |
| EP (1) | EP1838697B1 (enExample) |
| JP (1) | JP2008526881A (enExample) |
| KR (1) | KR20070098906A (enExample) |
| CN (1) | CN101115739A (enExample) |
| AR (1) | AR056917A1 (enExample) |
| AT (1) | ATE462701T1 (enExample) |
| AU (1) | AU2006205176A1 (enExample) |
| BR (1) | BRPI0606676A2 (enExample) |
| CA (1) | CA2593344A1 (enExample) |
| CR (1) | CR9221A (enExample) |
| DE (1) | DE602006013271D1 (enExample) |
| DK (1) | DK1838697T3 (enExample) |
| DO (1) | DOP2006000010A (enExample) |
| EA (1) | EA014156B1 (enExample) |
| ES (1) | ES2341281T3 (enExample) |
| GE (1) | GEP20105071B (enExample) |
| GT (1) | GT200600007A (enExample) |
| HN (1) | HN2006000970A (enExample) |
| IL (1) | IL184366A0 (enExample) |
| MX (1) | MX2007008377A (enExample) |
| NO (1) | NO20074055L (enExample) |
| NZ (1) | NZ556218A (enExample) |
| PE (2) | PE20060836A1 (enExample) |
| SG (1) | SG158864A1 (enExample) |
| TW (1) | TW200637844A (enExample) |
| UA (1) | UA92733C2 (enExample) |
| WO (1) | WO2006076243A1 (enExample) |
| ZA (1) | ZA200705473B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602004009295T2 (de) | 2003-01-14 | 2008-07-03 | Arena Pharmaceuticals, Inc., San Diego | 1,2,3-trisubstituierte aryl- und heteroarylderivate als modulatoren des metabolismus zur vorbeugung und behandlung von metabolismus-bedingten krankheiten wie diabetes oder hyperglykämie |
| AR045047A1 (es) * | 2003-07-11 | 2005-10-12 | Arena Pharm Inc | Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos |
| MY148521A (en) * | 2005-01-10 | 2013-04-30 | Arena Pharm Inc | Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto |
| CA2714703A1 (en) * | 2008-02-22 | 2009-08-27 | Irm Llc | Compounds and compositions as modulators of gpr119 activity |
| SG10201500639TA (en) | 2010-01-27 | 2015-03-30 | Arena Pharm Inc | Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof |
| US20130109703A1 (en) | 2010-03-18 | 2013-05-02 | Boehringer Ingelheim International Gmbh | Combination of a GPR119 Agonist and the DPP-IV Inhibitor Linagliptin for Use in the Treatment of Diabetes and Related Conditions |
| WO2012025811A1 (en) | 2010-08-23 | 2012-03-01 | Lupin Limited | Indolylpyrimidines as modulators of gpr119 |
| PH12013500547A1 (en) | 2010-09-22 | 2013-06-10 | Arena Pharm Inc | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| US9000175B2 (en) | 2010-11-26 | 2015-04-07 | Lupin Limited | Bicyclic GPR119 modulators |
| EA031618B1 (ru) | 2011-06-09 | 2019-01-31 | Ризен Фармасьютикалз Са | Соединения-модуляторы gpr-119 |
| ES2995737T3 (en) | 2015-01-06 | 2025-02-11 | Arena Pharm Inc | Compound for use in treating conditions related to the s1p1 receptor |
| MA42807A (fr) | 2015-06-22 | 2018-07-25 | Arena Pharm Inc | Sel l-arginine cristallin d'acide (r)-2-(7-(4-cyclopentyl-3-(trifluorométhyl)benzyloxy)-1,2,3,4-tétrahydrocyclo-penta[b]indol-3-yl)acétique (composé 1) pour une utilisation dans des troubles associés au récepteur de s1p1 |
| JP7106528B2 (ja) | 2016-09-20 | 2022-07-26 | グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッド | Ｔｒｐｖ４拮抗薬 |
| EP3515889A1 (en) | 2016-09-20 | 2019-07-31 | GlaxoSmithKline Intellectual Property (No. 2) Limited | Trpv4 antagonists |
| TW201825458A (zh) | 2016-09-20 | 2018-07-16 | 英商葛蘭素史克智慧財產（第二）有限公司 | Ｔｒｐｖ４拮抗劑 |
| WO2018151873A1 (en) | 2017-02-16 | 2018-08-23 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of primary biliary cholangitis |
| EP3801459B1 (en) | 2018-06-06 | 2024-08-07 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the s1p1 receptor |
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| EP1074549B1 (en) | 1999-08-06 | 2003-11-19 | F. Hoffmann-La Roche Ag | Tetrahydro-benzo(d)azepines and their use as antagonists at metabotropic glutamate receptors |
| JP2001089452A (ja) | 1999-09-22 | 2001-04-03 | Sankyo Co Ltd | ピリミジン誘導体 |
| US6414002B1 (en) | 1999-09-22 | 2002-07-02 | Bristol-Myers Squibb Company | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method |
| DE19962936A1 (de) | 1999-12-24 | 2001-06-28 | Bayer Ag | Neue beta-Aminosäureverbindungen als Integrinantagonisten |
| EP1287133B1 (en) | 2000-05-18 | 2006-12-13 | Bayer HealthCare AG | Regulation of human dopamine-like g protein-coupled receptor |
| CA2429426A1 (en) | 2000-11-17 | 2002-05-23 | Takeda Chemical Industries, Ltd. | Isoxazole derivatives |
| US6525064B1 (en) | 2000-12-08 | 2003-02-25 | 3M Innovative Properties Company | Sulfonamido substituted imidazopyridines |
| US6545016B1 (en) | 2000-12-08 | 2003-04-08 | 3M Innovative Properties Company | Amide substituted imidazopyridines |
| US6545017B1 (en) | 2000-12-08 | 2003-04-08 | 3M Innovative Properties Company | Urea substituted imidazopyridines |
| US6815456B2 (en) * | 2001-04-20 | 2004-11-09 | Wyeth | Heterocyclyloxy-, -thioxy- and -aminobenzazole derivatives as 5-hydroxytryptamine-6 ligands |
| GB0117899D0 (en) | 2001-07-23 | 2001-09-12 | Astrazeneca Ab | Chemical compounds |
| DE10237722A1 (de) | 2002-08-17 | 2004-08-19 | Aventis Pharma Deutschland Gmbh | Indol- oder Benzimidazolderivate zur Modulation der IKappaB-Kinase |
| DE602004009295T2 (de) | 2003-01-14 | 2008-07-03 | Arena Pharmaceuticals, Inc., San Diego | 1,2,3-trisubstituierte aryl- und heteroarylderivate als modulatoren des metabolismus zur vorbeugung und behandlung von metabolismus-bedingten krankheiten wie diabetes oder hyperglykämie |
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| US7083933B1 (en) | 2003-05-09 | 2006-08-01 | Prosidion Limited | Methods for identification of modulators of OSGPR116 activity |
| SE0301368D0 (sv) * | 2003-05-09 | 2003-05-09 | Astrazeneca Ab | Chemical compounds |
| AR045047A1 (es) * | 2003-07-11 | 2005-10-12 | Arena Pharm Inc | Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos |
| EP2292620A3 (en) | 2003-07-14 | 2011-06-22 | Arena Pharmaceuticals, Inc. | Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prohylaxis and treatment of disorders related thereto |
| MY148521A (en) | 2005-01-10 | 2013-04-30 | Arena Pharm Inc | Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto |
-
2006
- 2006-01-05 DO DO2006000010A patent/DOP2006000010A/es unknown
- 2006-01-06 PE PE2006000044A patent/PE20060836A1/es not_active Application Discontinuation
- 2006-01-06 PE PE2009000963A patent/PE20091401A1/es not_active Application Discontinuation
- 2006-01-09 DK DK06717730.3T patent/DK1838697T3/da active
- 2006-01-09 CA CA002593344A patent/CA2593344A1/en not_active Withdrawn
- 2006-01-09 AT AT06717730T patent/ATE462701T1/de not_active IP Right Cessation
- 2006-01-09 GT GT200600007A patent/GT200600007A/es unknown
- 2006-01-09 AR ARP060100070A patent/AR056917A1/es not_active Application Discontinuation
- 2006-01-09 CN CNA2006800018668A patent/CN101115739A/zh not_active Withdrawn
- 2006-01-09 WO PCT/US2006/000565 patent/WO2006076243A1/en not_active Ceased
- 2006-01-09 KR KR1020077018267A patent/KR20070098906A/ko not_active Withdrawn
- 2006-01-09 JP JP2007550519A patent/JP2008526881A/ja not_active Withdrawn
- 2006-01-09 DE DE602006013271T patent/DE602006013271D1/de active Active
- 2006-01-09 HN HN2006000970A patent/HN2006000970A/es unknown
- 2006-01-09 AU AU2006205176A patent/AU2006205176A1/en not_active Withdrawn
- 2006-01-09 BR BRPI0606676-3A patent/BRPI0606676A2/pt not_active IP Right Cessation
- 2006-01-09 GE GEAP200610222A patent/GEP20105071B/en unknown
- 2006-01-09 NZ NZ556218A patent/NZ556218A/en not_active IP Right Cessation
- 2006-01-09 EP EP06717730A patent/EP1838697B1/en active Active
- 2006-01-09 US US11/327,923 patent/US7812159B2/en not_active Expired - Fee Related
- 2006-01-09 TW TW095100805A patent/TW200637844A/zh unknown
- 2006-01-09 ES ES06717730T patent/ES2341281T3/es active Active
- 2006-01-09 SG SG201000106-3A patent/SG158864A1/en unknown
- 2006-01-09 MX MX2007008377A patent/MX2007008377A/es active IP Right Grant
- 2006-01-09 UA UAA200709151A patent/UA92733C2/ru unknown
- 2006-01-09 EA EA200701470A patent/EA014156B1/ru not_active IP Right Cessation
-
2007
- 2007-07-02 CR CR9221A patent/CR9221A/es not_active Application Discontinuation
- 2007-07-02 IL IL184366A patent/IL184366A0/en unknown
- 2007-07-04 ZA ZA200705473A patent/ZA200705473B/xx unknown
- 2007-08-06 NO NO20074055A patent/NO20074055L/no not_active Application Discontinuation
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