PE20091401A1 - Procedimientos para preparar eteres aromaticos - Google Patents
Procedimientos para preparar eteres aromaticosInfo
- Publication number
- PE20091401A1 PE20091401A1 PE2009000963A PE2009000963A PE20091401A1 PE 20091401 A1 PE20091401 A1 PE 20091401A1 PE 2009000963 A PE2009000963 A PE 2009000963A PE 2009000963 A PE2009000963 A PE 2009000963A PE 20091401 A1 PE20091401 A1 PE 20091401A1
- Authority
- PE
- Peru
- Prior art keywords
- acyloxyl
- alkenyl
- alkyl
- compound
- formula
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
REFERIDA A UN PROCEDIMIENTO DE PREPARACION DE UN COMPUESTO ETER AROMATICO DE FORMULA (I) QUE CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA II CON UN COMPUESTO DE FORMULA III EN PRESENCIA DE UNA BASE TAL COMO CARBONATO DE POTASIO (K2CO3) Y UNA SAL TAL COMO YODURO DE POTASIO (KI) A UNA TEMPERATURA DE ENTRE 120ºC A 140ºC, EN UN DISOLVENTE TAL COMO DIMETILSULFOXIDO (DMSO), DONDE X ES N O CR7; Y ES N O CR8; Z ES ACILO C1-C5, ACILOXILO C1-C5, ALQUENILO C2-C6, ENTRE OTROS; R1 ES H, ACILOXILO C1-C5, ALQUENILO C2-C6, ALCOXILO C1-C4, ENTRE OTROS; R2 ES R22, -C(O)-R22, -C(S)-R22, ENTE OTROS; R3 ES ALQUILO C1-C3, ALCOXILO C1-C4, CARBOXILO, ENTRE OTROS; R4 ES H, CICLOALQUILO C3-C7, ALQUILO C1-C8, ENTRE OTROS; R7 Y R8 SON H, ACILOXILO C1-C5, ALQUENILO C2-C6, ENTRE OTROS; R11 ES ACILO C1-C5, AMINO, ENTRE OTROS; R12, R13, R14 Y R15 SON H, ACILO C1-C5, ACILOXILO C1-C5, ENTRE OTROS; R22 ES H, ALQUILO C1-C8, FENILO, ENTRE OTROS; n ES 0 O 1; m ES UN ENTERO DE 0 A 4; L2 ES UN GRUPO SALIENTE TAL COMO CLORO. DICHOS COMPUESTOS SON MODULADORES DEL METABOLISMO DE LA GLUCOSA Y SON UTILES EN EL TRATAMIENTO DE TRASTORNOS METABOLICOS TALES COMO DIABETES Y OBESIDAD
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64262705P | 2005-01-10 | 2005-01-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20091401A1 true PE20091401A1 (es) | 2009-09-18 |
Family
ID=36297260
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2006000044A PE20060836A1 (es) | 2005-01-10 | 2006-01-06 | Procedimientos para preparar eteres aromaticos |
PE2009000963A PE20091401A1 (es) | 2005-01-10 | 2006-01-06 | Procedimientos para preparar eteres aromaticos |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2006000044A PE20060836A1 (es) | 2005-01-10 | 2006-01-06 | Procedimientos para preparar eteres aromaticos |
Country Status (30)
Country | Link |
---|---|
US (1) | US7812159B2 (es) |
EP (1) | EP1838697B1 (es) |
JP (1) | JP2008526881A (es) |
KR (1) | KR20070098906A (es) |
CN (1) | CN101115739A (es) |
AR (1) | AR056917A1 (es) |
AT (1) | ATE462701T1 (es) |
AU (1) | AU2006205176A1 (es) |
BR (1) | BRPI0606676A2 (es) |
CA (1) | CA2593344A1 (es) |
CR (1) | CR9221A (es) |
DE (1) | DE602006013271D1 (es) |
DK (1) | DK1838697T3 (es) |
DO (1) | DOP2006000010A (es) |
EA (1) | EA014156B1 (es) |
ES (1) | ES2341281T3 (es) |
GE (1) | GEP20105071B (es) |
GT (1) | GT200600007A (es) |
HK (1) | HK1102810A1 (es) |
HN (1) | HN2006000970A (es) |
IL (1) | IL184366A0 (es) |
MX (1) | MX2007008377A (es) |
NO (1) | NO20074055L (es) |
NZ (1) | NZ556218A (es) |
PE (2) | PE20060836A1 (es) |
SG (1) | SG158864A1 (es) |
TW (1) | TW200637844A (es) |
UA (1) | UA92733C2 (es) |
WO (1) | WO2006076243A1 (es) |
ZA (1) | ZA200705473B (es) |
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ES2295816T3 (es) | 2003-01-14 | 2008-04-16 | Arena Pharmaceuticals, Inc. | Derivados arilo y heteroarilo 1,2,3-trisustituidos como moduladores del metabolismo, y profilaxis y tratamiento de transtornos relacionados con los mismos, tales como la diabetes y la hiperglucemia. |
AR045047A1 (es) * | 2003-07-11 | 2005-10-12 | Arena Pharm Inc | Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos |
MY148521A (en) * | 2005-01-10 | 2013-04-30 | Arena Pharm Inc | Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto |
BRPI0907584A2 (pt) * | 2008-02-22 | 2015-07-21 | Irm Llc | Composto e composições como moduladores de atividade de gpr119 |
CN103221391B (zh) | 2010-01-27 | 2018-07-06 | 艾尼纳制药公司 | (R)-2-(7-(4-环戊基-3-(三氟甲基)苄基氧基)-1,2,3,4-四氢环戊二烯并[b]吲哚-3-基)乙酸及其盐的制备方法 |
EP2547339A1 (en) | 2010-03-18 | 2013-01-23 | Boehringer Ingelheim International GmbH | Combination of a gpr119 agonist and the dpp-iv inhibitor linagliptin for use in the treatment of diabetes and related conditions |
WO2012025811A1 (en) | 2010-08-23 | 2012-03-01 | Lupin Limited | Indolylpyrimidines as modulators of gpr119 |
CN103539791B (zh) | 2010-09-22 | 2017-01-11 | 艾尼纳制药公司 | Gpr119 受体调节剂和对与其相关的障碍的治疗 |
AU2011333472A1 (en) | 2010-11-26 | 2013-06-06 | Lupin Limited | Bicyclic GPR119 modulators |
KR101913619B1 (ko) | 2011-06-09 | 2018-12-28 | 리젠 파마슈티컬스 소시에떼 아노님 | Gpr-119의 조절제로서의 신규한 화합물 |
CN107405332A (zh) | 2015-01-06 | 2017-11-28 | 艾尼纳制药公司 | 治疗与s1p1受体有关的病症的方法 |
US10301262B2 (en) | 2015-06-22 | 2019-05-28 | Arena Pharmaceuticals, Inc. | Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta [b]indol-3-yl)acetic acid(Compund1) for use in SIPI receptor-associated disorders |
WO2018055527A1 (en) | 2016-09-20 | 2018-03-29 | Glaxosmithkline Intellectual Property (No.2) Limited | Trpv4 antagonists |
CN109790116B (zh) | 2016-09-20 | 2022-10-28 | 葛兰素史密斯克莱知识产权(第2 号)有限公司 | Trpv4拮抗剂 |
TW201825458A (zh) | 2016-09-20 | 2018-07-16 | 英商葛蘭素史克智慧財產(第二)有限公司 | Trpv4拮抗劑 |
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2006
- 2006-01-05 DO DO2006000010A patent/DOP2006000010A/es unknown
- 2006-01-06 PE PE2006000044A patent/PE20060836A1/es not_active Application Discontinuation
- 2006-01-06 PE PE2009000963A patent/PE20091401A1/es not_active Application Discontinuation
- 2006-01-09 AT AT06717730T patent/ATE462701T1/de not_active IP Right Cessation
- 2006-01-09 MX MX2007008377A patent/MX2007008377A/es active IP Right Grant
- 2006-01-09 TW TW095100805A patent/TW200637844A/zh unknown
- 2006-01-09 CN CNA2006800018668A patent/CN101115739A/zh not_active Withdrawn
- 2006-01-09 AR ARP060100070A patent/AR056917A1/es not_active Application Discontinuation
- 2006-01-09 AU AU2006205176A patent/AU2006205176A1/en not_active Withdrawn
- 2006-01-09 BR BRPI0606676-3A patent/BRPI0606676A2/pt not_active IP Right Cessation
- 2006-01-09 GT GT200600007A patent/GT200600007A/es unknown
- 2006-01-09 CA CA002593344A patent/CA2593344A1/en not_active Withdrawn
- 2006-01-09 KR KR1020077018267A patent/KR20070098906A/ko not_active Application Discontinuation
- 2006-01-09 HN HN2006000970A patent/HN2006000970A/es unknown
- 2006-01-09 NZ NZ556218A patent/NZ556218A/en not_active IP Right Cessation
- 2006-01-09 ES ES06717730T patent/ES2341281T3/es active Active
- 2006-01-09 US US11/327,923 patent/US7812159B2/en not_active Expired - Fee Related
- 2006-01-09 GE GEAP200610222A patent/GEP20105071B/en unknown
- 2006-01-09 EP EP06717730A patent/EP1838697B1/en active Active
- 2006-01-09 JP JP2007550519A patent/JP2008526881A/ja not_active Withdrawn
- 2006-01-09 EA EA200701470A patent/EA014156B1/ru not_active IP Right Cessation
- 2006-01-09 SG SG201000106-3A patent/SG158864A1/en unknown
- 2006-01-09 DE DE602006013271T patent/DE602006013271D1/de active Active
- 2006-01-09 WO PCT/US2006/000565 patent/WO2006076243A1/en active Application Filing
- 2006-01-09 DK DK06717730.3T patent/DK1838697T3/da active
- 2006-01-09 UA UAA200709151A patent/UA92733C2/ru unknown
-
2007
- 2007-07-02 CR CR9221A patent/CR9221A/es not_active Application Discontinuation
- 2007-07-02 IL IL184366A patent/IL184366A0/en unknown
- 2007-07-04 ZA ZA200705473A patent/ZA200705473B/xx unknown
- 2007-08-06 NO NO20074055A patent/NO20074055L/no not_active Application Discontinuation
- 2007-10-15 HK HK07111088.3A patent/HK1102810A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NO20074055L (no) | 2007-09-25 |
ES2341281T3 (es) | 2010-06-17 |
GT200600007A (es) | 2006-08-01 |
HK1102810A1 (en) | 2007-12-07 |
DK1838697T3 (da) | 2010-06-28 |
IL184366A0 (en) | 2007-10-31 |
US20060155129A1 (en) | 2006-07-13 |
SG158864A1 (en) | 2010-02-26 |
US7812159B2 (en) | 2010-10-12 |
JP2008526881A (ja) | 2008-07-24 |
WO2006076243A1 (en) | 2006-07-20 |
CR9221A (es) | 2007-10-23 |
DE602006013271D1 (de) | 2010-05-12 |
EP1838697B1 (en) | 2010-03-31 |
HN2006000970A (es) | 2010-04-19 |
EP1838697A1 (en) | 2007-10-03 |
DOP2006000010A (es) | 2006-07-31 |
BRPI0606676A2 (pt) | 2009-07-07 |
EA014156B1 (ru) | 2010-10-29 |
UA92733C2 (ru) | 2010-12-10 |
AU2006205176A1 (en) | 2006-07-20 |
NZ556218A (en) | 2010-10-29 |
CA2593344A1 (en) | 2006-07-20 |
ZA200705473B (en) | 2009-07-29 |
GEP20105071B (en) | 2010-09-10 |
PE20060836A1 (es) | 2006-09-02 |
KR20070098906A (ko) | 2007-10-05 |
MX2007008377A (es) | 2007-09-07 |
CN101115739A (zh) | 2008-01-30 |
ATE462701T1 (de) | 2010-04-15 |
EA200701470A1 (ru) | 2008-02-28 |
AR056917A1 (es) | 2007-11-07 |
TW200637844A (en) | 2006-11-01 |
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