MX341173B - Proceso de fluorinado de derivados de anilida y derivados de fluorinado de benzotiazole en la forma de agentes de generacion de imagen in vivo. - Google Patents

Proceso de fluorinado de derivados de anilida y derivados de fluorinado de benzotiazole en la forma de agentes de generacion de imagen in vivo.

Info

Publication number
MX341173B
MX341173B MX2013013741A MX2013013741A MX341173B MX 341173 B MX341173 B MX 341173B MX 2013013741 A MX2013013741 A MX 2013013741A MX 2013013741 A MX2013013741 A MX 2013013741A MX 341173 B MX341173 B MX 341173B
Authority
MX
Mexico
Prior art keywords
derivatives
fluorinate
benzothiazole
vivo imaging
imaging agents
Prior art date
Application number
MX2013013741A
Other languages
English (en)
Inventor
Michael Fairway Steven
Eamon Storey Anthony
Louise Jones Clare
Raymond Christophe Bouvet Denis
Lasbistes Nicolas
Williams Lorenzo
Mark Gibson Alexander
James Nairne Robert
Karimi Farhad
Langstrom Bengt
Original Assignee
Ge Healthcare As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare As filed Critical Ge Healthcare As
Publication of MX341173B publication Critical patent/MX341173B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
    • C07C209/74—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton by halogenation, hydrohalogenation, dehalogenation, or dehydrohalogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
    • C07C211/45—Monoamines
    • C07C211/46—Aniline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/24—Stationary reactors without moving elements inside
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a un proceso para la preparación de un compuesto de la fórmula (I): R1 es seleccionado de C1-6alquilo, C2-6alquenilo y C2-6alquinilo; el cual comprende (I) la reacción con fluoruro, en forma adecuada [18F]fluoruro, de un compuesto correspondiente de la fórmula (II): en donde R2 es seleccionado de hidrógeno, C1-10alquilo, C1 10haloalquilo, C6-14arilo, C6-14arilalquilo, (CH2CH2O)qCH3 en donde q es un entero de 1 a 10; R1 es tal como se define para el compuesto de la fórmula (I); y R3 es un grupo de partida. También se reivindican ciertos precursores novedosos de la fórmula (II) y equipos radiofarmacéuticos que contienen dichos precursores.
MX2013013741A 2005-08-12 2006-08-11 Proceso de fluorinado de derivados de anilida y derivados de fluorinado de benzotiazole en la forma de agentes de generacion de imagen in vivo. MX341173B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0516564.2A GB0516564D0 (en) 2005-08-12 2005-08-12 Fluorination process
PCT/GB2006/003009 WO2007020400A1 (en) 2005-08-12 2006-08-11 Fluorination process of anilide derivatives and benzothiazole fluorinate derivatives as in vivo imaging agents

Publications (1)

Publication Number Publication Date
MX341173B true MX341173B (es) 2016-08-10

Family

ID=35098197

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2013013741A MX341173B (es) 2005-08-12 2006-08-11 Proceso de fluorinado de derivados de anilida y derivados de fluorinado de benzotiazole en la forma de agentes de generacion de imagen in vivo.
MX2008002068A MX2008002068A (es) 2005-08-12 2006-08-11 Proceso de fluorinado de derivados de anilida y derivados de fluorinado de benzotiazole en la forma de agentes de generacion de imagen in vivo.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2008002068A MX2008002068A (es) 2005-08-12 2006-08-11 Proceso de fluorinado de derivados de anilida y derivados de fluorinado de benzotiazole en la forma de agentes de generacion de imagen in vivo.

Country Status (21)

Country Link
US (3) US8410312B2 (es)
EP (1) EP1915330B1 (es)
JP (2) JP5566605B2 (es)
KR (2) KR101409608B1 (es)
CN (2) CN102731432B (es)
AU (1) AU2006281216B2 (es)
BR (1) BRPI0614752B1 (es)
CA (1) CA2618448C (es)
DK (1) DK1915330T3 (es)
ES (1) ES2527864T3 (es)
GB (1) GB0516564D0 (es)
HK (1) HK1177463A1 (es)
IL (1) IL188933A0 (es)
MX (2) MX341173B (es)
NO (1) NO341560B1 (es)
NZ (1) NZ565333A (es)
PL (1) PL1915330T3 (es)
PT (1) PT1915330E (es)
RU (1) RU2419601C2 (es)
WO (1) WO2007020400A1 (es)
ZA (1) ZA200801860B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0516564D0 (en) * 2005-08-12 2005-09-21 Ge Healthcare Ltd Fluorination process
US20100150835A1 (en) * 2007-02-27 2010-06-17 Bengt Langstrom Synthesis of [18F] Fluoromethyl Benzene Using Benzyl Pentafluorobenzenesulfonate
DK2182988T3 (da) * 2007-08-30 2014-05-26 Ge Healthcare Ltd Radiofarmaceutisk præparat
CA2710799C (en) 2008-01-03 2015-11-24 Ge Healthcare Limited Fluoride processing method
CA2737028C (en) 2008-09-23 2017-06-27 Wista Laboratories Ltd. Ligands for aggregated tau molecules
GB0921967D0 (en) * 2009-12-17 2010-02-03 Ge Healthcare Ltd Novel Aryloxyanilide Derivatives
GB201019303D0 (en) 2010-11-15 2010-12-29 Strom Hans E P Agents and methods for visualising analytes
CN103613589B (zh) * 2013-11-29 2016-03-30 江苏华益科技有限公司 一种用于神经退行性疾病领域的新型pet显像剂前体及标准品的合成方法
EP3226884B1 (en) 2014-12-04 2021-02-17 GE Healthcare Limited Method of removing acetaldehyde from radioactive pharmaceuticals
JP6485914B2 (ja) * 2015-10-28 2019-03-20 日本メジフィジックス株式会社 フルテメタモルの製造方法
JP6955347B2 (ja) * 2017-02-28 2021-10-27 日本メジフィジックス株式会社 フルテメタモルの製造方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3878206A (en) * 1973-06-06 1975-04-15 Morton Norwich Products Inc 9-(Substituted amino)imidazo{8 4,5-f{9 quinolines
FR2449677B1 (fr) 1979-02-26 1986-03-28 Fabre Sa Pierre Nouveaux derives de benzoyl-2 glycylanilides substitues, leur preparation et leur application en tant que medicaments anxiolytiques
FR2693781B1 (fr) * 1992-07-15 1994-10-28 Otis Elevator Co Dispositif de réglage de la tension d'un câble faisant boucle.
DE4402056A1 (de) 1994-01-25 1995-07-27 Basf Ag p-Phenylendiamin-Derivate und sie enthaltende fungizide Mittel
US7270800B2 (en) * 2000-08-24 2007-09-18 University Of Pittsburgh Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
GB0229686D0 (en) * 2002-12-20 2003-01-29 Amersham Plc Solid-phase fluorination of benzothiazoles
CN102532055B (zh) * 2003-03-14 2016-05-11 匹兹堡大学联邦制高等教育 苯并噻唑衍生物化合物、组合物及用途
CA2438032C (en) 2003-03-14 2013-05-07 University Of Pittsburgh Benzothiazole derivative compounds, compositions and uses
CN102973954A (zh) * 2004-07-02 2013-03-20 匹兹堡大学高等教育联邦体系 淀粉样蛋白成像作为抗淀粉样蛋白疗法的功效的替代标记物
GB0516564D0 (en) * 2005-08-12 2005-09-21 Ge Healthcare Ltd Fluorination process

Also Published As

Publication number Publication date
RU2419601C2 (ru) 2011-05-27
KR20080035618A (ko) 2008-04-23
JP2009507775A (ja) 2009-02-26
NO341560B1 (no) 2017-12-04
GB0516564D0 (en) 2005-09-21
IL188933A0 (en) 2008-04-13
US8410312B2 (en) 2013-04-02
HK1177463A1 (zh) 2013-08-23
WO2007020400A1 (en) 2007-02-22
US9126961B2 (en) 2015-09-08
CN102731432B (zh) 2015-10-21
AU2006281216A1 (en) 2007-02-22
AU2006281216B2 (en) 2012-01-19
US20100234611A1 (en) 2010-09-16
NO20081167L (no) 2008-03-05
CN102731432A (zh) 2012-10-17
CA2618448A1 (en) 2007-02-22
US9468694B2 (en) 2016-10-18
KR101392538B1 (ko) 2014-05-07
ES2527864T3 (es) 2015-01-30
BRPI0614752A2 (pt) 2012-12-04
PL1915330T3 (pl) 2015-03-31
RU2008103989A (ru) 2009-09-20
PT1915330E (pt) 2015-01-16
BRPI0614752B1 (pt) 2024-01-09
KR20130114279A (ko) 2013-10-16
EP1915330A1 (en) 2008-04-30
KR101409608B1 (ko) 2014-06-18
DK1915330T3 (en) 2015-01-19
US20130225829A1 (en) 2013-08-29
JP2014028837A (ja) 2014-02-13
CA2618448C (en) 2014-05-06
EP1915330B1 (en) 2014-12-10
US20150328344A1 (en) 2015-11-19
NZ565333A (en) 2011-07-29
MX2008002068A (es) 2008-04-16
CN101282920A (zh) 2008-10-08
CN101282920B (zh) 2014-06-04
JP5566605B2 (ja) 2014-08-06
ZA200801860B (en) 2008-12-31

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