CN101115739A - 制备4-(苯氧基-5-甲基-嘧啶-4-基氧基)哌啶-1-甲酸衍生物和相关化合物的方法 - Google Patents

制备4-(苯氧基-5-甲基-嘧啶-4-基氧基)哌啶-1-甲酸衍生物和相关化合物的方法 Download PDF

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Publication number
CN101115739A
CN101115739A CNA2006800018668A CN200680001866A CN101115739A CN 101115739 A CN101115739 A CN 101115739A CN A2006800018668 A CNA2006800018668 A CN A2006800018668A CN 200680001866 A CN200680001866 A CN 200680001866A CN 101115739 A CN101115739 A CN 101115739A
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China
Prior art keywords
alkyl
formamide
haloalkyl
alkoxy
alkylthio
Prior art date
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Withdrawn
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CNA2006800018668A
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English (en)
Chinese (zh)
Inventor
陶菲克·加尔巴维
约翰·R·弗里奇
阿什维·M·克里希南
贝弗利·沃尔加斯特·思鲁普
娜奥米·S·卡托
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Arena Pharmaceuticals Inc
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Arena Pharmaceuticals Inc
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Publication of CN101115739A publication Critical patent/CN101115739A/zh
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CNA2006800018668A 2005-01-10 2006-01-09 制备4-(苯氧基-5-甲基-嘧啶-4-基氧基)哌啶-1-甲酸衍生物和相关化合物的方法 Withdrawn CN101115739A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64262705P 2005-01-10 2005-01-10
US60/642,627 2005-01-10

Publications (1)

Publication Number Publication Date
CN101115739A true CN101115739A (zh) 2008-01-30

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Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2006800018668A Withdrawn CN101115739A (zh) 2005-01-10 2006-01-09 制备4-(苯氧基-5-甲基-嘧啶-4-基氧基)哌啶-1-甲酸衍生物和相关化合物的方法

Country Status (29)

Country Link
US (1) US7812159B2 (enExample)
EP (1) EP1838697B1 (enExample)
JP (1) JP2008526881A (enExample)
KR (1) KR20070098906A (enExample)
CN (1) CN101115739A (enExample)
AR (1) AR056917A1 (enExample)
AT (1) ATE462701T1 (enExample)
AU (1) AU2006205176A1 (enExample)
BR (1) BRPI0606676A2 (enExample)
CA (1) CA2593344A1 (enExample)
CR (1) CR9221A (enExample)
DE (1) DE602006013271D1 (enExample)
DK (1) DK1838697T3 (enExample)
DO (1) DOP2006000010A (enExample)
EA (1) EA014156B1 (enExample)
ES (1) ES2341281T3 (enExample)
GE (1) GEP20105071B (enExample)
GT (1) GT200600007A (enExample)
HN (1) HN2006000970A (enExample)
IL (1) IL184366A0 (enExample)
MX (1) MX2007008377A (enExample)
NO (1) NO20074055L (enExample)
NZ (1) NZ556218A (enExample)
PE (2) PE20060836A1 (enExample)
SG (1) SG158864A1 (enExample)
TW (1) TW200637844A (enExample)
UA (1) UA92733C2 (enExample)
WO (1) WO2006076243A1 (enExample)
ZA (1) ZA200705473B (enExample)

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DE602004009295T2 (de) 2003-01-14 2008-07-03 Arena Pharmaceuticals, Inc., San Diego 1,2,3-trisubstituierte aryl- und heteroarylderivate als modulatoren des metabolismus zur vorbeugung und behandlung von metabolismus-bedingten krankheiten wie diabetes oder hyperglykämie
AR045047A1 (es) * 2003-07-11 2005-10-12 Arena Pharm Inc Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
MY148521A (en) * 2005-01-10 2013-04-30 Arena Pharm Inc Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto
CA2714703A1 (en) * 2008-02-22 2009-08-27 Irm Llc Compounds and compositions as modulators of gpr119 activity
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PH12013500547A1 (en) 2010-09-22 2013-06-10 Arena Pharm Inc Modulators of the gpr119 receptor and the treatment of disorders related thereto
US9000175B2 (en) 2010-11-26 2015-04-07 Lupin Limited Bicyclic GPR119 modulators
EA031618B1 (ru) 2011-06-09 2019-01-31 Ризен Фармасьютикалз Са Соединения-модуляторы gpr-119
ES2995737T3 (en) 2015-01-06 2025-02-11 Arena Pharm Inc Compound for use in treating conditions related to the s1p1 receptor
MA42807A (fr) 2015-06-22 2018-07-25 Arena Pharm Inc Sel l-arginine cristallin d'acide (r)-2-(7-(4-cyclopentyl-3-(trifluorométhyl)benzyloxy)-1,2,3,4-tétrahydrocyclo-penta[b]indol-3-yl)acétique (composé 1) pour une utilisation dans des troubles associés au récepteur de s1p1
JP7106528B2 (ja) 2016-09-20 2022-07-26 グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッド Ｔｒｐｖ４拮抗薬
EP3515889A1 (en) 2016-09-20 2019-07-31 GlaxoSmithKline Intellectual Property (No. 2) Limited Trpv4 antagonists
TW201825458A (zh) 2016-09-20 2018-07-16 英商葛蘭素史克智慧財產（第二）有限公司 Ｔｒｐｖ４拮抗劑
WO2018151873A1 (en) 2017-02-16 2018-08-23 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of primary biliary cholangitis
EP3801459B1 (en) 2018-06-06 2024-08-07 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the s1p1 receptor

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Also Published As

Publication number Publication date
EP1838697A1 (en) 2007-10-03
GT200600007A (es) 2006-08-01
JP2008526881A (ja) 2008-07-24
MX2007008377A (es) 2007-09-07
AR056917A1 (es) 2007-11-07
ES2341281T3 (es) 2010-06-17
UA92733C2 (ru) 2010-12-10
EA014156B1 (ru) 2010-10-29
US7812159B2 (en) 2010-10-12
ATE462701T1 (de) 2010-04-15
AU2006205176A1 (en) 2006-07-20
PE20091401A1 (es) 2009-09-18
CR9221A (es) 2007-10-23
TW200637844A (en) 2006-11-01
WO2006076243A1 (en) 2006-07-20
DOP2006000010A (es) 2006-07-31
GEP20105071B (en) 2010-09-10
NZ556218A (en) 2010-10-29
US20060155129A1 (en) 2006-07-13
HN2006000970A (es) 2010-04-19
SG158864A1 (en) 2010-02-26
BRPI0606676A2 (pt) 2009-07-07
DE602006013271D1 (de) 2010-05-12
CA2593344A1 (en) 2006-07-20
EA200701470A1 (ru) 2008-02-28
ZA200705473B (en) 2009-07-29
PE20060836A1 (es) 2006-09-02
IL184366A0 (en) 2007-10-31
DK1838697T3 (da) 2010-06-28
KR20070098906A (ko) 2007-10-05
EP1838697B1 (en) 2010-03-31
HK1102810A1 (en) 2007-12-07
NO20074055L (no) 2007-09-25

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