JP2019527228A5 - - Google Patents
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- Publication number
- JP2019527228A5 JP2019527228A5 JP2019503748A JP2019503748A JP2019527228A5 JP 2019527228 A5 JP2019527228 A5 JP 2019527228A5 JP 2019503748 A JP2019503748 A JP 2019503748A JP 2019503748 A JP2019503748 A JP 2019503748A JP 2019527228 A5 JP2019527228 A5 JP 2019527228A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- hydrogen
- alkyl group
- base
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1613054.4A GB201613054D0 (en) | 2016-07-28 | 2016-07-28 | New compound and process |
| GB1613054.4 | 2016-07-28 | ||
| PCT/GB2017/052190 WO2018020249A1 (en) | 2016-07-28 | 2017-07-27 | New compound and process |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019527228A JP2019527228A (ja) | 2019-09-26 |
| JP2019527228A5 true JP2019527228A5 (enExample) | 2021-06-17 |
| JP6985367B2 JP6985367B2 (ja) | 2021-12-22 |
Family
ID=56936838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019503748A Active JP6985367B2 (ja) | 2016-07-28 | 2017-07-27 | 新規化合物および方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US10710998B2 (enExample) |
| EP (1) | EP3490988B1 (enExample) |
| JP (1) | JP6985367B2 (enExample) |
| KR (1) | KR102396059B1 (enExample) |
| CN (1) | CN109641891B (enExample) |
| CY (1) | CY1122138T1 (enExample) |
| DK (1) | DK3490988T3 (enExample) |
| ES (1) | ES2751948T3 (enExample) |
| GB (1) | GB201613054D0 (enExample) |
| HR (1) | HRP20192109T1 (enExample) |
| HU (1) | HUE046509T2 (enExample) |
| LT (1) | LT3490988T (enExample) |
| PL (1) | PL3490988T3 (enExample) |
| PT (1) | PT3490988T (enExample) |
| RS (1) | RS59566B1 (enExample) |
| SI (1) | SI3490988T1 (enExample) |
| SM (1) | SMT201900582T1 (enExample) |
| TW (1) | TWI739871B (enExample) |
| WO (1) | WO2018020249A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3142701T1 (en) | 2014-05-12 | 2018-08-31 | Verona Pharma Plc | NEW TREATMENT |
| GB201502260D0 (en) | 2015-02-11 | 2015-04-01 | Verona Pharma Plc | Salt of Pyrimido[6,1-A]Isoquinolin-4-one compound |
| MX2022008805A (es) * | 2020-01-17 | 2022-08-11 | Lupin Ltd | Metodos, procesos e intermedios para preparar compuestos cromanos. |
| KR20240004495A (ko) | 2021-04-29 | 2024-01-11 | 쑤저우 선카디아 바이오파마수티컬즈 컴퍼니 리미티드 | 이소퀴놀론 화합물과 이의 용도 |
| EP4450500A4 (en) * | 2021-12-14 | 2025-10-15 | Xizang Haisco Pharmaceutical Co Ltd | TRICYCLIC FUSED HETEROCYCLIC PDE3/4 DUAL INHIBITOR AND ITS USE |
| GB202202297D0 (en) | 2022-02-21 | 2022-04-06 | Verona Pharma Plc | Formulation production process |
| EP4378942A1 (en) | 2022-12-02 | 2024-06-05 | Sandoz AG | Crystal form of a pde3/4 inhibitor |
| TW202506117A (zh) | 2023-06-26 | 2025-02-16 | 英商維羅納製藥Ｐｌｃ公司 | 顆粒組成物 |
| WO2025003643A1 (en) | 2023-06-26 | 2025-01-02 | Verona Pharma Plc | Particulate composition comprising ensifetrine |
| WO2025052119A1 (en) | 2023-09-06 | 2025-03-13 | Verona Pharma Plc | Ensifentrine for use in treating chronic obstructive pulmonary disease (copd) |
| US20250249008A1 (en) | 2024-02-07 | 2025-08-07 | Verona Pharma Plc | Pharmaceutical compositions of ensifentrine for chronic obstructive pulmonary disease |
| WO2025168706A1 (en) | 2024-02-07 | 2025-08-14 | Verona Pharma Plc | Pharmaceutical compositions of ensifentrine for chronic obstructive pulmonary disease |
| WO2025176871A1 (en) | 2024-02-23 | 2025-08-28 | Inke, S.A. | Process for preparing pyrimido[6,1-a]isoquinoline-4-ones |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ185900A (en) | 1976-12-10 | 1981-04-24 | Hoechst Ag | Pyrimido (6,1-a) isoquinolin-4-ones medicaments intermediate isoquinolines |
| FI64370C (fi) | 1977-05-05 | 1983-11-10 | Hoechst Ag | Foerfarande foer framstaellning av terapeutiskt anvaendbara pyimido-(6,1-a)isokinolin-2-imino-4-onderivat |
| DE2847693A1 (de) | 1978-11-03 | 1980-05-22 | Hoechst Ag | Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen |
| DE3135831A1 (de) | 1981-09-10 | 1983-04-28 | Hoechst Ag, 6230 Frankfurt | 9,10-substituierte 2-mesitylimino-3-alkyl-3,4,6,7-tetrahydro-2h-pyrimido(6,1-a)isochinolin-4-one, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| CA1237429A (en) | 1983-05-05 | 1988-05-31 | Frank Kienzle | Pyrimidone derivatives |
| CN100415743C (zh) * | 1999-03-31 | 2008-09-03 | 韦尔纳利斯有限公司 | 嘧啶并[6,1-a] 异喹啉-4-酮衍生物 |
| AR082601A1 (es) | 2010-08-09 | 2012-12-19 | Verona Pharma Plc | Formas cristalinas de compuestos de pirimido[6,1-a]isoquinolin-4-ona |
| US9700558B2 (en) | 2013-03-15 | 2017-07-11 | Verona Pharma Plc | Drug combination of PDE3/PDE4 inhibitor and muscarinic receptor antagonist |
| SI3142701T1 (en) | 2014-05-12 | 2018-08-31 | Verona Pharma Plc | NEW TREATMENT |
| HUE055527T2 (hu) | 2014-09-15 | 2021-12-28 | Verona Pharma Plc | RPL554-t tartalmazó folyékony inhalációs készítmény |
| GB201502260D0 (en) | 2015-02-11 | 2015-04-01 | Verona Pharma Plc | Salt of Pyrimido[6,1-A]Isoquinolin-4-one compound |
-
2016
- 2016-07-28 GB GBGB1613054.4A patent/GB201613054D0/en not_active Ceased
-
2017
- 2017-07-27 PT PT177488806T patent/PT3490988T/pt unknown
- 2017-07-27 DK DK17748880T patent/DK3490988T3/da active
- 2017-07-27 ES ES17748880T patent/ES2751948T3/es active Active
- 2017-07-27 EP EP17748880.6A patent/EP3490988B1/en active Active
- 2017-07-27 KR KR1020197004436A patent/KR102396059B1/ko active Active
- 2017-07-27 JP JP2019503748A patent/JP6985367B2/ja active Active
- 2017-07-27 SM SM20190582T patent/SMT201900582T1/it unknown
- 2017-07-27 CN CN201780046788.1A patent/CN109641891B/zh active Active
- 2017-07-27 HU HUE17748880A patent/HUE046509T2/hu unknown
- 2017-07-27 TW TW106125312A patent/TWI739871B/zh active
- 2017-07-27 HR HRP20192109TT patent/HRP20192109T1/hr unknown
- 2017-07-27 SI SI201730098T patent/SI3490988T1/sl unknown
- 2017-07-27 LT LTEP17748880.6T patent/LT3490988T/lt unknown
- 2017-07-27 PL PL17748880T patent/PL3490988T3/pl unknown
- 2017-07-27 RS RS20191474A patent/RS59566B1/sr unknown
- 2017-07-27 WO PCT/GB2017/052190 patent/WO2018020249A1/en not_active Ceased
- 2017-07-27 US US16/309,435 patent/US10710998B2/en active Active
-
2019
- 2019-10-04 CY CY20191101046T patent/CY1122138T1/el unknown
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