RS59566B1 - Novo jedinjenje i postupak - Google Patents
Novo jedinjenje i postupakInfo
- Publication number
- RS59566B1 RS59566B1 RS20191474A RSP20191474A RS59566B1 RS 59566 B1 RS59566 B1 RS 59566B1 RS 20191474 A RS20191474 A RS 20191474A RS P20191474 A RSP20191474 A RS P20191474A RS 59566 B1 RS59566 B1 RS 59566B1
- Authority
- RS
- Serbia
- Prior art keywords
- compound
- formula
- hydrogen
- reaction
- carbonate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1613054.4A GB201613054D0 (en) | 2016-07-28 | 2016-07-28 | New compound and process |
| EP17748880.6A EP3490988B1 (en) | 2016-07-28 | 2017-07-27 | New compound and process |
| PCT/GB2017/052190 WO2018020249A1 (en) | 2016-07-28 | 2017-07-27 | New compound and process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS59566B1 true RS59566B1 (sr) | 2019-12-31 |
Family
ID=56936838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20191474A RS59566B1 (sr) | 2016-07-28 | 2017-07-27 | Novo jedinjenje i postupak |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US10710998B2 (enExample) |
| EP (1) | EP3490988B1 (enExample) |
| JP (1) | JP6985367B2 (enExample) |
| KR (1) | KR102396059B1 (enExample) |
| CN (1) | CN109641891B (enExample) |
| CY (1) | CY1122138T1 (enExample) |
| DK (1) | DK3490988T3 (enExample) |
| ES (1) | ES2751948T3 (enExample) |
| GB (1) | GB201613054D0 (enExample) |
| HR (1) | HRP20192109T1 (enExample) |
| HU (1) | HUE046509T2 (enExample) |
| LT (1) | LT3490988T (enExample) |
| PL (1) | PL3490988T3 (enExample) |
| PT (1) | PT3490988T (enExample) |
| RS (1) | RS59566B1 (enExample) |
| SI (1) | SI3490988T1 (enExample) |
| SM (1) | SMT201900582T1 (enExample) |
| TW (1) | TWI739871B (enExample) |
| WO (1) | WO2018020249A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3231444T1 (sl) | 2014-05-12 | 2020-04-30 | Verona Pharma Plc | Novo zdravljenje |
| GB201502260D0 (en) | 2015-02-11 | 2015-04-01 | Verona Pharma Plc | Salt of Pyrimido[6,1-A]Isoquinolin-4-one compound |
| EP4090654B1 (en) * | 2020-01-17 | 2025-07-09 | Lupin Limited | Methods, processes and intermediates for preparing chroman compounds |
| JP2024517583A (ja) | 2021-04-29 | 2024-04-23 | ▲蘇▼州盛迪▲亞▼生物医▲薬▼有限公司 | イソキノリノン系化合物及びその用途 |
| WO2023109802A1 (zh) * | 2021-12-14 | 2023-06-22 | 海思科医药集团股份有限公司 | 三环稠杂环类pde3/4双重抑制及其用途 |
| GB202202297D0 (en) | 2022-02-21 | 2022-04-06 | Verona Pharma Plc | Formulation production process |
| EP4378942A1 (en) | 2022-12-02 | 2024-06-05 | Sandoz AG | Crystal form of a pde3/4 inhibitor |
| WO2025003643A1 (en) | 2023-06-26 | 2025-01-02 | Verona Pharma Plc | Particulate composition comprising ensifetrine |
| TW202506117A (zh) | 2023-06-26 | 2025-02-16 | 英商維羅納製藥Ｐｌｃ公司 | 顆粒組成物 |
| US20250073240A1 (en) | 2023-09-06 | 2025-03-06 | Verona Pharma Plc | New treatment |
| US20250249008A1 (en) | 2024-02-07 | 2025-08-07 | Verona Pharma Plc | Pharmaceutical compositions of ensifentrine for chronic obstructive pulmonary disease |
| WO2025168706A1 (en) | 2024-02-07 | 2025-08-14 | Verona Pharma Plc | Pharmaceutical compositions of ensifentrine for chronic obstructive pulmonary disease |
| WO2025176871A1 (en) | 2024-02-23 | 2025-08-28 | Inke, S.A. | Process for preparing pyrimido[6,1-a]isoquinoline-4-ones |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ185900A (en) | 1976-12-10 | 1981-04-24 | Hoechst Ag | Pyrimido (6,1-a) isoquinolin-4-ones medicaments intermediate isoquinolines |
| FI64370C (fi) | 1977-05-05 | 1983-11-10 | Hoechst Ag | Foerfarande foer framstaellning av terapeutiskt anvaendbara pyimido-(6,1-a)isokinolin-2-imino-4-onderivat |
| DE2847693A1 (de) | 1978-11-03 | 1980-05-22 | Hoechst Ag | Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen |
| DE3135831A1 (de) | 1981-09-10 | 1983-04-28 | Hoechst Ag, 6230 Frankfurt | 9,10-substituierte 2-mesitylimino-3-alkyl-3,4,6,7-tetrahydro-2h-pyrimido(6,1-a)isochinolin-4-one, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| CA1237429A (en) | 1983-05-05 | 1988-05-31 | Frank Kienzle | Pyrimidone derivatives |
| EP1165558B1 (en) | 1999-03-31 | 2003-09-24 | Vernalis Limited | Derivatives of pyrimido[6,1-a]isoquinolin-4-one |
| PH12013500261A1 (en) | 2010-08-09 | 2013-03-04 | Verona Pharma Plc | Crystalline form of pyrimidio[6,1-a]isoquinolin-4-one compound |
| PT2968313T (pt) | 2013-03-15 | 2018-02-21 | Verona Pharma Plc | Combinação de fármacos |
| SI3231444T1 (sl) | 2014-05-12 | 2020-04-30 | Verona Pharma Plc | Novo zdravljenje |
| DK3494962T3 (da) | 2014-09-15 | 2021-06-21 | Verona Pharma Plc | Flydende inhalationsformulering omfattende RPL554 |
| GB201502260D0 (en) | 2015-02-11 | 2015-04-01 | Verona Pharma Plc | Salt of Pyrimido[6,1-A]Isoquinolin-4-one compound |
-
2016
- 2016-07-28 GB GBGB1613054.4A patent/GB201613054D0/en not_active Ceased
-
2017
- 2017-07-27 KR KR1020197004436A patent/KR102396059B1/ko active Active
- 2017-07-27 ES ES17748880T patent/ES2751948T3/es active Active
- 2017-07-27 US US16/309,435 patent/US10710998B2/en active Active
- 2017-07-27 LT LTEP17748880.6T patent/LT3490988T/lt unknown
- 2017-07-27 TW TW106125312A patent/TWI739871B/zh active
- 2017-07-27 RS RS20191474A patent/RS59566B1/sr unknown
- 2017-07-27 JP JP2019503748A patent/JP6985367B2/ja active Active
- 2017-07-27 HU HUE17748880A patent/HUE046509T2/hu unknown
- 2017-07-27 DK DK17748880T patent/DK3490988T3/da active
- 2017-07-27 WO PCT/GB2017/052190 patent/WO2018020249A1/en not_active Ceased
- 2017-07-27 PT PT177488806T patent/PT3490988T/pt unknown
- 2017-07-27 EP EP17748880.6A patent/EP3490988B1/en active Active
- 2017-07-27 SI SI201730098T patent/SI3490988T1/sl unknown
- 2017-07-27 PL PL17748880T patent/PL3490988T3/pl unknown
- 2017-07-27 SM SM20190582T patent/SMT201900582T1/it unknown
- 2017-07-27 CN CN201780046788.1A patent/CN109641891B/zh active Active
- 2017-07-27 HR HRP20192109TT patent/HRP20192109T1/hr unknown
-
2019
- 2019-10-04 CY CY20191101046T patent/CY1122138T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TWI739871B (zh) | 2021-09-21 |
| EP3490988A1 (en) | 2019-06-05 |
| TW201806951A (zh) | 2018-03-01 |
| KR102396059B1 (ko) | 2022-05-10 |
| JP6985367B2 (ja) | 2021-12-22 |
| CN109641891B (zh) | 2021-05-04 |
| HUE046509T2 (hu) | 2020-03-30 |
| SI3490988T1 (sl) | 2019-11-29 |
| EP3490988B1 (en) | 2019-08-28 |
| ES2751948T3 (es) | 2020-04-02 |
| KR20190034231A (ko) | 2019-04-01 |
| GB201613054D0 (en) | 2016-09-14 |
| US20190330206A1 (en) | 2019-10-31 |
| PL3490988T3 (pl) | 2020-02-28 |
| SMT201900582T1 (it) | 2019-11-13 |
| LT3490988T (lt) | 2019-10-10 |
| PT3490988T (pt) | 2019-10-28 |
| CY1122138T1 (el) | 2020-11-25 |
| WO2018020249A1 (en) | 2018-02-01 |
| HRP20192109T1 (hr) | 2020-02-21 |
| DK3490988T3 (da) | 2019-10-28 |
| CN109641891A (zh) | 2019-04-16 |
| JP2019527228A (ja) | 2019-09-26 |
| US10710998B2 (en) | 2020-07-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RS59566B1 (sr) | Novo jedinjenje i postupak | |
| CA3039090C (en) | Process for preparing btk inhibitors | |
| CN102448942A (zh) | 艾曲波帕和艾曲波帕盐的多晶型物及其制备方法 | |
| WO2014093579A2 (en) | Crystalline forms of 3-(imidazo[1,2-b] pyridazin-3-ylethynyl)-4-methyl-n-(4-[(4-methylpiperazin-1-yl) methyl]-3-(trifluoromethyl)phenyl)benzamide and its mono hydrochloride salt | |
| JP2024505911A (ja) | アミド形成によるサルカプロジン酸の新規合成 | |
| WO2017025981A1 (en) | Process for the preparation of methyl 4,6-diamino-2-[l-(2-fhiorobenzvr)-lh-pyrazolo i3,4-blpvridin-3-vn-5-pyrimidinyl(methvl)carbamate and its polymorphs thereof | |
| EP4046687A1 (en) | Method for producing centanafadine | |
| AU2014389984A1 (en) | Process of preparing a quinazoline derivative | |
| US20220363680A1 (en) | Processes for the synthesis of valbenazine | |
| US10947170B2 (en) | Process for the preparation of deuterated ethanol from D2O | |
| TW201625632A (zh) | Ｐｉ３ｋ抑制劑及其鹽之合成 | |
| HK40002783B (en) | New compound and process | |
| HK40002783A (en) | New compound and process | |
| JP7320113B2 (ja) | ヘテロシクリデンアセトアミド誘導体の製造方法 | |
| WO2019064222A1 (en) | CRYSTALLINE FORMS OF LENALIDOMIDE | |
| GB2317888A (en) | Acridone derivatives and preparation of 8-hydroxy-imidazoacridinone derivatives | |
| CN110872270A (zh) | 一种环己烷衍生物的盐 | |
| Xia et al. | A convenient synthesis of N, N, N'-trisubstituted ethylenediamine derivatives from 2-methyl-2-imidazoline | |
| WO2023230236A1 (en) | Process for preparing jak inhibitors and intermediates thereof | |
| JP2024525477A (ja) | ４－アミノ－ｎ－（１－（（３－クロロ－２－フルオロフェニル）アミノ）－６－メチルイソキノリン－５－イル）チエノ［３，２－ｄ］ピリミジン－７－カルボキサミドのビス－メシレート塩及びその中間体の合成 | |
| HK40090878A (zh) | 用於制备1-甲基-6-[6-r2-5-甲基-8-(甲基氨基)-4-[(3as，6as)-5-甲基-2，3，3a，4，6，6a-六氢吡咯并[2，3-c]吡咯-1-基]-9h-吡啶并[2，3-b]吲哚-3-基]-4-氧代-1，8-萘啶-3-甲酸盐酸盐的方法 | |
| CN120535430A (zh) | 一种无定形奥马环素及其对甲苯磺酸盐的制备方法 | |
| HK40031447B (en) | Method for preparing sulfonamides drugs | |
| HK40031447A (en) | Method for preparing sulfonamides drugs | |
| CA3161387A1 (en) | Process for the preparation of purine derivatives exhibiting cdk inhibitory activity |