JP2008520702A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008520702A5 JP2008520702A5 JP2007543263A JP2007543263A JP2008520702A5 JP 2008520702 A5 JP2008520702 A5 JP 2008520702A5 JP 2007543263 A JP2007543263 A JP 2007543263A JP 2007543263 A JP2007543263 A JP 2007543263A JP 2008520702 A5 JP2008520702 A5 JP 2008520702A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- triazole
- mercapto
- phenyl
- dihydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62897904P | 2004-11-18 | 2004-11-18 | |
| US60/628,979 | 2004-11-18 | ||
| US70935805P | 2005-08-18 | 2005-08-18 | |
| US60/709,358 | 2005-08-18 | ||
| US72504405P | 2005-10-06 | 2005-10-06 | |
| US60/725,044 | 2005-10-06 | ||
| PCT/US2005/041779 WO2006055760A1 (en) | 2004-11-18 | 2005-11-17 | Triazole compounds that modulate hsp90 activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008520702A JP2008520702A (ja) | 2008-06-19 |
| JP2008520702A5 true JP2008520702A5 (enExample) | 2009-01-08 |
| JP4954083B2 JP4954083B2 (ja) | 2012-06-13 |
Family
ID=35966006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007543263A Expired - Fee Related JP4954083B2 (ja) | 2004-11-18 | 2005-11-17 | Hsp90活性を調節するトリアゾール化合物 |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US7825148B2 (enExample) |
| EP (3) | EP2298748B1 (enExample) |
| JP (1) | JP4954083B2 (enExample) |
| KR (2) | KR101374553B1 (enExample) |
| CN (2) | CN103554042B (enExample) |
| AU (1) | AU2005306484C1 (enExample) |
| BR (1) | BRPI0518315B8 (enExample) |
| CA (1) | CA2586612C (enExample) |
| DK (1) | DK1817295T3 (enExample) |
| ES (2) | ES2594874T3 (enExample) |
| HR (1) | HRP20130095T1 (enExample) |
| IL (1) | IL183108A (enExample) |
| ME (1) | ME01498B (enExample) |
| MX (1) | MX2007005940A (enExample) |
| NZ (1) | NZ555158A (enExample) |
| PL (1) | PL1817295T3 (enExample) |
| PT (1) | PT1817295E (enExample) |
| RS (1) | RS52642B (enExample) |
| TW (1) | TWI380983B (enExample) |
| WO (1) | WO2006055760A1 (enExample) |
Families Citing this family (111)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7538241B2 (en) * | 2003-12-26 | 2009-05-26 | Kyowa Hakko Kogyo Co., Ltd. | Hsp90 family protein inhibitors |
| EP2298748B1 (en) * | 2004-11-18 | 2016-07-20 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate HSP90 activity |
| DE102005007304A1 (de) * | 2005-02-17 | 2006-08-24 | Merck Patent Gmbh | Triazolderivate |
| JP5044730B2 (ja) * | 2005-03-09 | 2012-10-10 | 日本化薬株式会社 | 新規なhsp90阻害剤 |
| US20080306054A1 (en) | 2005-04-13 | 2008-12-11 | Astex Therapeutics Limited | Pharmaceutical Compounds |
| US7608635B2 (en) | 2005-08-12 | 2009-10-27 | Synta Pharmaceuticals Corp. | Pyrazole compounds that modulate HSP90 activity |
| EP1928846B1 (en) | 2005-08-18 | 2014-06-04 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate hsp90 activity |
| CA2618724A1 (en) | 2005-08-18 | 2007-02-22 | Synta Pharmaceuticals Corp. | Imidazole compounds that modulate hsp90 activity |
| US7754725B2 (en) | 2006-03-01 | 2010-07-13 | Astex Therapeutics Ltd. | Dihydroxyphenyl isoindolymethanones |
| JP5249016B2 (ja) | 2006-03-28 | 2013-07-31 | 日本化薬株式会社 | タキサン類の高分子結合体 |
| US20070250391A1 (en) * | 2006-04-05 | 2007-10-25 | Prade Hendrik D | Merchandising system and method for food and non-food items for a meal kit |
| CA2652656A1 (en) | 2006-05-18 | 2007-11-29 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight conjugate of podophyllotoxins |
| TW200806637A (en) * | 2006-05-25 | 2008-02-01 | Synta Pharmaceuticals Corp | Synthesis of triazole compounds that modulate HSP90 activity |
| TW200804313A (en) * | 2006-05-25 | 2008-01-16 | Synta Pharmaceuticals Corp | Triazole compounds that modulate HSP90 activity |
| AU2007267803B2 (en) | 2006-05-25 | 2011-08-25 | Synta Pharmaceuticals Corp. | Method for treating non-Hodgkin's lymphoma |
| CA2653329C (en) * | 2006-05-25 | 2018-01-16 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate hsp90 activity |
| TWI490212B (zh) * | 2006-05-25 | 2015-07-01 | Synta Pharmaceuticals Corp | 調節hsp90活性之三唑化合物 |
| AU2012200157B2 (en) * | 2006-05-25 | 2014-08-21 | Synta Pharmaceuticals Corp. | Method for treating proliferative disorders associated with protooncogene products |
| EP2034995A2 (en) * | 2006-05-25 | 2009-03-18 | Synta Pharmaceuticals Corporation | Method for treating proliferative disorders associated with protooncogene products |
| US20080027047A1 (en) * | 2006-05-25 | 2008-01-31 | Weiwen Ying | Compounds that modulate HSP90 activity and methods for identifying same |
| AU2007284537B2 (en) * | 2006-08-17 | 2012-04-12 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate HSP90 activity |
| WO2008041610A1 (fr) | 2006-10-03 | 2008-04-10 | Nippon Kayaku Kabushiki Kaisha | Mélange d'un dérivé de résorcinol avec un polymère |
| WO2008044041A1 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical combinations |
| GB0620259D0 (en) * | 2006-10-12 | 2006-11-22 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| WO2008044045A1 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical combinations |
| JP5518478B2 (ja) | 2006-10-12 | 2014-06-11 | アステックス、セラピューティックス、リミテッド | 医薬化合物 |
| US20110046125A1 (en) * | 2006-10-19 | 2011-02-24 | Synta Pharmaceuticals Corp. | Method for treating infections |
| FR2907453B1 (fr) | 2006-10-24 | 2008-12-26 | Sanofi Aventis Sa | Nouveaux derives du fluorene,compositions les contenant et utilisation |
| WO2008057246A2 (en) * | 2006-10-26 | 2008-05-15 | Synta Pharmaceuticals Corp. | Method for treating inflammatory disorders |
| EP2080779B1 (en) | 2006-11-06 | 2016-05-18 | Nippon Kayaku Kabushiki Kaisha | Polymeric derivative of nucleic acid metabolic antagonist |
| EP2090607B1 (en) | 2006-11-08 | 2015-05-20 | Nippon Kayaku Kabushiki Kaisha | Polymeric derivative of nucleic acid metabolic antagonist |
| DE102007002715A1 (de) * | 2007-01-18 | 2008-07-24 | Merck Patent Gmbh | Triazolderivat |
| CN101679319B (zh) * | 2007-02-08 | 2014-07-09 | 辛塔医药品有限公司 | 用于治疗增生性病症如癌症的三唑类化合物 |
| TW200904417A (en) * | 2007-02-20 | 2009-02-01 | Synta Pharmaceuticals Corp | Triazole compounds that modulate Hsp90 activity |
| US8993608B2 (en) * | 2007-03-12 | 2015-03-31 | Synta Pharmaceuticals Corp. | Method for inhibiting topoisomerase II |
| WO2008153730A2 (en) * | 2007-05-25 | 2008-12-18 | Synta Pharmaceuticals Corp. | Method for treating proliferative disorders associated with mutations in c-met |
| TWI438199B (zh) * | 2007-08-13 | 2014-05-21 | Synta Pharmaceuticals Corp | 調控hsp90活性的三唑化合物 |
| USRE46190E1 (en) | 2007-09-28 | 2016-11-01 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight conjugate of steroids |
| JP4792128B2 (ja) * | 2007-10-12 | 2011-10-12 | アークル インコーポレイテッド | 癌に対するhsp90阻害剤としての5−(2−ヒドロキシフェニル)テトラゾール |
| GB0722680D0 (en) * | 2007-11-19 | 2007-12-27 | Topotarget As | Therapeutic compounds and their use |
| KR100947696B1 (ko) * | 2007-11-23 | 2010-03-16 | 재단법인서울대학교산학협력재단 | 1,2,4-트리아졸 유도체를 함유하는 Hsp90 억제제 및이를 이용한 항암제 |
| KR20100115789A (ko) | 2008-02-04 | 2010-10-28 | 머큐리 테라퓨틱스, 인코포레이티드 | Ampk 조절자 |
| FR2928645A1 (fr) | 2008-03-14 | 2009-09-18 | Sanofi Aventis Sa | Nouveaux derives de carbazole inhibiteurs d'hsp90, compositions les contenant et utilisation |
| JP5687899B2 (ja) | 2008-03-18 | 2015-03-25 | 日本化薬株式会社 | 生理活性物質の高分子結合体 |
| WO2009136572A1 (ja) | 2008-05-08 | 2009-11-12 | 日本化薬株式会社 | 葉酸若しくは葉酸誘導体の高分子結合体 |
| US9156836B2 (en) * | 2008-05-16 | 2015-10-13 | Synta Pharmaceuticals Corp. | Tricyclic triazole compounds that modulate HSP90 activity |
| US8450500B2 (en) | 2008-06-04 | 2013-05-28 | Synta Pharmaceuticals Corp. | Pyrrole compounds that modulate HSP90 activity |
| WO2009158026A1 (en) | 2008-06-27 | 2009-12-30 | Synta Pharmaceuticals Corp. | Hydrazonamide compounds that modulate hsp90 activity |
| EP2323737A2 (en) | 2008-08-08 | 2011-05-25 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate hsp90 activity |
| ES2415234T3 (es) * | 2008-08-08 | 2013-07-24 | Synta Pharmaceuticals Corp. | Compuestos de triazol que modulan la actividad Hsp90 |
| EP2431403B1 (en) | 2009-05-15 | 2016-09-28 | Nipponkayaku Kabushikikaisha | Polymer conjugate of bioactive substance having hydroxy group |
| AR077405A1 (es) * | 2009-07-10 | 2011-08-24 | Sanofi Aventis | Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer |
| FR2949467B1 (fr) | 2009-09-03 | 2011-11-25 | Sanofi Aventis | Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation |
| AU2010308306A1 (en) | 2009-10-19 | 2012-05-10 | Synta Pharmaceuticals Corp. | Combination cancer therapy with HSP90 inhibitory compounds |
| WO2011133521A2 (en) | 2010-04-19 | 2011-10-27 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of a hsp90 inhibitory compounds and a vegf inhibitor |
| EP2560640A1 (en) * | 2010-04-19 | 2013-02-27 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of a hsp90 inhibitory compounds and a egfr inhibitor |
| AU2011255438A1 (en) | 2010-05-20 | 2013-01-10 | Synta Pharmaceuticals Corp. | Method of treating lung adenocarcinoma with Hsp90 inhibitory compounds |
| US20130172333A1 (en) | 2010-05-20 | 2013-07-04 | Synta Pharmaceuticals Corp. | Formulation and dosing of hsp90 inhibitory compounds |
| EP2575810A1 (en) | 2010-05-24 | 2013-04-10 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of a hsp90 inhibitory compound and a topoisomerase ii inhibitor |
| JPWO2012026433A1 (ja) | 2010-08-23 | 2013-10-28 | 第一三共株式会社 | 三環性ピラゾロピリミジン誘導体のフリー体結晶 |
| AU2011302344B2 (en) | 2010-09-13 | 2015-01-15 | Synta Pharmaceuticals Corp. | HSP90 inhibitors for treating non-small cell lung cancers in wild-type EGFR and/or KRAS patients |
| WO2012067138A1 (ja) | 2010-11-17 | 2012-05-24 | 日本化薬株式会社 | 新規なシチジン系代謝拮抗剤の高分子誘導体 |
| CA2817564A1 (en) | 2010-11-18 | 2012-05-24 | Ronald K. Blackman | Preselection of subjects for therapeutic treatment based on hypoxic status |
| EP2640384A1 (en) | 2010-11-18 | 2013-09-25 | Synta Pharmaceuticals Corp. | Preselection of subjects for therapeutic treatment with oxygen sensitive agents based on hypoxic status |
| WO2012078757A2 (en) | 2010-12-08 | 2012-06-14 | Synta Pharmaceuticals Corp. | Combination breast cancer therapy with hsp90 inhibitory compounds |
| JP2014501232A (ja) | 2010-12-20 | 2014-01-20 | シグマ−タウ・リサーチ・スウィッツァーランド・ソシエテ・アノニム | 抗腫瘍活性を有するアリールトリアゾール化合物 |
| EP2663305A1 (en) | 2011-01-11 | 2013-11-20 | Synta Pharmaceuticals Corp. | Combination therapy of hsp90 inhibitory compounds with proteasome inhibitors |
| EP2678013A1 (en) | 2011-02-23 | 2014-01-01 | Synta Pharmaceuticals Corp. | Combination therapy of hsp90 inhibitory compounds with radiotherapy |
| EP2678014A2 (en) * | 2011-02-24 | 2014-01-01 | Synta Pharmaceuticals Corp. | Prostate cancer therapy with hsp90 inhibitory compounds |
| WO2012116247A1 (en) | 2011-02-25 | 2012-08-30 | Synta Pharmaceuticals Corp. | Hsp90 inhibitory compounds in treating jak/stat signaling-mediated cancers |
| US20140228418A1 (en) * | 2011-05-23 | 2014-08-14 | Synta Pharmaceuticals Corp. | Combination therapy of hsp90 inhibitory compounds with mek inhibitors |
| US20140315943A1 (en) | 2011-05-24 | 2014-10-23 | Synta Pharmaceuticals Corp. | Combination therapy of hsp90 inhibitory compounds with mtor/p13k inhibitors |
| US20140194388A1 (en) * | 2011-05-26 | 2014-07-10 | Synta Pharmaceuticals Corp. | Combination therapy of hsp90 inhibitory compounds with chk inhibitors |
| JP2014520808A (ja) | 2011-07-07 | 2014-08-25 | シンタ ファーマシューティカルズ コーポレーション | Hsp90阻害化合物を用いた癌の治療 |
| JP2014524469A (ja) * | 2011-08-19 | 2014-09-22 | シンタ ファーマシューティカルズ コーポレーション | 代謝拮抗剤とhsp90阻害剤の組み合わせ癌療法 |
| ES2635117T3 (es) | 2011-09-11 | 2017-10-02 | Nippon Kayaku Kabushiki Kaisha | Método para la fabricación de un copolímero de bloques |
| JP2014534228A (ja) | 2011-11-02 | 2014-12-18 | シンタ ファーマシューティカルズ コーポレーション | 白金含有剤とhsp90阻害剤の組合せ療法 |
| WO2013067162A1 (en) | 2011-11-02 | 2013-05-10 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of hsp90 inhibitors with topoisomerase i inhibitors |
| EP2780010A1 (en) | 2011-11-14 | 2014-09-24 | Synta Pharmaceuticals Corp. | Combination therapy of hsp90 inhibitors with braf inhibitors |
| AU2013239663A1 (en) * | 2012-03-28 | 2014-10-09 | Synta Pharmaceuticals Corp. | Triazole derivatives as HSP90 inhibitors |
| US20140079636A1 (en) | 2012-04-16 | 2014-03-20 | Dinesh U. Chimmanamada | Targeted therapeutics |
| AU2013259267A1 (en) | 2012-05-10 | 2014-11-06 | Synta Pharmaceuticals Corp. | Treating cancer with Hsp90 inhibitory compounds |
| EP2887804B1 (en) | 2012-05-22 | 2021-01-27 | Trustees of Dartmouth College | Cycloalkanyl[b]indoles useful as glp-1 modulators |
| US20150283147A1 (en) * | 2012-10-19 | 2015-10-08 | Synta Pharmaceuticals Corp. | Treating polycystic kidney disease with hsp90 inhibitory compounds |
| EP3035938B1 (en) | 2013-09-10 | 2020-08-19 | Madrigal Pharmaceuticals, Inc. | Targeted therapeutics |
| WO2015066053A2 (en) * | 2013-10-28 | 2015-05-07 | Synta Pharmaceuticals Corp. | Targeted therapeutics |
| CN106456795A (zh) | 2014-03-03 | 2017-02-22 | 辛塔医药品有限公司 | 靶向治疗学 |
| KR101711732B1 (ko) * | 2014-04-30 | 2017-03-02 | 경북대학교 산학협력단 | 3-아릴-1,2,4-트라이아졸 유도체 및 이의 용도 |
| WO2015167211A1 (ko) * | 2014-04-30 | 2015-11-05 | 경북대학교 산학협력단 | 3-아릴-1,2,4-트라이아졸 유도체 및 이의 용도 |
| RS62713B1 (sr) | 2014-08-11 | 2022-01-31 | Acerta Pharma Bv | Terapeutske kombinacije btk inhibitora i bcl-2 inhibitora |
| HRP20220738T1 (hr) | 2014-08-11 | 2022-08-19 | Acerta Pharma B.V. | Terapijske kombinacije inhibitora btk, inhibitora pd-1 i/ili inhibitora pd-l1 |
| US20170224819A1 (en) | 2014-08-11 | 2017-08-10 | Acerta Pharma B.V. | Therapeutic Combinations of a BTK Inhibitor, a PI3K Inhibitor, a JAK-2 Inhibitor, and/or a CDK 4/6 Inhibitor |
| CN107108591B (zh) * | 2015-01-22 | 2020-05-05 | 正大天晴药业集团股份有限公司 | 作为hsp90抑制剂的间苯二酚类衍生物 |
| BR112017016973A2 (pt) | 2015-02-09 | 2018-04-03 | Synta Pharmaceuticals Corp. | terapia de combinação de inibidores de hsp90 e inibidores de pd-1 para tratamento de câncer |
| AU2016263564B2 (en) | 2015-05-20 | 2019-12-05 | Amgen Inc. | Triazole agonists of the APJ receptor |
| CN106349233B (zh) * | 2015-07-15 | 2021-06-01 | 上海翰森生物医药科技有限公司 | 3,4-二苯基-4h-1,2,4-三唑衍生物及其制备方法和应用 |
| EP3380970B1 (en) | 2015-11-24 | 2023-01-04 | Sanford Burnham Prebys Medical Discovery Institute | Novel azole derivatives as apelin receptor agonist |
| MX2018010223A (es) | 2016-02-29 | 2018-11-09 | Synta Pharmaceuticals Corp | Terapia combinada para tratamiento de cancer de ovario. |
| US9988369B2 (en) | 2016-05-03 | 2018-06-05 | Amgen Inc. | Heterocyclic triazole compounds as agonists of the APJ receptor |
| US10906890B2 (en) | 2016-11-16 | 2021-02-02 | Amgen Inc. | Triazole phenyl compounds as agonists of the APJ receptor |
| US11191762B2 (en) | 2016-11-16 | 2021-12-07 | Amgen Inc. | Alkyl substituted triazole compounds as agonists of the APJ Receptor |
| US10689367B2 (en) | 2016-11-16 | 2020-06-23 | Amgen Inc. | Triazole pyridyl compounds as agonists of the APJ receptor |
| WO2018097944A1 (en) | 2016-11-16 | 2018-05-31 | Amgen Inc. | Triazole furan compounds as agonists of the apj receptor |
| US11046680B1 (en) | 2016-11-16 | 2021-06-29 | Amgen Inc. | Heteroaryl-substituted triazoles as APJ receptor agonists |
| WO2018093577A1 (en) | 2016-11-16 | 2018-05-24 | Amgen Inc. | Cycloalkyl substituted triazole compounds as agonists of the apj receptor |
| CN109666022B (zh) * | 2017-10-17 | 2021-06-15 | 中国科学院上海药物研究所 | 三氮唑衍生物及其制备方法和用途 |
| MA50509A (fr) | 2017-11-03 | 2021-06-02 | Amgen Inc | Agonistes de triazole fusionnés du récepteur apj |
| MA52487A (fr) | 2018-05-01 | 2021-03-10 | Amgen Inc | Pyrimidinones substituées en tant qu'agonistes du récepteur apj |
| EP3653611A1 (en) * | 2018-11-15 | 2020-05-20 | Centre National De La Recherche Scientifique | Inhibitors of metallo-beta-lactamases |
| ES2974634T3 (es) | 2018-12-21 | 2024-06-28 | Celgene Corp | Inhibidores de tienopiridinas de RIPK2 |
| AU2020253385B2 (en) * | 2019-04-03 | 2025-06-26 | Fusion Pharmaceuticals Inc. | Hsp90-binding conjugates and formulations thereof |
Family Cites Families (133)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB928919A (en) * | 1960-08-16 | 1963-06-19 | Bellon Labor Sa Roger | Triazole derivatives and a process for their preparation |
| US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
| US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| US4178253A (en) * | 1977-04-05 | 1979-12-11 | Ciba-Geigy Corporation | Corrosion inhibited lubricant compositions |
| US4269846A (en) * | 1979-10-29 | 1981-05-26 | Usv Pharmaceutical Corporation | Heterocyclic compounds useful as anti-allergy agents |
| JPS5770820A (en) | 1980-10-20 | 1982-05-01 | Haruo Ogura | Immunoregulating agent |
| JPS5910574A (ja) | 1982-07-07 | 1984-01-20 | Fujisawa Pharmaceut Co Ltd | トリアゾ−ル誘導体およびその製造法 |
| FR2546887B1 (fr) | 1983-05-30 | 1985-08-30 | Paris 7 Universite | Procede de preparation de dihydro-2,4 triazol-1,2,4 thiones-3 disubstituees en positions 4 et 5 et nouveaux composes pouvant etre prepares par ce procede |
| IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| US4624995A (en) * | 1985-04-09 | 1986-11-25 | Minnesota Mining And Manufacturing Company | Triazolinethione-containing polymer |
| US4740568A (en) * | 1985-04-09 | 1988-04-26 | Minnesota Mining And Manufacturing Company | Triazolinethione-containing polymer |
| US5436252A (en) * | 1986-12-19 | 1995-07-25 | Merrell Dow Pharmaceuticals Inc. | 5-aryl-3H-1,2,4-triazol-3-ones and their use in the treatment of neurodegenerative disorders |
| US5006650A (en) * | 1987-02-11 | 1991-04-09 | The Upjohn Company | Novel N-1 substituted beta-lactams as antibiotics |
| DE3729070A1 (de) * | 1987-09-01 | 1989-03-09 | Bayer Ag | Substituierte triazolinone |
| US5241074A (en) * | 1988-05-09 | 1993-08-31 | Bayer Aktiengesellschaft | Sulphonylaminocarbonyltriazolinones |
| US5073543A (en) | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
| IT1229203B (it) | 1989-03-22 | 1991-07-25 | Bioresearch Spa | Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative. |
| US5120548A (en) | 1989-11-07 | 1992-06-09 | Merck & Co., Inc. | Swelling modulated polymeric drug delivery device |
| US5733566A (en) | 1990-05-15 | 1998-03-31 | Alkermes Controlled Therapeutics Inc. Ii | Controlled release of antiparasitic agents in animals |
| US5219722A (en) * | 1990-09-21 | 1993-06-15 | Konica Corporation | Silver halide color photographic light-sensitive material |
| SK278998B6 (sk) * | 1991-02-01 | 1998-05-06 | Merck Sharp & Dohme Limited | Deriváty imidazolu, triazolu a tetrazolu, spôsob i |
| US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| DE69330713T2 (de) * | 1992-03-13 | 2002-07-04 | Merck Sharp & Dohme Ltd., Hoddesdon | Imidazol-, triazol- und tetrazolderivate |
| TW218017B (enExample) * | 1992-04-28 | 1993-12-21 | Takeda Pharm Industry Co Ltd | |
| DE4222771A1 (de) * | 1992-07-10 | 1994-01-13 | Bayer Ag | Heterocyclyltriazolinone |
| DE4234801A1 (de) * | 1992-10-15 | 1994-04-21 | Bayer Ag | Sulfonylaminocarbonyltriazolinone |
| US5591767A (en) | 1993-01-25 | 1997-01-07 | Pharmetrix Corporation | Liquid reservoir transdermal patch for the administration of ketorolac |
| DE4303376A1 (de) * | 1993-02-05 | 1994-08-11 | Bayer Ag | Substituierte Triazolinone |
| DE4303676A1 (de) * | 1993-02-09 | 1994-08-11 | Bayer Ag | 1-Aryltriazolin(thi)one |
| DE4411913A1 (de) * | 1994-04-07 | 1995-10-12 | Bayer Ag | Substituierte Sulfonylaminocarbonyltriazolinone |
| US5538988A (en) * | 1994-04-26 | 1996-07-23 | Martinez; Gregory R. | Benzocycloalkylazolethione derivatives |
| US5489598A (en) | 1994-06-08 | 1996-02-06 | Warner-Lambert Company | Cytoprotection utilizing aryltriazol-3-thiones |
| IT1270594B (it) | 1994-07-07 | 1997-05-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida |
| JP3372365B2 (ja) * | 1994-08-19 | 2003-02-04 | 富士写真フイルム株式会社 | ハロゲン化銀写真感光材料およびそれを用いた画像形成方法 |
| DE19502579A1 (de) * | 1995-01-27 | 1996-08-01 | Bayer Ag | Sulfonylamino(thio)carbonyl-triazolin(thi)one |
| US6080772A (en) | 1995-06-07 | 2000-06-27 | Sugen, Inc. | Thiazole compounds and methods of modulating signal transduction |
| DE19521162A1 (de) * | 1995-06-09 | 1996-12-12 | Bayer Ag | N-Aryl-1,2,4-triazolin-5-one |
| DE19525162A1 (de) * | 1995-07-11 | 1997-01-16 | Bayer Ag | Sulfonylamino(thio)carbonylverbindungen |
| DE69615376T2 (de) | 1995-07-13 | 2002-09-05 | Knoll Gmbh | Piperazin-derivate als heilmittel |
| DE19540737A1 (de) * | 1995-11-02 | 1997-05-07 | Bayer Ag | Substituierte Sulfonylamino(thio)carbonylverbindungen |
| DE19609059A1 (de) * | 1996-03-08 | 1997-09-11 | Bayer Ag | Substituierte Arylsulfonylamino(thio)carbonyl-triazolin(thi)one |
| US6274171B1 (en) | 1996-03-25 | 2001-08-14 | American Home Products Corporation | Extended release formulation of venlafaxine hydrochloride |
| ZA974703B (en) * | 1996-05-30 | 1997-12-30 | Bayer Ag | Substituted sulfonylamino(thio)carbonyl compounds. |
| TW467902B (en) * | 1996-07-31 | 2001-12-11 | Bristol Myers Squibb Co | Diphenyl heterocycles as potassium channel modulators |
| DE19632945A1 (de) * | 1996-08-16 | 1998-02-19 | Bayer Ag | Substituierte Sulfonylamino(thio)carbonylverbindungen |
| JP2001504121A (ja) * | 1996-11-12 | 2001-03-27 | セプラコール,インク. | 2r,4s,r,s―および2s,4r,r,s―ヒドロキシイトラコナゾール―およびヒドロキシサパーコナゾール誘導体 |
| US5968921A (en) * | 1997-10-24 | 1999-10-19 | Orgegon Health Sciences University | Compositions and methods for promoting nerve regeneration |
| JP3788676B2 (ja) * | 1997-11-11 | 2006-06-21 | 富士写真フイルム株式会社 | 有機エレクトロルミネツセンス素子材料およびそれを使用した有機エレクトロルミネツセンス素子 |
| WO1999046246A1 (de) * | 1998-03-09 | 1999-09-16 | Basf Aktiengesellschaft | Hetarylsubstituierte benzylphenylether, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen und tierischen schädlingen |
| US6185567B1 (en) * | 1998-05-29 | 2001-02-06 | The Trustees Of The University Of Pennsylvania | Authenticated access to internet based research and data services |
| IT1302034B1 (it) * | 1998-08-31 | 2000-07-20 | Enirisorse Spa | Catalizzatori superacidi solidi per l'isomerizzazione di idrocarburi eprocedimento sol-gel per il loro ottenimento |
| JP2000100570A (ja) | 1998-09-25 | 2000-04-07 | Toray Ind Inc | 発光素子 |
| JP2000284412A (ja) | 1999-03-30 | 2000-10-13 | Fuji Photo Film Co Ltd | 熱現像写真材料 |
| US6492406B1 (en) | 1999-05-21 | 2002-12-10 | Astrazeneca Ab | Pharmaceutically active compounds |
| US20040110684A1 (en) * | 1999-08-02 | 2004-06-10 | Universite Catholique De Louvain | Novel pharmaceutical compositions for modulating angiogenesis |
| AU2001247759A1 (en) * | 2000-03-24 | 2001-10-08 | Duke University | Characterization of grp94-ligand interactions and purification, screening, and therapeutic methods relating thereto |
| US20030216385A1 (en) * | 2000-05-19 | 2003-11-20 | Takahiko Tobe | Triazole derivatives |
| WO2001087855A1 (en) | 2000-05-19 | 2001-11-22 | Yamanouchi Pharmaceutical Co., Ltd. | Triazole derivatives |
| WO2002002123A1 (en) * | 2000-06-29 | 2002-01-10 | Trustees Of Boston University | Use of geldanamycin and related compounds for prophylaxis or treatment of fibrogenic disorders |
| ATE526019T1 (de) * | 2000-07-28 | 2011-10-15 | Sloan Kettering Inst Cancer | Verfahren zur behandlung von zellproliferationen störungen und virusinfektionen |
| EP1337275A4 (en) | 2000-11-02 | 2007-05-09 | Sloan Kettering Inst Cancer | METHOD FOR ENHANCING THE EFFICACY OF CYTOTOXIC AGENTS USING HSP 90 INHIBITORS |
| WO2002066447A1 (en) | 2001-02-21 | 2002-08-29 | Ono Pharmaceutical Co., Ltd. | 4h-1,2,4-triazole-3(2h)-thione deratives as sphingomyelinase inhibitors |
| EP1423080A4 (en) | 2001-03-01 | 2009-06-03 | Conforma Therapeutics Corp | PROCESS FOR TREATING PROLIFERATIVE GENETIC DISORDERS WITH HSP90 INHIBITORS |
| EP1387678A1 (en) * | 2001-05-03 | 2004-02-11 | Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften E.V. | Compounds that inhibit hsp90 and stimulate hsp70 and hsp40, useful in the prevention or treatment of diseases associated with protein aggregation and amyloid formation |
| JP2004529188A (ja) * | 2001-05-23 | 2004-09-24 | スローン − ケッタリング インスティチュート フォー キャンサー リサーチ | 上昇に関連した癌の治療法 |
| JP4102124B2 (ja) | 2001-08-01 | 2008-06-18 | 富士フイルム株式会社 | ハロゲン化銀乳剤およびハロゲン化銀写真感光材料 |
| WO2003013430A2 (en) | 2001-08-06 | 2003-02-20 | Kosan Biosciences, Inc. | Benzoquinone ansamycins |
| CA2468184A1 (fr) | 2001-11-28 | 2003-06-05 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R A.S.) | Derives de 5-sulfanyl-4h-1,2,4-triazoles et leur utilisation en tant que medicament |
| JP2005520795A (ja) | 2001-12-12 | 2005-07-14 | コンフォーマ・セラピューティクス・コーポレイション | Hsp90阻害活性を有するプリン類似体 |
| EP1456180B1 (en) * | 2001-12-21 | 2007-10-03 | Vernalis (Cambridge) Limited | 3-(2,4)dihydroxyphenyl-4-phenylpyrazoles and their medical use |
| DE60322680D1 (de) | 2002-02-07 | 2008-09-18 | Univ Missouri | Opioid-rezeptor-aktive 4-(3-hydroxyphenyl) oder 4-(3-alkoxyphenyl)-1,2,4-triazol-verbindungen |
| GB0207362D0 (en) | 2002-03-28 | 2002-05-08 | Univ Liverpool | Chemotherapy |
| GB0208516D0 (en) | 2002-04-15 | 2002-05-22 | Univ Liverpool | Chemotherapy |
| GB0228417D0 (en) | 2002-12-05 | 2003-01-08 | Cancer Rec Tech Ltd | Pyrazole compounds |
| GB0229618D0 (en) | 2002-12-19 | 2003-01-22 | Cancer Rec Tech Ltd | Pyrazole compounds |
| SI1611112T1 (sl) | 2003-02-11 | 2012-12-31 | Vernalis (R&D) Limited | Izoksazolne spojine kot inhibitorji vroäśinskih ĺ ok proteinov |
| EP1457499A1 (en) | 2003-03-12 | 2004-09-15 | Tufts University School Of Medicine | Inhibitors of extracellular Hsp90 |
| EP1605931A4 (en) | 2003-03-13 | 2009-04-29 | Conforma Therapeutics Corp | MEDICINAL FORMULATIONS WITH LONG AND MEDIUM-CHAINED TRIGLYCERIDES |
| KR101083621B1 (ko) | 2003-03-17 | 2011-11-16 | 쎄코 툴스 에이비 | 상이한 반경을 지닌 코너부를 가지는 인덱서블 인서트 |
| BR0301799A (pt) | 2003-04-09 | 2005-03-22 | Elzo Ferreira | Uso do processo de extração do extrato, da seiva, da tintura, da massa e dos produtos deles derivados, originários da planta xaxim - dicksonia sellowiana - presl - hooker 1844 pertencente à famìlia das dicksoniaceae para emprego nas seguintes áreas e setores: quìmica humana, industrial, farmacológica, biologia humana e animal, medicinal, fitomedicinal, fitoterápica, alopata, alimentìcia, nutricêutico, vitamìnico, dermatológica, cosmética e veterinária |
| WO2004089367A1 (en) | 2003-04-11 | 2004-10-21 | Novo Nordisk A/S | Pharmaceutical use of substituted 1,2,4-triazoles |
| WO2004089416A2 (en) | 2003-04-11 | 2004-10-21 | Novo Nordisk A/S | Combination of an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor and an antihypertensive agent |
| EP1615667A2 (en) * | 2003-04-11 | 2006-01-18 | Novo Nordisk A/S | Combinations of an 11-beta-hydroxysteroid dehydrogenase type 1 inhibitor and a glucocorticoid receptor agonist |
| SE0301232D0 (sv) | 2003-04-25 | 2003-04-25 | Astrazeneca Ab | Novel use |
| GB0309637D0 (en) | 2003-04-28 | 2003-06-04 | Cancer Rec Tech Ltd | Pyrazole compounds |
| US20050054625A1 (en) * | 2003-05-30 | 2005-03-10 | Kosan Biosciences, Inc. | Method for treating diseases using HSP90-inhibiting agents in combination with nuclear export inhibitors |
| US20050026893A1 (en) * | 2003-05-30 | 2005-02-03 | Kosan Biosciences, Inc. | Method for treating diseases using HSP90-inhibiting agents in combination with immunosuppressants |
| US20050020534A1 (en) * | 2003-05-30 | 2005-01-27 | Kosan Biosciences, Inc. | Method for treating diseases using HSP90-inhibiting agents in combination with antimetabolites |
| US20050020556A1 (en) * | 2003-05-30 | 2005-01-27 | Kosan Biosciences, Inc. | Method for treating diseases using HSP90-inhibiting agents in combination with platinum coordination complexes |
| US20050020557A1 (en) * | 2003-05-30 | 2005-01-27 | Kosan Biosciences, Inc. | Method for treating diseases using HSP90-inhibiting agents in combination with enzyme inhibitors |
| US20050054589A1 (en) * | 2003-05-30 | 2005-03-10 | Kosan Biosciences, Inc. | Method for treating diseases using HSP90-inhibiting agents in combination with antibiotics |
| US7691838B2 (en) * | 2003-05-30 | 2010-04-06 | Kosan Biosciences Incorporated | Method for treating diseases using HSP90-inhibiting agents in combination with antimitotics |
| GB0315111D0 (en) * | 2003-06-27 | 2003-07-30 | Cancer Rec Tech Ltd | Substituted 5-membered ring compounds and their use |
| WO2005016920A1 (en) | 2003-08-15 | 2005-02-24 | Vertex Pharmaceuticals Incorporated | Pyrrole compositions useful as inhibitors of c-met |
| JP2005084612A (ja) | 2003-09-11 | 2005-03-31 | Fuji Photo Film Co Ltd | ハロゲン化銀乳剤、ハロゲン化銀感光材料、および熱現像感光材料 |
| EP1673355A1 (en) * | 2003-09-22 | 2006-06-28 | Pfizer Limited | Substituted triazole derivatives as oxytocin antagonists |
| US20080085902A1 (en) | 2003-09-23 | 2008-04-10 | Guido Bold | Combination Of A Vegf Receptor Inhibitor Or With A Chemotherapeutic Agent |
| EP1697352B1 (en) | 2003-09-24 | 2012-06-27 | Vertex Pharmceuticals Incorporated | 4-azole substituted imidazole compositions useful as inhibitors or c-met receptor tyrosine kinase |
| US20050085531A1 (en) | 2003-10-03 | 2005-04-21 | Hodge Carl N. | Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof |
| JP2007509045A (ja) | 2003-10-18 | 2007-04-12 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | 尿失禁および関連疾患の処置用のgabaアゴニストとしての5−置換2−(フェニルメチル)チオ−4−フェニル−4h−1,2,4−トリアゾール誘導体および関連化合物 |
| WO2005044194A2 (en) | 2003-10-28 | 2005-05-19 | Pharmacia Corporation | TREATMENT OR PREVENTION OF NEOPLASIA BY USE OF AN Hsp90 INHIBITOR |
| MXPA06004657A (es) | 2003-10-28 | 2006-06-27 | Pharmacia Corp | Combinaciones que comprenden un inhibidor de hsp90 y un inhibidor de fosfodiesterasa para tratar o prevenir la neoplasia. |
| CA2558224A1 (en) * | 2004-03-08 | 2005-09-22 | Wyeth | Ion channel modulators |
| WO2005097758A1 (en) * | 2004-03-26 | 2005-10-20 | Amphora Discovery Corporation | Certain triazole-based compounds, compositions, and uses thereof |
| DE102004039280A1 (de) | 2004-08-13 | 2006-02-23 | Merck Patent Gmbh | 1,5-Diphenyl-pyrazole |
| DE102004049078A1 (de) | 2004-10-08 | 2006-04-13 | Merck Patent Gmbh | Phenylpyrazole |
| EP2298748B1 (en) * | 2004-11-18 | 2016-07-20 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate HSP90 activity |
| DE102005007304A1 (de) | 2005-02-17 | 2006-08-24 | Merck Patent Gmbh | Triazolderivate |
| JP5044730B2 (ja) | 2005-03-09 | 2012-10-10 | 日本化薬株式会社 | 新規なhsp90阻害剤 |
| JP2008137894A (ja) | 2005-03-22 | 2008-06-19 | Nippon Kayaku Co Ltd | 新規なアセチレン誘導体 |
| US7473784B2 (en) | 2005-08-01 | 2009-01-06 | Bristol-Myers Squibb Company | Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors |
| US7608635B2 (en) * | 2005-08-12 | 2009-10-27 | Synta Pharmaceuticals Corp. | Pyrazole compounds that modulate HSP90 activity |
| EP1928846B1 (en) * | 2005-08-18 | 2014-06-04 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate hsp90 activity |
| CA2618724A1 (en) * | 2005-08-18 | 2007-02-22 | Synta Pharmaceuticals Corp. | Imidazole compounds that modulate hsp90 activity |
| TW200804313A (en) * | 2006-05-25 | 2008-01-16 | Synta Pharmaceuticals Corp | Triazole compounds that modulate HSP90 activity |
| AU2007267803B2 (en) * | 2006-05-25 | 2011-08-25 | Synta Pharmaceuticals Corp. | Method for treating non-Hodgkin's lymphoma |
| TWI490212B (zh) * | 2006-05-25 | 2015-07-01 | Synta Pharmaceuticals Corp | 調節hsp90活性之三唑化合物 |
| US20080027047A1 (en) * | 2006-05-25 | 2008-01-31 | Weiwen Ying | Compounds that modulate HSP90 activity and methods for identifying same |
| CA2653329C (en) * | 2006-05-25 | 2018-01-16 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate hsp90 activity |
| EP2034995A2 (en) * | 2006-05-25 | 2009-03-18 | Synta Pharmaceuticals Corporation | Method for treating proliferative disorders associated with protooncogene products |
| AU2007284537B2 (en) | 2006-08-17 | 2012-04-12 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate HSP90 activity |
| US20110046125A1 (en) | 2006-10-19 | 2011-02-24 | Synta Pharmaceuticals Corp. | Method for treating infections |
| WO2008057246A2 (en) | 2006-10-26 | 2008-05-15 | Synta Pharmaceuticals Corp. | Method for treating inflammatory disorders |
| CN101679319B (zh) | 2007-02-08 | 2014-07-09 | 辛塔医药品有限公司 | 用于治疗增生性病症如癌症的三唑类化合物 |
| TW200904417A (en) | 2007-02-20 | 2009-02-01 | Synta Pharmaceuticals Corp | Triazole compounds that modulate Hsp90 activity |
| US8993608B2 (en) | 2007-03-12 | 2015-03-31 | Synta Pharmaceuticals Corp. | Method for inhibiting topoisomerase II |
| WO2008118391A2 (en) | 2007-03-27 | 2008-10-02 | Synta Pharmaceuticals Corp. | Triazinone and diazinone derivatives useful as hsp90 inhibitors |
| WO2008153730A2 (en) | 2007-05-25 | 2008-12-18 | Synta Pharmaceuticals Corp. | Method for treating proliferative disorders associated with mutations in c-met |
| TWI438199B (zh) | 2007-08-13 | 2014-05-21 | Synta Pharmaceuticals Corp | 調控hsp90活性的三唑化合物 |
| US8548104B2 (en) * | 2010-11-23 | 2013-10-01 | Siano Mobile Silicon Ltd. | Receiver with configurable clock frequencies |
-
2005
- 2005-11-17 EP EP10075452.2A patent/EP2298748B1/en not_active Expired - Lifetime
- 2005-11-17 CA CA2586612A patent/CA2586612C/en not_active Expired - Lifetime
- 2005-11-17 KR KR1020077013728A patent/KR101374553B1/ko not_active Expired - Fee Related
- 2005-11-17 EP EP10075465.4A patent/EP2295416B1/en not_active Expired - Lifetime
- 2005-11-17 PT PT58517889T patent/PT1817295E/pt unknown
- 2005-11-17 AU AU2005306484A patent/AU2005306484C1/en not_active Ceased
- 2005-11-17 KR KR1020137030848A patent/KR20140006070A/ko not_active Ceased
- 2005-11-17 MX MX2007005940A patent/MX2007005940A/es active IP Right Grant
- 2005-11-17 ES ES10075452.2T patent/ES2594874T3/es not_active Expired - Lifetime
- 2005-11-17 US US11/282,119 patent/US7825148B2/en active Active
- 2005-11-17 ES ES05851788T patent/ES2399241T3/es not_active Expired - Lifetime
- 2005-11-17 CN CN201310207740.8A patent/CN103554042B/zh not_active Expired - Fee Related
- 2005-11-17 CN CN2005800418702A patent/CN101072759B/zh not_active Expired - Fee Related
- 2005-11-17 ME MEP-2013-16A patent/ME01498B/me unknown
- 2005-11-17 PL PL05851788T patent/PL1817295T3/pl unknown
- 2005-11-17 HR HRP20130095TT patent/HRP20130095T1/hr unknown
- 2005-11-17 RS RS20130040A patent/RS52642B/sr unknown
- 2005-11-17 BR BRPI0518315A patent/BRPI0518315B8/pt not_active IP Right Cessation
- 2005-11-17 JP JP2007543263A patent/JP4954083B2/ja not_active Expired - Fee Related
- 2005-11-17 WO PCT/US2005/041779 patent/WO2006055760A1/en not_active Ceased
- 2005-11-17 DK DK05851788.9T patent/DK1817295T3/da active
- 2005-11-17 EP EP05851788A patent/EP1817295B1/en not_active Expired - Lifetime
- 2005-11-17 NZ NZ555158A patent/NZ555158A/en not_active IP Right Cessation
- 2005-11-18 TW TW094140588A patent/TWI380983B/zh not_active IP Right Cessation
-
2007
- 2007-05-10 IL IL183108A patent/IL183108A/en active IP Right Grant
-
2009
- 2009-10-23 US US12/604,970 patent/US9090569B2/en active Active
-
2010
- 2010-06-14 US US12/815,322 patent/US8362055B2/en not_active Expired - Fee Related
-
2012
- 2012-07-16 US US13/550,324 patent/US8901308B2/en not_active Expired - Lifetime
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010500993A5 (enExample) | ||
| JP2009538321A5 (enExample) | ||
| US7767665B2 (en) | 1,3-benzothiazinone derivatives and use thereof | |
| JP2013508378A5 (enExample) | ||
| AU2007267843B2 (en) | Method for treating proliferative disorders associated with protooncogene products | |
| JP2017505762A5 (enExample) | ||
| JP2009538320A5 (enExample) | ||
| JP2022505835A5 (enExample) | ||
| HRP20130095T1 (hr) | Spojevi triazola koji moduliraju aktivnost hsp90 | |
| CA2651363A1 (en) | Triazolopyrazine derivatives useful as anti-cancer agents | |
| JP2009538322A5 (enExample) | ||
| JP2010536753A5 (enExample) | ||
| JP2018520195A5 (enExample) | ||
| JP2012524111A5 (enExample) | ||
| JP2016164184A5 (enExample) | ||
| JP2005510473A5 (enExample) | ||
| JP2010518085A5 (enExample) | ||
| JP2009534386A5 (enExample) | ||
| JP2003502405A5 (enExample) | ||
| JP2018515525A5 (enExample) | ||
| JP2003510359A5 (enExample) | ||
| JP2013505930A5 (enExample) | ||
| JP2008537930A5 (enExample) | ||
| JP2010500334A5 (enExample) | ||
| JP2010540666A5 (enExample) |