KR101374553B1 - Ｈｓｐ90 활성을 조절하는 트리아졸 화합물 - Google Patents

Ｈｓｐ90 활성을 조절하는 트리아졸 화합물 Download PDF

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KR101374553B1
KR101374553B1 KR1020077013728A KR20077013728A KR101374553B1 KR 101374553 B1 KR101374553 B1 KR 101374553B1 KR 1020077013728 A KR1020077013728 A KR 1020077013728A KR 20077013728 A KR20077013728 A KR 20077013728A KR 101374553 B1 KR101374553 B1 KR 101374553B1
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substituted
unsubstituted
triazole
mercapto
phenyl
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KR20070086353A (ko
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웨이웬 잉
데이비드 제임스
쉬지에 창
테레사 피르체블로카
정현 채
디네쉬 유. 침마나마다
치완 이
엘레나 코스틱
하워드 피. 엔지
케빈 포레이
첸지안 두
제임스 바소움
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신타 파마슈티칼스 코프.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

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  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020077013728A 2004-11-18 2005-11-17 Ｈｓｐ90 활성을 조절하는 트리아졸 화합물 Expired - Fee Related KR101374553B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US62897904P 2004-11-18 2004-11-18
US60/628,979 2004-11-18
US70935805P 2005-08-18 2005-08-18
US60/709,358 2005-08-18
US72504405P 2005-10-06 2005-10-06
US60/725,044 2005-10-06
PCT/US2005/041779 WO2006055760A1 (en) 2004-11-18 2005-11-17 Triazole compounds that modulate hsp90 activity

Related Child Applications (1)

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KR1020137030848A Division KR20140006070A (ko) 2004-11-18 2005-11-17 Ｈｓｐ90 활성을 조절하는 트리아졸 화합물

Publications (2)

Publication Number Publication Date
KR20070086353A KR20070086353A (ko) 2007-08-27
KR101374553B1 true KR101374553B1 (ko) 2014-03-17

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KR1020077013728A Expired - Fee Related KR101374553B1 (ko) 2004-11-18 2005-11-17 Ｈｓｐ90 활성을 조절하는 트리아졸 화합물
KR1020137030848A Ceased KR20140006070A (ko) 2004-11-18 2005-11-17 Ｈｓｐ90 활성을 조절하는 트리아졸 화합물

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KR1020137030848A Ceased KR20140006070A (ko) 2004-11-18 2005-11-17 Ｈｓｐ90 활성을 조절하는 트리아졸 화합물

Country Status (20)

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US (4) US7825148B2 (enExample)
EP (3) EP2298748B1 (enExample)
JP (1) JP4954083B2 (enExample)
KR (2) KR101374553B1 (enExample)
CN (2) CN101072759B (enExample)
AU (1) AU2005306484C1 (enExample)
BR (1) BRPI0518315B8 (enExample)
CA (1) CA2586612C (enExample)
DK (1) DK1817295T3 (enExample)
ES (2) ES2594874T3 (enExample)
HR (1) HRP20130095T1 (enExample)
IL (1) IL183108A (enExample)
ME (1) ME01498B (enExample)
MX (1) MX2007005940A (enExample)
NZ (1) NZ555158A (enExample)
PL (1) PL1817295T3 (enExample)
PT (1) PT1817295E (enExample)
RS (1) RS52642B (enExample)
TW (1) TWI380983B (enExample)
WO (1) WO2006055760A1 (enExample)

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AU2005306484B2 (en) 2010-03-18
PL1817295T3 (pl) 2013-04-30
DK1817295T3 (da) 2013-02-18
CN103554042A (zh) 2014-02-05
ME01498B (me) 2014-04-20
CN103554042B (zh) 2016-08-10
US20060167070A1 (en) 2006-07-27
BRPI0518315A2 (pt) 2008-11-11
US8901308B2 (en) 2014-12-02
US8362055B2 (en) 2013-01-29
WO2006055760A1 (en) 2006-05-26
ES2594874T3 (es) 2016-12-23
BRPI0518315B8 (pt) 2021-05-25
KR20070086353A (ko) 2007-08-27
EP2295416A3 (en) 2011-05-04
EP2295416B1 (en) 2016-01-27
TW200637831A (en) 2006-11-01
EP2295416A2 (en) 2011-03-16
JP2008520702A (ja) 2008-06-19
TWI380983B (zh) 2013-01-01
HRP20130095T1 (hr) 2013-03-31
AU2005306484A1 (en) 2006-05-26
EP1817295A1 (en) 2007-08-15
US20120330009A1 (en) 2012-12-27
EP2298748B1 (en) 2016-07-20
CN101072759A (zh) 2007-11-14
AU2005306484C1 (en) 2015-07-23
US20110105749A1 (en) 2011-05-05
CA2586612C (en) 2016-10-11
IL183108A0 (en) 2007-09-20
US20110009397A1 (en) 2011-01-13
MX2007005940A (es) 2007-06-19
US7825148B2 (en) 2010-11-02
EP2298748A2 (en) 2011-03-23
CA2586612A1 (en) 2006-05-26
BRPI0518315B1 (pt) 2020-11-17
NZ555158A (en) 2010-09-30
EP1817295B1 (en) 2012-11-07
KR20140006070A (ko) 2014-01-15
RS52642B (sr) 2013-06-28
WO2006055760A9 (en) 2006-09-21
US9090569B2 (en) 2015-07-28
JP4954083B2 (ja) 2012-06-13
PT1817295E (pt) 2013-02-18
HK1107700A1 (en) 2008-04-11
EP2298748A3 (en) 2011-04-27
IL183108A (en) 2016-05-31
ES2399241T3 (es) 2013-03-26
CN101072759B (zh) 2013-06-19

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