JP2008537930A5 - - Google Patents
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- Publication number
- JP2008537930A5 JP2008537930A5 JP2008500782A JP2008500782A JP2008537930A5 JP 2008537930 A5 JP2008537930 A5 JP 2008537930A5 JP 2008500782 A JP2008500782 A JP 2008500782A JP 2008500782 A JP2008500782 A JP 2008500782A JP 2008537930 A5 JP2008537930 A5 JP 2008537930A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- fluoro
- optionally substituted
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000000217 alkyl group Chemical group 0.000 claims 115
- 125000001153 fluoro group Chemical group F* 0.000 claims 21
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 13
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 9
- 229910052799 carbon Inorganic materials 0.000 claims 9
- 229910052757 nitrogen Inorganic materials 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 125000000623 heterocyclic group Chemical group 0.000 claims 6
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 208000037260 Atherosclerotic Plaque Diseases 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 3
- 150000002148 esters Chemical class 0.000 claims 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 239000011593 sulfur Substances 0.000 claims 3
- 239000000556 agonist Substances 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 125000003386 piperidinyl group Chemical group 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 229940122502 Cholesterol absorption inhibitor Drugs 0.000 claims 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 1
- 102000023984 PPAR alpha Human genes 0.000 claims 1
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 claims 1
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 claims 1
- 229940080774 Peroxisome proliferator-activated receptor gamma agonist Drugs 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 230000003143 atherosclerotic effect Effects 0.000 claims 1
- 125000002393 azetidinyl group Chemical group 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000003354 cholesterol ester transfer protein inhibitor Substances 0.000 claims 1
- 229940125881 cholesteryl ester transfer protein inhibitor Drugs 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- XUWHAWMETYGRKB-UHFFFAOYSA-N delta-valerolactam Natural products O=C1CCCCN1 XUWHAWMETYGRKB-UHFFFAOYSA-N 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000009977 dual effect Effects 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 1
- 230000004968 inflammatory condition Effects 0.000 claims 1
- 150000002617 leukotrienes Chemical class 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- 108091008725 peroxisome proliferator-activated receptors alpha Proteins 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000003373 pyrazinyl group Chemical group 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- -1 substituted Chemical class 0.000 claims 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 1
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
- 150000003952 β-lactams Chemical class 0.000 claims 1
- 150000003953 γ-lactams Chemical class 0.000 claims 1
- 150000003954 δ-lactams Chemical class 0.000 claims 1
- 0 CCC(C1)CC1(c1cccc(*)c1)c1cc(OC*)ccc1* Chemical compound CCC(C1)CC1(c1cccc(*)c1)c1cc(OC*)ccc1* 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65989805P | 2005-03-09 | 2005-03-09 | |
| PCT/US2006/007717 WO2006098912A1 (en) | 2005-03-09 | 2006-03-03 | Diphenyl substituted cycloalkanes, compositions containing such compounds and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008537930A JP2008537930A (ja) | 2008-10-02 |
| JP2008537930A5 true JP2008537930A5 (enExample) | 2009-04-09 |
Family
ID=36992014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008500782A Withdrawn JP2008537930A (ja) | 2005-03-09 | 2006-03-03 | ジフェニル置換シクロアルカン、前記化合物を含む組成物及び使用方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20090197883A1 (enExample) |
| EP (1) | EP1858513A4 (enExample) |
| JP (1) | JP2008537930A (enExample) |
| CN (1) | CN101137376A (enExample) |
| AU (1) | AU2006223508A1 (enExample) |
| CA (1) | CA2600860A1 (enExample) |
| WO (1) | WO2006098912A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006044602A2 (en) | 2004-10-18 | 2006-04-27 | Merck & Co., Inc. | Diphenyl substituted alkanes as flap inhiibitors |
| US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
| GB2431927B (en) | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
| WO2007056210A2 (en) * | 2005-11-04 | 2007-05-18 | Merck & Co., Inc. | Diphenylmethane derivatives as inhibitors of leukotriene biosynthesis |
| US8399666B2 (en) | 2005-11-04 | 2013-03-19 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
| CN101466677A (zh) | 2006-04-11 | 2009-06-24 | 默克公司 | 二芳基取代的烷烃 |
| ATE543810T1 (de) | 2006-09-01 | 2012-02-15 | Merck Sharp & Dohme | Hemmer des 5-lipoxygenase aktivierenden proteins (flap) |
| TW200920369A (en) | 2007-10-26 | 2009-05-16 | Amira Pharmaceuticals Inc | 5-lipoxygenase activating protein (flap) inhibitor |
| JP5324082B2 (ja) * | 2007-12-20 | 2013-10-23 | 大阪瓦斯株式会社 | ９，９−ビス（カルボキシアリール）フルオレン類およびそのエステルの製造方法 |
| US20110160249A1 (en) | 2008-05-23 | 2011-06-30 | Schaab Kevin Murray | 5-lipoxygenase-activating protein inhibitor |
| MX2011001090A (es) * | 2008-07-28 | 2011-03-15 | Gilead Sciences Inc | Compuestos de inhibidor de desacetilasa de histona de cicloalquilideno y heterocicloalquilideno. |
| US8546431B2 (en) | 2008-10-01 | 2013-10-01 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
| WO2011035186A1 (en) * | 2009-09-17 | 2011-03-24 | Vanderbilt University | Substituted heteroarylamide analogs as mglur5 negative allosteric modulators and methods of making and using the same |
| TW201215607A (en) * | 2010-07-02 | 2012-04-16 | Lundbeck & Co As H | Aryl-and heteroarylamid derivatives as PDE10A enzyme inhibitor |
| KR101898610B1 (ko) | 2010-08-31 | 2018-09-14 | 서울대학교산학협력단 | ＰＰＡＲδ 활성물질의 태자 재프로그래밍 용도 |
| CA2931097A1 (en) | 2013-11-19 | 2015-05-28 | Vanderbilt University | Substituted imidazopyridine and triazolopyridine compounds as negative allosteric modulators of mglur5 |
| US9533982B2 (en) | 2014-03-20 | 2017-01-03 | Vanderbilt University | Substituted bicyclic heteroaryl carboxamide analogs as mGluR5 negative allosteric modulators |
| US9550778B2 (en) | 2014-10-03 | 2017-01-24 | Vanderbilt University | Substituted 6-aryl-imidazopyridine and 6-aryl-triazolopyridine carboxamide analogs as negative allosteric modulators of mGluR5 |
| EP3268085A4 (en) | 2015-03-13 | 2018-10-31 | The Board of Trustees of The Leland Stanford Junior University | Ltb4 inhibition to prevent and treat human lymphedema |
| CN106008474A (zh) * | 2016-04-23 | 2016-10-12 | 上海大学 | N2选择性烯醇醚取代的三氮唑衍生物及其制备方法 |
| WO2019213499A1 (en) * | 2018-05-04 | 2019-11-07 | Saint Louis University | Compounds and methods targeting gper for treatment of diseases associated with calcium |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW206220B (enExample) * | 1991-07-01 | 1993-05-21 | Ciba Geigy Ag | |
| US5691351A (en) * | 1996-02-06 | 1997-11-25 | Abbott Laboratories | Bis-(Heteroarylmethoxyphenyl)cycloalkyl carboxylates as inhibitors of leukotriene biosynthesis |
| US6756400B2 (en) * | 2000-08-31 | 2004-06-29 | Theravance, Inc. | Sodium channel modulators |
| JP2006528630A (ja) * | 2003-07-24 | 2006-12-21 | メルク エンド カムパニー インコーポレーテッド | ジフェニル置換シクロアルカン類、そのような化合物を含む組成物、ならびに使用方法 |
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2006
- 2006-03-03 CN CNA200680007409XA patent/CN101137376A/zh active Pending
- 2006-03-03 AU AU2006223508A patent/AU2006223508A1/en not_active Abandoned
- 2006-03-03 WO PCT/US2006/007717 patent/WO2006098912A1/en not_active Ceased
- 2006-03-03 CA CA002600860A patent/CA2600860A1/en not_active Abandoned
- 2006-03-03 JP JP2008500782A patent/JP2008537930A/ja not_active Withdrawn
- 2006-03-03 US US11/885,851 patent/US20090197883A1/en not_active Abandoned
- 2006-03-03 EP EP06736956A patent/EP1858513A4/en not_active Withdrawn