JP2008508320A5 - - Google Patents
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- JP2008508320A5 JP2008508320A5 JP2007523880A JP2007523880A JP2008508320A5 JP 2008508320 A5 JP2008508320 A5 JP 2008508320A5 JP 2007523880 A JP2007523880 A JP 2007523880A JP 2007523880 A JP2007523880 A JP 2007523880A JP 2008508320 A5 JP2008508320 A5 JP 2008508320A5
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| EP2537857B1 (en) * | 2007-12-21 | 2017-01-18 | GlaxoSmithKline Biologicals SA | Mutant forms of streptolysin O |
| NZ594029A (en) | 2009-01-12 | 2014-01-31 | Novartis Ag | Cna_b domain antigens in vaccines against gram positive bacteria |
| ITMI20090946A1 (it) | 2009-05-28 | 2010-11-29 | Novartis Ag | Espressione di proteine ricombinanti |
| ES2531115T3 (es) * | 2009-06-01 | 2015-03-10 | Novartis Ag | Combinaciones de clados de RrgB neumocócicos |
| EP2475385A1 (en) * | 2009-09-10 | 2012-07-18 | Novartis AG | Combination vaccines against respiratory tract diseases |
| US20120189636A1 (en) * | 2009-10-02 | 2012-07-26 | Tokyo Women's Medical University | Human serum amyloid-a3 antibody and use thereof |
| GB201003333D0 (en) * | 2010-02-26 | 2010-04-14 | Novartis Ag | Immunogenic proteins and compositions |
| GB201114923D0 (en) * | 2011-08-30 | 2011-10-12 | Novartis Ag | Immunogenic proteins and compositions |
| DE102011121069A1 (de) * | 2011-12-13 | 2013-06-13 | Martin-Luther-Universität Halle-Wittenberg | Vakzinierung mittels rekombinanter Hefe durch Erzeugung einer protektiven humoralen Immunantwort gegen definierte Antigene |
| WO2014013375A1 (en) | 2012-07-16 | 2014-01-23 | Pfizer Inc. | Saccharides and uses thereof |
| CA2928851A1 (en) | 2012-07-19 | 2014-01-23 | Alethia Biotherapeutics Inc. | Anti-siglec-15 antibodies |
| WO2014047625A1 (en) | 2012-09-24 | 2014-03-27 | Montana State University | Recombinant lactococcus lactis expressing escherichia coli colonization factor antigen i (cfa/i) fimbriae and their methods of use |
| SG11201700673RA (en) | 2014-08-05 | 2017-02-27 | Glaxosmithkline Biolog Sa | Carrier molecule for antigens |
| US10738338B2 (en) | 2016-10-18 | 2020-08-11 | The Research Foundation for the State University | Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate |
| TWI598360B (zh) * | 2016-12-19 | 2017-09-11 | 義守大學 | Ｆｓｂｍ重組蛋白及其用途 |
| AU2019364829B2 (en) * | 2018-10-25 | 2025-11-20 | Ajinomoto Co., Inc. | Method for secretory production of protein |
Family Cites Families (173)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU548947A1 (ru) | 1975-09-05 | 1980-02-05 | Всесоюзный Ордена Ленина Институт Экспериментальной Ветеринарии Васхнил | Вакцина дл специфической профилактики и трерапии трихофитии лошадей |
| NO153458C (no) | 1978-06-07 | 1986-03-26 | Inst Experimentalnoi Veterinar | Fremgangsm¨te for fremstilling av vaksine for profylakse o g behandling av ringorm hos pelsdyr og kaniner for¨rsaket av trichophyton mentagrophytes. |
| US5360897A (en) | 1981-08-31 | 1994-11-01 | The University Of Rochester | Immunogenic conjugates of streptococcus pneumonial capsular polymer and toxin or in toxiad |
| US4454121A (en) * | 1982-07-27 | 1984-06-12 | The University Of Tennessee Research Corporation | Synthetic peptides corresponding to antigenic determinants of the M protein of Streptococcus pyogenes |
| SE8205892D0 (sv) | 1982-10-18 | 1982-10-18 | Bror Morein | Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| FR2550094B1 (fr) * | 1983-08-01 | 1986-03-21 | Anvar | Compositions de vaccins conditionnees pour la vaccination de sujets immunitairement non naifs contre un agent pathogene determine et contenant un haptene comportant lui-meme un site antigenique caracteristique dudit agent pathogene ou un oligomere de cet haptene |
| US5324513A (en) | 1984-03-07 | 1994-06-28 | Institut Pasteur | Composition useful for the fabrication of vaccines |
| US5171568A (en) | 1984-04-06 | 1992-12-15 | Chiron Corporation | Recombinant herpes simplex gb-gd vaccine |
| US6090406A (en) | 1984-04-12 | 2000-07-18 | The Liposome Company, Inc. | Potentiation of immune responses with liposomal adjuvants |
| US5916588A (en) | 1984-04-12 | 1999-06-29 | The Liposome Company, Inc. | Peptide-containing liposomes, immunogenic liposomes and methods of preparation and use |
| US5098704A (en) | 1984-06-18 | 1992-03-24 | Chiron Corporation | Hepatitis surface antigen particle vaccine |
| US4722840A (en) | 1984-09-12 | 1988-02-02 | Chiron Corporation | Hybrid particle immunogens |
| JP2661044B2 (ja) | 1986-06-17 | 1997-10-08 | カイロン コーポレイション | 肝炎δの診断薬およびワクチン |
| US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| HU216017B (hu) | 1987-11-18 | 1999-04-28 | Chiron Corp. | Eljárás HCV-1 polipeptidek, HCV-1 polinukleotidok, rekombináns vektorok és gazdasejtek, valamint immunesszé kit, hepatitis C vírusfertőzés elleni vakcinák, a fertőzés kimutatására szolgáló diagnosztikumok előállítására, és immunvizsgálati és vírustenyészt |
| US5098827A (en) * | 1988-02-26 | 1992-03-24 | The University Of Florida | Novel bacterial markers for pathogenic group B streptococci |
| JPH04500203A (ja) | 1988-08-25 | 1992-01-16 | ザ リポソーム カンパニー，インコーポレイテッド | インフルエンザワクチンおよび新規なアジュバント |
| US5354846A (en) * | 1988-11-18 | 1994-10-11 | Michael Kehoe | Streptolysin O antigen derivatives, its production and uses |
| GB8827038D0 (en) | 1988-11-18 | 1988-12-21 | Kehoe M | Streptolysin o antigens & uses |
| DE3841091A1 (de) | 1988-12-07 | 1990-06-13 | Behringwerke Ag | Synthetische antigene, verfahren zu ihrer herstellung und ihre verwendung |
| HUT58804A (en) | 1988-12-16 | 1992-03-30 | James Cleland Paton | Process for producing pneumolysine mutants and pneumococcus vaccines |
| GB2233977B (en) | 1989-01-04 | 1993-03-31 | Michael Kehoe | Cytolytic streptolysin o mutants and uses |
| CA2006700A1 (en) | 1989-01-17 | 1990-07-17 | Antonello Pessi | Synthetic peptides and their use as universal carriers for the preparation of immunogenic conjugates suitable for the development of synthetic vaccines |
| JP2656995B2 (ja) | 1989-03-17 | 1997-09-24 | カイロン コーポレイション | Ｎａｎｂｖの診断用薬 |
| CA2011896C (en) | 1989-04-21 | 2001-05-08 | Mark Werner | Ringworm vaccine |
| MC2188A1 (fr) | 1989-05-18 | 1992-09-16 | Chiron Corp | Diagnostic du nanbv:polynucleotides permettant de depister le virus de l'hepatite c |
| HU212924B (en) | 1989-05-25 | 1996-12-30 | Chiron Corp | Adjuvant formulation comprising a submicron oil droplet emulsion |
| KR920703114A (ko) | 1989-07-14 | 1992-12-17 | 원본미기재 | 접합체 백신을 위한 시토킨 및 호르몬 운반체 |
| IT1237764B (it) | 1989-11-10 | 1993-06-17 | Eniricerche Spa | Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici. |
| US5821088A (en) * | 1990-05-11 | 1998-10-13 | Siga Pharmaceuticals, Inc. | Use of gram-positive bacteria to express recombinant proteins |
| US6737521B1 (en) * | 1990-05-11 | 2004-05-18 | The Rockefeller University | Delivery and expression of a hybrid surface protein on the surface of gram positive bacteria |
| GB2276169A (en) | 1990-07-05 | 1994-09-21 | Celltech Ltd | Antibodies specific for carcinoembryonic antigen |
| DE69113564T2 (de) | 1990-08-13 | 1996-05-30 | American Cyanamid Co | Faser-Hemagglutinin von Bordetella pertussis als Träger für konjugierten Impfstoff. |
| US5153312A (en) | 1990-09-28 | 1992-10-06 | American Cyanamid Company | Oligosaccharide conjugate vaccines |
| US5277904A (en) | 1990-10-26 | 1994-01-11 | Pier Allan C | Broad spectrum dermatophyte vaccine |
| US5284652A (en) | 1990-10-26 | 1994-02-08 | Pier Allan C | Dermatophyte vaccine |
| US5391712A (en) | 1991-08-30 | 1995-02-21 | Beckman Instruments, Inc. | Non-hemolytic streptolysin O variants |
| US5378620A (en) | 1991-08-30 | 1995-01-03 | Beckman Instruments, Inc. | Streptolysin O derivatives |
| CA2383007A1 (en) | 1992-03-02 | 1993-09-16 | Chiron S.P.A. | Helicobacter pylori proteins useful for vaccines and diagnostics |
| IT1262896B (it) | 1992-03-06 | 1996-07-22 | Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini. | |
| EP0671948B1 (en) | 1992-06-25 | 1997-08-13 | SMITHKLINE BEECHAM BIOLOGICALS s.a. | Vaccine composition containing adjuvants |
| IL102687A (en) | 1992-07-30 | 1997-06-10 | Yeda Res & Dev | Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them |
| DE4240056A1 (de) * | 1992-11-28 | 1994-06-01 | Boehringer Mannheim Gmbh | Streptolysin O Peptidantigene und Verfahren zur Bestimmung von Streptolysin-Antikörper |
| ATE260976T1 (de) | 1993-02-01 | 2004-03-15 | Beckman Coulter Inc | Mitogener faktor, sein gen und verfahren zur dessen mikrodetektion |
| DK0689454T4 (da) | 1993-03-23 | 2005-05-30 | Smithkline Beecham Biolog | Vaccinepræparater indeholdende 3-O-deacyleret monophosphoryl-lipid A |
| DE69433107T2 (de) * | 1993-06-23 | 2004-07-08 | Beckman Coulter, Inc., Fullerton | Rekombinante dnase b aus streptococcus pyogenes |
| US5585098A (en) * | 1993-11-23 | 1996-12-17 | Ovimmune, Inc. | Oral administration of chicken yolk immunoglobulins to lower somatic cell count in the milk of lactating ruminants |
| GB9326174D0 (en) | 1993-12-22 | 1994-02-23 | Biocine Sclavo | Mucosal adjuvant |
| GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
| US6239116B1 (en) | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6429199B1 (en) | 1994-07-15 | 2002-08-06 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules for activating dendritic cells |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| PT804559E (pt) * | 1994-10-07 | 2005-08-31 | Univ Rockefeller | Enzima para clivagem da regiao ancora de proteinas de superficie de bacterias gram-positivas |
| AUPM873294A0 (en) | 1994-10-12 | 1994-11-03 | Csl Limited | Saponin preparations and use thereof in iscoms |
| AUPM885194A0 (en) * | 1994-10-14 | 1994-11-10 | Council Of The Queensland Institute Of Medical Research, The | Synthetic peptides and vaccines comprising same |
| IL117483A (en) | 1995-03-17 | 2008-03-20 | Bernard Brodeur | MENINGITIDIS NEISSERIA shell protein is resistant to proteinase K. |
| UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| US6284884B1 (en) * | 1995-06-07 | 2001-09-04 | North American Vaccine, Inc. | Antigenic group B streptococcus type II and type III polysaccharide fragments having a 2,5-anhydro-D-mannose terminal structure and conjugate vaccine thereof |
| US6936259B2 (en) * | 1995-06-08 | 2005-08-30 | University Of Saskatchewan | CAMP factor of Streptococcus uberis |
| GB9513261D0 (en) | 1995-06-29 | 1995-09-06 | Smithkline Beecham Biolog | Vaccines |
| US5846547A (en) * | 1996-01-22 | 1998-12-08 | Regents Of The University Of Minnesota | Streptococcal C5a peptidase vaccine |
| US6346392B1 (en) | 1996-11-27 | 2002-02-12 | Smithkline Beecham Corporation | Polynucleotides encoding a novel glutamine transport ATP-binding protein |
| IES76925B2 (en) | 1996-07-03 | 1997-11-19 | Provost | Subunit Vaccine for Streptococcus Equi |
| EP0821070A1 (en) | 1996-07-22 | 1998-01-28 | Carelli, Claude Marcel Henri | Pit-1 gene polymorphism and trait selection in animals |
| DE19630390A1 (de) | 1996-07-26 | 1998-01-29 | Chiron Behring Gmbh & Co | Proteine, insbesondere Membranproteine von Helicobacter pylori, ihre Herstellung und Verwendung |
| AU725733B2 (en) | 1996-09-04 | 2000-10-19 | Takara Bio Inc. | Fungal antigens and process for producing the same |
| US6420135B1 (en) | 1996-10-31 | 2002-07-16 | Human Genome Sciences, Inc. | Streptococcus pneumoniae polynucleotides and sequences |
| WO1998019689A1 (en) | 1996-11-01 | 1998-05-14 | Smithkline Beecham Corporation | Novel coding sequences |
| US7033765B1 (en) * | 1997-02-20 | 2006-04-25 | Toronto Research Chemicals, Inc. | Site-specific drug delivery |
| WO1998040100A1 (en) | 1997-03-10 | 1998-09-17 | Ottawa Civic Loeb Research Institute | USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE AS AN ADJUVANT |
| US6426074B1 (en) * | 1997-03-19 | 2002-07-30 | The Brigham And Women's Hospital Inc. | Group B Streptococcus vaccine |
| US6818222B1 (en) | 1997-03-21 | 2004-11-16 | Chiron Corporation | Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants |
| US6299881B1 (en) | 1997-03-24 | 2001-10-09 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts |
| AU735444B2 (en) * | 1997-05-06 | 2001-07-05 | Human Genome Sciences, Inc. | (Enterococcus faecalis) polynucleotides and polypeptides |
| US6635623B1 (en) * | 1997-06-13 | 2003-10-21 | Baylor College Of Medicine | Lipoproteins as nucleic acid vectors |
| GB9712347D0 (en) | 1997-06-14 | 1997-08-13 | Smithkline Beecham Biolog | Vaccine |
| GB9713156D0 (en) | 1997-06-20 | 1997-08-27 | Microbiological Res Authority | Vaccines |
| US5948413A (en) | 1997-07-17 | 1999-09-07 | Board Of Trustees Operating Michigan State University | Method and vaccine for treatment of pythiosis insidiosi in humans and lower animals |
| EP1009382B1 (en) | 1997-09-05 | 2003-06-18 | GlaxoSmithKline Biologicals S.A. | Oil in water emulsions containing saponins |
| EP1003875B1 (en) | 1997-09-12 | 2006-12-27 | University of Tennessee Research Foundation | Group a streptococcal vaccines |
| AU9507698A (en) | 1997-09-26 | 1999-04-23 | Med Immune, Inc. | (lmb) gene of (streptococcus agalactiae) |
| US6406883B1 (en) | 1997-09-26 | 2002-06-18 | Luetticken Rudolf | Lmb gene of Streptococcus agalactiae |
| US6756361B1 (en) | 1997-10-14 | 2004-06-29 | Nabi | Enterococcus antigens and vaccines |
| ES2273439T3 (es) * | 1997-10-17 | 2007-05-01 | Societe Des Produits Nestle S.A. | Nueva especie de bacteria lactica. |
| JP4472866B2 (ja) | 1997-11-06 | 2010-06-02 | カイロン ソチエタ ア レスポンサビリタ リミタータ | ナイセリア抗原 |
| WO1999026969A1 (en) | 1997-11-21 | 1999-06-03 | University Of Otago | Zoocin a immunity factor |
| DE69836977T2 (de) | 1997-11-21 | 2007-10-18 | Serono Genetics Institute S.A. | Chlamydia pneumoniae genomische sequenzen und polypeptiden, fragmenten und anwendungen davon für nachweis, prevention und heilung |
| GB9725084D0 (en) | 1997-11-28 | 1998-01-28 | Medeva Europ Ltd | Vaccine compositions |
| KR100769104B1 (ko) | 1997-11-28 | 2007-10-23 | 세로노 제네틱스 인스티튜트 에스.에이. | 클라미디아 트라코마티스 게놈 서열과 폴리펩티드, 이의단편 및 이의 용도, 특히, 감염의 진단, 예방 및 치료 용도 |
| CA2312900A1 (en) | 1997-12-02 | 1999-06-10 | Powderject Vaccines, Inc. | Transdermal delivery of particulate vaccine compositions |
| JP2002508156A (ja) * | 1997-12-31 | 2002-03-19 | ストレスジェン バイオテクノロジーズ コーポレイション | Ｈｓｐ６０ファミリーのＳｔｒｅｐｔｏｃｏｃｃｕｓ熱ショックタンパク質 |
| SG152917A1 (en) | 1998-01-14 | 2009-06-29 | Chiron Srl | Neisseria meningitidis antigens |
| US7041814B1 (en) * | 1998-02-18 | 2006-05-09 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to Enterobacter cloacae for diagnostics and therapeutics |
| AP2000001886A0 (en) | 1998-02-20 | 2000-09-30 | Iaf Biochem Int | Group B streptococcus antigens. |
| GB9807721D0 (en) | 1998-04-08 | 1998-06-10 | Chiron Spa | Antigen |
| EP1069910A1 (en) | 1998-04-09 | 2001-01-24 | GlaxoSmithKline Biologicals S.A. | Adjuvant compositions |
| GB9808327D0 (en) | 1998-04-20 | 1998-06-17 | Chiron Spa | Antidiotypic compounds |
| DK1093517T3 (da) | 1998-05-01 | 2008-06-23 | Novartis Vaccines & Diagnostic | Neisseria-meningitidis-antigener og præparater |
| US6562798B1 (en) | 1998-06-05 | 2003-05-13 | Dynavax Technologies Corp. | Immunostimulatory oligonucleotides with modified bases and methods of use thereof |
| US6660520B2 (en) * | 1998-06-05 | 2003-12-09 | Smithkline Beecham Corporation | Nrde |
| US7098182B2 (en) * | 1998-07-27 | 2006-08-29 | Microbial Technics Limited | Nucleic acids and proteins from group B streptococcus |
| WO2000006736A2 (en) | 1998-07-27 | 2000-02-10 | Microbial Technics Limited | Nucleic acids and proteins from group b streptococcus |
| US6936252B2 (en) * | 1998-07-27 | 2005-08-30 | Microbial Technics Limited | Streptococcus pneumoniae proteins and nucleic acid molecules |
| GB9817052D0 (en) | 1998-08-05 | 1998-09-30 | Smithkline Beecham Biolog | Vaccine |
| BR9914374A (pt) | 1998-10-09 | 2002-09-17 | Chiron Corp | Sequências genÈmicas de neisseria e métodos para seu uso |
| PL201482B1 (pl) | 1998-10-16 | 2009-04-30 | Smithkline Beecham Biolog | Sposoby wytwarzania kompozycji szczepionki oraz kompozycja szczepionki |
| CA2350775A1 (en) | 1998-11-12 | 2000-05-18 | The Regents Of The University Of California | Chlamydia pneumoniae genome sequence |
| GB9828000D0 (en) | 1998-12-18 | 1999-02-10 | Chiron Spa | Antigens |
| US7128918B1 (en) * | 1998-12-23 | 2006-10-31 | Id Biomedical Corporation | Streptococcus antigens |
| DK1163000T3 (da) | 1999-03-19 | 2008-04-28 | Glaxosmithkline Biolog Sa | Vacciner imod antigener fra bakterier |
| EP1165796A2 (en) | 1999-04-09 | 2002-01-02 | Techlab, Inc. | Recombinant clostridium toxin a protein carrier for polysaccharide conjugate vaccines |
| US7101692B2 (en) * | 1999-04-15 | 2006-09-05 | The Regents Of The University Of California | Identification of sortase gene |
| WO2000067161A2 (en) | 1999-05-04 | 2000-11-09 | Grant Lee H | Method and apparatus for categorizing and retrieving network pages and sites |
| US6833356B1 (en) * | 1999-08-25 | 2004-12-21 | Medimmune, Inc. | Pneumococcal protein homologs and fragments for vaccines |
| PL355163A1 (en) | 1999-09-24 | 2004-04-05 | Smithkline Beecham Biologicals S.A. | Use of combination of polyoxyethylene sorbitan ester and octoxynol as adjuvant and its use in vaccines |
| BR0014285A (pt) | 1999-09-24 | 2002-05-21 | Smithkline Beecham Biolog | Adjuvantes compreendendo um éster ou éter de alquila de polioxietileno e pelo menos um tensoativo não-iÈnico |
| CA2384713A1 (en) | 1999-09-29 | 2001-04-05 | Human Genome Sciences, Inc. | Colon and colon cancer associated polynucleotides and polypeptides |
| CA2871789C (en) | 2000-01-17 | 2017-04-04 | Novartis Vaccines And Diagnostics S.R.L. | Outer membrane vesicle (omv) vaccine comprising n. meningitidis serogroup b outer membrane proteins |
| CA2396871A1 (en) | 2000-01-20 | 2001-12-20 | Ottawa Health Research Institute | Immunostimulatory nucleic acids for inducing a th2 immune response |
| US6400152B1 (en) * | 2000-01-31 | 2002-06-04 | General Electric Company | Spiral trajectory calculations for MRI |
| US6777547B1 (en) * | 2000-01-31 | 2004-08-17 | Andreas Podbielski | Collagen-binding proteins from streptococcus pyogenes |
| US20020061569A1 (en) * | 2000-03-21 | 2002-05-23 | Robert Haselbeck | Identification of essential genes in prokaryotes |
| GB0007432D0 (en) | 2000-03-27 | 2000-05-17 | Microbiological Res Authority | Proteins for use as carriers in conjugate vaccines |
| AUPQ801700A0 (en) * | 2000-06-07 | 2000-06-29 | Peplin Research Pty Ltd | Enzyme and viral activation |
| WO2002002606A2 (en) | 2000-07-03 | 2002-01-10 | Chiron S.P.A. | Immunisation against chlamydia pneumoniae |
| BR0112497A (pt) * | 2000-07-06 | 2003-11-25 | Shire Biochem Inc | Antìgenos de streptococcus pyogenes |
| DK1320542T3 (da) * | 2000-08-08 | 2007-09-10 | St Jude Childrens Res Hospital | Gruppe B streptokokpolypeptider-nukleinsyrer og terapeutiske sammensætninger og vacciner deraf |
| EP1322656B1 (en) | 2000-09-26 | 2008-01-16 | Idera Pharmaceuticals, Inc. | Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes |
| WO2002026761A1 (en) * | 2000-09-29 | 2002-04-04 | Regents Of The University Of Minnesota | Triterpenes having fungicidal activity against yeast |
| US7160547B2 (en) * | 2000-10-10 | 2007-01-09 | University Of Tennessee Research Corporation | Streptococcal streptolysin S vaccines |
| US20020086023A1 (en) * | 2000-10-10 | 2002-07-04 | University Of Tennessee Research Corporation | Streptococcal streptolysin S vaccines |
| JP2002135314A (ja) | 2000-10-26 | 2002-05-10 | Sharp Corp | 通信制御方法および通信機器 |
| ES2330083T3 (es) | 2000-10-27 | 2009-12-04 | Novartis Vaccines And Diagnostics S.R.L. | Acidos nucleicos y proteinas de estreptococos de los grupos a y b. |
| GB0103424D0 (en) | 2001-02-12 | 2001-03-28 | Chiron Spa | Gonococcus proteins |
| WO2002064162A2 (en) | 2001-02-13 | 2002-08-22 | Government Of The United States, As Represented By The Secretary Of The Army | Vaccine for transcutaneous immunization |
| EP2316482A1 (en) | 2001-03-19 | 2011-05-04 | Intercell USA, Inc. | Transcutaneous immunostimulation |
| GB0107658D0 (en) * | 2001-03-27 | 2001-05-16 | Chiron Spa | Streptococcus pneumoniae |
| JP2004533236A (ja) * | 2001-04-13 | 2004-11-04 | ワイエス | 化膿性連鎖球菌（Ｓｔｒｅｐｔｏｃｏｃｃｕｓｐｙｏｇｅｎｅｓ）の表面タンパク質 |
| US20070128229A1 (en) * | 2002-04-12 | 2007-06-07 | Wyeth | Surface proteins of Streptococcus pyogenes |
| FR2824074A1 (fr) * | 2001-04-26 | 2002-10-31 | Pasteur Institut | Sequence du genome streptococcus agalactiae, application au developpement de vaccins, d'outils de diagnostic, et a l'identification de cibles therapeutiques |
| ATE557041T1 (de) * | 2001-05-18 | 2012-05-15 | Us Gov Health & Human Serv | Peptid-vakzinen gegen streptokokken der gruppe a |
| GB0118249D0 (en) * | 2001-07-26 | 2001-09-19 | Chiron Spa | Histidine vaccines |
| US20060073530A1 (en) * | 2001-08-15 | 2006-04-06 | Olaf Schneewind | Methods and compositions involving sortase B |
| WO2003024480A2 (en) | 2001-09-14 | 2003-03-27 | Cytos Biotechnology Ag | In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles |
| ES2335979T3 (es) | 2001-09-14 | 2010-04-07 | Cytos Biotechnology Ag | Empaquetamiento de cpg inmunoestimuladores en particulas similares a virus: metodo de preparacion y su uso. |
| GB0123580D0 (en) | 2001-10-01 | 2001-11-21 | Glaxosmithkline Biolog Sa | Vaccine |
| WO2003035836A2 (en) | 2001-10-24 | 2003-05-01 | Hybridon Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends |
| US20040029129A1 (en) * | 2001-10-25 | 2004-02-12 | Liangsu Wang | Identification of essential genes in microorganisms |
| ATE543906T1 (de) | 2002-02-11 | 2012-02-15 | Id Biomedical Corp | Antigen von streptococcus aus der b-gruppe |
| GB2385274B (en) * | 2002-02-13 | 2004-04-14 | Ming-Jeng Shue | Vaginal suppository delivery device |
| US20050181388A1 (en) * | 2002-04-02 | 2005-08-18 | Affinium Pharmaceuticals, Inc. | Novel purified polypeptides from bacteria |
| WO2003087353A2 (en) * | 2002-04-08 | 2003-10-23 | Affinium Pharmaceuticals, Inc. | Purified polypeptides involved in membrane biogenesis |
| GB0210128D0 (en) * | 2002-05-02 | 2002-06-12 | Chiron Spa | Nucleic acids and proteins from streptococcus groups A & B |
| AU2003260102A1 (en) * | 2002-08-26 | 2004-03-11 | Chiron Corporation | Conserved and specific streptococcal genomes |
| ES2504166T3 (es) | 2002-09-13 | 2014-10-08 | Novartis Vaccines And Diagnostics, Inc. | Vacuna de estreptococo del grupo B |
| TW566366U (en) * | 2002-09-27 | 2003-12-11 | Wus Tech Co Ltd | Labor-saving portable battery equipment for power-driven walking assisted scooter |
| CN102174533A (zh) * | 2002-10-15 | 2011-09-07 | 英特塞尔股份公司 | 编码b族链球菌粘着因子的核酸、b族链球菌的粘着因子和它们的用途 |
| AU2004218284B2 (en) | 2003-03-04 | 2009-07-23 | Intercell Ag | Streptococcus pyogenes antigens |
| CA2522379C (en) | 2003-04-10 | 2012-10-23 | Chiron Corporation | The severe acute respiratory syndrome coronavirus |
| US7438912B2 (en) * | 2003-05-07 | 2008-10-21 | Intercell Ag | S.agalactiae antigens I + II |
| JP4896715B2 (ja) | 2003-06-26 | 2012-03-14 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | Ｃｈｌａｍｙｄｉａｔｒａｃｈｏｍａｔｉｓに対する免疫原性組成物 |
| ES2505695T3 (es) * | 2003-07-31 | 2014-10-10 | Novartis Vaccines And Diagnostics, Inc. | Composiciones inmunógenas para Streptococcus pyogenes |
| AU2003904237A0 (en) * | 2003-08-08 | 2003-08-21 | Garvan Institute Of Medical Research | Novel translocation assay |
| US8945589B2 (en) * | 2003-09-15 | 2015-02-03 | Novartis Vaccines And Diagnostics, Srl | Immunogenic compositions for Streptococcus agalactiae |
| WO2005076010A2 (en) * | 2004-02-06 | 2005-08-18 | Council Of Scientific And Industrial Research | Computational method for identifying adhesin and adhesin-like proteins of therapeutic potential |
| US20060041961A1 (en) * | 2004-03-25 | 2006-02-23 | Abad Mark S | Genes and uses for pant improvement |
| WO2005108419A1 (en) | 2004-05-07 | 2005-11-17 | Lea-Ann Kirkham | Mutant cholesterol-binding cytolysin proteins |
| CA2575548A1 (en) * | 2004-07-29 | 2006-07-27 | John L. Telford | Immunogenic compositions for gram positive bacteria such as streptococcus agalactiae |
| AU2005335216A1 (en) | 2004-10-05 | 2007-02-15 | Wyeth | Probe arrays for detecting multiple strains of different species |
| EP1770171A1 (en) | 2005-09-29 | 2007-04-04 | Universität Zu Köln | DNA microarray for rapid identification of Candida albicans in blood cultures. |
| EP2292648A3 (en) | 2006-07-07 | 2011-06-08 | Intercell AG | Small Streptococcus pyogenes antigens and their use |
| AT514720B1 (de) | 2013-08-30 | 2016-03-15 | Blum Gmbh Julius | Stellvorrichtung |
-
2005
- 2005-07-29 CA CA002575548A patent/CA2575548A1/en not_active Abandoned
- 2005-07-29 EP EP05856900A patent/EP1784211A4/en not_active Withdrawn
- 2005-07-29 JP JP2007523880A patent/JP2008508320A/ja active Pending
- 2005-07-29 US US11/658,842 patent/US20090317420A1/en not_active Abandoned
- 2005-07-29 EP EP13159533.2A patent/EP2612679A1/en not_active Withdrawn
- 2005-07-29 US US11/192,046 patent/US20060165716A1/en not_active Abandoned
- 2005-07-29 WO PCT/US2005/027239 patent/WO2006078318A2/en not_active Ceased
-
2010
- 2010-10-18 US US12/906,510 patent/US8778358B2/en not_active Expired - Fee Related
-
2011
- 2011-07-22 JP JP2011161176A patent/JP2011206061A/ja active Pending
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