JP2008212155A5 - - Google Patents
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- JP2008212155A5 JP2008212155A5 JP2008095756A JP2008095756A JP2008212155A5 JP 2008212155 A5 JP2008212155 A5 JP 2008212155A5 JP 2008095756 A JP2008095756 A JP 2008095756A JP 2008095756 A JP2008095756 A JP 2008095756A JP 2008212155 A5 JP2008212155 A5 JP 2008212155A5
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- Prior art keywords
- nucleic acid
- microorganism
- protein
- promoter
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000623 proteins and genes Proteins 0.000 claims 65
- 150000007523 nucleic acids Chemical group 0.000 claims 61
- 108020004707 nucleic acids Proteins 0.000 claims 58
- 102000039446 nucleic acids Human genes 0.000 claims 58
- 230000000694 effects Effects 0.000 claims 41
- 235000018102 proteins Nutrition 0.000 claims 34
- 102000004169 proteins and genes Human genes 0.000 claims 34
- 244000005700 microbiome Species 0.000 claims 30
- 230000006696 biosynthetic metabolic pathway Effects 0.000 claims 22
- 238000013518 transcription Methods 0.000 claims 13
- 230000035897 transcription Effects 0.000 claims 13
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 230000001105 regulatory effect Effects 0.000 claims 6
- 230000002103 transcriptional effect Effects 0.000 claims 6
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 5
- OAJLVMGLJZXSGX-SLAFOUTOSA-L (2s,3s,4r,5r)-2-(6-aminopurin-9-yl)-5-methanidyloxolane-3,4-diol;cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7 Chemical compound [Co+3].O[C@H]1[C@@H](O)[C@@H]([CH2-])O[C@@H]1N1C2=NC=NC(N)=C2N=C1.[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O OAJLVMGLJZXSGX-SLAFOUTOSA-L 0.000 claims 4
- 108010075604 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase Proteins 0.000 claims 4
- 102000011848 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase Human genes 0.000 claims 4
- 101000889837 Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) Protein CysO Proteins 0.000 claims 4
- 108010043428 Glycine hydroxymethyltransferase Proteins 0.000 claims 4
- 102000001253 Protein Kinase Human genes 0.000 claims 4
- 102000019394 Serine hydroxymethyltransferases Human genes 0.000 claims 4
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 4
- 239000004473 Threonine Substances 0.000 claims 4
- 235000001014 amino acid Nutrition 0.000 claims 4
- 229940024606 amino acid Drugs 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- -1 organic acids Nucleic acids Chemical class 0.000 claims 4
- 108010023317 1-phosphofructokinase Proteins 0.000 claims 2
- OSJPPGNTCRNQQC-UWTATZPHSA-N 3-phospho-D-glyceric acid Chemical compound OC(=O)[C@H](O)COP(O)(O)=O OSJPPGNTCRNQQC-UWTATZPHSA-N 0.000 claims 2
- 108091000044 4-hydroxy-tetrahydrodipicolinate synthase Proteins 0.000 claims 2
- 102100031126 6-phosphogluconolactonase Human genes 0.000 claims 2
- 108010029731 6-phosphogluconolactonase Proteins 0.000 claims 2
- 108010014885 Arginine-tRNA ligase Proteins 0.000 claims 2
- 102100036131 Arginine-tRNA ligase, cytoplasmic Human genes 0.000 claims 2
- 108010055400 Aspartate kinase Proteins 0.000 claims 2
- 108020004652 Aspartate-Semialdehyde Dehydrogenase Proteins 0.000 claims 2
- 108010076010 Cystathionine beta-lyase Proteins 0.000 claims 2
- 101710088194 Dehydrogenase Proteins 0.000 claims 2
- 108030003594 Diaminopimelate decarboxylases Proteins 0.000 claims 2
- 108010014468 Dihydrodipicolinate Reductase Proteins 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 108010081616 FAD-dependent malate dehydrogenase Proteins 0.000 claims 2
- 108010017464 Fructose-Bisphosphatase Proteins 0.000 claims 2
- 102000027487 Fructose-Bisphosphatase Human genes 0.000 claims 2
- 108010018962 Glucosephosphate Dehydrogenase Proteins 0.000 claims 2
- 101710083973 Homocysteine synthase Proteins 0.000 claims 2
- 108010064711 Homoserine dehydrogenase Proteins 0.000 claims 2
- 102000003960 Ligases Human genes 0.000 claims 2
- 108090000364 Ligases Proteins 0.000 claims 2
- 239000004472 Lysine Substances 0.000 claims 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
- 102000005954 Methylenetetrahydrofolate Reductase (NADPH2) Human genes 0.000 claims 2
- 108010030837 Methylenetetrahydrofolate Reductase (NADPH2) Proteins 0.000 claims 2
- 108091000041 Phosphoenolpyruvate Carboxylase Proteins 0.000 claims 2
- 108010022684 Phosphofructokinase-1 Proteins 0.000 claims 2
- 102000012435 Phosphofructokinase-1 Human genes 0.000 claims 2
- 108010038555 Phosphoglycerate dehydrogenase Proteins 0.000 claims 2
- 102100021762 Phosphoserine phosphatase Human genes 0.000 claims 2
- 108010053763 Pyruvate Carboxylase Proteins 0.000 claims 2
- 108010042687 Pyruvate Oxidase Proteins 0.000 claims 2
- 102100039895 Pyruvate carboxylase, mitochondrial Human genes 0.000 claims 2
- 108091022908 Serine O-acetyltransferase Proteins 0.000 claims 2
- 108010053816 Sulfite Reductase (Ferredoxin) Proteins 0.000 claims 2
- 108010006873 Threonine Dehydratase Proteins 0.000 claims 2
- 108010022394 Threonine synthase Proteins 0.000 claims 2
- 102000006843 Threonine synthase Human genes 0.000 claims 2
- 102100033451 Thyroid hormone receptor beta Human genes 0.000 claims 2
- 102100028601 Transaldolase Human genes 0.000 claims 2
- 108020004530 Transaldolase Proteins 0.000 claims 2
- 102000004357 Transferases Human genes 0.000 claims 2
- 108090000992 Transferases Proteins 0.000 claims 2
- 108010043652 Transketolase Proteins 0.000 claims 2
- 102000014701 Transketolase Human genes 0.000 claims 2
- 102000005924 Triose-Phosphate Isomerase Human genes 0.000 claims 2
- 108700015934 Triose-phosphate isomerases Proteins 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 150000001491 aromatic compounds Chemical class 0.000 claims 2
- 229960002685 biotin Drugs 0.000 claims 2
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N biotin Natural products N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- 235000020958 biotin Nutrition 0.000 claims 2
- 239000011616 biotin Substances 0.000 claims 2
- 150000001720 carbohydrates Chemical class 0.000 claims 2
- 235000014633 carbohydrates Nutrition 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 230000001419 dependent effect Effects 0.000 claims 2
- 108010056578 diaminopimelate dehydrogenase Proteins 0.000 claims 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- 150000002009 diols Chemical class 0.000 claims 2
- 230000029142 excretion Effects 0.000 claims 2
- 229930195729 fatty acid Natural products 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- 150000004665 fatty acids Chemical class 0.000 claims 2
- 238000012239 gene modification Methods 0.000 claims 2
- 230000005017 genetic modification Effects 0.000 claims 2
- 235000013617 genetically modified food Nutrition 0.000 claims 2
- 102000006602 glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 claims 2
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 claims 2
- 108010034653 homoserine O-acetyltransferase Proteins 0.000 claims 2
- 108010071598 homoserine kinase Proteins 0.000 claims 2
- 238000003780 insertion Methods 0.000 claims 2
- 230000037431 insertion Effects 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 239000002777 nucleoside Substances 0.000 claims 2
- 125000003835 nucleoside group Chemical group 0.000 claims 2
- 235000005985 organic acids Nutrition 0.000 claims 2
- 102000030592 phosphoserine aminotransferase Human genes 0.000 claims 2
- 108010088694 phosphoserine aminotransferase Proteins 0.000 claims 2
- 108010076573 phosphoserine phosphatase Proteins 0.000 claims 2
- 108060006633 protein kinase Proteins 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 239000011782 vitamin Substances 0.000 claims 2
- 235000013343 vitamin Nutrition 0.000 claims 2
- 229940088594 vitamin Drugs 0.000 claims 2
- 229930003231 vitamin Natural products 0.000 claims 2
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10359594A DE10359594A1 (de) | 2003-12-18 | 2003-12-18 | PEF-TU-Expressionseinheiten |
| DE10359594.5 | 2003-12-18 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006544325A Division JP2007514425A (ja) | 2003-12-18 | 2004-12-15 | Ｐｅｆ−ｔｕ発現ユニット |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008212155A JP2008212155A (ja) | 2008-09-18 |
| JP2008212155A5 true JP2008212155A5 (enExample) | 2009-09-24 |
| JP5710095B2 JP5710095B2 (ja) | 2015-04-30 |
Family
ID=34683543
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006544325A Withdrawn JP2007514425A (ja) | 2003-12-18 | 2004-12-15 | Ｐｅｆ−ｔｕ発現ユニット |
| JP2008095756A Expired - Fee Related JP5710095B2 (ja) | 2003-12-18 | 2008-04-02 | Ｐｅｆ−ｔｕ発現ユニット |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006544325A Withdrawn JP2007514425A (ja) | 2003-12-18 | 2004-12-15 | Ｐｅｆ−ｔｕ発現ユニット |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7785779B2 (enExample) |
| EP (2) | EP1697525A2 (enExample) |
| JP (2) | JP2007514425A (enExample) |
| KR (1) | KR101162226B1 (enExample) |
| CN (2) | CN101255419B (enExample) |
| AR (1) | AR047150A1 (enExample) |
| AU (1) | AU2004298546A1 (enExample) |
| BR (1) | BRPI0417710A (enExample) |
| CA (1) | CA2548349A1 (enExample) |
| DE (1) | DE10359594A1 (enExample) |
| ES (1) | ES2439946T3 (enExample) |
| IN (2) | IN2006CH02598A (enExample) |
| MX (1) | MXPA06006131A (enExample) |
| NO (1) | NO20062683L (enExample) |
| PL (1) | PL1908842T3 (enExample) |
| RU (1) | RU2006125501A (enExample) |
| TW (1) | TW200530398A (enExample) |
| WO (1) | WO2005059093A2 (enExample) |
| ZA (1) | ZA200605863B (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10359594A1 (de) | 2003-12-18 | 2005-07-28 | Basf Ag | PEF-TU-Expressionseinheiten |
| DE102004035065A1 (de) | 2004-07-20 | 2006-02-16 | Basf Ag | P-ET-TS-Expressionseinheiten |
| KR100620092B1 (ko) * | 2004-12-16 | 2006-09-08 | 씨제이 주식회사 | 코리네박테리움 속 세포로부터 유래된 신규한 프로모터서열, 그를 포함하는 발현 카세트 및 벡터, 상기 벡터를포함하는 숙주 세포 및 그를 이용하여 유전자를 발현하는방법 |
| DE102004061846A1 (de) | 2004-12-22 | 2006-07-13 | Basf Ag | Mehrfachpromotoren |
| ES2539280T3 (es) | 2006-10-24 | 2015-06-29 | Basf Se | Procedimiento de reducción de la expresión génica mediante el uso de codones modificado |
| EP2121954A2 (en) | 2007-02-19 | 2009-11-25 | Evonik Degussa GmbH | Coryneform bacteria with formate-thf-synthetase and/or glycine cleavage activity |
| JP2010130899A (ja) | 2007-03-14 | 2010-06-17 | Ajinomoto Co Inc | Ｌ−グルタミン酸系アミノ酸生産微生物及びアミノ酸の製造法 |
| WO2008126896A1 (ja) | 2007-04-10 | 2008-10-23 | Ajinomoto Co., Inc. | 有機酸の製造方法 |
| EP2192170B1 (en) | 2007-09-04 | 2017-02-15 | Ajinomoto Co., Inc. | Amino acid-producing microorganism and method of producing amino acid |
| EP2268826A2 (en) * | 2008-04-30 | 2011-01-05 | Evonik Degussa GmbH | Production process for methionine using microorganisms with reduced isocitrate dehydrogenase activity |
| US8647642B2 (en) | 2008-09-18 | 2014-02-11 | Aviex Technologies, Llc | Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment |
| US9005957B2 (en) | 2008-10-20 | 2015-04-14 | Cj Cheiljedang Corporation | Corynebacterium genus microorganism having ability to produce N-acetyl glucosamine and method for producing N-acetyl glucosamine or glucosamine using the same |
| WO2011073278A1 (en) | 2009-12-17 | 2011-06-23 | Basf Se | Processes and recombinant microorganisms for the production of cadaverine |
| EP2678421B1 (en) | 2011-02-22 | 2018-04-11 | Basf Se | Processes and recombinant microorganisms for the production of cadaverine |
| DE102011118019A1 (de) | 2011-06-28 | 2013-01-03 | Evonik Degussa Gmbh | Varianten des Promotors des für die Glyzerinaldehyd-3-phosphat-Dehydrogenase kodierenden gap-Gens |
| AR086790A1 (es) | 2011-06-29 | 2014-01-22 | Metabolic Explorer Sa | Un microorganismo para la produccion de metionina con importacion de glucosa mejorada |
| US9506093B2 (en) | 2012-06-18 | 2016-11-29 | Metabolic Explorer | Recombinant microorganism for the fermentative production of methionine |
| KR20140066553A (ko) | 2012-11-23 | 2014-06-02 | 삼성전자주식회사 | 코리네박테리움 속 균주의 신규 프로모터 |
| CN103361345B (zh) * | 2013-06-15 | 2016-05-04 | 福州大学 | 重组调控生物元器件强化次级代谢产物生物合成的方法 |
| MX374056B (es) | 2013-08-30 | 2020-07-27 | Evonik Operations Gmbh | Microorganismo para la produccion de metionina con actividad de metionina sintasa y eflujo de metionina mejorados. |
| RU2723714C2 (ru) | 2014-09-01 | 2020-06-17 | Эвоник Оперейшнс Гмбх | Способ и микроорганизм для ферментативного продуцирования метионина с улучшенным выходом метионина |
| KR101677368B1 (ko) | 2015-04-02 | 2016-11-18 | 씨제이제일제당 (주) | 신규 프로모터 및 이의 용도 |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| CN108026548A (zh) | 2015-05-19 | 2018-05-11 | 卢塞特英国国际有限公司 | 生物制备甲基丙烯酸及其衍生物的方法 |
| MY184139A (en) | 2015-08-07 | 2021-03-22 | Evonik Operations Gmbh | Protein thiocarboxylate-dependent l-methionine production by fermentation |
| EP3365427B1 (en) | 2015-10-23 | 2020-08-19 | Metabolic Explorer | Microorganism modified for the assimilation of levulinic acid |
| US11034985B2 (en) | 2015-11-27 | 2021-06-15 | Evonik Operations Gmbh | Method for producing L-methionine |
| EP3296404A1 (en) | 2016-09-15 | 2018-03-21 | Evonik Degussa GmbH | Modified microorganism for production of methionine |
| GB201619827D0 (en) | 2016-11-23 | 2017-01-04 | Lucite Int Uk Ltd | Process for the production of methyl methacrylate |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| EP3415622A1 (en) | 2017-06-14 | 2018-12-19 | Evonik Degussa GmbH | Method for production of fine chemicals using a corynebacterium secreting modified alpha-1,6-glucosidases |
| JP7498598B2 (ja) * | 2020-05-29 | 2024-06-12 | 花王株式会社 | 新規プロモーター |
| US20250051785A1 (en) | 2021-12-13 | 2025-02-13 | Kao Corporation | Novel promoter |
| GB2621337A (en) | 2022-08-08 | 2024-02-14 | Mitsubishi Chemical Uk Ltd | Process for the biological production of methacrylic acid and derivatives thereof |
| WO2025118096A1 (zh) * | 2023-12-04 | 2025-06-12 | 武汉远大弘元股份有限公司 | 一种改造的强启动子、含其的菌株及它们在氨基酸生产中的应用 |
| CN119331870A (zh) * | 2024-11-11 | 2025-01-21 | 暨南大学 | 核酸分子、转录元件、表达载体、宿主及其应用 |
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| DE10112992A1 (de) | 2001-03-17 | 2002-09-26 | Degussa | Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien |
| BR0208136B1 (pt) * | 2001-03-30 | 2014-10-21 | Ajinomoto Kk | Método para produzir uma proteína heteróloga |
| AU2002325923A1 (en) | 2001-08-06 | 2003-05-19 | Degussa Ag | Production of l-lysine by genetically modified corynebacterium glutamicum strains |
| DE10154180A1 (de) * | 2001-11-05 | 2003-05-15 | Basf Ag | gene die für genetische Stabilitäts-, genexpressions-und Faltungsproteine codieren |
| US7005031B2 (en) | 2002-01-16 | 2006-02-28 | 3M Innovative Properties Company | Pressure sensitive adhesives having quaternary ammonium functionality, articles, and methods |
| US7313177B2 (en) | 2003-05-10 | 2007-12-25 | Hewlett-Packard Development Company, L.P. | Reset scheme for I/O pads in a source synchronous system |
| DE10359595A1 (de) | 2003-12-18 | 2005-07-28 | Basf Ag | Pgro-Expressionseinheiten |
| DE10359594A1 (de) | 2003-12-18 | 2005-07-28 | Basf Ag | PEF-TU-Expressionseinheiten |
| MXPA06006759A (es) * | 2003-12-18 | 2006-09-04 | Basf Ag | Metodos para la preparacion de lisina por fermentacion de corynebacterium glutamicum. |
| DE10359660A1 (de) | 2003-12-18 | 2005-07-28 | Basf Ag | Psod-Expressionseinheiten |
-
2003
- 2003-12-18 DE DE10359594A patent/DE10359594A1/de not_active Withdrawn
-
2004
- 2004-12-15 AU AU2004298546A patent/AU2004298546A1/en not_active Abandoned
- 2004-12-15 KR KR1020067014165A patent/KR101162226B1/ko not_active Expired - Fee Related
- 2004-12-15 IN IN2598CH2006 patent/IN2006CH02598A/en unknown
- 2004-12-15 JP JP2006544325A patent/JP2007514425A/ja not_active Withdrawn
- 2004-12-15 EP EP04803887A patent/EP1697525A2/de not_active Withdrawn
- 2004-12-15 MX MXPA06006131A patent/MXPA06006131A/es not_active Application Discontinuation
- 2004-12-15 CA CA002548349A patent/CA2548349A1/en not_active Abandoned
- 2004-12-15 EP EP07123785.3A patent/EP1908842B1/de not_active Expired - Lifetime
- 2004-12-15 TW TW93138985A patent/TW200530398A/zh unknown
- 2004-12-15 PL PL07123785T patent/PL1908842T3/pl unknown
- 2004-12-15 US US10/582,918 patent/US7785779B2/en active Active
- 2004-12-15 CN CN2008100089537A patent/CN101255419B/zh not_active Expired - Fee Related
- 2004-12-15 BR BRPI0417710-0A patent/BRPI0417710A/pt not_active IP Right Cessation
- 2004-12-15 CN CNA2004800379281A patent/CN1894412A/zh active Pending
- 2004-12-15 WO PCT/EP2004/014266 patent/WO2005059093A2/de not_active Ceased
- 2004-12-15 ES ES07123785.3T patent/ES2439946T3/es not_active Expired - Lifetime
- 2004-12-15 RU RU2006125501/13A patent/RU2006125501A/ru unknown
- 2004-12-17 AR ARP040104735A patent/AR047150A1/es not_active Application Discontinuation
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2006
- 2006-06-09 NO NO20062683A patent/NO20062683L/no not_active Application Discontinuation
- 2006-07-17 ZA ZA200605863A patent/ZA200605863B/xx unknown
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2008
- 2008-01-24 IN IN415CH2008 patent/IN2008CH00415A/en unknown
- 2008-02-27 US US12/038,603 patent/US8044191B2/en not_active Expired - Lifetime
- 2008-04-02 JP JP2008095756A patent/JP5710095B2/ja not_active Expired - Fee Related
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