JP2008237218A5 - - Google Patents
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- Publication number
- JP2008237218A5 JP2008237218A5 JP2008095696A JP2008095696A JP2008237218A5 JP 2008237218 A5 JP2008237218 A5 JP 2008237218A5 JP 2008095696 A JP2008095696 A JP 2008095696A JP 2008095696 A JP2008095696 A JP 2008095696A JP 2008237218 A5 JP2008237218 A5 JP 2008237218A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- promoter activity
- microorganism
- transcription
- nucleic acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000007523 nucleic acids Chemical group 0.000 claims 67
- 108020004707 nucleic acids Proteins 0.000 claims 61
- 102000039446 nucleic acids Human genes 0.000 claims 61
- 108090000623 proteins and genes Proteins 0.000 claims 58
- 230000000694 effects Effects 0.000 claims 40
- 235000018102 proteins Nutrition 0.000 claims 31
- 102000004169 proteins and genes Human genes 0.000 claims 31
- 244000005700 microbiome Species 0.000 claims 28
- 238000013518 transcription Methods 0.000 claims 26
- 230000035897 transcription Effects 0.000 claims 26
- 230000006696 biosynthetic metabolic pathway Effects 0.000 claims 20
- 238000000034 method Methods 0.000 claims 9
- 230000001105 regulatory effect Effects 0.000 claims 8
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 6
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 6
- OAJLVMGLJZXSGX-SLAFOUTOSA-L (2s,3s,4r,5r)-2-(6-aminopurin-9-yl)-5-methanidyloxolane-3,4-diol;cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7 Chemical compound [Co+3].O[C@H]1[C@@H](O)[C@@H]([CH2-])O[C@@H]1N1C2=NC=NC(N)=C2N=C1.[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O OAJLVMGLJZXSGX-SLAFOUTOSA-L 0.000 claims 4
- 108010075604 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase Proteins 0.000 claims 4
- 102000011848 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase Human genes 0.000 claims 4
- 101000889837 Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) Protein CysO Proteins 0.000 claims 4
- 108010043428 Glycine hydroxymethyltransferase Proteins 0.000 claims 4
- 102000003960 Ligases Human genes 0.000 claims 4
- 108090000364 Ligases Proteins 0.000 claims 4
- 102000001253 Protein Kinase Human genes 0.000 claims 4
- 102000019394 Serine hydroxymethyltransferases Human genes 0.000 claims 4
- 235000001014 amino acid Nutrition 0.000 claims 4
- 229940024606 amino acid Drugs 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 108010023317 1-phosphofructokinase Proteins 0.000 claims 2
- OSJPPGNTCRNQQC-UWTATZPHSA-N 3-phospho-D-glyceric acid Chemical compound OC(=O)[C@H](O)COP(O)(O)=O OSJPPGNTCRNQQC-UWTATZPHSA-N 0.000 claims 2
- IRLPACMLTUPBCL-KQYNXXCUSA-N 5'-adenylyl sulfate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OS(O)(=O)=O)[C@@H](O)[C@H]1O IRLPACMLTUPBCL-KQYNXXCUSA-N 0.000 claims 2
- 108020001657 6-phosphogluconate dehydrogenase Proteins 0.000 claims 2
- 102000004567 6-phosphogluconate dehydrogenase Human genes 0.000 claims 2
- 102100031126 6-phosphogluconolactonase Human genes 0.000 claims 2
- 108010029731 6-phosphogluconolactonase Proteins 0.000 claims 2
- 108010014885 Arginine-tRNA ligase Proteins 0.000 claims 2
- 102100036131 Arginine-tRNA ligase, cytoplasmic Human genes 0.000 claims 2
- 108010055400 Aspartate kinase Proteins 0.000 claims 2
- 108020004652 Aspartate-Semialdehyde Dehydrogenase Proteins 0.000 claims 2
- 108030003594 Diaminopimelate decarboxylases Proteins 0.000 claims 2
- 108010014468 Dihydrodipicolinate Reductase Proteins 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 108010081616 FAD-dependent malate dehydrogenase Proteins 0.000 claims 2
- 108010046335 Ferredoxin-NADP Reductase Proteins 0.000 claims 2
- 108010017464 Fructose-Bisphosphatase Proteins 0.000 claims 2
- 102000027487 Fructose-Bisphosphatase Human genes 0.000 claims 2
- 108010018962 Glucosephosphate Dehydrogenase Proteins 0.000 claims 2
- 101710083973 Homocysteine synthase Proteins 0.000 claims 2
- 108010064711 Homoserine dehydrogenase Proteins 0.000 claims 2
- 239000004472 Lysine Substances 0.000 claims 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
- 102000005954 Methylenetetrahydrofolate Reductase (NADPH2) Human genes 0.000 claims 2
- 108010030837 Methylenetetrahydrofolate Reductase (NADPH2) Proteins 0.000 claims 2
- 108010061618 O-succinylhomoserine (thiol)-lyase Proteins 0.000 claims 2
- 101710116000 Phosphoadenosine phosphosulfate reductase Proteins 0.000 claims 2
- 108091000041 Phosphoenolpyruvate Carboxylase Proteins 0.000 claims 2
- 108010022684 Phosphofructokinase-1 Proteins 0.000 claims 2
- 102000012435 Phosphofructokinase-1 Human genes 0.000 claims 2
- 108010038555 Phosphoglycerate dehydrogenase Proteins 0.000 claims 2
- 102100021762 Phosphoserine phosphatase Human genes 0.000 claims 2
- 108010053763 Pyruvate Carboxylase Proteins 0.000 claims 2
- 108010042687 Pyruvate Oxidase Proteins 0.000 claims 2
- 102100039895 Pyruvate carboxylase, mitochondrial Human genes 0.000 claims 2
- 108091022908 Serine O-acetyltransferase Proteins 0.000 claims 2
- 108010053816 Sulfite Reductase (Ferredoxin) Proteins 0.000 claims 2
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 2
- 239000004473 Threonine Substances 0.000 claims 2
- 108010006873 Threonine Dehydratase Proteins 0.000 claims 2
- 101710180758 Threonine efflux protein Proteins 0.000 claims 2
- 108010022394 Threonine synthase Proteins 0.000 claims 2
- 102000006843 Threonine synthase Human genes 0.000 claims 2
- 102100033451 Thyroid hormone receptor beta Human genes 0.000 claims 2
- 108020004530 Transaldolase Proteins 0.000 claims 2
- 102100028601 Transaldolase Human genes 0.000 claims 2
- 108010043652 Transketolase Proteins 0.000 claims 2
- 102000014701 Transketolase Human genes 0.000 claims 2
- 102000005924 Triose-Phosphate Isomerase Human genes 0.000 claims 2
- 108700015934 Triose-phosphate isomerases Proteins 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 229960002685 biotin Drugs 0.000 claims 2
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N biotin Natural products N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- 235000020958 biotin Nutrition 0.000 claims 2
- 239000011616 biotin Substances 0.000 claims 2
- 150000001720 carbohydrates Chemical class 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 230000001419 dependent effect Effects 0.000 claims 2
- 108010056578 diaminopimelate dehydrogenase Proteins 0.000 claims 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- 150000002009 diols Chemical class 0.000 claims 2
- 229930195729 fatty acid Natural products 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- 150000004665 fatty acids Chemical class 0.000 claims 2
- 238000012239 gene modification Methods 0.000 claims 2
- 230000005017 genetic modification Effects 0.000 claims 2
- 235000013617 genetically modified food Nutrition 0.000 claims 2
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 claims 2
- 102000006602 glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 claims 2
- 108010034653 homoserine O-acetyltransferase Proteins 0.000 claims 2
- 108010071598 homoserine kinase Proteins 0.000 claims 2
- 238000003780 insertion Methods 0.000 claims 2
- 230000037431 insertion Effects 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 239000002777 nucleoside Substances 0.000 claims 2
- 125000003835 nucleoside group Chemical group 0.000 claims 2
- 150000007524 organic acids Chemical class 0.000 claims 2
- 230000037361 pathway Effects 0.000 claims 2
- 102000030592 phosphoserine aminotransferase Human genes 0.000 claims 2
- 108010088694 phosphoserine aminotransferase Proteins 0.000 claims 2
- 108010076573 phosphoserine phosphatase Proteins 0.000 claims 2
- 108060006633 protein kinase Proteins 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 239000011782 vitamin Substances 0.000 claims 2
- 235000013343 vitamin Nutrition 0.000 claims 2
- 229940088594 vitamin Drugs 0.000 claims 2
- 229930003231 vitamin Natural products 0.000 claims 2
- 230000001276 controlling effect Effects 0.000 claims 1
- 235000005985 organic acids Nutrition 0.000 claims 1
- 235000020004 porter Nutrition 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10359595.3 | 2003-12-18 | ||
| DE10359595A DE10359595A1 (de) | 2003-12-18 | 2003-12-18 | Pgro-Expressionseinheiten |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006544324A Division JP2007536908A (ja) | 2003-12-18 | 2004-12-15 | Ｐｇｒｏ発現ユニット |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008237218A JP2008237218A (ja) | 2008-10-09 |
| JP2008237218A5 true JP2008237218A5 (enExample) | 2009-09-24 |
| JP4808742B2 JP4808742B2 (ja) | 2011-11-02 |
Family
ID=34683544
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006544324A Withdrawn JP2007536908A (ja) | 2003-12-18 | 2004-12-15 | Ｐｇｒｏ発現ユニット |
| JP2008095696A Expired - Fee Related JP4808742B2 (ja) | 2003-12-18 | 2008-04-02 | Ｐｇｒｏ発現ユニット |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006544324A Withdrawn JP2007536908A (ja) | 2003-12-18 | 2004-12-15 | Ｐｇｒｏ発現ユニット |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20090246836A1 (enExample) |
| EP (2) | EP1921150B1 (enExample) |
| JP (2) | JP2007536908A (enExample) |
| KR (1) | KR100876655B1 (enExample) |
| CN (2) | CN1898388A (enExample) |
| BR (1) | BRPI0417770A (enExample) |
| CA (1) | CA2548306A1 (enExample) |
| CY (1) | CY1114595T1 (enExample) |
| DE (1) | DE10359595A1 (enExample) |
| IN (2) | IN2006CH02600A (enExample) |
| PL (1) | PL1921150T3 (enExample) |
| PT (1) | PT1921150E (enExample) |
| RU (1) | RU2006125497A (enExample) |
| TW (1) | TW200533749A (enExample) |
| WO (1) | WO2005059143A1 (enExample) |
| ZA (1) | ZA200605862B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10359594A1 (de) | 2003-12-18 | 2005-07-28 | Basf Ag | PEF-TU-Expressionseinheiten |
| DE102004061846A1 (de) | 2004-12-22 | 2006-07-13 | Basf Ag | Mehrfachpromotoren |
| EP2082045B1 (en) * | 2006-10-24 | 2015-03-18 | Basf Se | Method of reducing gene expression using modified codon usage |
| JP2010518827A (ja) * | 2007-02-19 | 2010-06-03 | エボニック デグサ ゲーエムベーハー | ペントースリン酸経路の酵素を過剰発現させることによりコリネバクテリウムにおいてメチオニンを生産する方法 |
| AU2009228322B2 (en) * | 2008-03-27 | 2013-09-26 | Alliance For Sustainable Energy, Llc | High expression Zymomonas promoters |
| US8647642B2 (en) | 2008-09-18 | 2014-02-11 | Aviex Technologies, Llc | Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| WO2018126287A1 (en) * | 2016-12-30 | 2018-07-05 | Ntxbio, Llc | Cell-free expression system having novel inorganic polyphosphate-based energy regeneration |
| EP3415622A1 (en) | 2017-06-14 | 2018-12-19 | Evonik Degussa GmbH | Method for production of fine chemicals using a corynebacterium secreting modified alpha-1,6-glucosidases |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5835197A (ja) * | 1981-08-26 | 1983-03-01 | Kyowa Hakko Kogyo Co Ltd | プラスミドｐｃｇ２ |
| US4601893A (en) * | 1984-02-08 | 1986-07-22 | Pfizer Inc. | Laminate device for controlled and prolonged release of substances to an ambient environment and method of use |
| GB2165546B (en) * | 1984-08-21 | 1989-05-17 | Asahi Chemical Ind | A plasmid containing a gene for tetracycline resistance and dna fragments derived therefrom |
| DE4027453A1 (de) | 1990-08-30 | 1992-03-05 | Degussa | Neue plasmide aus corynebacterium glutamicum und davon abgeleitete plasmidvektoren |
| EP0710283A4 (en) * | 1993-07-22 | 1997-07-02 | Merck & Co Inc | THE EXPRESSION OF HUMAN INTERLEUKIN-1-g (b) IN A TRANSGENIC ANIMAL |
| EP0693558B1 (en) | 1994-07-19 | 2002-12-04 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Trehalose and its production and use |
| DE4440118C1 (de) | 1994-11-11 | 1995-11-09 | Forschungszentrum Juelich Gmbh | Die Genexpression in coryneformen Bakterien regulierende DNA |
| DE69834562T2 (de) * | 1997-02-20 | 2007-05-10 | Mitsubishi Rayon Co., Ltd. | Verfahren für die produktion von malonsäurederivaten |
| JPH10229891A (ja) | 1997-02-20 | 1998-09-02 | Mitsubishi Rayon Co Ltd | マロン酸誘導体の製造法 |
| ES2178979T1 (es) * | 1999-06-25 | 2003-01-16 | Basf Ag | Genes de corynebacterium glutamicum que codifican proteinas implicadas en el metabolismo del carbono y la produccion de energia. |
| US20030049804A1 (en) * | 1999-06-25 | 2003-03-13 | Markus Pompejus | Corynebacterium glutamicum genes encoding metabolic pathway proteins |
| US7892798B2 (en) * | 1999-06-25 | 2011-02-22 | Evonik Degussa Gmbh | Nucleic acid molecules encoding metabolic regulatory proteins from Corynebacterium glutamicum, useful for increasing the production of methionone by a microorganism |
| US7270984B1 (en) * | 1999-06-25 | 2007-09-18 | Basf Aktiengesellschaft | Polynucleotides encoding a 6-phosphogluconolactonase polypeptide from corynebacterium glutamicum |
| JP4623825B2 (ja) * | 1999-12-16 | 2011-02-02 | 協和発酵バイオ株式会社 | 新規ポリヌクレオチド |
| DE10046870A1 (de) | 2000-09-20 | 2002-03-28 | Basf Ag | Verfahren zur Veränderung des Genoms von Corynebakterien |
| WO2002040679A2 (en) | 2000-11-15 | 2002-05-23 | Archer-Daniels-Midland Company | Corynebacterium glutamicum promoters |
| CN100334213C (zh) * | 2000-12-22 | 2007-08-29 | 巴斯福股份公司 | 棒状杆菌基因 |
| DE10112992A1 (de) * | 2001-03-17 | 2002-09-26 | Degussa | Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien |
| US7005031B2 (en) * | 2002-01-16 | 2006-02-28 | 3M Innovative Properties Company | Pressure sensitive adhesives having quaternary ammonium functionality, articles, and methods |
-
2003
- 2003-12-18 DE DE10359595A patent/DE10359595A1/de not_active Withdrawn
-
2004
- 2004-12-15 BR BRPI0417770-3A patent/BRPI0417770A/pt not_active IP Right Cessation
- 2004-12-15 RU RU2006125497/13A patent/RU2006125497A/ru unknown
- 2004-12-15 US US10/582,822 patent/US20090246836A1/en not_active Abandoned
- 2004-12-15 CN CNA2004800380880A patent/CN1898388A/zh active Pending
- 2004-12-15 EP EP07123783.8A patent/EP1921150B1/de not_active Expired - Lifetime
- 2004-12-15 WO PCT/EP2004/014263 patent/WO2005059143A1/de not_active Ceased
- 2004-12-15 KR KR1020067014365A patent/KR100876655B1/ko not_active Expired - Lifetime
- 2004-12-15 CN CN2008100020226A patent/CN101230352B/zh not_active Expired - Lifetime
- 2004-12-15 CA CA002548306A patent/CA2548306A1/en not_active Abandoned
- 2004-12-15 EP EP04803884A patent/EP1697524A1/de not_active Withdrawn
- 2004-12-15 PL PL07123783T patent/PL1921150T3/pl unknown
- 2004-12-15 PT PT71237838T patent/PT1921150E/pt unknown
- 2004-12-15 TW TW93139001A patent/TW200533749A/zh unknown
- 2004-12-15 JP JP2006544324A patent/JP2007536908A/ja not_active Withdrawn
-
2006
- 2006-07-17 ZA ZA200605862A patent/ZA200605862B/xx unknown
- 2006-07-17 IN IN2600CH2006 patent/IN2006CH02600A/en unknown
-
2008
- 2008-02-21 IN IN439CH2008 patent/IN2008CH00439A/en unknown
- 2008-04-02 JP JP2008095696A patent/JP4808742B2/ja not_active Expired - Fee Related
-
2013
- 2013-11-11 CY CY20131100999T patent/CY1114595T1/el unknown
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