BRPI0417710A - usos de um ácido nucleico, de uma unidade de expressão, e da seqüência de ácido nucleico, ácido nucleico, unidade de expressão, métodos para alterar ou induzir as taxas de transcrição e de expressão de genes em microorganismos comparado com o tipo selvagem, e para preparar produtos biossintéticos, lisina, metionina, e treonina, cassete de expressão, vetor de expressão, microorganismo geneticamente modificado, e, unidade de expressão - Google Patents
usos de um ácido nucleico, de uma unidade de expressão, e da seqüência de ácido nucleico, ácido nucleico, unidade de expressão, métodos para alterar ou induzir as taxas de transcrição e de expressão de genes em microorganismos comparado com o tipo selvagem, e para preparar produtos biossintéticos, lisina, metionina, e treonina, cassete de expressão, vetor de expressão, microorganismo geneticamente modificado, e, unidade de expressãoInfo
- Publication number
- BRPI0417710A BRPI0417710A BRPI0417710-0A BRPI0417710A BRPI0417710A BR PI0417710 A BRPI0417710 A BR PI0417710A BR PI0417710 A BRPI0417710 A BR PI0417710A BR PI0417710 A BRPI0417710 A BR PI0417710A
- Authority
- BR
- Brazil
- Prior art keywords
- expression
- nucleic acid
- expression unit
- unit
- methods
- Prior art date
Links
- 230000014509 gene expression Effects 0.000 title abstract 16
- 150000007523 nucleic acids Chemical class 0.000 title abstract 7
- 244000005700 microbiome Species 0.000 title abstract 6
- 108020004707 nucleic acids Proteins 0.000 title abstract 6
- 102000039446 nucleic acids Human genes 0.000 title abstract 6
- 238000013518 transcription Methods 0.000 title abstract 5
- 230000035897 transcription Effects 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- 230000001939 inductive effect Effects 0.000 title abstract 3
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 title abstract 2
- 239000004472 Lysine Substances 0.000 title abstract 2
- 230000001851 biosynthetic effect Effects 0.000 title abstract 2
- 239000013604 expression vector Substances 0.000 title abstract 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 title 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 title 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 title 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 title 1
- 239000004473 Threonine Substances 0.000 title 1
- -1 expression cassette Substances 0.000 title 1
- 229930182817 methionine Natural products 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/12—Methionine; Cysteine; Cystine
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10359594A DE10359594A1 (de) | 2003-12-18 | 2003-12-18 | PEF-TU-Expressionseinheiten |
| PCT/EP2004/014266 WO2005059093A2 (de) | 2003-12-18 | 2004-12-15 | P ef-tu-expressionseinheiten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0417710A true BRPI0417710A (pt) | 2007-03-20 |
Family
ID=34683543
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0417710-0A BRPI0417710A (pt) | 2003-12-18 | 2004-12-15 | usos de um ácido nucleico, de uma unidade de expressão, e da seqüência de ácido nucleico, ácido nucleico, unidade de expressão, métodos para alterar ou induzir as taxas de transcrição e de expressão de genes em microorganismos comparado com o tipo selvagem, e para preparar produtos biossintéticos, lisina, metionina, e treonina, cassete de expressão, vetor de expressão, microorganismo geneticamente modificado, e, unidade de expressão |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7785779B2 (enExample) |
| EP (2) | EP1908842B1 (enExample) |
| JP (2) | JP2007514425A (enExample) |
| KR (1) | KR101162226B1 (enExample) |
| CN (2) | CN1894412A (enExample) |
| AR (1) | AR047150A1 (enExample) |
| AU (1) | AU2004298546A1 (enExample) |
| BR (1) | BRPI0417710A (enExample) |
| CA (1) | CA2548349A1 (enExample) |
| DE (1) | DE10359594A1 (enExample) |
| ES (1) | ES2439946T3 (enExample) |
| IN (2) | IN2006CH02598A (enExample) |
| MX (1) | MXPA06006131A (enExample) |
| NO (1) | NO20062683L (enExample) |
| PL (1) | PL1908842T3 (enExample) |
| RU (1) | RU2006125501A (enExample) |
| TW (1) | TW200530398A (enExample) |
| WO (1) | WO2005059093A2 (enExample) |
| ZA (1) | ZA200605863B (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10359594A1 (de) | 2003-12-18 | 2005-07-28 | Basf Ag | PEF-TU-Expressionseinheiten |
| DE102004035065A1 (de) * | 2004-07-20 | 2006-02-16 | Basf Ag | P-ET-TS-Expressionseinheiten |
| KR100620092B1 (ko) * | 2004-12-16 | 2006-09-08 | 씨제이 주식회사 | 코리네박테리움 속 세포로부터 유래된 신규한 프로모터서열, 그를 포함하는 발현 카세트 및 벡터, 상기 벡터를포함하는 숙주 세포 및 그를 이용하여 유전자를 발현하는방법 |
| DE102004061846A1 (de) | 2004-12-22 | 2006-07-13 | Basf Ag | Mehrfachpromotoren |
| PL2082045T3 (pl) | 2006-10-24 | 2015-07-31 | Basf Se | Sposób zmniejszania ekspresji genów poprzez modyfikację częstości występowania kodonów |
| JP2010518837A (ja) | 2007-02-19 | 2010-06-03 | エボニック デグサ ゲーエムベーハー | ホルメート−ｔｈｆ−シンテターゼおよび／またはグリシン開裂活性を有するコリネ型細菌 |
| JP2010130899A (ja) | 2007-03-14 | 2010-06-17 | Ajinomoto Co Inc | Ｌ−グルタミン酸系アミノ酸生産微生物及びアミノ酸の製造法 |
| WO2008126896A1 (ja) | 2007-04-10 | 2008-10-23 | Ajinomoto Co., Inc. | 有機酸の製造方法 |
| BRPI0816429A2 (pt) | 2007-09-04 | 2019-09-24 | Ajinomoto Kk | microorganismo, e, método para a produção de um l-aminoácido. |
| MX2010011720A (es) * | 2008-04-30 | 2010-11-30 | Evonik Degussa Gmbh | Procedimiento de produccion de metionina usando microorganismos con actividad reducida de isocitrato deshidrogenasa. |
| US8647642B2 (en) | 2008-09-18 | 2014-02-11 | Aviex Technologies, Llc | Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment |
| US9005957B2 (en) | 2008-10-20 | 2015-04-14 | Cj Cheiljedang Corporation | Corynebacterium genus microorganism having ability to produce N-acetyl glucosamine and method for producing N-acetyl glucosamine or glucosamine using the same |
| JP5960604B2 (ja) | 2009-12-17 | 2016-08-02 | ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ | カダベリンの生産のための方法及び組換え微生物 |
| CN103492553B (zh) | 2011-02-22 | 2018-06-12 | 巴斯夫欧洲公司 | 用于生产尸胺的方法和重组微生物 |
| DE102011118019A1 (de) | 2011-06-28 | 2013-01-03 | Evonik Degussa Gmbh | Varianten des Promotors des für die Glyzerinaldehyd-3-phosphat-Dehydrogenase kodierenden gap-Gens |
| AR086790A1 (es) | 2011-06-29 | 2014-01-22 | Metabolic Explorer Sa | Un microorganismo para la produccion de metionina con importacion de glucosa mejorada |
| US9506093B2 (en) | 2012-06-18 | 2016-11-29 | Metabolic Explorer | Recombinant microorganism for the fermentative production of methionine |
| KR20140066553A (ko) | 2012-11-23 | 2014-06-02 | 삼성전자주식회사 | 코리네박테리움 속 균주의 신규 프로모터 |
| CN103361345B (zh) * | 2013-06-15 | 2016-05-04 | 福州大学 | 重组调控生物元器件强化次级代谢产物生物合成的方法 |
| WO2015028674A1 (en) | 2013-08-30 | 2015-03-05 | Metabolic Explorer | Microorganism for methionine production with improved methionine synthase activity and methionine efflux |
| RU2723714C2 (ru) | 2014-09-01 | 2020-06-17 | Эвоник Оперейшнс Гмбх | Способ и микроорганизм для ферментативного продуцирования метионина с улучшенным выходом метионина |
| KR101677368B1 (ko) | 2015-04-02 | 2016-11-18 | 씨제이제일제당 (주) | 신규 프로모터 및 이의 용도 |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| WO2016185211A1 (en) | 2015-05-19 | 2016-11-24 | Lucite International Uk Limited | Process for the biological productiion of methacrylic acid and derivatives thereof |
| BR112018002048A2 (pt) | 2015-08-07 | 2018-09-18 | Evonik Degussa Gmbh | ?micro-organismo geneticamente modificado e método para a produção fermentativa de metionina? |
| EP3365427B1 (en) | 2015-10-23 | 2020-08-19 | Metabolic Explorer | Microorganism modified for the assimilation of levulinic acid |
| CN108291243A (zh) | 2015-11-27 | 2018-07-17 | 赢创德固赛有限公司 | 生产l-甲硫氨酸的方法 |
| EP3296404A1 (en) | 2016-09-15 | 2018-03-21 | Evonik Degussa GmbH | Modified microorganism for production of methionine |
| GB201619827D0 (en) | 2016-11-23 | 2017-01-04 | Lucite Int Uk Ltd | Process for the production of methyl methacrylate |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| EP3415622A1 (en) | 2017-06-14 | 2018-12-19 | Evonik Degussa GmbH | Method for production of fine chemicals using a corynebacterium secreting modified alpha-1,6-glucosidases |
| JP7498598B2 (ja) * | 2020-05-29 | 2024-06-12 | 花王株式会社 | 新規プロモーター |
| EP4450621A4 (en) | 2021-12-13 | 2026-01-14 | Kao Corp | NEW DEVELOPER |
| GB2621337A (en) | 2022-08-08 | 2024-02-14 | Mitsubishi Chemical Uk Ltd | Process for the biological production of methacrylic acid and derivatives thereof |
| WO2025118096A1 (zh) * | 2023-12-04 | 2025-06-12 | 武汉远大弘元股份有限公司 | 一种改造的强启动子、含其的菌株及它们在氨基酸生产中的应用 |
| CN119331870A (zh) * | 2024-11-11 | 2025-01-21 | 暨南大学 | 核酸分子、转录元件、表达载体、宿主及其应用 |
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| DE10046870A1 (de) | 2000-09-20 | 2002-03-28 | Basf Ag | Verfahren zur Veränderung des Genoms von Corynebakterien |
| DE10056615A1 (de) | 2000-11-15 | 2002-05-29 | Zahnradfabrik Friedrichshafen | Gleitgelagerte, geschweißte Baueinheit |
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| DE10112992A1 (de) | 2001-03-17 | 2002-09-26 | Degussa | Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien |
| EP1375664B1 (en) * | 2001-03-30 | 2009-11-04 | Ajinomoto Co., Inc. | Method for the secretion and production of protein |
| CN100554426C (zh) | 2001-08-06 | 2009-10-28 | 德古萨股份公司 | 用遗传修饰的谷氨酸棒杆菌生产l-赖氨酸 |
| DE10154180A1 (de) * | 2001-11-05 | 2003-05-15 | Basf Ag | gene die für genetische Stabilitäts-, genexpressions-und Faltungsproteine codieren |
| US7005031B2 (en) | 2002-01-16 | 2006-02-28 | 3M Innovative Properties Company | Pressure sensitive adhesives having quaternary ammonium functionality, articles, and methods |
| US7313177B2 (en) | 2003-05-10 | 2007-12-25 | Hewlett-Packard Development Company, L.P. | Reset scheme for I/O pads in a source synchronous system |
| KR20060125804A (ko) * | 2003-12-18 | 2006-12-06 | 바스프 악티엔게젤샤프트 | 코리네박테륨 글루타미쿰의 발효에 의한 리신의 제조 방법 |
| DE10359595A1 (de) | 2003-12-18 | 2005-07-28 | Basf Ag | Pgro-Expressionseinheiten |
| DE10359660A1 (de) | 2003-12-18 | 2005-07-28 | Basf Ag | Psod-Expressionseinheiten |
| DE10359594A1 (de) | 2003-12-18 | 2005-07-28 | Basf Ag | PEF-TU-Expressionseinheiten |
-
2003
- 2003-12-18 DE DE10359594A patent/DE10359594A1/de not_active Withdrawn
-
2004
- 2004-12-15 PL PL07123785T patent/PL1908842T3/pl unknown
- 2004-12-15 MX MXPA06006131A patent/MXPA06006131A/es not_active Application Discontinuation
- 2004-12-15 CA CA002548349A patent/CA2548349A1/en not_active Abandoned
- 2004-12-15 JP JP2006544325A patent/JP2007514425A/ja not_active Withdrawn
- 2004-12-15 IN IN2598CH2006 patent/IN2006CH02598A/en unknown
- 2004-12-15 AU AU2004298546A patent/AU2004298546A1/en not_active Abandoned
- 2004-12-15 CN CNA2004800379281A patent/CN1894412A/zh active Pending
- 2004-12-15 EP EP07123785.3A patent/EP1908842B1/de not_active Expired - Lifetime
- 2004-12-15 US US10/582,918 patent/US7785779B2/en active Active
- 2004-12-15 TW TW93138985A patent/TW200530398A/zh unknown
- 2004-12-15 WO PCT/EP2004/014266 patent/WO2005059093A2/de not_active Ceased
- 2004-12-15 EP EP04803887A patent/EP1697525A2/de not_active Withdrawn
- 2004-12-15 KR KR1020067014165A patent/KR101162226B1/ko not_active Expired - Fee Related
- 2004-12-15 CN CN2008100089537A patent/CN101255419B/zh not_active Expired - Fee Related
- 2004-12-15 ES ES07123785.3T patent/ES2439946T3/es not_active Expired - Lifetime
- 2004-12-15 RU RU2006125501/13A patent/RU2006125501A/ru unknown
- 2004-12-15 BR BRPI0417710-0A patent/BRPI0417710A/pt not_active IP Right Cessation
- 2004-12-17 AR ARP040104735A patent/AR047150A1/es not_active Application Discontinuation
-
2006
- 2006-06-09 NO NO20062683A patent/NO20062683L/no not_active Application Discontinuation
- 2006-07-17 ZA ZA200605863A patent/ZA200605863B/xx unknown
-
2008
- 2008-01-24 IN IN415CH2008 patent/IN2008CH00415A/en unknown
- 2008-02-27 US US12/038,603 patent/US8044191B2/en not_active Expired - Lifetime
- 2008-04-02 JP JP2008095756A patent/JP5710095B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AR047150A1 (es) | 2006-01-11 |
| JP2007514425A (ja) | 2007-06-07 |
| EP1908842A2 (de) | 2008-04-09 |
| IN2008CH00415A (enExample) | 2008-09-19 |
| EP1908842B1 (de) | 2013-09-18 |
| CA2548349A1 (en) | 2005-06-30 |
| JP5710095B2 (ja) | 2015-04-30 |
| NO20062683L (no) | 2006-09-11 |
| US20080166775A1 (en) | 2008-07-10 |
| RU2006125501A (ru) | 2008-01-27 |
| US8044191B2 (en) | 2011-10-25 |
| AU2004298546A1 (en) | 2005-06-30 |
| DE10359594A1 (de) | 2005-07-28 |
| KR20070000431A (ko) | 2007-01-02 |
| EP1908842A3 (de) | 2008-08-27 |
| TW200530398A (en) | 2005-09-16 |
| CN1894412A (zh) | 2007-01-10 |
| US20080118948A1 (en) | 2008-05-22 |
| WO2005059093A2 (de) | 2005-06-30 |
| JP2008212155A (ja) | 2008-09-18 |
| MXPA06006131A (es) | 2006-08-11 |
| PL1908842T3 (pl) | 2014-03-31 |
| WO2005059093A3 (de) | 2006-03-02 |
| US7785779B2 (en) | 2010-08-31 |
| ZA200605863B (en) | 2008-01-30 |
| KR101162226B1 (ko) | 2012-07-04 |
| CN101255419A (zh) | 2008-09-03 |
| IN2006CH02598A (enExample) | 2007-06-08 |
| EP1697525A2 (de) | 2006-09-06 |
| ES2439946T3 (es) | 2014-01-27 |
| CN101255419B (zh) | 2012-06-20 |
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