DE10359594A1 - PEF-TU-Expressionseinheiten - Google Patents
PEF-TU-Expressionseinheiten Download PDFInfo
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- DE10359594A1 DE10359594A1 DE10359594A DE10359594A DE10359594A1 DE 10359594 A1 DE10359594 A1 DE 10359594A1 DE 10359594 A DE10359594 A DE 10359594A DE 10359594 A DE10359594 A DE 10359594A DE 10359594 A1 DE10359594 A1 DE 10359594A1
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Classifications
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/12—Methionine; Cysteine; Cystine
Landscapes
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
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- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
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| BRPI0417710-0A BRPI0417710A (pt) | 2003-12-18 | 2004-12-15 | usos de um ácido nucleico, de uma unidade de expressão, e da seqüência de ácido nucleico, ácido nucleico, unidade de expressão, métodos para alterar ou induzir as taxas de transcrição e de expressão de genes em microorganismos comparado com o tipo selvagem, e para preparar produtos biossintéticos, lisina, metionina, e treonina, cassete de expressão, vetor de expressão, microorganismo geneticamente modificado, e, unidade de expressão |
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| KR100620092B1 (ko) * | 2004-12-16 | 2006-09-08 | 씨제이 주식회사 | 코리네박테리움 속 세포로부터 유래된 신규한 프로모터서열, 그를 포함하는 발현 카세트 및 벡터, 상기 벡터를포함하는 숙주 세포 및 그를 이용하여 유전자를 발현하는방법 |
| ES2539280T3 (es) | 2006-10-24 | 2015-06-29 | Basf Se | Procedimiento de reducción de la expresión génica mediante el uso de codones modificado |
| EP2121954A2 (en) | 2007-02-19 | 2009-11-25 | Evonik Degussa GmbH | Coryneform bacteria with formate-thf-synthetase and/or glycine cleavage activity |
| JP2010130899A (ja) | 2007-03-14 | 2010-06-17 | Ajinomoto Co Inc | Ｌ−グルタミン酸系アミノ酸生産微生物及びアミノ酸の製造法 |
| WO2008126896A1 (ja) | 2007-04-10 | 2008-10-23 | Ajinomoto Co., Inc. | 有機酸の製造方法 |
| EP2192170B1 (en) | 2007-09-04 | 2017-02-15 | Ajinomoto Co., Inc. | Amino acid-producing microorganism and method of producing amino acid |
| EP2268826A2 (en) * | 2008-04-30 | 2011-01-05 | Evonik Degussa GmbH | Production process for methionine using microorganisms with reduced isocitrate dehydrogenase activity |
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| US9005957B2 (en) | 2008-10-20 | 2015-04-14 | Cj Cheiljedang Corporation | Corynebacterium genus microorganism having ability to produce N-acetyl glucosamine and method for producing N-acetyl glucosamine or glucosamine using the same |
| WO2011073278A1 (en) | 2009-12-17 | 2011-06-23 | Basf Se | Processes and recombinant microorganisms for the production of cadaverine |
| EP2678421B1 (en) | 2011-02-22 | 2018-04-11 | Basf Se | Processes and recombinant microorganisms for the production of cadaverine |
| DE102011118019A1 (de) | 2011-06-28 | 2013-01-03 | Evonik Degussa Gmbh | Varianten des Promotors des für die Glyzerinaldehyd-3-phosphat-Dehydrogenase kodierenden gap-Gens |
| AR086790A1 (es) | 2011-06-29 | 2014-01-22 | Metabolic Explorer Sa | Un microorganismo para la produccion de metionina con importacion de glucosa mejorada |
| US9506093B2 (en) | 2012-06-18 | 2016-11-29 | Metabolic Explorer | Recombinant microorganism for the fermentative production of methionine |
| KR20140066553A (ko) | 2012-11-23 | 2014-06-02 | 삼성전자주식회사 | 코리네박테리움 속 균주의 신규 프로모터 |
| CN103361345B (zh) * | 2013-06-15 | 2016-05-04 | 福州大学 | 重组调控生物元器件强化次级代谢产物生物合成的方法 |
| MX374056B (es) | 2013-08-30 | 2020-07-27 | Evonik Operations Gmbh | Microorganismo para la produccion de metionina con actividad de metionina sintasa y eflujo de metionina mejorados. |
| RU2723714C2 (ru) | 2014-09-01 | 2020-06-17 | Эвоник Оперейшнс Гмбх | Способ и микроорганизм для ферментативного продуцирования метионина с улучшенным выходом метионина |
| KR101677368B1 (ko) | 2015-04-02 | 2016-11-18 | 씨제이제일제당 (주) | 신규 프로모터 및 이의 용도 |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| CN108026548A (zh) | 2015-05-19 | 2018-05-11 | 卢塞特英国国际有限公司 | 生物制备甲基丙烯酸及其衍生物的方法 |
| MY184139A (en) | 2015-08-07 | 2021-03-22 | Evonik Operations Gmbh | Protein thiocarboxylate-dependent l-methionine production by fermentation |
| EP3365427B1 (en) | 2015-10-23 | 2020-08-19 | Metabolic Explorer | Microorganism modified for the assimilation of levulinic acid |
| US11034985B2 (en) | 2015-11-27 | 2021-06-15 | Evonik Operations Gmbh | Method for producing L-methionine |
| EP3296404A1 (en) | 2016-09-15 | 2018-03-21 | Evonik Degussa GmbH | Modified microorganism for production of methionine |
| GB201619827D0 (en) | 2016-11-23 | 2017-01-04 | Lucite Int Uk Ltd | Process for the production of methyl methacrylate |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| EP3415622A1 (en) | 2017-06-14 | 2018-12-19 | Evonik Degussa GmbH | Method for production of fine chemicals using a corynebacterium secreting modified alpha-1,6-glucosidases |
| JP7498598B2 (ja) * | 2020-05-29 | 2024-06-12 | 花王株式会社 | 新規プロモーター |
| US20250051785A1 (en) | 2021-12-13 | 2025-02-13 | Kao Corporation | Novel promoter |
| GB2621337A (en) | 2022-08-08 | 2024-02-14 | Mitsubishi Chemical Uk Ltd | Process for the biological production of methacrylic acid and derivatives thereof |
| WO2025118096A1 (zh) * | 2023-12-04 | 2025-06-12 | 武汉远大弘元股份有限公司 | 一种改造的强启动子、含其的菌株及它们在氨基酸生产中的应用 |
| CN119331870A (zh) * | 2024-11-11 | 2025-01-21 | 暨南大学 | 核酸分子、转录元件、表达载体、宿主及其应用 |
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| US6696561B1 (en) | 1909-07-09 | 2004-02-24 | Basf Aktiengesellschaft | Corynebacterium glutamicum genes encoding proteins involved in membrane synthesis and membrane transport |
| JPS5835197A (ja) | 1981-08-26 | 1983-03-01 | Kyowa Hakko Kogyo Co Ltd | プラスミドｐｃｇ２ |
| US4601893A (en) | 1984-02-08 | 1986-07-22 | Pfizer Inc. | Laminate device for controlled and prolonged release of substances to an ambient environment and method of use |
| GB2165546B (en) | 1984-08-21 | 1989-05-17 | Asahi Chemical Ind | A plasmid containing a gene for tetracycline resistance and dna fragments derived therefrom |
| DE4027453A1 (de) | 1990-08-30 | 1992-03-05 | Degussa | Neue plasmide aus corynebacterium glutamicum und davon abgeleitete plasmidvektoren |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1908841A1 (de) | 2004-12-22 | 2008-04-09 | Basf Se | Mehrfachpromotoren und deren Verwendung zur Genexpression |
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| IN2008CH00415A (enExample) | 2008-09-19 |
| RU2006125501A (ru) | 2008-01-27 |
| AU2004298546A1 (en) | 2005-06-30 |
| IN2006CH02598A (enExample) | 2007-06-08 |
| BRPI0417710A (pt) | 2007-03-20 |
| US20080118948A1 (en) | 2008-05-22 |
| WO2005059093A2 (de) | 2005-06-30 |
| JP5710095B2 (ja) | 2015-04-30 |
| EP1697525A2 (de) | 2006-09-06 |
| CN1894412A (zh) | 2007-01-10 |
| CA2548349A1 (en) | 2005-06-30 |
| CN101255419B (zh) | 2012-06-20 |
| US7785779B2 (en) | 2010-08-31 |
| TW200530398A (en) | 2005-09-16 |
| JP2008212155A (ja) | 2008-09-18 |
| US8044191B2 (en) | 2011-10-25 |
| US20080166775A1 (en) | 2008-07-10 |
| EP1908842A2 (de) | 2008-04-09 |
| JP2007514425A (ja) | 2007-06-07 |
| EP1908842B1 (de) | 2013-09-18 |
| ES2439946T3 (es) | 2014-01-27 |
| AR047150A1 (es) | 2006-01-11 |
| MXPA06006131A (es) | 2006-08-11 |
| WO2005059093A3 (de) | 2006-03-02 |
| KR101162226B1 (ko) | 2012-07-04 |
| CN101255419A (zh) | 2008-09-03 |
| PL1908842T3 (pl) | 2014-03-31 |
| EP1908842A3 (de) | 2008-08-27 |
| KR20070000431A (ko) | 2007-01-02 |
| NO20062683L (no) | 2006-09-11 |
| ZA200605863B (en) | 2008-01-30 |
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