CN101255419B - P ef-tu表达单元 - Google Patents

P ef-tu表达单元 Download PDF

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Publication number
CN101255419B
CN101255419B CN2008100089537A CN200810008953A CN101255419B CN 101255419 B CN101255419 B CN 101255419B CN 2008100089537 A CN2008100089537 A CN 2008100089537A CN 200810008953 A CN200810008953 A CN 200810008953A CN 101255419 B CN101255419 B CN 101255419B
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CN
China
Prior art keywords
nucleic acid
active
activity
coding
expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN2008100089537A
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English (en)
Chinese (zh)
Other versions
CN101255419A (zh
Inventor
B·克勒格尔
O·策尔德尔
C·克洛普罗格
H·施罗德
S·哈夫纳
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BASF SE
Daesang Corp
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BASF SE
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Publication of CN101255419A publication Critical patent/CN101255419A/zh
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Publication of CN101255419B publication Critical patent/CN101255419B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN2008100089537A 2003-12-18 2004-12-15 P ef-tu表达单元 Expired - Fee Related CN101255419B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10359594.5 2003-12-18
DE10359594A DE10359594A1 (de) 2003-12-18 2003-12-18 PEF-TU-Expressionseinheiten

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNA2004800379281A Division CN1894412A (zh) 2003-12-18 2004-12-15 Pef－tu表达单元

Publications (2)

Publication Number Publication Date
CN101255419A CN101255419A (zh) 2008-09-03
CN101255419B true CN101255419B (zh) 2012-06-20

Family

ID=34683543

Family Applications (2)

Application Number Title Priority Date Filing Date
CN2008100089537A Expired - Fee Related CN101255419B (zh) 2003-12-18 2004-12-15 P ef-tu表达单元
CNA2004800379281A Pending CN1894412A (zh) 2003-12-18 2004-12-15 Pef－tu表达单元

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNA2004800379281A Pending CN1894412A (zh) 2003-12-18 2004-12-15 Pef－tu表达单元

Country Status (19)

Country Link
US (2) US7785779B2 (enExample)
EP (2) EP1908842B1 (enExample)
JP (2) JP2007514425A (enExample)
KR (1) KR101162226B1 (enExample)
CN (2) CN101255419B (enExample)
AR (1) AR047150A1 (enExample)
AU (1) AU2004298546A1 (enExample)
BR (1) BRPI0417710A (enExample)
CA (1) CA2548349A1 (enExample)
DE (1) DE10359594A1 (enExample)
ES (1) ES2439946T3 (enExample)
IN (2) IN2006CH02598A (enExample)
MX (1) MXPA06006131A (enExample)
NO (1) NO20062683L (enExample)
PL (1) PL1908842T3 (enExample)
RU (1) RU2006125501A (enExample)
TW (1) TW200530398A (enExample)
WO (1) WO2005059093A2 (enExample)
ZA (1) ZA200605863B (enExample)

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DE102004035065A1 (de) * 2004-07-20 2006-02-16 Basf Ag P-ET-TS-Expressionseinheiten
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DE102004061846A1 (de) 2004-12-22 2006-07-13 Basf Ag Mehrfachpromotoren
HUE025440T2 (en) * 2006-10-24 2016-04-28 Basf Se A method for reducing gene expression using modified codon usage
CN101849016A (zh) 2007-02-19 2010-09-29 羸创德固赛有限责任公司 具有甲酰基-thf-合成酶和/或甘氨酸切割活性的棒状杆菌
JP2010130899A (ja) 2007-03-14 2010-06-17 Ajinomoto Co Inc Ｌ−グルタミン酸系アミノ酸生産微生物及びアミノ酸の製造法
WO2008126896A1 (ja) 2007-04-10 2008-10-23 Ajinomoto Co., Inc. 有機酸の製造方法
WO2009031565A1 (ja) 2007-09-04 2009-03-12 Ajinomoto Co., Inc. アミノ酸生産微生物及びアミノ酸の製造法
MX2010011720A (es) * 2008-04-30 2010-11-30 Evonik Degussa Gmbh Procedimiento de produccion de metionina usando microorganismos con actividad reducida de isocitrato deshidrogenasa.
US8647642B2 (en) 2008-09-18 2014-02-11 Aviex Technologies, Llc Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
ES2584531T3 (es) 2008-10-20 2016-09-28 Cj Cheiljedang Corporation Microorganismo del género Corynebacterium que tiene capacidad para producir N-acetilglucosamina y método para producir N-acetilglucosamina o glucosamina usando el mismo
WO2011073278A1 (en) 2009-12-17 2011-06-23 Basf Se Processes and recombinant microorganisms for the production of cadaverine
EP2678421B1 (en) 2011-02-22 2018-04-11 Basf Se Processes and recombinant microorganisms for the production of cadaverine
DE102011118019A1 (de) 2011-06-28 2013-01-03 Evonik Degussa Gmbh Varianten des Promotors des für die Glyzerinaldehyd-3-phosphat-Dehydrogenase kodierenden gap-Gens
AR086790A1 (es) 2011-06-29 2014-01-22 Metabolic Explorer Sa Un microorganismo para la produccion de metionina con importacion de glucosa mejorada
WO2013190343A1 (en) 2012-06-18 2013-12-27 Metabolic Explorer Recombinant microorganism for the fermentative production of methionine
KR20140066553A (ko) 2012-11-23 2014-06-02 삼성전자주식회사 코리네박테리움 속 균주의 신규 프로모터
CN103361345B (zh) * 2013-06-15 2016-05-04 福州大学 重组调控生物元器件强化次级代谢产物生物合成的方法
ES2693789T3 (es) 2013-08-30 2018-12-13 Evonik Degussa Gmbh Microorganismo para la producción de metionina con mejor actividad de metionina sintasa y flujo de metionina
MY194223A (en) 2014-09-01 2022-11-22 Evonik Operations Gmbh Method and microorganism for methionine production by fermentation with improved methionine efflux
KR101677368B1 (ko) 2015-04-02 2016-11-18 씨제이제일제당 (주) 신규 프로모터 및 이의 용도
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
EA201792538A1 (ru) 2015-05-19 2018-06-29 ЛУСАЙТ ИНТЕРНЭШНЛ ЮКей ЛИМИТЕД Способ биологического получения метакриловой кислоты
EP3331998B1 (en) 2015-08-07 2020-06-24 Evonik Operations GmbH Protein thiocarboxylate-dependent l-methionine production by fermentation
EP3365427B1 (en) 2015-10-23 2020-08-19 Metabolic Explorer Microorganism modified for the assimilation of levulinic acid
WO2017089077A1 (en) 2015-11-27 2017-06-01 Evonik Degussa Gmbh Method for producing l-methionine
EP3296404A1 (en) 2016-09-15 2018-03-21 Evonik Degussa GmbH Modified microorganism for production of methionine
GB201619827D0 (en) 2016-11-23 2017-01-04 Lucite Int Uk Ltd Process for the production of methyl methacrylate
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
EP3415622A1 (en) 2017-06-14 2018-12-19 Evonik Degussa GmbH Method for production of fine chemicals using a corynebacterium secreting modified alpha-1,6-glucosidases
JP7498598B2 (ja) * 2020-05-29 2024-06-12 花王株式会社 新規プロモーター
WO2023112933A1 (ja) 2021-12-13 2023-06-22 花王株式会社 新規プロモーター
GB2621337A (en) 2022-08-08 2024-02-14 Mitsubishi Chemical Uk Ltd Process for the biological production of methacrylic acid and derivatives thereof
WO2025118096A1 (zh) * 2023-12-04 2025-06-12 武汉远大弘元股份有限公司 一种改造的强启动子、含其的菌株及它们在氨基酸生产中的应用
CN119331870A (zh) * 2024-11-11 2025-01-21 暨南大学 核酸分子、转录元件、表达载体、宿主及其应用

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WO2003040180A2 (de) * 2001-11-05 2003-05-15 Basf Aktiengesellschaft Gene von corynebacterium glutamicum, die für genetische stabilitäts-, genexpressions- und faltungsproteine kodieren

Also Published As

Publication number Publication date
US20080118948A1 (en) 2008-05-22
WO2005059093A2 (de) 2005-06-30
CN1894412A (zh) 2007-01-10
JP2007514425A (ja) 2007-06-07
DE10359594A1 (de) 2005-07-28
MXPA06006131A (es) 2006-08-11
IN2008CH00415A (enExample) 2008-09-19
WO2005059093A3 (de) 2006-03-02
KR20070000431A (ko) 2007-01-02
IN2006CH02598A (enExample) 2007-06-08
PL1908842T3 (pl) 2014-03-31
JP2008212155A (ja) 2008-09-18
EP1697525A2 (de) 2006-09-06
ES2439946T3 (es) 2014-01-27
JP5710095B2 (ja) 2015-04-30
AR047150A1 (es) 2006-01-11
BRPI0417710A (pt) 2007-03-20
RU2006125501A (ru) 2008-01-27
EP1908842A2 (de) 2008-04-09
TW200530398A (en) 2005-09-16
CN101255419A (zh) 2008-09-03
EP1908842B1 (de) 2013-09-18
US20080166775A1 (en) 2008-07-10
US8044191B2 (en) 2011-10-25
AU2004298546A1 (en) 2005-06-30
KR101162226B1 (ko) 2012-07-04
US7785779B2 (en) 2010-08-31
NO20062683L (no) 2006-09-11
EP1908842A3 (de) 2008-08-27
CA2548349A1 (en) 2005-06-30
ZA200605863B (en) 2008-01-30

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