JP2007530446A - 鼻適用のための放出制御送達システム - Google Patents
鼻適用のための放出制御送達システム Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P11/02—Nasal agents, e.g. decongestants
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
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Abstract
Description
増粘剤またはゲル化剤、必要ならば界面活性剤を十分な量の水に添加し、高速混合によって分散させる(混合物1)。第2の容器では、水および/または親油性担体、必要ならば界面活性剤を導入する(混合物2)。空気導入を極めて注意深く回避しながら混合物2にホルモンを添加する。混合物2を混合物1に添加し、必要ならばpHおよび張度を調節し、最終混合物を均一化して殺菌する。
親油性担体および乳化剤を攪拌容器内に充填し、粘性調節剤の約75%を混入する。活性成分の均一分散が得られるまで攪拌下でホルモンを添加する。次いで、粘性調節剤の残りを用いて製剤を必要とする粘度まで調節する。
テストステロンを含有する様々な製剤(図1参照)を比較すると、本発明の特定の油性製剤においてCmaxが顕著に低下することが明らかであり、これは毒物学上の検討事項を考慮すると望ましい。さらに非結合のテストステロンのレベルが少なくとも10時間にわたってまさに一定であり、これはテストステロン放出の生理的日周リズムに類似している。
Claims (14)
- 鼻適用のための製剤であって、
a)少なくとも1種類の性ホルモン剤、
b)少なくとも1種類の親油性または部分的に親油性の担体、
c)活性を低下させる表面張力と、前記製剤を水と接触させる際の原位置でのエマルションの生成に有効な量とを有する化合物または化合物の混合物、
を有してなることを特徴とする製剤。 - 前記親油性担体が油を含むことを特徴とする請求項1に記載の製剤。
- 前記油が植物油であることを特徴とする請求項2に記載の製剤。
- 前記油がヒマシ油であることを特徴とする請求項3に記載の製剤。
- 油の量が、製剤の30重量%〜98重量%を占めることを特徴とする請求項2〜4のいずれか1項に記載の製剤。
- 成分(c)が、レシチンと、多価アルコール脂肪酸エステルと、ソルビタン脂肪酸エステルと、ポリオキシエチレンソルビタン脂肪酸エステルと、ポリオキシエチレン脂肪酸エステルと、スクロース脂肪酸エステルと、ポリグリセロール脂肪酸エステルとからなる群から選択される少なくとも1種類の界面活性剤および/またはソルビトールと、グリセリンと、ポリエチレングリコールと、マクロゴールグリセロール脂肪酸エステルとからなる群から選択される少なくとも1種類の湿潤剤、またはこれらの混合物を含むことを特徴とする請求項1〜5のいずれか1項に記載の製剤。
- 成分(c)がオレオイルマクロゴールグリセリド、またはオレオイルマクロゴールグリセリドの混合物を含むことを特徴とする請求項6に記載の製剤。
- 成分(c)が1〜20重量%の量で前記製剤中に含まれることを特徴とする請求項6または7に記載の製剤。
- 粘性調節剤をさらに含むことを特徴とする請求項1〜8のいずれか1項に記載の製剤。
- 前記粘性調節剤が、セルロースおよびセルロース誘導体、多糖類、カルボマー、ポリビニルアルコール、ポビドン、コロイド状二酸化ケイ素、セチルアルコール、ステアリン酸、蜜ろう、ペトロラタム、トリグリセリドおよびラノリン、またはこれらの混合物からなる群から選択される増粘剤あるいはゲル化剤を含むことを特徴とする請求項9に記載の製剤。
- 前記増粘剤がコロイド状二酸化ケイ素であることを特徴とする請求項10に記載の製剤。
- 前記粘性調節剤が0.5〜10重量%の量で前記製剤中に含まれることを特徴とする請求項9〜11のいずれか1項に記載の製剤。
- 前記性ホルモン剤がテストステロンであることを特徴とする請求項1〜12のいずれか1項に記載の製剤。
- 前記性ホルモン剤が0.5〜6重量%の量で前記製剤中に含まれることを特徴とする請求項1〜13のいずれか1項に記載の製剤。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03025769A EP1530965B1 (en) | 2003-11-11 | 2003-11-11 | Controlled release delivery system of sexual hormones for nasal application |
PCT/EP2004/012122 WO2005044273A1 (en) | 2003-11-11 | 2004-10-27 | Controlled release delivery system for nasal applications |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2007530446A true JP2007530446A (ja) | 2007-11-01 |
JP4616270B2 JP4616270B2 (ja) | 2011-01-19 |
Family
ID=34429314
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006538697A Expired - Fee Related JP4616270B2 (ja) | 2003-11-11 | 2004-10-27 | 鼻適用のための放出制御送達システム |
Country Status (23)
Country | Link |
---|---|
US (6) | US20050100564A1 (ja) |
EP (1) | EP1530965B1 (ja) |
JP (1) | JP4616270B2 (ja) |
KR (1) | KR100861443B1 (ja) |
AR (1) | AR047722A1 (ja) |
AT (1) | ATE319426T1 (ja) |
AU (1) | AU2004286781B2 (ja) |
BR (1) | BRPI0416370B8 (ja) |
CA (1) | CA2541498C (ja) |
DE (1) | DE60303854T2 (ja) |
DK (1) | DK1530965T3 (ja) |
ES (1) | ES2258694T3 (ja) |
HR (1) | HRP20060147B1 (ja) |
MY (1) | MY131483A (ja) |
NO (1) | NO338665B1 (ja) |
PL (1) | PL219338B1 (ja) |
PT (1) | PT1530965E (ja) |
RU (1) | RU2331423C2 (ja) |
SA (1) | SA04250363B1 (ja) |
SI (1) | SI1530965T1 (ja) |
TW (1) | TWI350176B (ja) |
WO (1) | WO2005044273A1 (ja) |
ZA (1) | ZA200603115B (ja) |
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US10111888B2 (en) | 2011-05-13 | 2018-10-30 | Acerus Biopharma Inc. | Intranasal 0.15% and 0.24% testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder |
WO2019103108A1 (ja) * | 2017-11-27 | 2019-05-31 | あすか製薬株式会社 | 粉末経鼻投与製剤 |
JP2020073469A (ja) * | 2011-05-15 | 2020-05-14 | エーセラス バイオファーマ インコーポレイテッド | 経鼻投与のための徐放テストステロン鼻腔内ゲル、方法および複数回用量プレフィルアプリケーターシステム |
US10668084B2 (en) | 2011-05-13 | 2020-06-02 | Acerus Biopharma Inc. | Intranasal lower dosage strength testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder |
US11090312B2 (en) | 2013-03-15 | 2021-08-17 | Acerus Biopharma Inc. | Methods of treating hypogonadism with transnasal testerosterone bio-adhesive gel formulations in male with allergic rhinitis, and methods for preventing an allergic rhinitis event |
JP2022517724A (ja) * | 2018-12-14 | 2022-03-10 | アセラス バイオファーマ インコーポレーテッド | テストステロンの活性エステル誘導体、組成物、およびそれらの使用 |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
BR102015020878B1 (pt) * | 2015-08-28 | 2019-08-27 | F B M Ind Farmaceutica Ltda | formulação farmacêutica nasal de testosterona e “kit” em forma de cartela de dispositivos nasais unitários para aplicação de monodose de testosterona. |
BR112018067554A2 (pt) * | 2016-03-02 | 2019-03-06 | Medcara Pharmaceuticals, Llc | formulações de testosterona e métodos de tratamento com as mesmas |
KR20180126582A (ko) | 2016-04-01 | 2018-11-27 | 쎄러퓨틱스엠디, 인코퍼레이티드 | 스테로이드 호르몬 약제학적 조성물 |
US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
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WO2017208209A1 (en) | 2016-06-03 | 2017-12-07 | M et P Pharma AG | Nasal pharmaceutical compositions with a porous excipient |
CN110461340A (zh) | 2017-01-20 | 2019-11-15 | 马特恩制药股份公司 | 用于降低暴露于空气污染物的风险的鼻用药物组合物 |
HRP20231706T1 (hr) | 2017-02-02 | 2024-03-15 | Otolanum Ag | Intranazalni pripravak koji sadrži betahistin |
SG11202006374VA (en) | 2018-01-11 | 2020-07-29 | M et P Pharma AG | Treatment of demyelinating diseases |
AU2019253577A1 (en) | 2018-04-09 | 2019-12-12 | Elgan Pharma Ltd | Oxytocin compositions and methods of use |
CN112512505A (zh) | 2018-04-17 | 2021-03-16 | 马特恩制药股份公司 | 用于鼻内递送孕烯醇酮的组合物和方法 |
BR112021007877A2 (pt) * | 2018-10-26 | 2021-08-03 | Viramal Limited | composição em gel mucoadesiva |
US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE943792C (de) * | 1949-02-18 | 1956-06-01 | Organon Nv | Verfahren zur Herstellung von injizierbaren Hormonpraeparaten |
GB1569286A (en) * | 1975-10-27 | 1980-06-11 | Schering Ag | Oily depot solutions of gestagents for intramuscular injection |
JP2002541111A (ja) * | 1999-04-01 | 2002-12-03 | アクゾ・ノベル・エヌ・ベー | ウンデカン酸テストステロンとヒマシ油を含む調合物 |
JP2003509453A (ja) * | 1999-09-21 | 2003-03-11 | アールティーピー・ファーマ・インコーポレーテッド | 生物学的に活性な物質の、表面改質された粒状組成物 |
JP2003519085A (ja) * | 1998-10-24 | 2003-06-17 | ウエスト・ファーマシューティカル・サービセズ・ドラッグ・デリバリー・アンド・クリニカル・リサーチ・センター・リミテッド | ヒドロキシル化された油を有するo/wエマルジョン |
WO2003063833A1 (en) * | 2002-02-01 | 2003-08-07 | Pfizer Products Inc. | Pharmaceutical compositions of amorphous dispersions of drugs and lipophilic microphase-forming materials |
Family Cites Families (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1032874A (en) | 1964-02-13 | 1966-06-15 | Du Pont | Stabilized polyoxymethylenes |
NL7506407A (nl) * | 1975-05-30 | 1976-12-02 | Akzo Nv | Werkwijze ter bereiding van een oraal werkzaam far- maceutisch preparaat. |
NL7510104A (nl) * | 1975-08-27 | 1977-03-01 | Akzo Nv | Werkwijze ter bereiding van een oraal werkzaam farmaceutisch preparaat. |
US4315925A (en) * | 1980-05-30 | 1982-02-16 | University Of Kentucky Research Foundation | Method of administering natural female sex hormones |
US4581225A (en) * | 1984-04-25 | 1986-04-08 | Eli Lilly And Company | Sustained release intranasal formulation and method of use thereof |
US4752425A (en) * | 1986-09-18 | 1988-06-21 | Liposome Technology, Inc. | High-encapsulation liposome processing method |
US5049387A (en) * | 1987-03-09 | 1991-09-17 | Alza Corporation | Inducing skin tolerance to a sensitizing drug |
US5690954A (en) * | 1987-05-22 | 1997-11-25 | Danbiosyst Uk Limited | Enhanced uptake drug delivery system having microspheres containing an active drug and a bioavailability improving material |
JP2543708B2 (ja) * | 1987-07-13 | 1996-10-16 | 旭化成工業株式会社 | 難溶性薬物を封入したエマルジョン製剤の製造方法 |
NL8801670A (nl) * | 1988-07-01 | 1990-02-01 | Walter Adrianus Josephus Johan | Farmaceutisch preparaat. |
GB2237510B (en) | 1989-11-04 | 1993-09-15 | Danbiosyst Uk | Small particle drug compositions for nasal administration |
US5397771A (en) * | 1990-05-10 | 1995-03-14 | Bechgaard International Research And Development A/S | Pharmaceutical preparation |
US5221698A (en) | 1991-06-27 | 1993-06-22 | The Regents Of The University Of Michigan | Bioactive composition |
US5756071A (en) * | 1992-06-03 | 1998-05-26 | Arrowdean Limited | Method for nasally administering aerosols of therapeutic agents to enhance penetration of the blood brain barrier |
SE9301171D0 (sv) * | 1993-04-07 | 1993-04-07 | Ab Astra | Pharmaceutical composition containing lipophilic drugs |
KR100220546B1 (ko) | 1994-02-04 | 1999-09-15 | 벵 헤르슬로프 | 호지성 담체 제제 |
GB9405304D0 (en) * | 1994-03-16 | 1994-04-27 | Scherer Ltd R P | Delivery systems for hydrophobic drugs |
US5635203A (en) | 1994-09-29 | 1997-06-03 | Alza Corporation | Transdermal device having decreased delamination |
US5747058A (en) | 1995-06-07 | 1998-05-05 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system |
GB9608719D0 (en) | 1996-04-26 | 1996-07-03 | Scherer Ltd R P | Pharmaceutical compositions |
GB9707934D0 (en) | 1997-04-18 | 1997-06-04 | Danbiosyst Uk | Improved delivery of drugs to mucosal surfaces |
US6624200B2 (en) | 1998-08-25 | 2003-09-23 | Columbia Laboratories, Inc. | Bioadhesive progressive hydration tablets |
US5877216A (en) * | 1997-10-28 | 1999-03-02 | Vivus, Incorporated | Treatment of female sexual dysfunction |
US5897894A (en) * | 1997-12-29 | 1999-04-27 | General Mills, Inc. | Microwave popcorn with coarse salt crystals and method of preparation |
GB9828861D0 (en) | 1998-12-31 | 1999-02-17 | Danbiosyst Uk | Compositions |
US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
US6294192B1 (en) | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
US6761903B2 (en) | 1999-06-30 | 2004-07-13 | Lipocine, Inc. | Clear oil-containing pharmaceutical compositions containing a therapeutic agent |
US6287588B1 (en) | 1999-04-29 | 2001-09-11 | Macromed, Inc. | Agent delivering system comprised of microparticle and biodegradable gel with an improved releasing profile and methods of use thereof |
WO2000076522A1 (en) | 1999-06-11 | 2000-12-21 | Watson Pharmaceuticals, Inc. | Administration of non-oral androgenic steroids to women |
US20030236236A1 (en) | 1999-06-30 | 2003-12-25 | Feng-Jing Chen | Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs |
US6309663B1 (en) | 1999-08-17 | 2001-10-30 | Lipocine Inc. | Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents |
US6720001B2 (en) | 1999-10-18 | 2004-04-13 | Lipocine, Inc. | Emulsion compositions for polyfunctional active ingredients |
WO2001041732A1 (en) | 1999-12-06 | 2001-06-14 | Gore Stanley L | Compositions and methods for intranasal delivery of active agents to the brain |
US8980290B2 (en) | 2000-08-03 | 2015-03-17 | Antares Pharma Ipl Ag | Transdermal compositions for anticholinergic agents |
US7198801B2 (en) | 2000-08-03 | 2007-04-03 | Antares Pharma Ipl Ag | Formulations for transdermal or transmucosal application |
US20030139384A1 (en) | 2000-08-30 | 2003-07-24 | Dudley Robert E. | Method for treating erectile dysfunction and increasing libido in men |
US20040092494A9 (en) | 2000-08-30 | 2004-05-13 | Dudley Robert E. | Method of increasing testosterone and related steroid concentrations in women |
US20020072509A1 (en) | 2000-10-11 | 2002-06-13 | Stein Donald Gerald | Methods for the treatment of a traumatic central nervous system injury |
US6730330B2 (en) * | 2001-02-14 | 2004-05-04 | Gw Pharma Limited | Pharmaceutical formulations |
WO2002069906A2 (en) * | 2001-03-06 | 2002-09-12 | Cellegy Pharmaceuticals, Inc. | Compounds and methods for the treatment of urogenital disorders |
US6833478B2 (en) | 2001-07-13 | 2004-12-21 | Sri International | N,N-dinitramide salts as solubilizing agents for biologically active agents |
OA12856A (en) | 2002-03-15 | 2006-09-15 | Unimed Pharmaceuticals Inc | Androgen pharmaceutical composition and method for treating depression. |
US6855332B2 (en) * | 2002-07-03 | 2005-02-15 | Lyfjathroun Hf. | Absorption promoting agent |
US7029657B2 (en) | 2002-08-02 | 2006-04-18 | Balance Pharmaceuticals, Inc. | Nasal spray steroid formulation and method |
US6958142B2 (en) | 2002-08-02 | 2005-10-25 | Balance Pharmaceuticals, Inc. | Nasal spray formulation and method |
US20040259852A1 (en) | 2003-06-18 | 2004-12-23 | White Hillary D. | Trandsdermal compositions and methods for treatment of fibromyalgia and chronic fatigue syndrome |
PT1530965E (pt) * | 2003-11-11 | 2006-05-31 | Udo Mattern | Sistema de administracao de libertacao controlada de hormonas sexuais para aplicacao nasal |
US8784869B2 (en) | 2003-11-11 | 2014-07-22 | Mattern Pharma Ag | Controlled release delivery system for nasal applications and methods of treatment |
WO2005065185A2 (en) | 2003-12-24 | 2005-07-21 | Collegium Pharmaceuticals, Inc. | Temperature-stable formulations, and methods of development thereof |
US20060140820A1 (en) | 2004-12-28 | 2006-06-29 | Udo Mattern | Use of a container of an inorganic additive containing plastic material |
CN101600417B (zh) | 2006-10-04 | 2012-05-30 | M&P专利股份公司 | 用于神经递质的经鼻施用的控制释放递送系统 |
-
2003
- 2003-11-11 PT PT03025769T patent/PT1530965E/pt unknown
- 2003-11-11 DE DE60303854T patent/DE60303854T2/de not_active Expired - Lifetime
- 2003-11-11 DK DK03025769T patent/DK1530965T3/da active
- 2003-11-11 ES ES03025769T patent/ES2258694T3/es not_active Expired - Lifetime
- 2003-11-11 AT AT03025769T patent/ATE319426T1/de active
- 2003-11-11 EP EP03025769A patent/EP1530965B1/en not_active Expired - Lifetime
- 2003-11-11 SI SI200330194T patent/SI1530965T1/sl unknown
-
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- 2004-02-04 US US10/772,964 patent/US20050100564A1/en not_active Abandoned
- 2004-09-23 MY MYPI20043889A patent/MY131483A/en unknown
- 2004-10-04 TW TW093129982A patent/TWI350176B/zh not_active IP Right Cessation
- 2004-10-05 AR ARP040103611A patent/AR047722A1/es not_active Application Discontinuation
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- 2004-10-27 AU AU2004286781A patent/AU2004286781B2/en not_active Ceased
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- 2004-10-27 KR KR1020067009182A patent/KR100861443B1/ko active IP Right Grant
- 2004-10-27 PL PL379867A patent/PL219338B1/pl unknown
- 2004-10-27 WO PCT/EP2004/012122 patent/WO2005044273A1/en not_active Application Discontinuation
- 2004-10-27 CA CA002541498A patent/CA2541498C/en active Active
- 2004-10-27 BR BRPI0416370A patent/BRPI0416370B8/pt not_active IP Right Cessation
- 2004-10-27 RU RU2006120468/15A patent/RU2331423C2/ru active
- 2004-11-02 SA SA04250363A patent/SA04250363B1/ar unknown
-
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- 2006-04-18 HR HRP20060147AA patent/HRP20060147B1/hr not_active IP Right Cessation
- 2006-06-07 NO NO20062619A patent/NO338665B1/no not_active IP Right Cessation
- 2006-11-15 US US11/560,187 patent/US20070149454A1/en not_active Abandoned
-
2010
- 2010-06-08 US US12/796,165 patent/US20100311707A1/en not_active Abandoned
-
2011
- 2011-07-29 US US13/194,853 patent/US8784882B2/en not_active Expired - Lifetime
- 2011-07-30 US US13/194,928 patent/US8574622B2/en not_active Expired - Lifetime
- 2011-12-10 US US13/316,494 patent/US8877230B2/en not_active Expired - Lifetime
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE943792C (de) * | 1949-02-18 | 1956-06-01 | Organon Nv | Verfahren zur Herstellung von injizierbaren Hormonpraeparaten |
GB1569286A (en) * | 1975-10-27 | 1980-06-11 | Schering Ag | Oily depot solutions of gestagents for intramuscular injection |
JP2003519085A (ja) * | 1998-10-24 | 2003-06-17 | ウエスト・ファーマシューティカル・サービセズ・ドラッグ・デリバリー・アンド・クリニカル・リサーチ・センター・リミテッド | ヒドロキシル化された油を有するo/wエマルジョン |
JP2002541111A (ja) * | 1999-04-01 | 2002-12-03 | アクゾ・ノベル・エヌ・ベー | ウンデカン酸テストステロンとヒマシ油を含む調合物 |
JP2003509453A (ja) * | 1999-09-21 | 2003-03-11 | アールティーピー・ファーマ・インコーポレーテッド | 生物学的に活性な物質の、表面改質された粒状組成物 |
WO2003063833A1 (en) * | 2002-02-01 | 2003-08-07 | Pfizer Products Inc. | Pharmaceutical compositions of amorphous dispersions of drugs and lipophilic microphase-forming materials |
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