HRP20060147B1 - Terapijski sustav s kontroliranim otpuštanjem za nazalnu primjenu - Google Patents
Terapijski sustav s kontroliranim otpuštanjem za nazalnu primjenuInfo
- Publication number
- HRP20060147B1 HRP20060147B1 HRP20060147AA HRP20060147A HRP20060147B1 HR P20060147 B1 HRP20060147 B1 HR P20060147B1 HR P20060147A A HRP20060147A A HR P20060147AA HR P20060147 A HRP20060147 A HR P20060147A HR P20060147 B1 HRP20060147 B1 HR P20060147B1
- Authority
- HR
- Croatia
- Prior art keywords
- controlled release
- delivery system
- release delivery
- nasal applications
- formulation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Otolaryngology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Diabetes (AREA)
- Pregnancy & Childbirth (AREA)
- Pulmonology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Ovaj izum odnosi se na pernazalno primjenjiv pripravak za kontrolirano otpuštanje spolnih hormona u sistemski krvotok, naročito pripravak koji aktivnim sastojcima omogućava apsorbiranje na kontinuirani način, omogućavajući tako bolju biodostupnost pri vrlo niskim dozama, te dulje djelovanje.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03025769A EP1530965B1 (en) | 2003-11-11 | 2003-11-11 | Controlled release delivery system of sexual hormones for nasal application |
PCT/EP2004/012122 WO2005044273A1 (en) | 2003-11-11 | 2004-10-27 | Controlled release delivery system for nasal applications |
Publications (2)
Publication Number | Publication Date |
---|---|
HRP20060147A2 HRP20060147A2 (en) | 2006-11-30 |
HRP20060147B1 true HRP20060147B1 (hr) | 2014-02-14 |
Family
ID=34429314
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20060147AA HRP20060147B1 (hr) | 2003-11-11 | 2006-04-18 | Terapijski sustav s kontroliranim otpuštanjem za nazalnu primjenu |
Country Status (23)
Country | Link |
---|---|
US (6) | US20050100564A1 (hr) |
EP (1) | EP1530965B1 (hr) |
JP (1) | JP4616270B2 (hr) |
KR (1) | KR100861443B1 (hr) |
AR (1) | AR047722A1 (hr) |
AT (1) | ATE319426T1 (hr) |
AU (1) | AU2004286781B2 (hr) |
BR (1) | BRPI0416370B8 (hr) |
CA (1) | CA2541498C (hr) |
DE (1) | DE60303854T2 (hr) |
DK (1) | DK1530965T3 (hr) |
ES (1) | ES2258694T3 (hr) |
HR (1) | HRP20060147B1 (hr) |
MY (1) | MY131483A (hr) |
NO (1) | NO338665B1 (hr) |
PL (1) | PL219338B1 (hr) |
PT (1) | PT1530965E (hr) |
RU (1) | RU2331423C2 (hr) |
SA (1) | SA04250363B1 (hr) |
SI (1) | SI1530965T1 (hr) |
TW (1) | TWI350176B (hr) |
WO (1) | WO2005044273A1 (hr) |
ZA (1) | ZA200603115B (hr) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6399176B1 (en) | 1996-10-01 | 2002-06-04 | Magotteaux International S.A. | Composite wear component |
JP4222944B2 (ja) | 2001-12-04 | 2009-02-12 | マゴット アンテルナショナル エス.アー. | 強化された摩耗抵抗性を持つ鋳造部品 |
US8784869B2 (en) | 2003-11-11 | 2014-07-22 | Mattern Pharma Ag | Controlled release delivery system for nasal applications and methods of treatment |
EP1530965B1 (en) | 2003-11-11 | 2006-03-08 | Mattern, Udo | Controlled release delivery system of sexual hormones for nasal application |
KR101292492B1 (ko) | 2004-05-11 | 2013-08-01 | 이모셔널 브레인 비.브이. | 약제학적 제형물 및 여성 성기능 부전의 치료에서 그것의용도 |
US20060140820A1 (en) | 2004-12-28 | 2006-06-29 | Udo Mattern | Use of a container of an inorganic additive containing plastic material |
EP1790343A1 (en) | 2005-11-11 | 2007-05-30 | Emotional Brain B.V. | Pharmaceuticals formulations and uses thereof in the treatment of female sexual dysfunction |
GB2437488A (en) * | 2006-04-25 | 2007-10-31 | Optinose As | Pharmaceutical oily formulation for nasal or buccal administration |
CN101600417B (zh) * | 2006-10-04 | 2012-05-30 | M&P专利股份公司 | 用于神经递质的经鼻施用的控制释放递送系统 |
US8147980B2 (en) | 2006-11-01 | 2012-04-03 | Aia Engineering, Ltd. | Wear-resistant metal matrix ceramic composite parts and methods of manufacturing thereof |
EP1925307A1 (en) | 2006-11-03 | 2008-05-28 | Emotional Brain B.V. | Use of 3-alpha-androstanediol in the treatment of sexual dysfunction |
DE102010023949A1 (de) * | 2010-06-16 | 2011-12-22 | F. Holzer Gmbh | In-situ Lecithin-Mikroemulsionsgel-Formulierung |
GB2482868A (en) | 2010-08-16 | 2012-02-22 | Franciscus Wilhelmus Henricus Maria Merkus | A testosterone liquid spray formulation for oromucosal administration |
US20130040922A1 (en) * | 2011-05-13 | 2013-02-14 | Trimel Pharmaceuticals Corporation | Intranasal 0.45% and 0.48% testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder |
AR086400A1 (es) | 2011-05-13 | 2013-12-11 | Trimel Pharmaceuticals Corp | Formulaciones en gel intranasal de testosterona en dosis de menor potencia y uso de las mismas para el tratamiento de la anorgasmia o el trastorno de deseo sexual hipoactivo |
US9757388B2 (en) | 2011-05-13 | 2017-09-12 | Acerus Pharmaceuticals Srl | Intranasal methods of treating women for anorgasmia with 0.6% and 0.72% testosterone gels |
KR20140033407A (ko) * | 2011-05-13 | 2014-03-18 | 트리멜 바이오파마 에스알엘 | 비강내 저 용량 강도 테스토스테론 겔 제형 및 성불감증 또는 성욕 감퇴 장애를 치료하기 위한 이의 용도 |
US20130045958A1 (en) * | 2011-05-13 | 2013-02-21 | Trimel Pharmaceuticals Corporation | Intranasal 0.15% and 0.24% testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder |
EP2709588B1 (en) * | 2011-05-15 | 2021-08-25 | Acerus Biopharma Inc. | Controlled release nasal testosterone gels, methods and pre-filled multi-dose applicator systems for pernasal administration |
EA202192397A3 (ru) * | 2011-05-16 | 2022-03-31 | Эйсерус Биофарма Инк. | Интраназальные биоадгезивные тестостероновые составы в виде гелей и их применение для лечения мужского гипогонадизма |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
PT2782584T (pt) | 2011-11-23 | 2021-09-02 | Therapeuticsmd Inc | Preparações e terapias de substituição para hormonoterapias naturais combinadas |
CN108841802B (zh) | 2012-05-11 | 2023-06-09 | 珍白斯凯尔有限公司 | 抗炎性肽及包含其的组合物 |
JP6262721B2 (ja) | 2012-05-11 | 2018-01-17 | ジェムバックス アンド カエル カンパニー,リミティド | 敗血症の予防用または治療用の組成物 |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
WO2014010971A1 (ko) | 2012-07-11 | 2014-01-16 | 주식회사 카엘젬백스 | 세포 투과성 펩티드, 그를 포함한 컨쥬게이트 및 그를 포함한 조성물 |
WO2014083432A2 (en) * | 2012-11-14 | 2014-06-05 | Trimel Biopharma Srl | Female intranasal lower dosage strength testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder |
WO2014076569A2 (en) * | 2012-11-14 | 2014-05-22 | Trimel Biopharma Srl | Controlled release topical testosterone formulations and methods |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
US11744838B2 (en) | 2013-03-15 | 2023-09-05 | Acerus Biopharma Inc. | Methods of treating hypogonadism with transnasal testosterone bio-adhesive gel formulations in male with allergic rhinitis, and methods for preventing an allergic rhinitis event |
KR102258864B1 (ko) | 2013-04-19 | 2021-06-01 | 주식회사 젬백스앤카엘 | 허혈성 손상 치료 및 예방용 조성물 |
WO2014196841A1 (en) | 2013-06-07 | 2014-12-11 | Kael-Gemvax Co., Ltd. | Biological markers useful in cancer immunotherapy |
CN105324123B (zh) | 2013-06-21 | 2022-02-08 | 珍白斯凯尔有限公司 | 激素分泌调节剂、包含该调节剂的组合物、和利用其控制激素分泌的方法 |
JP6382972B2 (ja) | 2013-10-23 | 2018-08-29 | ジェムバックス アンド カエル カンパニー,リミティド | 前立腺肥大治療用及びその予防用の組成物 |
JP6553605B2 (ja) | 2013-11-22 | 2019-07-31 | ジェムバックス アンド カエル カンパニー,リミティド | 血管新生抑制活性を有するペプチド、及びそれを含む組成物 |
ES2809251T3 (es) | 2013-12-17 | 2021-03-03 | Gemvax & Kael Co Ltd | Composición para tratar cáncer de próstata |
EP3130345B9 (en) | 2014-04-11 | 2022-05-04 | Gemvax & Kael Co., Ltd. | Peptide having fibrosis inhibitory activity and composition containing same |
KR102232320B1 (ko) | 2014-04-30 | 2021-03-26 | 주식회사 젬백스앤카엘 | 장기, 조직 또는 세포 이식용 조성물, 키트 및 이식 방법 |
MX2016014281A (es) | 2014-05-22 | 2017-02-22 | Therapeuticsmd Inc | Formulaciones y terapias de reemplazo de combinación de hormonas naturales. |
CA2951284A1 (en) | 2014-07-29 | 2016-02-04 | Therapeuticsmd, Inc. | Transdermal cream |
ES2877107T3 (es) | 2014-08-28 | 2021-11-16 | Univ Texas | Formulaciones de testosterona y procedimientos de tratamiento con ellas |
KR102413243B1 (ko) | 2014-12-23 | 2022-06-27 | 주식회사 젬백스앤카엘 | 안질환 치료 펩티드 및 이를 포함하는 안질환 치료용 조성물 |
US10835582B2 (en) | 2015-02-27 | 2020-11-17 | Gemvax & Kael Co. Ltd. | Peptide for preventing hearing loss, and composition comprising same |
EP3318265B1 (en) | 2015-07-02 | 2021-08-18 | Gemvax & Kael Co., Ltd. | Peptide having anti-viral effect and composition containing same |
US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
BR102015020878B1 (pt) * | 2015-08-28 | 2019-08-27 | F B M Ind Farmaceutica Ltda | formulação farmacêutica nasal de testosterona e “kit” em forma de cartela de dispositivos nasais unitários para aplicação de monodose de testosterona. |
CA3016542A1 (en) * | 2016-03-02 | 2017-09-08 | Board Of Regents, The University Of Texas System | Formulations of testosterone and methods of treatment therewith |
US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
KR20180126582A (ko) | 2016-04-01 | 2018-11-27 | 쎄러퓨틱스엠디, 인코퍼레이티드 | 스테로이드 호르몬 약제학적 조성물 |
CN109328068A (zh) | 2016-04-07 | 2019-02-12 | 珍白斯凯尔有限公司 | 具有增加端粒酶活性和延长端粒的效果的肽以及包含该肽的组合物 |
MX2018014906A (es) | 2016-06-03 | 2019-08-21 | M et P Pharma AG | Composiciones farmaceuticas nasales con un excipiente poroso. |
HUE063346T2 (hu) | 2017-01-20 | 2024-01-28 | M et P Pharma AG | Nazális gyógyszerészeti készítmények légszennyezõ anyagoknak való kitettség kockázatainak csökkentésére |
LT3698791T (lt) | 2017-02-02 | 2024-02-12 | Otolanum Ag | Intranazalinė kompozicija, apimanti betahistiną |
US11234928B2 (en) | 2017-11-27 | 2022-02-01 | Aska Pharmaceutical Co., Ltd. | Powder preparation for nasal administration |
CA3087840A1 (en) | 2018-01-11 | 2019-07-18 | M et P Pharma AG | Treatment of demyelinating diseases |
CA3066284A1 (en) | 2018-04-09 | 2019-10-17 | Katana Pharmaceuticals, Inc. | Oxytocin compositions and methods of use |
CA3097090A1 (en) | 2018-04-17 | 2019-10-24 | M et P Pharma AG | Compositions and methods for intranasal delivery of pregnenolone |
WO2020084548A1 (en) * | 2018-10-26 | 2020-04-30 | Viramal Limited | Mucoadhesive gel composition |
CN113365635A (zh) * | 2018-12-14 | 2021-09-07 | 阿克罗斯生物制药公司 | 睾酮的活性酯衍生物、组合物和其用途 |
US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4315925A (en) * | 1980-05-30 | 1982-02-16 | University Of Kentucky Research Foundation | Method of administering natural female sex hormones |
US4581225A (en) * | 1984-04-25 | 1986-04-08 | Eli Lilly And Company | Sustained release intranasal formulation and method of use thereof |
EP0349091A1 (en) * | 1988-07-01 | 1990-01-03 | Walter Adrianus Josephus Johannes Hermens | Pharmaceutical composition |
US5863554A (en) * | 1987-05-22 | 1999-01-26 | Danbiosyst Uk Limited | Enhanced uptake drug delivery system |
US6432440B1 (en) * | 1997-04-18 | 2002-08-13 | West Pharmaceutical Services Drug Delivery & Clinical Research Centre Limited | Pectin compositions and methods of use for improved delivery of drugs to mucosal surfaces |
Family Cites Families (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE943792C (de) * | 1949-02-18 | 1956-06-01 | Organon Nv | Verfahren zur Herstellung von injizierbaren Hormonpraeparaten |
GB1032874A (en) | 1964-02-13 | 1966-06-15 | Du Pont | Stabilized polyoxymethylenes |
NL7506407A (nl) * | 1975-05-30 | 1976-12-02 | Akzo Nv | Werkwijze ter bereiding van een oraal werkzaam far- maceutisch preparaat. |
NL7510104A (nl) * | 1975-08-27 | 1977-03-01 | Akzo Nv | Werkwijze ter bereiding van een oraal werkzaam farmaceutisch preparaat. |
DE2548413A1 (de) * | 1975-10-27 | 1977-04-28 | Schering Ag | Depotpraeparate in oeliger ungesaettigter loesung zur intramuskulaeren injektion |
US4752425A (en) * | 1986-09-18 | 1988-06-21 | Liposome Technology, Inc. | High-encapsulation liposome processing method |
US5049387A (en) * | 1987-03-09 | 1991-09-17 | Alza Corporation | Inducing skin tolerance to a sensitizing drug |
JP2543708B2 (ja) * | 1987-07-13 | 1996-10-16 | 旭化成工業株式会社 | 難溶性薬物を封入したエマルジョン製剤の製造方法 |
GB2237510B (en) | 1989-11-04 | 1993-09-15 | Danbiosyst Uk | Small particle drug compositions for nasal administration |
US5397771A (en) * | 1990-05-10 | 1995-03-14 | Bechgaard International Research And Development A/S | Pharmaceutical preparation |
US5221698A (en) | 1991-06-27 | 1993-06-22 | The Regents Of The University Of Michigan | Bioactive composition |
US5756071A (en) * | 1992-06-03 | 1998-05-26 | Arrowdean Limited | Method for nasally administering aerosols of therapeutic agents to enhance penetration of the blood brain barrier |
SE9301171D0 (sv) * | 1993-04-07 | 1993-04-07 | Ab Astra | Pharmaceutical composition containing lipophilic drugs |
NZ279954A (en) | 1994-02-04 | 1998-02-26 | Scotia Lipidteknik Ab | Lipophilic carrier preparation comprising a galacto-lipid material at least 50% of which comprises digalactosyldiacylglycerols |
GB9405304D0 (en) * | 1994-03-16 | 1994-04-27 | Scherer Ltd R P | Delivery systems for hydrophobic drugs |
US5635203A (en) | 1994-09-29 | 1997-06-03 | Alza Corporation | Transdermal device having decreased delamination |
US5747058A (en) | 1995-06-07 | 1998-05-05 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system |
GB9608719D0 (en) | 1996-04-26 | 1996-07-03 | Scherer Ltd R P | Pharmaceutical compositions |
US6624200B2 (en) | 1998-08-25 | 2003-09-23 | Columbia Laboratories, Inc. | Bioadhesive progressive hydration tablets |
US5877216A (en) * | 1997-10-28 | 1999-03-02 | Vivus, Incorporated | Treatment of female sexual dysfunction |
US5897894A (en) * | 1997-12-29 | 1999-04-27 | General Mills, Inc. | Microwave popcorn with coarse salt crystals and method of preparation |
GB9823246D0 (en) * | 1998-10-24 | 1998-12-16 | Danbiosyst Uk | A nasal drug delivery composition |
GB9828861D0 (en) | 1998-12-31 | 1999-02-17 | Danbiosyst Uk | Compositions |
US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
US6294192B1 (en) | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
US6761903B2 (en) | 1999-06-30 | 2004-07-13 | Lipocine, Inc. | Clear oil-containing pharmaceutical compositions containing a therapeutic agent |
IL145524A0 (en) * | 1999-04-01 | 2002-06-30 | Akzo Nobel Nv | Formulation comprising testosterone undecanoate and castor oil |
US6287588B1 (en) | 1999-04-29 | 2001-09-11 | Macromed, Inc. | Agent delivering system comprised of microparticle and biodegradable gel with an improved releasing profile and methods of use thereof |
JP5184727B2 (ja) | 1999-06-11 | 2013-04-17 | ワトソン ファーマシューティカルズ, インコーポレイテッド | 女性への非経口アンドロゲンステロイドの投与 |
US20030236236A1 (en) | 1999-06-30 | 2003-12-25 | Feng-Jing Chen | Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs |
US6309663B1 (en) | 1999-08-17 | 2001-10-30 | Lipocine Inc. | Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents |
DE60020382T2 (de) | 1999-09-21 | 2006-01-26 | Skyepharma Canada Inc., Verdun | Oberflächenmodifizierte teilchenförmige zusammensetzungen biologisch aktiver stoffe |
US6720001B2 (en) | 1999-10-18 | 2004-04-13 | Lipocine, Inc. | Emulsion compositions for polyfunctional active ingredients |
AU1261501A (en) | 1999-12-06 | 2001-06-18 | Stanley L. Gore | Compositions and methods for intranasal delivery of active agents to the brain |
US7198801B2 (en) | 2000-08-03 | 2007-04-03 | Antares Pharma Ipl Ag | Formulations for transdermal or transmucosal application |
US8980290B2 (en) | 2000-08-03 | 2015-03-17 | Antares Pharma Ipl Ag | Transdermal compositions for anticholinergic agents |
US20030139384A1 (en) | 2000-08-30 | 2003-07-24 | Dudley Robert E. | Method for treating erectile dysfunction and increasing libido in men |
US20040092494A9 (en) | 2000-08-30 | 2004-05-13 | Dudley Robert E. | Method of increasing testosterone and related steroid concentrations in women |
US20020072509A1 (en) | 2000-10-11 | 2002-06-13 | Stein Donald Gerald | Methods for the treatment of a traumatic central nervous system injury |
US6730330B2 (en) * | 2001-02-14 | 2004-05-04 | Gw Pharma Limited | Pharmaceutical formulations |
KR20040052489A (ko) * | 2001-03-06 | 2004-06-23 | 셀러지 파마세우티칼스, 인크 | 비뇨생식기 장애 치료용 화합물 및 그 방법 |
US6833478B2 (en) | 2001-07-13 | 2004-12-21 | Sri International | N,N-dinitramide salts as solubilizing agents for biologically active agents |
JP2005523262A (ja) * | 2002-02-01 | 2005-08-04 | ファイザー・プロダクツ・インク | 薬物及び親油性ミクロ相形成物質の非晶質分散物の医薬組成物 |
EA007431B1 (ru) | 2002-03-15 | 2006-10-27 | Юнимед Фармасьютикалз, Инк. | Андрогенная фармацевтическая композиция и способ для лечения депрессии |
US6855332B2 (en) * | 2002-07-03 | 2005-02-15 | Lyfjathroun Hf. | Absorption promoting agent |
US6958142B2 (en) | 2002-08-02 | 2005-10-25 | Balance Pharmaceuticals, Inc. | Nasal spray formulation and method |
US7029657B2 (en) | 2002-08-02 | 2006-04-18 | Balance Pharmaceuticals, Inc. | Nasal spray steroid formulation and method |
US20040259852A1 (en) | 2003-06-18 | 2004-12-23 | White Hillary D. | Trandsdermal compositions and methods for treatment of fibromyalgia and chronic fatigue syndrome |
US8784869B2 (en) | 2003-11-11 | 2014-07-22 | Mattern Pharma Ag | Controlled release delivery system for nasal applications and methods of treatment |
EP1530965B1 (en) * | 2003-11-11 | 2006-03-08 | Mattern, Udo | Controlled release delivery system of sexual hormones for nasal application |
WO2005065185A2 (en) | 2003-12-24 | 2005-07-21 | Collegium Pharmaceuticals, Inc. | Temperature-stable formulations, and methods of development thereof |
US20060140820A1 (en) | 2004-12-28 | 2006-06-29 | Udo Mattern | Use of a container of an inorganic additive containing plastic material |
CN101600417B (zh) | 2006-10-04 | 2012-05-30 | M&P专利股份公司 | 用于神经递质的经鼻施用的控制释放递送系统 |
-
2003
- 2003-11-11 EP EP03025769A patent/EP1530965B1/en not_active Expired - Lifetime
- 2003-11-11 ES ES03025769T patent/ES2258694T3/es not_active Expired - Lifetime
- 2003-11-11 DK DK03025769T patent/DK1530965T3/da active
- 2003-11-11 PT PT03025769T patent/PT1530965E/pt unknown
- 2003-11-11 SI SI200330194T patent/SI1530965T1/sl unknown
- 2003-11-11 AT AT03025769T patent/ATE319426T1/de active
- 2003-11-11 DE DE60303854T patent/DE60303854T2/de not_active Expired - Lifetime
-
2004
- 2004-02-04 US US10/772,964 patent/US20050100564A1/en not_active Abandoned
- 2004-09-23 MY MYPI20043889A patent/MY131483A/en unknown
- 2004-10-04 TW TW093129982A patent/TWI350176B/zh not_active IP Right Cessation
- 2004-10-05 AR ARP040103611A patent/AR047722A1/es not_active Application Discontinuation
- 2004-10-27 PL PL379867A patent/PL219338B1/pl unknown
- 2004-10-27 CA CA002541498A patent/CA2541498C/en not_active Expired - Lifetime
- 2004-10-27 JP JP2006538697A patent/JP4616270B2/ja not_active Expired - Fee Related
- 2004-10-27 AU AU2004286781A patent/AU2004286781B2/en not_active Ceased
- 2004-10-27 BR BRPI0416370A patent/BRPI0416370B8/pt not_active IP Right Cessation
- 2004-10-27 KR KR1020067009182A patent/KR100861443B1/ko active IP Right Grant
- 2004-10-27 RU RU2006120468/15A patent/RU2331423C2/ru active
- 2004-10-27 WO PCT/EP2004/012122 patent/WO2005044273A1/en not_active Application Discontinuation
- 2004-10-27 ZA ZA200603115A patent/ZA200603115B/en unknown
- 2004-11-02 SA SA04250363A patent/SA04250363B1/ar unknown
-
2006
- 2006-04-18 HR HRP20060147AA patent/HRP20060147B1/hr not_active IP Right Cessation
- 2006-06-07 NO NO20062619A patent/NO338665B1/no not_active IP Right Cessation
- 2006-11-15 US US11/560,187 patent/US20070149454A1/en not_active Abandoned
-
2010
- 2010-06-08 US US12/796,165 patent/US20100311707A1/en not_active Abandoned
-
2011
- 2011-07-29 US US13/194,853 patent/US8784882B2/en not_active Expired - Lifetime
- 2011-07-30 US US13/194,928 patent/US8574622B2/en not_active Expired - Lifetime
- 2011-12-10 US US13/316,494 patent/US8877230B2/en not_active Expired - Lifetime
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4315925A (en) * | 1980-05-30 | 1982-02-16 | University Of Kentucky Research Foundation | Method of administering natural female sex hormones |
US4581225A (en) * | 1984-04-25 | 1986-04-08 | Eli Lilly And Company | Sustained release intranasal formulation and method of use thereof |
US5863554A (en) * | 1987-05-22 | 1999-01-26 | Danbiosyst Uk Limited | Enhanced uptake drug delivery system |
EP0349091A1 (en) * | 1988-07-01 | 1990-01-03 | Walter Adrianus Josephus Johannes Hermens | Pharmaceutical composition |
US6432440B1 (en) * | 1997-04-18 | 2002-08-13 | West Pharmaceutical Services Drug Delivery & Clinical Research Centre Limited | Pectin compositions and methods of use for improved delivery of drugs to mucosal surfaces |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HRP20060147B1 (hr) | Terapijski sustav s kontroliranim otpuštanjem za nazalnu primjenu | |
AR059350A1 (es) | Formulacion farmaceutica para aerosoles con dos o mas principios activos y al menos una sustancia tensioactiva | |
ATE471144T1 (de) | Intranasale verabreichung von schnell wirkendem insulin | |
ECSP10010224A (es) | Formulaciones líquidas de hormona luteinizante (lh). | |
DE122011100049I1 (de) | Stabile pharmazeutische Losungsformulierungen fur unter Druck stehende Inhaliergerate fur die Verabreichung abgemessener Dosen. | |
ECSP088403A (es) | Formulacion farmaceutica de absorción oral y su método de administracion | |
EA200800360A1 (ru) | Формуляции с высоким содержанием лекарства и дозированные формы | |
WO2005016423A3 (en) | Delivery devices | |
TN2011000229A1 (en) | Antibody formulation | |
DK1389137T3 (da) | Sammensætninger til lungelægemiddellevering af protein | |
AR064614A1 (es) | Producto combinado par controlar parasitos en animales | |
WO2006135933A3 (en) | Stable fixed-dose unitary formulations containing tenofovir, a surfactant, efavirenz and emtricitabine | |
RS52367B (en) | GLATIRAMER ACETATE FORMULATION FORMATED VOLUMES AND APPLICATION PROCEDURES | |
DK2068825T3 (da) | Kontrolleret frisætningstilførselssystem til nasal påføring af neurotransmittere | |
MXPA06011467A (es) | Combinacion de sustancias activas que comprenden un carbinol combinado con al menos un farmaco antiinflamatorio no esteroideo (nsaid). | |
MX2009003030A (es) | Forma galenita para la administracion por via transmucosa de principios activos. | |
MX2010004388A (es) | Formulaciones de hormona paratiroidea y usos de las mismas. | |
ATE507818T1 (de) | Orale verabreichung eines calcitonins | |
NO20023551D0 (no) | Ibuprofen-inneholdende aktivt middel-preparat | |
BRPI0504082A (pt) | emulsões refrescantes medicinais | |
MX2010008285A (es) | Forma galenica para la administracion de triptanos por via trans-mucosa bucal. | |
HRP20070081T5 (hr) | Nazalni farmaceutski pripravak piribedila | |
UY27857A1 (es) | Medicamento para el tratamiento del "síndrome de respuesta inflamatoria sistémica" | |
CY1115072T1 (el) | Συνθεσεις υγρου σπρει για χορηγηση κανναβινοειδων μεσω παρειας | |
TH1701001848A (th) | อุปกรณ์สูดดม |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A1OB | Publication of a patent application | ||
ARAI | Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application | ||
PPPP | Transfer of rights |
Owner name: M & P PATENT AKTIENGESELLSCHAFT, C/O FUNDATIONANST |
|
B1PR | Patent granted | ||
ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20191017 Year of fee payment: 16 |
|
ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20201016 Year of fee payment: 17 |
|
ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20211019 Year of fee payment: 18 |
|
PBON | Lapse due to non-payment of renewal fee |
Effective date: 20221027 |