JP2007528901A5 - - Google Patents
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- JP2007528901A5 JP2007528901A5 JP2007503046A JP2007503046A JP2007528901A5 JP 2007528901 A5 JP2007528901 A5 JP 2007528901A5 JP 2007503046 A JP2007503046 A JP 2007503046A JP 2007503046 A JP2007503046 A JP 2007503046A JP 2007528901 A5 JP2007528901 A5 JP 2007528901A5
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- JP
- Japan
- Prior art keywords
- linker
- shell wall
- subunit
- amount
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims 21
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 15
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 15
- 229920001577 copolymer Polymers 0.000 claims 14
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 14
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical group CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims 12
- 239000002775 capsule Substances 0.000 claims 10
- 229920000642 polymer Polymers 0.000 claims 9
- 239000000314 lubricant Substances 0.000 claims 8
- 239000003795 chemical substances by application Substances 0.000 claims 7
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims 6
- 239000007787 solid Substances 0.000 claims 6
- 239000008186 active pharmaceutical agent Substances 0.000 claims 5
- 229940088679 drug related substance Drugs 0.000 claims 5
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 4
- 239000002552 dosage form Substances 0.000 claims 4
- 239000004094 surface-active agent Substances 0.000 claims 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- 239000008101 lactose Substances 0.000 claims 3
- 239000011159 matrix material Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 239000004014 plasticizer Substances 0.000 claims 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 3
- QZCLKYGREBVARF-UHFFFAOYSA-N Acetyl tributyl citrate Chemical compound CCCCOC(=O)CC(C(=O)OCCCC)(OC(C)=O)CC(=O)OCCCC QZCLKYGREBVARF-UHFFFAOYSA-N 0.000 claims 2
- PYGXAGIECVVIOZ-UHFFFAOYSA-N Dibutyl decanedioate Chemical compound CCCCOC(=O)CCCCCCCCC(=O)OCCCC PYGXAGIECVVIOZ-UHFFFAOYSA-N 0.000 claims 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
- 229920003151 Eudragit® RL polymer Polymers 0.000 claims 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- ZFOZVQLOBQUTQQ-UHFFFAOYSA-N Tributyl citrate Chemical compound CCCCOC(=O)CC(O)(C(=O)OCCCC)CC(=O)OCCCC ZFOZVQLOBQUTQQ-UHFFFAOYSA-N 0.000 claims 2
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical group CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims 2
- 238000010521 absorption reaction Methods 0.000 claims 2
- DOIRQSBPFJWKBE-UHFFFAOYSA-N dibutyl phthalate Chemical compound CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC DOIRQSBPFJWKBE-UHFFFAOYSA-N 0.000 claims 2
- FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 claims 2
- 239000007884 disintegrant Substances 0.000 claims 2
- 239000003623 enhancer Substances 0.000 claims 2
- 238000001125 extrusion Methods 0.000 claims 2
- 230000002496 gastric effect Effects 0.000 claims 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- DNKKLDKIFMDAPT-UHFFFAOYSA-N n,n-dimethylmethanamine;2-methylprop-2-enoic acid Chemical compound CN(C)C.CC(=C)C(O)=O.CC(=C)C(O)=O DNKKLDKIFMDAPT-UHFFFAOYSA-N 0.000 claims 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 2
- 239000000454 talc Substances 0.000 claims 2
- 229910052623 talc Inorganic materials 0.000 claims 2
- 235000012222 talc Nutrition 0.000 claims 2
- WEAPVABOECTMGR-UHFFFAOYSA-N triethyl 2-acetyloxypropane-1,2,3-tricarboxylate Chemical compound CCOC(=O)CC(C(=O)OCC)(OC(C)=O)CC(=O)OCC WEAPVABOECTMGR-UHFFFAOYSA-N 0.000 claims 2
- 239000001069 triethyl citrate Substances 0.000 claims 2
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims 2
- 235000013769 triethyl citrate Nutrition 0.000 claims 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 1
- 229920000623 Cellulose acetate phthalate Polymers 0.000 claims 1
- 229920001661 Chitosan Polymers 0.000 claims 1
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- 239000001856 Ethyl cellulose Substances 0.000 claims 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 1
- 229920003152 Eudragit® RS polymer Polymers 0.000 claims 1
- 102000004856 Lectins Human genes 0.000 claims 1
- 108090001090 Lectins Proteins 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229920001213 Polysorbate 20 Polymers 0.000 claims 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 claims 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- AOBORMOPSGHCAX-UHFFFAOYSA-N Tocophersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-UHFFFAOYSA-N 0.000 claims 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 1
- 229920001400 block copolymer Polymers 0.000 claims 1
- 235000019438 castor oil Nutrition 0.000 claims 1
- 239000004359 castor oil Substances 0.000 claims 1
- 229940081734 cellulose acetate phthalate Drugs 0.000 claims 1
- 229920001531 copovidone Polymers 0.000 claims 1
- 229960001681 croscarmellose sodium Drugs 0.000 claims 1
- 229960000913 crospovidone Drugs 0.000 claims 1
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 235000019325 ethyl cellulose Nutrition 0.000 claims 1
- 229920001249 ethyl cellulose Polymers 0.000 claims 1
- FSXVSUSRJXIJHB-UHFFFAOYSA-M ethyl prop-2-enoate;methyl 2-methylprop-2-enoate;trimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azanium;chloride Chemical compound [Cl-].CCOC(=O)C=C.COC(=O)C(C)=C.CC(=C)C(=O)OCC[N+](C)(C)C FSXVSUSRJXIJHB-UHFFFAOYSA-M 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 229910021485 fumed silica Inorganic materials 0.000 claims 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims 1
- 229920013821 hydroxy alkyl cellulose Polymers 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 claims 1
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 claims 1
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 229960001375 lactose Drugs 0.000 claims 1
- 239000000787 lecithin Substances 0.000 claims 1
- 235000010445 lecithin Nutrition 0.000 claims 1
- 229940067606 lecithin Drugs 0.000 claims 1
- 239000002523 lectin Substances 0.000 claims 1
- 235000019359 magnesium stearate Nutrition 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 229960001855 mannitol Drugs 0.000 claims 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims 1
- 235000013772 propylene glycol Nutrition 0.000 claims 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 claims 1
- 235000012239 silicon dioxide Nutrition 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 229960002668 sodium chloride Drugs 0.000 claims 1
- 239000008109 sodium starch glycolate Substances 0.000 claims 1
- 229920003109 sodium starch glycolate Polymers 0.000 claims 1
- 229940079832 sodium starch glycolate Drugs 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 229940032147 starch Drugs 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- -1 sucrose fatty acid ester Chemical class 0.000 claims 1
- ILJSQTXMGCGYMG-UHFFFAOYSA-N triacetic acid Chemical compound CC(=O)CC(=O)CC(O)=O ILJSQTXMGCGYMG-UHFFFAOYSA-N 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 239000000811 xylitol Substances 0.000 claims 1
- 229960002675 xylitol Drugs 0.000 claims 1
- 235000010447 xylitol Nutrition 0.000 claims 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical group OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55249904P | 2004-03-12 | 2004-03-12 | |
| PCT/US2005/008147 WO2005089726A1 (en) | 2004-03-12 | 2005-03-11 | Pharmaceutical formulations |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011262441A Division JP2012097088A (ja) | 2004-03-12 | 2011-11-30 | 医薬製剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007528901A JP2007528901A (ja) | 2007-10-18 |
| JP2007528901A5 true JP2007528901A5 (enExample) | 2008-04-10 |
Family
ID=34993424
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007503046A Ceased JP2007528901A (ja) | 2004-03-12 | 2005-03-11 | 医薬製剤 |
| JP2011262441A Withdrawn JP2012097088A (ja) | 2004-03-12 | 2011-11-30 | 医薬製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011262441A Withdrawn JP2012097088A (ja) | 2004-03-12 | 2011-11-30 | 医薬製剤 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US20070178156A1 (enExample) |
| EP (1) | EP1729744A4 (enExample) |
| JP (2) | JP2007528901A (enExample) |
| KR (3) | KR101242988B1 (enExample) |
| CN (1) | CN1953739B (enExample) |
| AR (1) | AR048033A1 (enExample) |
| AU (1) | AU2005222612C1 (enExample) |
| BR (1) | BRPI0508342A (enExample) |
| CA (1) | CA2559227A1 (enExample) |
| IL (1) | IL177566A (enExample) |
| MA (1) | MA28489B1 (enExample) |
| NO (1) | NO20064570L (enExample) |
| NZ (1) | NZ549264A (enExample) |
| PE (1) | PE20060003A1 (enExample) |
| RU (2) | RU2447885C2 (enExample) |
| TW (2) | TW201240679A (enExample) |
| WO (1) | WO2005089726A1 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2391707C (en) * | 1999-07-30 | 2010-05-11 | Smithkline Beecham Plc | Multi-component pharmaceutical dosage form |
| US7883721B2 (en) | 2001-01-30 | 2011-02-08 | Smithkline Beecham Limited | Pharmaceutical formulation |
| US7842308B2 (en) * | 2001-01-30 | 2010-11-30 | Smithkline Beecham Limited | Pharmaceutical formulation |
| TWI336260B (en) * | 2002-07-25 | 2011-01-21 | Glaxo Group Ltd | Dosage form suitable for retaining drug substance |
| EP2359817B1 (en) * | 2003-03-28 | 2018-01-10 | Sigmoid Pharma Limited | Solid oral dosage form containing seamless microcapsules |
| TW200526274A (en) | 2003-07-21 | 2005-08-16 | Smithkline Beecham Plc | Pharmaceutical formulations |
| EP2153824A1 (en) * | 2004-09-27 | 2010-02-17 | Sigmoid Pharma Limited | Seamless multiparticulate formulations |
| HRP20130246T1 (hr) | 2004-11-19 | 2013-04-30 | Glaxosmithkline Llc | Postupak personaliziranog izdavanja kombinacije lijekova u promjenjivoj koncentraciji iz proizvoda namijenjenih za individualiziranje terapije |
| EP1965772A1 (en) * | 2005-12-30 | 2008-09-10 | Accu-Break Technologies, Inc. | Adhesively bonded dosage form |
| AU2007215304B2 (en) | 2006-02-09 | 2012-06-14 | Alba Therapeutics Corporation | Formulations for a tight junction effector |
| CA2652620A1 (en) * | 2006-06-02 | 2007-12-13 | Teva Pharmaceutical Industries Ltd. | Stable formulation comprising moisture sensitive drug/s and manufacturing procedure thereof |
| WO2008052185A2 (en) | 2006-10-26 | 2008-05-02 | Alba Therapeutics Corp | Materials and methods for the treatment of celiac disease |
| WO2008122965A2 (en) | 2007-04-04 | 2008-10-16 | Sigmoid Pharma Limited | Pharmaceutical cyclosporin compositions |
| EP2061587A1 (en) * | 2007-04-26 | 2009-05-27 | Sigmoid Pharma Limited | Manufacture of multiple minicapsules |
| MX2009011641A (es) * | 2007-04-27 | 2010-03-04 | Endo Pharmaceuticals Solutions | Agentes de liberacion para dispositivo de implante y metodos para utilizar los mismos. |
| JP2010526054A (ja) * | 2007-05-01 | 2010-07-29 | シグモイド・ファーマ・リミテッド | 併用医薬組成物 |
| CN101827572A (zh) * | 2007-10-15 | 2010-09-08 | 葛兰素集团有限公司 | 用于释放药物组合物的有板条的胶囊壳 |
| WO2009050190A2 (en) | 2007-10-15 | 2009-04-23 | Glaxo Group Limited | Linkers for multipart dosage forms for release of one or more pharmaceutical compositions, and the resulting dosage forms |
| JP5190515B2 (ja) | 2007-10-15 | 2013-04-24 | カプスゲル・ベルギウム・ナムローゼ・フェンノートシャップ | 充填リンカーを製造する方法および装置 |
| EP2219624A2 (en) | 2007-11-08 | 2010-08-25 | Glaxo Group Limited | Pharmaceutical formulations |
| US8357395B2 (en) * | 2007-12-21 | 2013-01-22 | Mcneil-Ppc, Inc. | Manufacture of tablet |
| CA2727630A1 (en) * | 2008-06-13 | 2009-12-17 | Glaxo Group Limited | Pharmaceutical formulations |
| IT1393245B1 (it) * | 2008-07-24 | 2012-04-12 | Universita' Degli Studi Di Milano | Forme farmaceutiche per il rilascio tempo-specifico di farmaci |
| US8900634B2 (en) * | 2008-11-03 | 2014-12-02 | Nal Pharmaceuticals, Ltd. | Diethylstilbestrol dosage form and methods of treatment using thereof |
| UA125896C2 (uk) | 2009-01-09 | 2022-07-06 | Фвп Іп Апс | Фармацевтичний склад, що містить в матриці, яка піддається ерозії, один або більше ефірів фумарової кислоти |
| ES2530049T3 (es) | 2009-05-18 | 2015-02-26 | Sigmoid Pharma Limited | Composición que comprende gotas de aceite |
| EP2464341B1 (en) | 2009-08-12 | 2022-07-06 | Sublimity Therapeutics Limited | Immunomodulatory compositions comprising a polymer matrix and an oil phase |
| SG183993A1 (en) * | 2010-03-09 | 2012-10-30 | Alkermes Pharma Ireland Ltd | Alcohol resistant enteric pharmaceutical compositions |
| EP3354335A1 (en) * | 2010-10-26 | 2018-08-01 | Capsugel Belgium NV | Bulk enteric capsule shells |
| GB201020032D0 (en) | 2010-11-25 | 2011-01-12 | Sigmoid Pharma Ltd | Composition |
| KR20140076621A (ko) * | 2011-10-12 | 2014-06-20 | 다우 글로벌 테크놀로지스 엘엘씨 | 사출 성형된 투여형 |
| GB201212010D0 (en) | 2012-07-05 | 2012-08-22 | Sigmoid Pharma Ltd | Formulations |
| EP3065720A1 (en) | 2013-11-04 | 2016-09-14 | Capsugel Belgium NV | Methods and systems for improved bioavailability of active pharmaceutical ingredients including esomeprazole |
| GB201319791D0 (en) | 2013-11-08 | 2013-12-25 | Sigmoid Pharma Ltd | Formulations |
| TWI535784B (zh) | 2014-08-26 | 2016-06-01 | 財團法人工業技術研究院 | 剪切增稠配方、及包含其之複合材料 |
| HUE053624T2 (hu) | 2014-11-07 | 2021-07-28 | Sublimity Therapeutics Ltd | Ciklosporint tartalmazó készítmények |
| US20160331689A1 (en) | 2015-05-12 | 2016-11-17 | SE Tylose USA, Inc. | Aqueous enteric coating composition |
| CN108472249A (zh) * | 2015-10-23 | 2018-08-31 | 林德拉有限公司 | 用于治疗剂缓释的胃驻留系统及其使用方法 |
| JP7030052B2 (ja) | 2015-12-08 | 2022-03-04 | リンドラ セラピューティクス， インコーポレイティド | 胃滞留システムのための幾何学的構成 |
| AU2017268840B2 (en) | 2016-05-27 | 2022-02-10 | Nortiva Bio, Inc. | Materials architecture for gastric residence systems |
| AU2017336154B2 (en) | 2016-09-30 | 2023-11-09 | Nortiva Bio, Inc. | Gastric residence systems for sustained delivery of adamantane-class drugs |
| WO2018227147A1 (en) | 2017-06-09 | 2018-12-13 | Lyndra, Inc. | Gastric residence systems with release rate-modulating films |
| WO2019082171A1 (en) * | 2017-10-27 | 2019-05-02 | Alvit Pharma | ORAL CANNABINOID COMPOSITIONS HAVING ENHANCED BIOAVAILABILITY |
| CN112499717B (zh) * | 2020-12-10 | 2021-10-22 | 江南大学 | 一种聚合物包含膜在染料吸附中的应用 |
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- 2005-03-10 PE PE2005000274A patent/PE20060003A1/es not_active Application Discontinuation
- 2005-03-10 AR ARP050100929A patent/AR048033A1/es unknown
- 2005-03-10 TW TW101112145A patent/TW201240679A/zh unknown
- 2005-03-10 TW TW094107228A patent/TW200539903A/zh unknown
- 2005-03-11 US US10/598,810 patent/US20070178156A1/en not_active Abandoned
- 2005-03-11 KR KR1020067018523A patent/KR101242988B1/ko not_active Expired - Fee Related
- 2005-03-11 EP EP05727507A patent/EP1729744A4/en not_active Withdrawn
- 2005-03-11 AU AU2005222612A patent/AU2005222612C1/en not_active Ceased
- 2005-03-11 JP JP2007503046A patent/JP2007528901A/ja not_active Ceased
- 2005-03-11 RU RU2006136020/15A patent/RU2447885C2/ru not_active IP Right Cessation
- 2005-03-11 US US11/078,077 patent/US8147871B2/en not_active Expired - Fee Related
- 2005-03-11 NZ NZ549264A patent/NZ549264A/en unknown
- 2005-03-11 WO PCT/US2005/008147 patent/WO2005089726A1/en not_active Ceased
- 2005-03-11 BR BRPI0508342-7A patent/BRPI0508342A/pt not_active IP Right Cessation
- 2005-03-11 CN CN200580015367XA patent/CN1953739B/zh not_active Expired - Fee Related
- 2005-03-11 KR KR1020127031532A patent/KR20130010511A/ko not_active Ceased
- 2005-03-11 KR KR1020127004334A patent/KR20120044365A/ko not_active Ceased
- 2005-03-11 CA CA002559227A patent/CA2559227A1/en not_active Abandoned
-
2006
- 2006-08-17 IL IL177566A patent/IL177566A/en not_active IP Right Cessation
- 2006-09-27 MA MA29346A patent/MA28489B1/fr unknown
- 2006-10-10 NO NO20064570A patent/NO20064570L/no not_active Application Discontinuation
-
2011
- 2011-07-06 RU RU2011127852/15A patent/RU2011127852A/ru not_active Application Discontinuation
- 2011-11-30 JP JP2011262441A patent/JP2012097088A/ja not_active Withdrawn
-
2012
- 2012-01-31 US US13/362,429 patent/US20120196940A1/en not_active Abandoned
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