JP2011503048A5 - - Google Patents
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- JP2011503048A5 JP2011503048A5 JP2010532677A JP2010532677A JP2011503048A5 JP 2011503048 A5 JP2011503048 A5 JP 2011503048A5 JP 2010532677 A JP2010532677 A JP 2010532677A JP 2010532677 A JP2010532677 A JP 2010532677A JP 2011503048 A5 JP2011503048 A5 JP 2011503048A5
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- JP
- Japan
- Prior art keywords
- dosage form
- present
- hpmc
- form according
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000002552 dosage form Substances 0.000 claims 45
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical group CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims 40
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 30
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 30
- 239000000203 mixture Substances 0.000 claims 27
- 229920000639 hydroxypropylmethylcellulose acetate succinate Polymers 0.000 claims 25
- ZUAAPNNKRHMPKG-UHFFFAOYSA-N acetic acid;butanedioic acid;methanol;propane-1,2-diol Chemical compound OC.CC(O)=O.CC(O)CO.OC(=O)CCC(O)=O ZUAAPNNKRHMPKG-UHFFFAOYSA-N 0.000 claims 23
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims 20
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims 20
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 18
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 18
- 239000004014 plasticizer Substances 0.000 claims 14
- 238000009472 formulation Methods 0.000 claims 13
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 13
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 13
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 12
- 235000011187 glycerol Nutrition 0.000 claims 10
- 239000001087 glyceryl triacetate Substances 0.000 claims 10
- 235000013773 glyceryl triacetate Nutrition 0.000 claims 10
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 10
- 235000013772 propylene glycol Nutrition 0.000 claims 10
- 229960002622 triacetin Drugs 0.000 claims 10
- 229960003943 hypromellose Drugs 0.000 claims 8
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 claims 8
- 239000007787 solid Substances 0.000 claims 8
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims 7
- 238000004090 dissolution Methods 0.000 claims 7
- 239000000546 pharmaceutical excipient Substances 0.000 claims 7
- 239000001069 triethyl citrate Substances 0.000 claims 7
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims 7
- 235000013769 triethyl citrate Nutrition 0.000 claims 7
- 239000000314 lubricant Substances 0.000 claims 6
- 239000007884 disintegrant Substances 0.000 claims 4
- 230000002496 gastric effect Effects 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 3
- QZCLKYGREBVARF-UHFFFAOYSA-N Acetyl tributyl citrate Chemical compound CCCCOC(=O)CC(C(=O)OCCCC)(OC(C)=O)CC(=O)OCCCC QZCLKYGREBVARF-UHFFFAOYSA-N 0.000 claims 2
- PYGXAGIECVVIOZ-UHFFFAOYSA-N Dibutyl decanedioate Chemical compound CCCCOC(=O)CCCCCCCCC(=O)OCCCC PYGXAGIECVVIOZ-UHFFFAOYSA-N 0.000 claims 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- ZFOZVQLOBQUTQQ-UHFFFAOYSA-N Tributyl citrate Chemical compound CCCCOC(=O)CC(O)(C(=O)OCCCC)CC(=O)OCCCC ZFOZVQLOBQUTQQ-UHFFFAOYSA-N 0.000 claims 2
- 239000008186 active pharmaceutical agent Substances 0.000 claims 2
- DOIRQSBPFJWKBE-UHFFFAOYSA-N dibutyl phthalate Chemical compound CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC DOIRQSBPFJWKBE-UHFFFAOYSA-N 0.000 claims 2
- FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 claims 2
- 229940088679 drug related substance Drugs 0.000 claims 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 2
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 claims 2
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 claims 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 2
- WEAPVABOECTMGR-UHFFFAOYSA-N triethyl 2-acetyloxypropane-1,2,3-tricarboxylate Chemical compound CCOC(=O)CC(C(=O)OCC)(OC(C)=O)CC(=O)OCC WEAPVABOECTMGR-UHFFFAOYSA-N 0.000 claims 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 1
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- 229920003116 HPC-SSL Polymers 0.000 claims 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229920001213 Polysorbate 20 Polymers 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- 229910010413 TiO 2 Inorganic materials 0.000 claims 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 1
- 239000004359 castor oil Substances 0.000 claims 1
- 235000019438 castor oil Nutrition 0.000 claims 1
- 229920001531 copovidone Polymers 0.000 claims 1
- 229960001681 croscarmellose sodium Drugs 0.000 claims 1
- 229960000913 crospovidone Drugs 0.000 claims 1
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims 1
- 238000001125 extrusion Methods 0.000 claims 1
- 229910021485 fumed silica Inorganic materials 0.000 claims 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 229960001375 lactose Drugs 0.000 claims 1
- 235000019359 magnesium stearate Nutrition 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 229960001855 mannitol Drugs 0.000 claims 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims 1
- 239000003607 modifier Substances 0.000 claims 1
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 claims 1
- 235000012239 silicon dioxide Nutrition 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 229960002668 sodium chloride Drugs 0.000 claims 1
- 239000008109 sodium starch glycolate Substances 0.000 claims 1
- 229940079832 sodium starch glycolate Drugs 0.000 claims 1
- 229920003109 sodium starch glycolate Polymers 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 229940032147 starch Drugs 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 239000000454 talc Substances 0.000 claims 1
- 229910052623 talc Inorganic materials 0.000 claims 1
- 235000012222 talc Nutrition 0.000 claims 1
- ILJSQTXMGCGYMG-UHFFFAOYSA-N triacetic acid Chemical compound CC(=O)CC(=O)CC(O)=O ILJSQTXMGCGYMG-UHFFFAOYSA-N 0.000 claims 1
- 239000000811 xylitol Substances 0.000 claims 1
- 229960002675 xylitol Drugs 0.000 claims 1
- 235000010447 xylitol Nutrition 0.000 claims 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98638307P | 2007-11-08 | 2007-11-08 | |
| PCT/IB2008/003872 WO2009087483A2 (en) | 2007-11-08 | 2008-11-07 | Pharmaceutical formulations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011503048A JP2011503048A (ja) | 2011-01-27 |
| JP2011503048A5 true JP2011503048A5 (enExample) | 2012-01-26 |
Family
ID=40721919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010532677A Withdrawn JP2011503048A (ja) | 2007-11-08 | 2008-11-01 | 医薬製剤 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20110117190A1 (enExample) |
| EP (1) | EP2219624A2 (enExample) |
| JP (1) | JP2011503048A (enExample) |
| KR (1) | KR20100096141A (enExample) |
| CN (1) | CN101917978A (enExample) |
| AU (1) | AU2008346205B2 (enExample) |
| BR (1) | BRPI0820381A2 (enExample) |
| CA (1) | CA2705285A1 (enExample) |
| EA (1) | EA201070568A1 (enExample) |
| MX (1) | MX2010005092A (enExample) |
| TW (1) | TW200936186A (enExample) |
| WO (1) | WO2009087483A2 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7842308B2 (en) * | 2001-01-30 | 2010-11-30 | Smithkline Beecham Limited | Pharmaceutical formulation |
| GB0102342D0 (en) * | 2001-01-30 | 2001-03-14 | Smithkline Beecham Plc | Pharmaceutical formulation |
| US7883721B2 (en) * | 2001-01-30 | 2011-02-08 | Smithkline Beecham Limited | Pharmaceutical formulation |
| US7670612B2 (en) * | 2002-04-10 | 2010-03-02 | Innercap Technologies, Inc. | Multi-phase, multi-compartment capsular delivery apparatus and methods for using same |
| MY142179A (en) * | 2002-07-25 | 2010-10-15 | Glaxo Group Ltd | Multicomponent pharmaceutical dosage form |
| TW200526274A (en) * | 2003-07-21 | 2005-08-16 | Smithkline Beecham Plc | Pharmaceutical formulations |
| AR048033A1 (es) * | 2004-03-12 | 2006-03-22 | Smithkline Beecham Plc | Composicion farmaceutica para moldear componentes que comprende copolimero de poli(met)acrilato, cubierta, conector o espaciador de capsula moldeado por inyeccion que tiene la composicion farmaceutica y forma de dosificacion farmaceutica de multicomponentes a partir de dicha composicion |
| CN101827571A (zh) * | 2007-10-15 | 2010-09-08 | 葛兰素集团有限公司 | 用于释放一种或多种药物成分的多部分剂型的连接件及所得剂型 |
| EP2219583B1 (en) * | 2007-10-15 | 2012-11-21 | Capsugel Belgium NV | Method and apparatus for manufacturing filled linkers |
| EP2209455A1 (en) * | 2007-10-15 | 2010-07-28 | Glaxo Group Limited | Paneled capsule shells for release of pharmaceutical compositions |
| EP2219624A2 (en) * | 2007-11-08 | 2010-08-25 | Glaxo Group Limited | Pharmaceutical formulations |
| EP2320876A2 (en) * | 2008-06-13 | 2011-05-18 | Pfizer Inc. | Hydroxypropyl cellulose capsule shell |
| DE102008031426B4 (de) * | 2008-07-04 | 2014-07-31 | Schott Ag | Verfahren zur Herstellung einer Versiegelungsschicht für Dekorschichten, Glas- oder Glaskeramik-Artikel und dessen Verwendung |
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| GB201010083D0 (en) * | 2010-06-16 | 2010-07-21 | Univ Bradford | Compositions and methods |
| US20120251588A1 (en) * | 2011-03-30 | 2012-10-04 | Miyuki Fukasawa | Coating Composition, Solid Preparation Coated Therewith, and Method for Preparing Solid Preparation |
| WO2013055668A1 (en) * | 2011-10-12 | 2013-04-18 | Dow Global Technologies Llc | Injection-molded dosage form |
| EP2790729A4 (en) | 2011-12-12 | 2015-08-12 | Orbis Biosciences Inc | PARTICULATE FORMULATIONS WITH DELAYED RELEASE |
| ITTO20120596A1 (it) * | 2012-07-06 | 2014-01-07 | Consiglio Nazionale Ricerche | Procedimento e sistema per assemblare una forma di dosaggio orale, e forma di dosaggio orale |
| CA2913971C (en) * | 2013-05-31 | 2022-08-02 | Universal Stabilization Technologies, Inc. | Polymeric compositions containing ambient-temperature stable biopharmaceuticals & methods for formulation thereof |
| CN106163564B (zh) * | 2014-04-08 | 2018-10-09 | 陶氏环球技术有限责任公司 | 包含酯化纤维素醚的分散体 |
| CN106535878B (zh) | 2014-06-02 | 2022-11-01 | 科莱西奥生物科技有限公司 | 可张开的胃内滞留剂型 |
| TWI535784B (zh) | 2014-08-26 | 2016-06-01 | 財團法人工業技術研究院 | 剪切增稠配方、及包含其之複合材料 |
| EP3981392A1 (en) * | 2016-05-05 | 2022-04-13 | Triastek, Inc. | Controlled release dosage form |
| IL266377B2 (en) | 2016-12-02 | 2023-10-01 | Clexio Biosciences Ltd | Gastric residence system |
| US20180282527A1 (en) | 2017-03-30 | 2018-10-04 | Shin-Etsu Chemical Co., Ltd. | Injection molding composition containing hypromellose acetate succinate and method for producing same |
| US12214084B2 (en) | 2017-07-11 | 2025-02-04 | Qualicaps Co., Ltd. | Enteric hard capsule |
| WO2019111132A1 (en) | 2017-12-04 | 2019-06-13 | Clexio Biosciences Ltd. | Long acting gastric residence system |
| US12280153B2 (en) | 2018-06-22 | 2025-04-22 | Qualicaps Co., Ltd. | Enteric hard capsule |
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| DE19812688A1 (de) | 1998-03-23 | 1999-09-30 | Basf Ag | Verfahren zur Herstellung von festen Dosierungsformen |
| CA2391707C (en) * | 1999-07-30 | 2010-05-11 | Smithkline Beecham Plc | Multi-component pharmaceutical dosage form |
| AU2001241192A1 (en) * | 2000-03-23 | 2001-10-03 | Shionogi And Co., Ltd. | Enteric granular preparations of hardly water soluble drugs characterized by containing water-repellent component |
| GB0102342D0 (en) * | 2001-01-30 | 2001-03-14 | Smithkline Beecham Plc | Pharmaceutical formulation |
| DE60206889T2 (de) * | 2001-02-27 | 2006-07-27 | Astrazeneca Ab | Pharmazeutische formulierung enthaltend bicalutamid |
| MY142179A (en) * | 2002-07-25 | 2010-10-15 | Glaxo Group Ltd | Multicomponent pharmaceutical dosage form |
| EP1537880A4 (en) * | 2002-09-11 | 2009-07-01 | Takeda Pharmaceutical | Sustained release preparation |
| TW200526274A (en) * | 2003-07-21 | 2005-08-16 | Smithkline Beecham Plc | Pharmaceutical formulations |
| US20050129765A1 (en) * | 2003-11-14 | 2005-06-16 | Shaoling Li | Controlled release of topiramate in liquid dosage forms |
| US20070160677A1 (en) * | 2004-01-16 | 2007-07-12 | Pillai Raviraj S | Encapsulation of lipid-based formulations in enteric polymers |
| AR048033A1 (es) | 2004-03-12 | 2006-03-22 | Smithkline Beecham Plc | Composicion farmaceutica para moldear componentes que comprende copolimero de poli(met)acrilato, cubierta, conector o espaciador de capsula moldeado por inyeccion que tiene la composicion farmaceutica y forma de dosificacion farmaceutica de multicomponentes a partir de dicha composicion |
| MX2007012220A (es) * | 2005-04-06 | 2007-12-06 | Mallinckrodt Inc | Formulacion farmaceutica de liberacion por pulsos a base de matriz. |
| EP2209455A1 (en) * | 2007-10-15 | 2010-07-28 | Glaxo Group Limited | Paneled capsule shells for release of pharmaceutical compositions |
| CN101827571A (zh) * | 2007-10-15 | 2010-09-08 | 葛兰素集团有限公司 | 用于释放一种或多种药物成分的多部分剂型的连接件及所得剂型 |
| EP2219624A2 (en) * | 2007-11-08 | 2010-08-25 | Glaxo Group Limited | Pharmaceutical formulations |
-
2008
- 2008-11-01 EP EP08870466A patent/EP2219624A2/en not_active Ceased
- 2008-11-01 JP JP2010532677A patent/JP2011503048A/ja not_active Withdrawn
- 2008-11-07 WO PCT/IB2008/003872 patent/WO2009087483A2/en not_active Ceased
- 2008-11-07 EA EA201070568A patent/EA201070568A1/ru unknown
- 2008-11-07 MX MX2010005092A patent/MX2010005092A/es not_active Application Discontinuation
- 2008-11-07 US US12/741,596 patent/US20110117190A1/en not_active Abandoned
- 2008-11-07 KR KR1020107012468A patent/KR20100096141A/ko not_active Withdrawn
- 2008-11-07 AU AU2008346205A patent/AU2008346205B2/en not_active Ceased
- 2008-11-07 BR BRPI0820381-4A patent/BRPI0820381A2/pt not_active IP Right Cessation
- 2008-11-07 US US12/266,896 patent/US20090148518A1/en not_active Abandoned
- 2008-11-07 CN CN2008801243003A patent/CN101917978A/zh active Pending
- 2008-11-07 CA CA2705285A patent/CA2705285A1/en not_active Abandoned
- 2008-11-10 TW TW097143400A patent/TW200936186A/zh unknown
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