CN101917978A - 药物制剂 - Google Patents
药物制剂 Download PDFInfo
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- CN101917978A CN101917978A CN2008801243003A CN200880124300A CN101917978A CN 101917978 A CN101917978 A CN 101917978A CN 2008801243003 A CN2008801243003 A CN 2008801243003A CN 200880124300 A CN200880124300 A CN 200880124300A CN 101917978 A CN101917978 A CN 101917978A
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- CN
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- Prior art keywords
- dosage form
- hpmc
- amount
- stearyl alcohol
- plasticizer
- Prior art date
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- 210000001685 thyroid gland Anatomy 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 229940125725 tranquilizer Drugs 0.000 description 1
- 239000003204 tranquilizing agent Substances 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
- 229940075420 xanthine Drugs 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
# | HPMCAS-LG | HPC(如Klucel EF | HPC(如SSL) | HPMCP(如HP50/55S/55) | 甘油 | TEC | 三乙酸甘油酯 | 硬脂醇 |
1 | 60 | 20 | 10 | 10 | ||||
2 | 60 | 27.5 | 10 | 2.5 | ||||
3 | 40 | 40 | 17.5 | 2.5 | ||||
4 | 62.75 | 24.5 | 6.5 | 6.25 | ||||
5 | 62.75 | 24.5 | 6.5 | 6.25 | ||||
6 | 62.75 | 24.5 | 6.5 | 6.25 | ||||
7 | 62.75 | 24.5 | 6.5 | 6.25 | ||||
8 | 62.75 | 24 | 10 | 3.25 | ||||
9 | 62.75 | 24 | 10 | 3.25 | ||||
10 | 59.5 | 22 | 12 | 6.5 | ||||
11 | 59 | 24.5(50) | 10 | 6.5 | ||||
12 | 59 | 24.5(55S) | 10 | 6.5 |
13 | 59 | 24.5(50) | 10 | 6.5 | ||||
14 | 59 | 24.5(50) | 10 | 6.5 | ||||
15 | 59 | 19.5(50) | 15 | 6.5 | ||||
16 | 59 | 19.5(50) | 15 | 6.5 | ||||
17 | 41 | 40.5(50) | 12 | 6.5 | ||||
# | HPMCAS-LG | HPC(如Klucel EF | HPC(如SSL) | HPMCP(如HP50/55S/55) | 甘油 | TEC | 三乙酸甘油酯 | 硬脂醇 |
18 | 59 | 19.5(55S) | 15 | 6.5 | ||||
19 | 62.75 | 24.5 | 6.25 | 6.5 | ||||
20 | 50 | 15 | 15(50) | 5 | 10 | 5 | ||
21 | 61.4 | 18.9 | 13 | 6.7 | ||||
22 | 70.1 | 10.2 | 13 | 6.7 |
# | HPMCAS-LG | HPC(如SSL) | HPMCP(HP 50) | HPMCP(如HP55S/55) | 甘油 | TEC | 丙二醇 | 硬脂醇 | HPMC(如Pharmacoat603) |
1 | 61.4 | 20.5 | 4.3 | 8.7 | 5.1 | ||||
2 | 60 | 20 | 5 | 10 | 5 | ||||
3 | 60 | 20 | 5 | 10 | 5 | ||||
4 | 59 | 18.5 | 7.5 | 10 | 5 | ||||
5 | 57 | 3 | 20 | 5 | 10 | 5 | |||
6 | 60 | 20 | 5 | 10 | 5 | ||||
7 | 74 | 5 | 10 | 6 | 5 | ||||
8 | 56 | 18(55) | 5 | 10 | 6 | 5 | |||
9 | 56 | 18(55S) | 5 | 10 | 6 | 5 | |||
10 | 56 | 18 | 5 | 10 | 6 | 5 | |||
11 | 53 | 3 | 18 | 5 | 10 | 6 | 5 | ||
12 | 60 | 20 | 5 | 10 | 5 | ||||
13 | 57 | 3 | 20 | 5 | 10 | 5 | |||
14 | 50 | 7 | 20 | 5 | 10 | 5 | 3 | ||
15 | 45 | 20 | 15 | 5 | 10 | 5 | |||
16 | 45 | 20 | 15 | 10 | 5 | 5 | |||
17 | 50 | 20 | 15 | 5 | 5 | 5 | |||
18 | 50 | 15 | 15 | 5 | 10 | 5 | |||
19 | 59 | 19.5 | 10 | 5 | 6.5 | ||||
20 | 56.2 | 18.5 | 9.5 | 4.8 | 6.2 | 4.8 |
21 | 58.5 | 3 | 18.5 | 5 | 10 | 5 | |||
22 | 56 | 18 | 5 | 10 | 6 | 5 |
# | HPMCAS-LG | HPMCP(如HP50) | TEC | 三乙酸甘油酯 | 丙二醇 | ATBC | 硬脂醇 | TiO2 | 黄FeO |
1 | 58.5 | 20 | 10 | 5 | 6.5 | ||||
2 | 58 | 19.5 | 11 | 4 | 6.5 | .75 | .25 | ||
3 | 58 | 19.5 | 4 | 11 | 6.5 | .75 | .25 | ||
4 | 60 | 19 | 15 | 5 | .75 | .25 | |||
5 | 58 | 19.5 | 15 | 6.5 | .75 | .25 | |||
6 | 61.75 | 20.75 | 10 | 6.5 | .75 | .25 | |||
7 | 39 | 39 | 15 | 6 | .75 | .25 | |||
8 | 61.75 | 20.75 | 10 | 6.5 | .75 | .25 | |||
9 | 58 | 19.5 | 15 | 6.5 | .75 | .25 | |||
10 | 58 | 19.5 | 15 | 6.5 | .75 | .25 |
# | HPMCAS-LG | HPC(如KlucelEF) | HPC(如SSL) | HP50 | 甘油 | Peg 400 | 酒石酸 | 硬脂醇 | CaCO3 | 表面活性剂(如Tween80) |
1 | 62.75 | 19.5 | 6.5 | 5 | 6.25 | |||||
2 | 61.75 | 20.75 | 10 | 6.5 | 1 | |||||
3 | 60.75 | 20.75 | 10 | 6.5 | 2 | |||||
4 | 59 | 19.5 | 15 | 6.5 | ||||||
5 | 62.75 | 24.5 | 6.25 | 6.5 |
# | HPMCAS-LG | HPC(如KlucelEF) | HPC(如SSL) | 甘油 | 三乙酸甘油酯 | 硬脂醇 | SDS | TiO2 | BHT |
1 | 62.75 | 21.75 | 8 | 6.5 | 1 | ||||
2 | 62.75 | 21.75 | 8 | 6.5 | 1 | ||||
3 | 62.75 | 21.75 | 8 | 6.5 | 1 | ||||
4 | 62.75 | 20 | 10 | 6.25 | 1 | ||||
5 | 62.75 | 23 | 10 | 3.25 | 1 | ||||
6 | 62.75 | 20 | 10 | 6.25 | 1 | ||||
7 | 62.75 | 23 | 10 | 3.25 | 1 | ||||
8 | 59 | 20 | 10 | 20 | 1 |
# | HPMCAS-LG | HP 50 | 三乙酸甘油酯 | Miglyol | 硬脂醇 | AmberliteIRP88 | TiO2 | 黄FeO |
1 | 59 | 17 | 15 | 5 | 3 | .75 | .25 | |
2 | 61.75 | 20.75 | 10 | 6.5 | .75 | .25 | ||
3 | 59 | 24.5 | 10 | 6.5 |
配方 | 肠溶保护(>2hrs) | pH 6.8下的USP3释放时间 |
配方 | 肠溶保护(>2hrs) | pH 6.8下的USP3释放时间 |
HPMC-AS/HP-50/硬脂醇/HPC-SSL/甘油/丙二醇(58.5/18.5/5/3/5/10%w/w) | 是 | 24-36分钟 |
HPMC-AS/HP-50/硬脂醇/Pharmacoat 603/甘油/丙二醇(56/18/6/5/5/10%w/w) | 是 | 36-72分钟 |
HPMC-AS/硬脂醇/Pharmacoat 603/甘油/丙二醇(74/6/5/5/10%w/w) | 是 | 44-80分钟 |
HPMC-AS/HP-55/硬脂醇/Pharmacoat 603/甘油/丙二醇(56/18/6/5/5/10%w/w) | 是 | 48-92分钟 |
HPMC-AS/HP-50/PEG400/硬脂醇(59/19.5/15/6.5%w/w) | 是 | 40-64分钟 |
HPMC-AS/HP-50/硬脂醇/柠檬酸三乙酯/丙二醇/Pharmacoat 603(56.2/18.5/6.2/9.5/4.8/4.8%w/w) | 是 | 44-64分钟 |
HPMC-AS/HP-50/三乙酸甘油酯/硬脂醇(59/19.5/15/6.5%w/w) | 是 | 48-64分钟 |
HPMC-AS/HPC-SSL/硬脂醇/SDS/甘油(62.75/20/6.25/1/10%w/w) | 否/可变 | 不适用(已释放) |
HPMC-AS/Klucel EF/硬脂 | 是 | 44-68分钟 |
配方 | 肠溶保护(>2hrs) | pH 6.8下的USP3释放时间 |
醇/甘油(62.75/24.5/6.5/6.25%w/w)(在基于乙基纤维素的连接体的存在下进行) | ||
HPMC-AS/Klucel EF/硬脂醇/TiO2/三乙酸甘油酯(62.75/21.75/6.5/1/8%w/w) | 是 | 60-120+分钟 |
Claims (47)
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US98638307P | 2007-11-08 | 2007-11-08 | |
US60/986,383 | 2007-11-08 | ||
PCT/IB2008/003872 WO2009087483A2 (en) | 2007-11-08 | 2008-11-07 | Pharmaceutical formulations |
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US (2) | US20090148518A1 (zh) |
EP (1) | EP2219624A2 (zh) |
JP (1) | JP2011503048A (zh) |
KR (1) | KR20100096141A (zh) |
CN (1) | CN101917978A (zh) |
AU (1) | AU2008346205B2 (zh) |
BR (1) | BRPI0820381A2 (zh) |
CA (1) | CA2705285A1 (zh) |
EA (1) | EA201070568A1 (zh) |
MX (1) | MX2010005092A (zh) |
TW (1) | TW200936186A (zh) |
WO (1) | WO2009087483A2 (zh) |
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JP2011503048A (ja) * | 2007-11-08 | 2011-01-27 | グラクソ グループ リミテッド | 医薬製剤 |
-
2008
- 2008-11-01 JP JP2010532677A patent/JP2011503048A/ja not_active Withdrawn
- 2008-11-01 EP EP08870466A patent/EP2219624A2/en not_active Ceased
- 2008-11-07 MX MX2010005092A patent/MX2010005092A/es not_active Application Discontinuation
- 2008-11-07 KR KR1020107012468A patent/KR20100096141A/ko not_active Application Discontinuation
- 2008-11-07 AU AU2008346205A patent/AU2008346205B2/en not_active Ceased
- 2008-11-07 BR BRPI0820381-4A patent/BRPI0820381A2/pt not_active IP Right Cessation
- 2008-11-07 CN CN2008801243003A patent/CN101917978A/zh active Pending
- 2008-11-07 EA EA201070568A patent/EA201070568A1/ru unknown
- 2008-11-07 US US12/266,896 patent/US20090148518A1/en not_active Abandoned
- 2008-11-07 CA CA2705285A patent/CA2705285A1/en not_active Abandoned
- 2008-11-07 WO PCT/IB2008/003872 patent/WO2009087483A2/en active Application Filing
- 2008-11-07 US US12/741,596 patent/US20110117190A1/en not_active Abandoned
- 2008-11-10 TW TW097143400A patent/TW200936186A/zh unknown
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102727458A (zh) * | 2011-03-30 | 2012-10-17 | 信越化学工业株式会社 | 涂层组合物、涂布有该涂层组合物的固体制剂以及制备该固体制剂的方法 |
CN102727458B (zh) * | 2011-03-30 | 2015-01-14 | 信越化学工业株式会社 | 涂层组合物、涂布有该涂层组合物的固体制剂以及制备该固体制剂的方法 |
CN103874727A (zh) * | 2011-10-12 | 2014-06-18 | 陶氏环球技术有限责任公司 | 注塑的剂型 |
CN103874727B (zh) * | 2011-10-12 | 2016-05-11 | 陶氏环球技术有限责任公司 | 注塑的剂型 |
Also Published As
Publication number | Publication date |
---|---|
MX2010005092A (es) | 2010-05-27 |
BRPI0820381A2 (pt) | 2015-05-19 |
KR20100096141A (ko) | 2010-09-01 |
CA2705285A1 (en) | 2009-07-16 |
EA201070568A1 (ru) | 2010-12-30 |
WO2009087483A2 (en) | 2009-07-16 |
US20090148518A1 (en) | 2009-06-11 |
TW200936186A (en) | 2009-09-01 |
AU2008346205B2 (en) | 2012-07-19 |
US20110117190A1 (en) | 2011-05-19 |
EP2219624A2 (en) | 2010-08-25 |
AU2008346205A1 (en) | 2009-07-16 |
JP2011503048A (ja) | 2011-01-27 |
WO2009087483A3 (en) | 2009-10-22 |
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