CA2705285A1 - Pharmaceutical formulations - Google Patents
Pharmaceutical formulations Download PDFInfo
- Publication number
- CA2705285A1 CA2705285A1 CA2705285A CA2705285A CA2705285A1 CA 2705285 A1 CA2705285 A1 CA 2705285A1 CA 2705285 A CA2705285 A CA 2705285A CA 2705285 A CA2705285 A CA 2705285A CA 2705285 A1 CA2705285 A1 CA 2705285A1
- Authority
- CA
- Canada
- Prior art keywords
- dosage form
- hpmc
- form according
- present
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 12
- 239000000203 mixture Substances 0.000 claims abstract description 186
- 239000002552 dosage form Substances 0.000 claims abstract description 110
- 239000002775 capsule Substances 0.000 claims abstract description 90
- 239000007787 solid Substances 0.000 claims abstract description 56
- 229920000642 polymer Polymers 0.000 claims abstract description 52
- 229940088679 drug related substance Drugs 0.000 claims abstract description 40
- 239000008186 active pharmaceutical agent Substances 0.000 claims abstract description 33
- 108010001267 Protein Subunits Proteins 0.000 claims abstract description 18
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 126
- 229920000639 hydroxypropylmethylcellulose acetate succinate Polymers 0.000 claims description 125
- ZUAAPNNKRHMPKG-UHFFFAOYSA-N acetic acid;butanedioic acid;methanol;propane-1,2-diol Chemical compound OC.CC(O)=O.CC(O)CO.OC(=O)CCC(O)=O ZUAAPNNKRHMPKG-UHFFFAOYSA-N 0.000 claims description 116
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical group CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 109
- 238000009472 formulation Methods 0.000 claims description 97
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 90
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical group CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims description 78
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 62
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 62
- 239000004014 plasticizer Substances 0.000 claims description 62
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 58
- 238000004090 dissolution Methods 0.000 claims description 57
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims description 54
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 49
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 49
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 46
- 235000011187 glycerol Nutrition 0.000 claims description 42
- 239000001087 glyceryl triacetate Substances 0.000 claims description 41
- 235000013773 glyceryl triacetate Nutrition 0.000 claims description 41
- 229960002622 triacetin Drugs 0.000 claims description 41
- 239000003795 chemical substances by application Substances 0.000 claims description 35
- 239000000314 lubricant Substances 0.000 claims description 31
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 30
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 30
- 235000013772 propylene glycol Nutrition 0.000 claims description 30
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 claims description 28
- 230000002496 gastric effect Effects 0.000 claims description 27
- 239000001069 triethyl citrate Substances 0.000 claims description 25
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims description 25
- 235000013769 triethyl citrate Nutrition 0.000 claims description 25
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims description 24
- 229920003116 HPC-SSL Polymers 0.000 claims description 19
- 239000007884 disintegrant Substances 0.000 claims description 15
- 229960003943 hypromellose Drugs 0.000 claims description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims description 13
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 claims description 12
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 12
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 11
- 239000004094 surface-active agent Substances 0.000 claims description 10
- 239000001856 Ethyl cellulose Substances 0.000 claims description 8
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 8
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 8
- 229920001249 ethyl cellulose Polymers 0.000 claims description 8
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 8
- 239000004322 Butylated hydroxytoluene Substances 0.000 claims description 7
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims description 7
- 239000002202 Polyethylene glycol Substances 0.000 claims description 7
- 229940095259 butylated hydroxytoluene Drugs 0.000 claims description 7
- 235000010354 butylated hydroxytoluene Nutrition 0.000 claims description 7
- 229920001223 polyethylene glycol Polymers 0.000 claims description 7
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 6
- 238000012545 processing Methods 0.000 claims description 6
- 239000008107 starch Substances 0.000 claims description 6
- 229940032147 starch Drugs 0.000 claims description 6
- 235000019698 starch Nutrition 0.000 claims description 6
- 238000013268 sustained release Methods 0.000 claims description 6
- 239000012730 sustained-release form Substances 0.000 claims description 6
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 5
- 229920002472 Starch Polymers 0.000 claims description 5
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 5
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 5
- QZCLKYGREBVARF-UHFFFAOYSA-N Acetyl tributyl citrate Chemical compound CCCCOC(=O)CC(C(=O)OCCCC)(OC(C)=O)CC(=O)OCCCC QZCLKYGREBVARF-UHFFFAOYSA-N 0.000 claims description 4
- PYGXAGIECVVIOZ-UHFFFAOYSA-N Dibutyl decanedioate Chemical compound CCCCOC(=O)CCCCCCCCC(=O)OCCCC PYGXAGIECVVIOZ-UHFFFAOYSA-N 0.000 claims description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- ZFOZVQLOBQUTQQ-UHFFFAOYSA-N Tributyl citrate Chemical compound CCCCOC(=O)CC(O)(C(=O)OCCCC)CC(=O)OCCCC ZFOZVQLOBQUTQQ-UHFFFAOYSA-N 0.000 claims description 4
- 229920001531 copovidone Polymers 0.000 claims description 4
- DOIRQSBPFJWKBE-UHFFFAOYSA-N dibutyl phthalate Chemical compound CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC DOIRQSBPFJWKBE-UHFFFAOYSA-N 0.000 claims description 4
- FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 claims description 4
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 claims description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 4
- WEAPVABOECTMGR-UHFFFAOYSA-N triethyl 2-acetyloxypropane-1,2,3-tricarboxylate Chemical compound CCOC(=O)CC(C(=O)OCC)(OC(C)=O)CC(=O)OCC WEAPVABOECTMGR-UHFFFAOYSA-N 0.000 claims description 4
- 229920003155 Eudragit® RL 100 Polymers 0.000 claims description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 3
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims description 3
- 229920001213 Polysorbate 20 Polymers 0.000 claims description 3
- 239000008101 lactose Substances 0.000 claims description 3
- 229960001375 lactose Drugs 0.000 claims description 3
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims description 3
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims description 3
- 239000000454 talc Substances 0.000 claims description 3
- 229910052623 talc Inorganic materials 0.000 claims description 3
- 235000012222 talc Nutrition 0.000 claims description 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
- 229920002785 Croscarmellose sodium Polymers 0.000 claims description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 2
- 229930195725 Mannitol Natural products 0.000 claims description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 2
- 239000004359 castor oil Substances 0.000 claims description 2
- 235000019438 castor oil Nutrition 0.000 claims description 2
- 229960001681 croscarmellose sodium Drugs 0.000 claims description 2
- 229960000913 crospovidone Drugs 0.000 claims description 2
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims description 2
- 229910021485 fumed silica Inorganic materials 0.000 claims description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 2
- 235000019359 magnesium stearate Nutrition 0.000 claims description 2
- 239000000594 mannitol Substances 0.000 claims description 2
- 235000010355 mannitol Nutrition 0.000 claims description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 2
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims description 2
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims description 2
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 claims description 2
- 235000012239 silicon dioxide Nutrition 0.000 claims description 2
- 229940080313 sodium starch Drugs 0.000 claims description 2
- 235000000346 sugar Nutrition 0.000 claims description 2
- ILJSQTXMGCGYMG-UHFFFAOYSA-N triacetic acid Chemical compound CC(=O)CC(=O)CC(O)=O ILJSQTXMGCGYMG-UHFFFAOYSA-N 0.000 claims description 2
- 239000000811 xylitol Substances 0.000 claims description 2
- 235000010447 xylitol Nutrition 0.000 claims description 2
- 229960002675 xylitol Drugs 0.000 claims description 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 229960001855 mannitol Drugs 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 229960002668 sodium chloride Drugs 0.000 claims 1
- 238000001746 injection moulding Methods 0.000 abstract description 18
- 238000001125 extrusion Methods 0.000 abstract description 16
- 239000011159 matrix material Substances 0.000 abstract description 11
- 125000005647 linker group Chemical group 0.000 description 56
- 239000003814 drug Substances 0.000 description 29
- 238000002347 injection Methods 0.000 description 27
- 239000007924 injection Substances 0.000 description 27
- 229940079593 drug Drugs 0.000 description 26
- -1 succinoyl groups Chemical group 0.000 description 23
- 239000000463 material Substances 0.000 description 22
- 238000000034 method Methods 0.000 description 20
- 239000012530 fluid Substances 0.000 description 14
- 239000013543 active substance Substances 0.000 description 12
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 11
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 11
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- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 6
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 description 6
- 229960003105 metformin Drugs 0.000 description 6
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- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 5
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- 238000010521 absorption reaction Methods 0.000 description 5
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- 239000003623 enhancer Substances 0.000 description 5
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- 102100031287 Ubiquitin carboxyl-terminal hydrolase 3 Human genes 0.000 description 4
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 4
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- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 4
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Inorganic materials [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 4
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- 239000000843 powder Substances 0.000 description 4
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- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 3
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 3
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- NEDGUIRITORSKL-UHFFFAOYSA-N butyl 2-methylprop-2-enoate;2-(dimethylamino)ethyl 2-methylprop-2-enoate;methyl 2-methylprop-2-enoate Chemical compound COC(=O)C(C)=C.CCCCOC(=O)C(C)=C.CN(C)CCOC(=O)C(C)=C NEDGUIRITORSKL-UHFFFAOYSA-N 0.000 description 3
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- 102000002067 Protein Subunits Human genes 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- AOBORMOPSGHCAX-UHFFFAOYSA-N Tocophersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-UHFFFAOYSA-N 0.000 description 2
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- DVQHRBFGRZHMSR-UHFFFAOYSA-N sodium methyl 2,2-dimethyl-4,6-dioxo-5-(N-prop-2-enoxy-C-propylcarbonimidoyl)cyclohexane-1-carboxylate Chemical compound [Na+].C=CCON=C(CCC)[C-]1C(=O)CC(C)(C)C(C(=O)OC)C1=O DVQHRBFGRZHMSR-UHFFFAOYSA-N 0.000 description 1
- FCZYGJBVLGLYQU-UHFFFAOYSA-M sodium;2-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethoxy]ethanesulfonate Chemical compound [Na+].CC(C)(C)CC(C)(C)C1=CC=C(OCCOCCOCCS([O-])(=O)=O)C=C1 FCZYGJBVLGLYQU-UHFFFAOYSA-M 0.000 description 1
- 239000008279 sol Substances 0.000 description 1
- 239000006104 solid solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229940035044 sorbitan monolaurate Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 229920003179 starch-based polymer Polymers 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000000021 stimulant Substances 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000001975 sympathomimetic effect Effects 0.000 description 1
- 229940064707 sympathomimetics Drugs 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 229940065721 systemic for obstructive airway disease xanthines Drugs 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98638307P | 2007-11-08 | 2007-11-08 | |
| US60/986,383 | 2007-11-08 | ||
| PCT/IB2008/003872 WO2009087483A2 (en) | 2007-11-08 | 2008-11-07 | Pharmaceutical formulations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2705285A1 true CA2705285A1 (en) | 2009-07-16 |
Family
ID=40721919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2705285A Abandoned CA2705285A1 (en) | 2007-11-08 | 2008-11-07 | Pharmaceutical formulations |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20110117190A1 (enExample) |
| EP (1) | EP2219624A2 (enExample) |
| JP (1) | JP2011503048A (enExample) |
| KR (1) | KR20100096141A (enExample) |
| CN (1) | CN101917978A (enExample) |
| AU (1) | AU2008346205B2 (enExample) |
| BR (1) | BRPI0820381A2 (enExample) |
| CA (1) | CA2705285A1 (enExample) |
| EA (1) | EA201070568A1 (enExample) |
| MX (1) | MX2010005092A (enExample) |
| TW (1) | TW200936186A (enExample) |
| WO (1) | WO2009087483A2 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0102342D0 (en) * | 2001-01-30 | 2001-03-14 | Smithkline Beecham Plc | Pharmaceutical formulation |
| US7883721B2 (en) * | 2001-01-30 | 2011-02-08 | Smithkline Beecham Limited | Pharmaceutical formulation |
| US7842308B2 (en) * | 2001-01-30 | 2010-11-30 | Smithkline Beecham Limited | Pharmaceutical formulation |
| US7670612B2 (en) * | 2002-04-10 | 2010-03-02 | Innercap Technologies, Inc. | Multi-phase, multi-compartment capsular delivery apparatus and methods for using same |
| AR040672A1 (es) * | 2002-07-25 | 2005-04-13 | Glaxo Group Ltd | Forma de dosificacion farmaceutica multicomponenete, cuerpo apropiado para ser utilizado en la misma y procedimiento para prepararla |
| TW200526274A (en) * | 2003-07-21 | 2005-08-16 | Smithkline Beecham Plc | Pharmaceutical formulations |
| AR048033A1 (es) * | 2004-03-12 | 2006-03-22 | Smithkline Beecham Plc | Composicion farmaceutica para moldear componentes que comprende copolimero de poli(met)acrilato, cubierta, conector o espaciador de capsula moldeado por inyeccion que tiene la composicion farmaceutica y forma de dosificacion farmaceutica de multicomponentes a partir de dicha composicion |
| CN101827572A (zh) * | 2007-10-15 | 2010-09-08 | 葛兰素集团有限公司 | 用于释放药物组合物的有板条的胶囊壳 |
| CN101827571A (zh) * | 2007-10-15 | 2010-09-08 | 葛兰素集团有限公司 | 用于释放一种或多种药物成分的多部分剂型的连接件及所得剂型 |
| US8293159B2 (en) * | 2007-10-15 | 2012-10-23 | Capsugel Belgium | Method and apparatus for manufacturing filled linkers |
| JP2011503048A (ja) * | 2007-11-08 | 2011-01-27 | グラクソ グループ リミテッド | 医薬製剤 |
| EP2320876A2 (en) * | 2008-06-13 | 2011-05-18 | Pfizer Inc. | Hydroxypropyl cellulose capsule shell |
| DE102008031426B4 (de) * | 2008-07-04 | 2014-07-31 | Schott Ag | Verfahren zur Herstellung einer Versiegelungsschicht für Dekorschichten, Glas- oder Glaskeramik-Artikel und dessen Verwendung |
| DE102008031428A1 (de) * | 2008-07-04 | 2010-01-07 | Schott Ag | Dekorative Beschichtung von Glas- oder Glaskeramik-Artikeln |
| GB201010083D0 (en) * | 2010-06-16 | 2010-07-21 | Univ Bradford | Compositions and methods |
| US20120251588A1 (en) * | 2011-03-30 | 2012-10-04 | Miyuki Fukasawa | Coating Composition, Solid Preparation Coated Therewith, and Method for Preparing Solid Preparation |
| IN2014CN02610A (enExample) | 2011-10-12 | 2015-08-07 | Dow Global Technologies Llc | |
| CA2859174C (en) | 2011-12-12 | 2019-03-05 | Orbis Biosciences, Inc. | Sustained release particle formulations |
| ITTO20120596A1 (it) * | 2012-07-06 | 2014-01-07 | Consiglio Nazionale Ricerche | Procedimento e sistema per assemblare una forma di dosaggio orale, e forma di dosaggio orale |
| ES2856187T3 (es) * | 2013-05-31 | 2021-09-27 | Victor Bronshtein | Composiciones poliméricas que contienen productos biofarmacéuticos estables a temperatura ambiente y métodos para la formulación de las mismas |
| KR102322197B1 (ko) * | 2014-04-08 | 2021-11-09 | 뉴트리션 ＆ 바이오사이언시즈 유에스에이 1, 엘엘씨 | 에스테르화된 셀룰로오스 에테르를 포함하는 분산물 |
| JP6570043B2 (ja) | 2014-06-02 | 2019-09-04 | クレシオ・バイオサイエンシズ・リミテッド | 膨張性胃内滞留型剤形 |
| TWI535784B (zh) | 2014-08-26 | 2016-06-01 | 財團法人工業技術研究院 | 剪切增稠配方、及包含其之複合材料 |
| EP3452003A4 (en) * | 2016-05-05 | 2019-06-26 | Triastek, Inc. | DOSAGE FORM WITH CONTROLLED RELEASE |
| JP7071748B2 (ja) | 2016-12-02 | 2022-05-19 | クレキシオ バイオサイエンシーズ エルティーディー． | 胃内滞留システム |
| US20180282527A1 (en) * | 2017-03-30 | 2018-10-04 | Shin-Etsu Chemical Co., Ltd. | Injection molding composition containing hypromellose acetate succinate and method for producing same |
| KR20200026901A (ko) | 2017-07-11 | 2020-03-11 | 쿠오리카프스 가부시키가이샤 | 장용성 경질 캡슐 |
| EP3720537B1 (en) | 2017-12-04 | 2025-03-19 | Clexio Biosciences Ltd. | Long acting gastric residence system |
| WO2019245031A1 (ja) | 2018-06-22 | 2019-12-26 | クオリカプス株式会社 | 腸溶性硬質カプセル |
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| US3228789A (en) | 1962-10-22 | 1966-01-11 | Jacob A Glassman | Peroral capsules and tablets and the method for making same |
| FR1454013A (fr) | 1965-08-18 | 1966-07-22 | Pluripharm | Mode de présentation de deux médicaments associés |
| NL7610038A (en) | 1976-09-09 | 1978-03-13 | Tapanahony N V | Multichambered capsule for therapeutically active substances - has chambers of different solubility with contents differing quantitatively and qualitatively |
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| GR78492B (enExample) | 1982-03-26 | 1984-09-27 | Warner Lambert Co | |
| FR2524311A1 (fr) | 1982-04-05 | 1983-10-07 | Azalbert Gilles | Gelule compartimentee aux fins d'ingestions simultanees a effets differes |
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| DE19504831A1 (de) | 1995-02-14 | 1996-09-05 | Basf Ag | Feste Wirkstoffzubereitungen enthaltend Hydroxypropylcellulose |
| DE19504832A1 (de) | 1995-02-14 | 1996-08-22 | Basf Ag | Feste Wirkstoff-Zubereitungen |
| DE19509805A1 (de) | 1995-03-21 | 1996-09-26 | Basf Ag | Transparente, schnell freisetzende Zubereitungen von nichtsteroidalen Analgetica |
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| JPH09165494A (ja) | 1995-11-16 | 1997-06-24 | Yuka Shell Epoxy Kk | 硬化性エポキシ樹脂組成物およびその使用 |
| AU5107496A (en) * | 1996-03-13 | 1997-10-01 | Labtec Gesellschaft Fur Technologische Forschung Und Entwicklung Mbh | Medicament preparation for angiotensin converting enzyme (ace)-inhibitors |
| DE19733505A1 (de) | 1997-08-01 | 1999-02-04 | Knoll Ag | Schnell wirksames Analgeticum |
| DE19753298A1 (de) | 1997-12-01 | 1999-06-02 | Basf Ag | Verfahren zur Herstellung von festen Dosierungsformen |
| DE19753297A1 (de) | 1997-12-01 | 1999-06-02 | Basf Ag | Verfahren zur Herstellung von festen Dosierungsformen |
| DE19753299A1 (de) | 1997-12-01 | 1999-06-02 | Basf Ag | Verfahren zur Herstellung von festen Dosierungsformen |
| DE19753300A1 (de) | 1997-12-01 | 1999-06-02 | Basf Ag | Verfahren zur Herstellung von festen Dosierungsformen |
| DE19800927A1 (de) | 1998-01-13 | 1999-07-15 | Basf Ag | Verfahren zur Herstellung von festen Dosierungsformen |
| DE19812688A1 (de) | 1998-03-23 | 1999-09-30 | Basf Ag | Verfahren zur Herstellung von festen Dosierungsformen |
| EP1204410B1 (en) * | 1999-07-30 | 2012-09-12 | Capsugel Belgium NV | Multi-component pharmaceutical dosage form |
| AU2001241192A1 (en) * | 2000-03-23 | 2001-10-03 | Shionogi And Co., Ltd. | Enteric granular preparations of hardly water soluble drugs characterized by containing water-repellent component |
| GB0102342D0 (en) * | 2001-01-30 | 2001-03-14 | Smithkline Beecham Plc | Pharmaceutical formulation |
| NZ527532A (en) * | 2001-02-27 | 2004-12-24 | Astrazeneca Ab | Pharmaceutical formulation comprising bicalutamide |
| AR040672A1 (es) * | 2002-07-25 | 2005-04-13 | Glaxo Group Ltd | Forma de dosificacion farmaceutica multicomponenete, cuerpo apropiado para ser utilizado en la misma y procedimiento para prepararla |
| AU2003262059A1 (en) * | 2002-09-11 | 2004-04-30 | Takeda Pharmaceutical Company Limited | Sustained release preparation |
| TW200526274A (en) * | 2003-07-21 | 2005-08-16 | Smithkline Beecham Plc | Pharmaceutical formulations |
| CN1905857A (zh) * | 2003-11-14 | 2007-01-31 | 阿尔扎公司 | 液体剂型的托吡酯的受控释放 |
| EP1708687A1 (en) * | 2004-01-16 | 2006-10-11 | Glaxo Group Limited | Encapsulation of lipid-based formulations in enteric polymers |
| AR048033A1 (es) | 2004-03-12 | 2006-03-22 | Smithkline Beecham Plc | Composicion farmaceutica para moldear componentes que comprende copolimero de poli(met)acrilato, cubierta, conector o espaciador de capsula moldeado por inyeccion que tiene la composicion farmaceutica y forma de dosificacion farmaceutica de multicomponentes a partir de dicha composicion |
| US9713592B2 (en) * | 2005-04-06 | 2017-07-25 | Mallinckrodt Llc | Matrix-based pulse release pharmaceutical formulation |
| CN101827571A (zh) * | 2007-10-15 | 2010-09-08 | 葛兰素集团有限公司 | 用于释放一种或多种药物成分的多部分剂型的连接件及所得剂型 |
| CN101827572A (zh) * | 2007-10-15 | 2010-09-08 | 葛兰素集团有限公司 | 用于释放药物组合物的有板条的胶囊壳 |
| JP2011503048A (ja) * | 2007-11-08 | 2011-01-27 | グラクソ グループ リミテッド | 医薬製剤 |
-
2008
- 2008-11-01 JP JP2010532677A patent/JP2011503048A/ja not_active Withdrawn
- 2008-11-01 EP EP08870466A patent/EP2219624A2/en not_active Ceased
- 2008-11-07 CN CN2008801243003A patent/CN101917978A/zh active Pending
- 2008-11-07 US US12/741,596 patent/US20110117190A1/en not_active Abandoned
- 2008-11-07 KR KR1020107012468A patent/KR20100096141A/ko not_active Withdrawn
- 2008-11-07 WO PCT/IB2008/003872 patent/WO2009087483A2/en not_active Ceased
- 2008-11-07 MX MX2010005092A patent/MX2010005092A/es not_active Application Discontinuation
- 2008-11-07 CA CA2705285A patent/CA2705285A1/en not_active Abandoned
- 2008-11-07 BR BRPI0820381-4A patent/BRPI0820381A2/pt not_active IP Right Cessation
- 2008-11-07 EA EA201070568A patent/EA201070568A1/ru unknown
- 2008-11-07 AU AU2008346205A patent/AU2008346205B2/en not_active Ceased
- 2008-11-07 US US12/266,896 patent/US20090148518A1/en not_active Abandoned
- 2008-11-10 TW TW097143400A patent/TW200936186A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009087483A3 (en) | 2009-10-22 |
| WO2009087483A2 (en) | 2009-07-16 |
| JP2011503048A (ja) | 2011-01-27 |
| TW200936186A (en) | 2009-09-01 |
| KR20100096141A (ko) | 2010-09-01 |
| US20110117190A1 (en) | 2011-05-19 |
| CN101917978A (zh) | 2010-12-15 |
| MX2010005092A (es) | 2010-05-27 |
| EA201070568A1 (ru) | 2010-12-30 |
| AU2008346205B2 (en) | 2012-07-19 |
| BRPI0820381A2 (pt) | 2015-05-19 |
| US20090148518A1 (en) | 2009-06-11 |
| AU2008346205A1 (en) | 2009-07-16 |
| EP2219624A2 (en) | 2010-08-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20141107 |