JP2007510666A5 - - Google Patents
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- JP2007510666A5 JP2007510666A5 JP2006538513A JP2006538513A JP2007510666A5 JP 2007510666 A5 JP2007510666 A5 JP 2007510666A5 JP 2006538513 A JP2006538513 A JP 2006538513A JP 2006538513 A JP2006538513 A JP 2006538513A JP 2007510666 A5 JP2007510666 A5 JP 2007510666A5
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- Prior art keywords
- seq
- monoclonal antibody
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- Prior art date
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- 101100099884 Homo sapiens CD40 gene Proteins 0.000 claims 21
- 210000004408 hybridoma Anatomy 0.000 claims 17
- 239000000427 antigen Substances 0.000 claims 15
- 102000036639 antigens Human genes 0.000 claims 15
- 108091007433 antigens Proteins 0.000 claims 15
- 230000027455 binding Effects 0.000 claims 15
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 12
- 125000003275 alpha amino acid group Chemical group 0.000 claims 11
- 239000012634 fragment Substances 0.000 claims 11
- 229950004563 lucatumumab Drugs 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 6
- 208000023275 Autoimmune disease Diseases 0.000 claims 5
- 239000000556 agonist Substances 0.000 claims 5
- 230000000694 effects Effects 0.000 claims 5
- 208000027866 inflammatory disease Diseases 0.000 claims 5
- 108010063916 CD40 Antigens Proteins 0.000 claims 4
- 206010020751 Hypersensitivity Diseases 0.000 claims 4
- 208000026935 allergic disease Diseases 0.000 claims 4
- 230000000172 allergic effect Effects 0.000 claims 4
- 230000007815 allergy Effects 0.000 claims 4
- 208000010668 atopic eczema Diseases 0.000 claims 4
- 238000012875 competitive assay Methods 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 239000003018 immunosuppressive agent Substances 0.000 claims 4
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 201000000306 sarcoidosis Diseases 0.000 claims 4
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 4
- 206010052779 Transplant rejections Diseases 0.000 claims 3
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 3
- 208000032671 Allergic granulomatous angiitis Diseases 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 206010003827 Autoimmune hepatitis Diseases 0.000 claims 2
- 208000023328 Basedow disease Diseases 0.000 claims 2
- 208000008439 Biliary Liver Cirrhosis Diseases 0.000 claims 2
- 208000033222 Biliary cirrhosis primary Diseases 0.000 claims 2
- 208000031229 Cardiomyopathies Diseases 0.000 claims 2
- 208000030939 Chronic inflammatory demyelinating polyneuropathy Diseases 0.000 claims 2
- 208000006344 Churg-Strauss Syndrome Diseases 0.000 claims 2
- 208000015943 Coeliac disease Diseases 0.000 claims 2
- 208000011231 Crohn disease Diseases 0.000 claims 2
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 2
- 108010036949 Cyclosporine Proteins 0.000 claims 2
- 206010011985 Decubitus ulcer Diseases 0.000 claims 2
- 206010012438 Dermatitis atopic Diseases 0.000 claims 2
- 206010012442 Dermatitis contact Diseases 0.000 claims 2
- 208000018428 Eosinophilic granulomatosis with polyangiitis Diseases 0.000 claims 2
- 206010016654 Fibrosis Diseases 0.000 claims 2
- 108010068370 Glutens Proteins 0.000 claims 2
- 201000005569 Gout Diseases 0.000 claims 2
- 206010018634 Gouty Arthritis Diseases 0.000 claims 2
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 2
- 208000015023 Graves' disease Diseases 0.000 claims 2
- 208000030836 Hashimoto thyroiditis Diseases 0.000 claims 2
- 208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 claims 2
- 208000024781 Immune Complex disease Diseases 0.000 claims 2
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 2
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 2
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 2
- 208000005777 Lupus Nephritis Diseases 0.000 claims 2
- 201000002481 Myositis Diseases 0.000 claims 2
- 208000031845 Pernicious anaemia Diseases 0.000 claims 2
- 208000004210 Pressure Ulcer Diseases 0.000 claims 2
- 208000012654 Primary biliary cholangitis Diseases 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 2
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 2
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 2
- 208000033464 Reiter syndrome Diseases 0.000 claims 2
- 206010039710 Scleroderma Diseases 0.000 claims 2
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 2
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
- 206010053613 Type IV hypersensitivity reaction Diseases 0.000 claims 2
- 208000024780 Urticaria Diseases 0.000 claims 2
- 206010047115 Vasculitis Diseases 0.000 claims 2
- 208000002029 allergic contact dermatitis Diseases 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 201000008937 atopic dermatitis Diseases 0.000 claims 2
- 201000000448 autoimmune hemolytic anemia Diseases 0.000 claims 2
- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 claims 2
- 201000005795 chronic inflammatory demyelinating polyneuritis Diseases 0.000 claims 2
- 229960001265 ciclosporin Drugs 0.000 claims 2
- 239000003246 corticosteroid Substances 0.000 claims 2
- 201000003278 cryoglobulinemia Diseases 0.000 claims 2
- 229930182912 cyclosporin Natural products 0.000 claims 2
- 201000001981 dermatomyositis Diseases 0.000 claims 2
- 230000004761 fibrosis Effects 0.000 claims 2
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 claims 2
- 235000021312 gluten Nutrition 0.000 claims 2
- 208000024908 graft versus host disease Diseases 0.000 claims 2
- 230000002949 hemolytic effect Effects 0.000 claims 2
- 208000024326 hypersensitivity reaction type III disease Diseases 0.000 claims 2
- 208000013643 idiopathic inflammatory myopathy Diseases 0.000 claims 2
- 229960003444 immunosuppressant agent Drugs 0.000 claims 2
- 230000001861 immunosuppressant effect Effects 0.000 claims 2
- 229940125721 immunosuppressive agent Drugs 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 208000001875 irritant dermatitis Diseases 0.000 claims 2
- 206010025135 lupus erythematosus Diseases 0.000 claims 2
- 210000004698 lymphocyte Anatomy 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 206010028417 myasthenia gravis Diseases 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 208000005987 polymyositis Diseases 0.000 claims 2
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 2
- 208000002574 reactive arthritis Diseases 0.000 claims 2
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 2
- 229960002930 sirolimus Drugs 0.000 claims 2
- 230000004936 stimulating effect Effects 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims 2
- 230000002537 thrombolytic effect Effects 0.000 claims 2
- 210000001685 thyroid gland Anatomy 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- 208000025883 type III hypersensitivity disease Diseases 0.000 claims 2
- 230000005951 type IV hypersensitivity Effects 0.000 claims 2
- 208000027930 type IV hypersensitivity disease Diseases 0.000 claims 2
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51733703P | 2003-11-04 | 2003-11-04 | |
| US60/517,337 | 2003-11-04 | ||
| US52557903P | 2003-11-26 | 2003-11-26 | |
| US60/525,579 | 2003-11-26 | ||
| US56571004P | 2004-04-27 | 2004-04-27 | |
| US60/565,710 | 2004-04-27 | ||
| PCT/US2004/036957 WO2005044306A2 (en) | 2003-11-04 | 2004-11-04 | Use of antagonist anti-cd40 antibodies for treatment of autoimmune and inflammatory diseases and organ transplant rejection |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011040922A Division JP2011105769A (ja) | 2003-11-04 | 2011-02-25 | 自己免疫疾患および炎症性疾患ならびに臓器移植拒絶の処置のためのアンタゴニスト抗ｃｄ４０抗体の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007510666A JP2007510666A (ja) | 2007-04-26 |
| JP2007510666A5 true JP2007510666A5 (enExample) | 2007-11-22 |
| JP4746552B2 JP4746552B2 (ja) | 2011-08-10 |
Family
ID=34577667
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006538513A Expired - Lifetime JP4746552B2 (ja) | 2003-11-04 | 2004-11-04 | 自己免疫疾患および炎症性疾患ならびに臓器移植拒絶の処置のためのアンタゴニスト抗ｃｄ４０抗体の使用 |
| JP2006538514A Expired - Fee Related JP4765039B2 (ja) | 2003-11-04 | 2004-11-04 | Ｃｄ４０抗原を発現する癌に対する治療方法。 |
| JP2006538540A Expired - Lifetime JP5019881B2 (ja) | 2003-11-04 | 2004-11-04 | アンタゴニスト抗ｃｄ４０モノクローナル抗体およびそれらを使用するための方法 |
| JP2010277537A Withdrawn JP2011072317A (ja) | 2003-11-04 | 2010-12-13 | アンタゴニスト抗ｃｄ４０モノクローナル抗体およびそれらを使用するための方法 |
| JP2011033969A Withdrawn JP2011126900A (ja) | 2003-11-04 | 2011-02-18 | Ｃｄ４０抗原を発現する癌に対する治療方法。 |
| JP2011040922A Withdrawn JP2011105769A (ja) | 2003-11-04 | 2011-02-25 | 自己免疫疾患および炎症性疾患ならびに臓器移植拒絶の処置のためのアンタゴニスト抗ｃｄ４０抗体の使用 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006538514A Expired - Fee Related JP4765039B2 (ja) | 2003-11-04 | 2004-11-04 | Ｃｄ４０抗原を発現する癌に対する治療方法。 |
| JP2006538540A Expired - Lifetime JP5019881B2 (ja) | 2003-11-04 | 2004-11-04 | アンタゴニスト抗ｃｄ４０モノクローナル抗体およびそれらを使用するための方法 |
| JP2010277537A Withdrawn JP2011072317A (ja) | 2003-11-04 | 2010-12-13 | アンタゴニスト抗ｃｄ４０モノクローナル抗体およびそれらを使用するための方法 |
| JP2011033969A Withdrawn JP2011126900A (ja) | 2003-11-04 | 2011-02-18 | Ｃｄ４０抗原を発現する癌に対する治療方法。 |
| JP2011040922A Withdrawn JP2011105769A (ja) | 2003-11-04 | 2011-02-25 | 自己免疫疾患および炎症性疾患ならびに臓器移植拒絶の処置のためのアンタゴニスト抗ｃｄ４０抗体の使用 |
Country Status (22)
| Country | Link |
|---|---|
| EP (6) | EP1682178B8 (enExample) |
| JP (6) | JP4746552B2 (enExample) |
| KR (2) | KR101403910B1 (enExample) |
| CN (2) | CN1905897B (enExample) |
| AT (3) | ATE473016T1 (enExample) |
| AU (3) | AU2004287482B2 (enExample) |
| CA (3) | CA2544853C (enExample) |
| CY (3) | CY1110231T1 (enExample) |
| DE (3) | DE602004028037D1 (enExample) |
| DK (4) | DK1682180T3 (enExample) |
| EC (2) | ECSP066607A (enExample) |
| ES (3) | ES2333971T3 (enExample) |
| HR (2) | HRP20100066T1 (enExample) |
| IL (1) | IL175225A (enExample) |
| MA (1) | MA28331A1 (enExample) |
| PL (4) | PL1682180T3 (enExample) |
| PT (4) | PT1682178E (enExample) |
| RS (2) | RS53073B (enExample) |
| SG (1) | SG148143A1 (enExample) |
| SI (3) | SI1694360T1 (enExample) |
| WO (3) | WO2005044294A2 (enExample) |
| ZA (1) | ZA200604419B (enExample) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7658924B2 (en) | 2001-10-11 | 2010-02-09 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| US8277810B2 (en) | 2003-11-04 | 2012-10-02 | Novartis Vaccines & Diagnostics, Inc. | Antagonist anti-CD40 antibodies |
| KR101403910B1 (ko) * | 2003-11-04 | 2014-06-09 | 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 | 길항제 항-ｃｄ４０ 단클론성 항체 및 그것의 사용 방법 |
| ATE516819T1 (de) * | 2003-11-04 | 2011-08-15 | Novartis Vaccines & Diagnostic | Verfahren zur behandlung von b-zell-bedingtem krebs |
| WO2005108428A2 (en) * | 2004-02-26 | 2005-11-17 | Compugen Ltd. | Cd40 splice variants and their uses |
| EP1894012A2 (en) * | 2005-05-18 | 2008-03-05 | Novartis AG | Methods for diagnosis and treatment of proliferative disorders mediated by cd40 signaling |
| WO2006125117A2 (en) * | 2005-05-18 | 2006-11-23 | Novartis Ag | Methods for diagnosis and treatment of diseases having an autoimmune and/or inflammatory component |
| WO2006138181A2 (en) | 2005-06-14 | 2006-12-28 | Amgen Inc. | Self-buffering protein formulations |
| WO2007053661A2 (en) * | 2005-11-01 | 2007-05-10 | Novartis Ag | Uses of anti-cd40 antibodies |
| ES2400660T3 (es) * | 2005-11-01 | 2013-04-11 | Novartis Ag | Usos de anticuerpos anti-CD40 |
| CN101506236B (zh) | 2005-11-30 | 2012-12-12 | 雅培制药有限公司 | 抗淀粉样β蛋白的单克隆抗体及其用途 |
| RU2442793C2 (ru) | 2005-11-30 | 2012-02-20 | Эбботт Лэборетриз | АНТИТЕЛА ПРОТИВ ГЛОБУЛОМЕРА Аβ, ИХ АНТИГЕНСВЯЗЫВАЮЩИЕ ЧАСТИ, СООТВЕТСТВУЮЩИЕ ГИБРИДОМЫ, НУКЛЕИНОВЫЕ КИСЛОТЫ, ВЕКТОРЫ, КЛЕТКИ-ХОЗЯЕВА, СПОСОБЫ ПОЛУЧЕНИЯ УКАЗАННЫХ АНТИТЕЛ, КОМПОЗИЦИИ, СОДЕРЖАЩИЕ УКАЗАННЫЕ АНТИТЕЛА, ПРИМЕНЕНИЯ УКАЗАННЫХ АНТИТЕЛ И СПОСОБЫ ИСПОЛЬЗОВАНИЯ УКАЗАННЫХ АНТИТЕЛ |
| US9005974B2 (en) | 2005-12-09 | 2015-04-14 | Academish Medisch Centrum Bij De Universiteit Van Amsterdam | Means and methods for influencing the stability of cells |
| NZ592159A (en) | 2005-12-09 | 2012-12-21 | Amc Amsterdam | Means and methods for influencing the stability of antibody producing cells |
| AR059066A1 (es) | 2006-01-27 | 2008-03-12 | Amgen Inc | Combinaciones del inhibidor de la angiopoyetina -2 (ang2) y el inhibidor del factor de crecimiento endotelial vascular (vegf) |
| CN101426817B (zh) | 2006-04-21 | 2013-07-10 | 诺华有限公司 | 拮抗性抗-cd40抗体药物组合物 |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| JP5577098B2 (ja) * | 2006-12-21 | 2014-08-20 | アムジエン・インコーポレーテツド | ポリペプチドを含有する安定な緩衝化された製剤 |
| EP2124952A2 (en) | 2007-02-27 | 2009-12-02 | Abbott GmbH & Co. KG | Method for the treatment of amyloidoses |
| US7951368B2 (en) | 2007-06-25 | 2011-05-31 | Amgen Inc. | Compositions of specific binding agents to hepatocyte growth factor |
| BRPI0820707A2 (pt) * | 2007-11-07 | 2015-06-16 | Genentech Inc | Métodos e composição para avaliar a responsividade do linfoma de células b para o tratamento com anticorpos anti-cd40 |
| US20110002934A1 (en) * | 2007-11-09 | 2011-01-06 | Novartis Ag | Uses of anti-cd40 antibodies |
| JO2913B1 (en) | 2008-02-20 | 2015-09-15 | امجين إنك, | Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses |
| KR101787768B1 (ko) | 2009-04-18 | 2017-10-18 | 제넨테크, 인크. | 항-ｃｄ４０ 항체를 사용한 치료에 대한 ｂ-세포 림프종의 반응성 평가를 위한 방법 |
| AU2010271583B2 (en) | 2009-07-15 | 2015-02-12 | Kling Biotherapeutics B.V. | Means and methods for producing high affinity antibodies |
| US8987419B2 (en) | 2010-04-15 | 2015-03-24 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
| CN103298833B (zh) | 2010-08-14 | 2015-12-16 | Abbvie公司 | β淀粉样蛋白结合蛋白 |
| EP2635601B1 (en) | 2010-11-04 | 2016-07-20 | Boehringer Ingelheim International GmbH | Anti-il-23 antibodies |
| AU2016201742B2 (en) * | 2010-11-15 | 2017-11-02 | Novartis Ag | Silent Fc variants of anti-CD40 antibodies |
| AR083847A1 (es) * | 2010-11-15 | 2013-03-27 | Novartis Ag | Variantes de fc (fragmento constante) silenciosas de los anticuerpos anti-cd40 |
| WO2012075111A1 (en) | 2010-11-30 | 2012-06-07 | Novartis Ag | Uses of anti-cd40 antibodies in combination therapy for b cell-related cancers |
| EP2646466B1 (en) | 2010-12-02 | 2017-03-29 | AIMM Therapeutics B.V. | Means and methods for producing high affinity antibodies |
| JP5458188B2 (ja) * | 2011-02-17 | 2014-04-02 | 協和発酵キリン株式会社 | 抗ｃｄ４０抗体の高濃度製剤 |
| ES2653639T3 (es) * | 2011-02-28 | 2018-02-08 | Napajen Pharma, Inc. | Complejo ácido nucleico-polisacárido |
| PL2683406T3 (pl) | 2011-03-11 | 2019-11-29 | Beth Israel Deaconess Medical Ct Inc | Przeciwciała anty-cd40 i ich zastosowania |
| PL2699601T3 (pl) * | 2011-04-21 | 2018-05-30 | Bristol-Myers Squibb Company | Polipeptydy przeciwciała, które antagonizują CD40 |
| SG10201604104PA (en) | 2011-10-25 | 2016-07-28 | Prothena Therapeutics Ltd | Antibody formulations and methods |
| KR102057742B1 (ko) | 2011-11-17 | 2019-12-19 | 군드람 정 | 의학적 용도를 위한 이중특이성 항체 |
| WO2013165791A1 (en) * | 2012-05-03 | 2013-11-07 | Boehringer Ingelheim International Gmbh | Anti-il-23p19 antibodies |
| US20140004131A1 (en) | 2012-05-04 | 2014-01-02 | Novartis Ag | Antibody formulation |
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- 2004-11-04 SI SI200431280T patent/SI1682180T1/sl unknown
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- 2004-11-04 ES ES09075395T patent/ES2435410T3/es not_active Expired - Lifetime
- 2004-11-04 PT PT04810420T patent/PT1694360E/pt unknown
- 2004-11-04 AT AT04810420T patent/ATE476448T1/de active
- 2004-11-04 DK DK09075395.5T patent/DK2149585T3/da active
- 2004-11-04 EP EP04810420A patent/EP1694360B1/en not_active Expired - Lifetime
- 2004-11-04 JP JP2006538514A patent/JP4765039B2/ja not_active Expired - Fee Related
- 2004-11-04 EP EP09075395.5A patent/EP2149585B1/en not_active Expired - Lifetime
- 2004-11-04 WO PCT/US2004/036957 patent/WO2005044306A2/en not_active Ceased
- 2004-11-04 JP JP2006538540A patent/JP5019881B2/ja not_active Expired - Lifetime
- 2004-11-04 CN CN200480037489.4A patent/CN1938045B/zh not_active Expired - Lifetime
- 2004-11-04 DE DE602004028505T patent/DE602004028505D1/de not_active Expired - Lifetime
- 2004-11-04 KR KR1020067010894A patent/KR101125127B1/ko not_active Expired - Fee Related
- 2004-11-04 PL PL04810420T patent/PL1694360T3/pl unknown
- 2004-11-04 DK DK04810420.2T patent/DK1694360T3/da active
- 2004-11-04 AU AU2004287879A patent/AU2004287879C1/en not_active Ceased
- 2004-11-04 DK DK04810421.0T patent/DK1682178T3/da active
- 2004-11-04 AT AT04810510T patent/ATE447412T1/de active
-
2006
- 2006-04-26 IL IL175225A patent/IL175225A/en not_active IP Right Cessation
- 2006-06-05 EC EC2006006607A patent/ECSP066607A/es unknown
- 2006-06-05 MA MA29078A patent/MA28331A1/fr unknown
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2010
- 2010-01-15 CY CY20101100045T patent/CY1110231T1/el unknown
- 2010-09-28 CY CY20101100869T patent/CY1110803T1/el unknown
- 2010-10-18 CY CY20101100931T patent/CY1110839T1/el unknown
- 2010-12-13 JP JP2010277537A patent/JP2011072317A/ja not_active Withdrawn
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2011
- 2011-02-18 JP JP2011033969A patent/JP2011126900A/ja not_active Withdrawn
- 2011-02-25 JP JP2011040922A patent/JP2011105769A/ja not_active Withdrawn
- 2011-04-05 AU AU2011201529A patent/AU2011201529B2/en not_active Ceased
-
2012
- 2012-03-05 EC ECSP12006607 patent/ECSP12006607A/es unknown
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2013
- 2013-11-13 HR HRP20131085TT patent/HRP20131085T1/hr unknown
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